DouglasAdamRubinsonMDPhD(He/Him)

PubMed

• RAS/RAF co-mutation and ERBB2 copy number modulates HER2 heterogeneity and responsiveness to HER2-directed therapy in colorectal cancer.
  Singh, H., Sahgal, P., Kapner, K., Corsello, S., Gupta, H., Gujrathi, R., Li, Y., Cherniack, A., El Alam, R., Kerfoot, J., Andrews, E., Lee, A., Nambiar, C., Hannigan,...> ;Clinical Cancer Research. 2024 Feb 12
• Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders.
  Huffman, B., Singh, H., Ali, L., Horick, N., Wang, S., Hoffman, M., Metayer, K., Murray, S., Bird, A., Abrams, T., Biller, L., Chan, J., Meyerhardt, J., McCleary, N., ...> ;Journal for Immunotherapy of Cancer. 2024 Jan 25
• 1 citations
  Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers.
  Douglas A Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron,...> ;Cancer Discovery. 2024 Jan 18
• 1 citations
  A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Ad...
  Huffman, B., Feng, H., Parmar, K., Wang, J., Kapner, K., Kochupurakkal, B., Martignetti, D., Sadatrezaei, G., Abrams, T., Biller, L., Giannakis, M., Ng, K., Patel, A.,...> ;Clinical Cancer Research. 2023 Dec 15
• 1 citations
  Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer.
  Roni Ben-Ami, Qiao-Li Wang, Jinming Zhang, Julianna G Supplee, Johannes F Fahrmann, Roni Lehmann-Werman, Lauren K Brais, Jonathan Nowak, Chen Yuan, Maureen Loftus, Ana...> ;Gut. 2024 Mar 7
• Pancreatic Adenocarcinoma: Real World Evidence of Care Delivery in AccessHope Data.
  Afsaneh Barzi, Angela J Kim, Crystal K Liang, Howard West, D Wong, Carol Wright, Nitya Nathwani, Catherine M Vasko, Vincent Chung, Douglas A Rubinson, Todd Sachs> ;Journal of Personalized Medicine. 2023 Sep 15
• 3 citations
  Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer.
  Harshabad Singh, Rachel B Keller, Kevin S Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K Brai...> ;Clinical Cancer Research. 2023 Nov 14
• G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans.
  Victoire Cardot-Ruffino, Naima Bollenrucher, Luisa Delius, S Jennifer Wang, Lauren K Brais, Joshua Remland, C Elizabeth Keheler, Keri M Sullivan, Thomas A Abrams, Leah...> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
• Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer.
  Harshabad Singh, Samuel J Klempner, Nelya Melnitchouk, Deepak P Chander, Ovidiu George Negrea, Anuj K Patel, Benjamin L Schlechter, Douglas A Rubinson, Brandon M Huffm...> ;JCO Precision Oncology. 2023 Jun 1
• 1 citations
  USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.
  Naiara Perurena, Rebecca Lock, Rachel A Davis, Srivatsan Raghavan, Natalie F Pilla, Raymond Ng, Patrick Loi, Caroline J Guild, Abigail L Miller, Ewa Sicinska, James M ...> ;Cell Reports. Medicine. 2023 Apr 18
• 3 citations
  Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer.
  Kimberly Perez, Anna M Chiarella, James M Cleary, Nora Horick, Colin Weekes, Thomas Abrams, Lawrence Blaszkowsky, Peter Enzinger, Marios Giannakis, Lipika Goyal, Jeffr...> ;The Oncologist. 2023 May 8
• 2 citations
  Programmatic Precision Oncology Decision Support for Patients With Gastrointestinal Cancer.
  Rachel B Keller, Tali Mazor, Lynette Sholl, Andrew J Aguirre, Harshabad Singh, Nilay Sethi, Adam Bass, Ankur K Nagaraja, Lauren K Brais, Emma Hill, Connor Hennessey, M...> ;JCO Precision Oncology. 2023 Jan 1
• 4 citations
  Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma.
  Brandon M Huffman, Haley Ellis, Alexander C Jordan, William A Freed-Pastor, Kimberly Perez, Douglas A Rubinson, Nilay Sethi, Harshabad Singh, Rishi Surana, Brian M Wol...> ;Cancers. 2022 Dec 16
• 12 citations
  Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity.
  Hannah L Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S Winter, Kevin S Kapner, Scott P Ginebaugh, Sara A Väyrynen, Juha P Väyrynen, Chen Yu...> ;Cancer Research. 2023 Feb 3
• 6 citations
  The past, present, and future of chemotherapy with a focus on individualization of drug dosing.
  Louis DeRidder, Douglas A Rubinson, Robert Langer, Giovanni Traverso> ;Journal of Controlled Release. 2022 Dec 1
• Preface.
  Douglas A Rubinson, Matthew B Yurgelun> ;Hematology/oncology Clinics of North America. 2022 Oct 1
• 15 citations
  Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer.
  Andressa Dias Costa, Sara A Väyrynen, Akhil Chawla, Jinming Zhang, Juha P Väyrynen, Mai Chan Lau, Hannah L Williams, Chen Yuan, Vicente Morales-Oyarvide, Dalia Elganai...> ;Clinical Cancer Research. 2022 Dec 1
• 1 citations
  Cetuximab and Irinotecan With or Without Bevacizumab in Refractory Metastatic Colorectal Cancer: BOND-3, an ACCRU Network Randomized Clinical Trial.
  Marla Lipsyc-Sharf, Fang-Shu Ou, Matthew B Yurgelun, Douglas A Rubinson, Deborah Schrag, Shaker R Dakhil, Philip J Stella, Douglas J Weckstein, Donald B Wender, Meredi...> ;The Oncologist. 2022 Apr 5
• Physical activity in older adults with metastatic gastrointestinal cancer: a pilot and feasibility study.
  Justin C Brown, Elizabeth Brighton, Nancy Campbell, Nadine J McCleary, Thomas A Abrams, James M Cleary, Peter C Enzinger, Kimmie Ng, Douglas Rubinson, Brian M Wolpin, ...> ;BMJ Open Sport & Exercise Medicine. 2022 Jan 1
• 142 citations
  Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
  Srivatsan Raghavan, Peter S Winter, Andrew W Navia, Hannah L Williams, Alan DenAdel, Kristen E Lowder, Jennyfer Galvez-Reyes, Radha L Kalekar, Nolawit Mulugeta, Kevin ...> ;Cell. 2021 Dec 9
• 2 citations
  Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the PO...
  Douglas Rubinson, Brian M Wolpin, Ilana S Warsofsky, David P Ryan, Kimberly Perez, Osama Rahma, Harshabad Singh, Matthew B Yurgelun, Geoffrey I Shapiro, Andrew J Aguir...> ;Journal of Gastrointestinal Oncology. 2021 Dec 1
• 12 citations
  Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival.
  Leonie K. de Klerk, Anuj K. Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G Akarca, Nadine Jackson McCleary, James M. Cle...> ;Journal for Immunotherapy of Cancer. 2021 Sep 1
• 14 citations
  Pancreatic acinar cell carcinoma: A multi-center series on clinical characteristics and treatment outcomes.
  Vishwajith Sridharan, Mari Mino-Kenudson, James M. Cleary, Osama E. Rahma, Kimberly Perez, Jeffrey W. Clark, Thomas E. Clancy, Douglas A. Rubinson, Lipika Goyal, Fateh...> ;Pancreatology. 2021 May 15
• 29 citations
  FGFR2 Extracellular Domain In-Frame Deletions Are Therapeutically Targetable Genomic Alterations That Function as Oncogenic Drivers in Cholangiocarcinoma.
  James M. Cleary, Srivatsan Raghavan, Qibiao Wu, Yvonne Y. Li, Liam F. Spurr, Hersh Gupta, Douglas A. Rubinson, Isobel J Fetter, Jason L. Hornick, Jonathan A. Nowak, Gi...> ;Cancer Discovery. 2021 Apr 29
• 68 citations
  Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
  Shannon M. Liudahl, Courtney Betts, Shamilene Sivagnanam, Vicente Morales-Oyarvide, Annacarolina da Silva, Chen Yuan, Samuel Hwang, Alison Grossblatt-Wait, Kenna R. Le...> ;Cancer Discovery. 2021 Mar 16
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Journal Articles

• Diabetes, Weight Change, and Pancreatic Cancer Risk  
  Douglas A Rubinson, Kimmie Ng, Meir J Stampfer, Brian M Wolpin, JAMA Oncology
• Germline Cancer Susceptibility Gene Variants, Somatic Second Hits, and Survival Outcomes in Patients with Resected Pancreatic Cancer  
  Richard F Dunne, Leona A Doyle, William C Hahn, Jason L Hornick, Andrea J Bullock, Sapna Syngal, Albert C Koong, Natalia Khalaf, Brian M Wolpin, Douglas A Rubinson, Da..., Nature