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300 George StreetRm8300GNew Haven, CT 06515
Phone+1 203-737-2765
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Summary
- Dr. Grutzendler obtained his MD at Universidad Javeriana in Bogota, Colombia where he was born and raised. He completed a medical internship in Internal Medicine and a residency in Neurology at Washington University/Barnes-Jewish Hospital in St. Louis. This was followed by a combined clinical and research fellowship in the Alzheimer Disease Research Center and the Department of Neurobiology at Washington University and further neurobiology research training at the Skirball Institute of New York University. Dr. Grutzendler's clinical interests focus on neurodegenerative disorders with special emphasis in dementias such as Alzheimer's disease. He also leads a research laboratory focused on understanding brain function and the cellular basis of neurological diseases. Specifically he is interested in elucidating cellular and molecular mechanisms of neurodegeneration, development of methods for intravital brain imaging and targeted in vivo cellular manipulation, and translational neuroscience with therapeutics efforts within the field of neurodegeneration and nervous system injury.
Education & Training
New York University School of MedicinePost-Doctoral Fellowship, 2001 - 2003
Washington University/B-JH/SLCH ConsortiumFellowship, Dementia/Alzheimer's and Neurobiology , 1998 - 2000
Washington University/B-JH/SLCH ConsortiumResidency, Neurology, 1995 - 1998
Washington University/B-JH/SLCH ConsortiumInternship, Internal Medicine, 1994 - 1995
Pontifical Xavierian UniversityClass of 1991
Certifications & Licensure
CT State Medical License 2011 - 2027
IL State Medical License 2004 - 2014
American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- Connecticut Academy of Science and Engineering, Elected Member 2018
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016
- American Society for Clinical Investigation (Elected member) 2012
Publications & Presentations
PubMed
- Programming Brain Cell-Type-Selective Delivery In Vivo with Transporter-Guided Therapeutics.Roshan W Gunasekara, Lejie Zhang, Lei Tong, John Zhou, Hoang Kim Trinh
Biorxiv. 2026-06-18 - 1 citationsTREM2 and APOE are dispensable for microglial clearance of dying neurons revealed byimaging.Anupama Rai, Eyiyemisi C Damisah, Robert A Hill, Lei Tong, Jaime Grutzendler
Iscience. 2026-02-20 - Basic Science and Pathogenesis.Yifei Cai, Iguaracy Pinheiro-de-Sousa, Mykhaylo Slobodyanyuk, Fuyi Chen, Tram Huynh
Alzheimer's & Dementia. 2025-12-01
Press Mentions
Scientists Identify the Primary Driver of Alzheimer’s DiseaseAugust 9th, 2025
Major Scientific Breakthrough Uncovers the Cause of Alzheimer’s DiseaseFebruary 21st, 2025
Scientists Discover the Cause of Alzheimer’s Disease, Impacting Millions WorldwideFebruary 11th, 2025
Grant Support
- Augmenting AXL and MERTK function to restrain cognitive decline and improve health span in mouse models of Alzheimer's DiseaseUNIVERSITY OF MINNESOTA2023–2028
- Vascular Mechanisms of Dementia: Cell-Type Specific Therapeutic and Imaging StrategiesYALE UNIVERSITY2022–2027
- Augmenting AXL and MERTK function to restrain cognitive decline and improve health span in mouse models of Alzheimer's DiseaseYALE UNIVERSITY2023–2026
- Mechanisms of axonal protection by astrocytes and microglia inAlzheimer diseaseYALE UNIVERSITY2022–2026
- Vascular Mechanisms of Dementia: Cell-Type Specific Therapeutic and Imaging StrategiesYALE UNIVERSITY2022–2025
Other Languages
- Spanish
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