Jay Dilip Raman MD FACS

Urology•Hershey, PA

Minimally Invasive Surgery, Surgical Oncology

Professor and Chair Department of Urology Penn State Health Milton S. Hershey Medical Center

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500 University DrHershey, PA 17033
Phone+1 717-531-8887
Fax+1 717-531-4475

Summary

Jay D. Raman, MD, FACS, FRCS(Glasg) is Professor and Chair of Urology at the Penn State Health Milton S. Hershey Medical Center.

He received his undergraduate degree from the Massachusetts Institute of Technology (MIT) in 1997 and graduated AOA from Cornell University Medical College in 2001. Dr. Raman completed his Urology Residency at New York Presbyterian Hospital - Cornell Medical Center followed by a Fellowship in Minimally Invasive Surgery at the University of Texas Southwestern Medical Center in Dallas.

Dr. Raman has been an attending physician at Penn State Health Milton S. Hershey Medical Center since 2008. He was promoted to Associate Professor (2011) and Professor (2016) of Surgery. He served as Division Chief of Urology from 2015 – 2020 prior to becoming the Chair of the Department of Urology in 2021.

Dr. Raman’s clinical practice focuses on robotic-assisted surgery for upper and lower tract urologic cancers. His basic science research centers on infectious complications following prostate needle biopsy, while his major clinical research efforts revolve around staging and therapy for upper-tract urothelial carcinoma as well as complications of urologic surgery.

To date, he has co-authored over 400 manuscripts, book chapters, and editorials and serves on the editorial board for three journals and as a reviewer for 12 journals. He has received over 1.8 million dollars of federal, foundation, and industry funding on over 10 prospective clinical trials.

Dr. Raman is Past-Chair of the American Urologic Association Office of Education and Past-President of the Mid-Atlantic AUA section. He is the current Program Chair for the Advisory Council of Urology within the American College of Surgeons.

Penn State Health - Dr. Jay Raman

Dr. Jay Raman, Chair of the Department of Urology at Penn State Health, and Gene Veno's surgeon, joined us again to share more details on Gene's story and to ta

Infections Following Prostate Needle Biopsy An Evidence-Based Approach to Tackli

Jay D. Raman, MD addresses infections following prostate needle biopsy, presenting an evidence-based approach to managing this common problem. He notes the prev

High-intensity focused ultrasound: Noninvasive prostate cancer treatment

Gene Veno's life changed after watching an abc27 News special on prostate cancer. Intrigued by a new, noninvasive treatment called high-intensity focused ultras

The Future of Urology Education: How to Stay Up to Date w/ Dr. Jay Raman | BackT

In this episode of BackTable Urology, Dr. Bagrodia and Dr. Jay Raman, the chair of urology at Penn State Health, discuss advancements and future directions of m

Defense secretary's diagnosis highlights stigma surrounding prostate cancer

The diagnosis of Defense Secretary Lloyd Austin's prostate cancer, and his initial decision not to disclose it, has put that cancer back at the center of some a

Biden's prostate cancer diagnosis should serve as reminder to men to get screene

The former president at 82 is beyond the age cutoff when regular screenings for prostate cancer are no longer recommended, however for men in their 50s and 60s,

After Biden's diagnosis, a look at prostate cancer's impact on men in the U.S.

Former President Biden has been diagnosed with an aggressive form of prostate cancer. Among men in the U.S., prostate cancer is the most common cancer and the s

AUA 2025 Microhematuria Guideline Amendment

UroToday

Clinical Expertise

Urologic oncology, Minimally invasive urologic surgery, Nephrectomy, Local Neoplasm Recurrence, Retrospective Studies, Kidney Neoplasms, Laparoscopy, Health outcomes research, Prognosis, Urologic Neoplasms, Adrenal disease, Prostatectomy, Biopsies, Combined modality therapy, Hydronephrosis, Neoplasm staging, Immunohistochemistry, Ureteroscopy, Lymph node excision, Logistic models, Testicular cancer, Bladder cancer, Kidney cancer, Robotic partial nephrectomy, Prostate cancer

Education & Training

University of Texas Southwestern Medical CenterFellowship, Minimally Invasive Urologic Surgery, 2007 - 2008
New York Presbyterian Hospital (Cornell Campus)Residency, Urology, 2003 - 2007
New York Presbyterian Hospital (Cornell Campus)Residency, Surgery, 2001 - 2003
Weill Cornell MedicineClass of 2001
Massachusetts Institute of TechnologyB.S., 1997

Certifications & Licensure

PA State Medical License 2008 - 2026
NY State Medical License 2003 - 2008
TX State Medical License 2007 - 2008
American Board of Urology Urology
American College of SurgeonsFellow
Endourology SocietyFellowship Certification
Society of Urologic OncologyMember

Awards, Honors, & Recognition

First Place 42nd Annual Ralph E. Hopkins Urology Seminar, 2023
Top Doctors Castle Connolly, 2020-2023
AUA Distinguished Service Nominee Mid-Atlantic Section of AUA, 2019
AUA Gold Cystoscope Award Nominee Mid-Atlantic AUA Section, 2017
Young Urologist of the Year American Urological Association, 2015
Best Reviewer of the Year Journal of Urology, 2014
Essay Contest (2nd prize) Endourology Society, 2008
Outstanding Resident Award Society of Laparoscopic Surgeons, 2007
Distinguished Housestaff Award New York Presbyterian Hospital, 2006
John W. Coleman Resident Teaching Award in Urology 2006
John Metcalf Polk Prize for Highest Academic Achievement 2001
E. Darracott Vaughan Jr. Prize for Excellence in Urology v 2001
Scholar Teagle Foundation, 2001
Alpha Omego Alpha (AOA) Medical Honor Society 1999
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Clinical Trials

The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study Start of enrollment: 2017 Apr 04
Completed
Phase 3
Multi Institutional Study in Patient Presenting With Hematuria Start of enrollment: 2017 Mar 31
Active, not recruiting
Neoadjuvant Apalutamide (ARN509) and Radical Prostatectomy in Treatment of Intermediate to High Risk Prostate Cancer Start of enrollment: 2017 Jun 20
Completed
Phase 2
A Phase 2b Study of UGN-102 for Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer Start of enrollment: 2018 Oct 15
Completed
Phase 2
STRATA: Safe Testing of Risk for AsymptomaTic MicrohematuriA Start of enrollment: 2019 Sep 11
COMPLETED
NA
A Phase 3 Single-Arm Study of UGN-102 for Treatment of Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer Start of enrollment: 2022 Mar 01
ACTIVE_NOT_RECRUITING
PHASE3
Roles: Contact, Principal Investigator
ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study Start of enrollment: 2021 Mar 22
RECRUITING
PHASE3
Roles: Contact
A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer Start of enrollment: 2025 May 02
RECRUITING
PHASE3
Study to Assess the Impact of the Urine Test Cxbladder Triage Plus on the Number of Cystoscopies Performed on Patients With Invisible Blood in Their Urine. Start of enrollment: 2025 Apr 29
RECRUITING
NA
A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT Start of enrollment: 2023 Dec 14
RECRUITING
PHASE3
Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC Start of enrollment: 2024 Sep 16
RECRUITING
PHASE2
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Publications & Presentations

PubMed

Utilization of genetic evaluation in patients with kidney cancer who meet guidelines for genetic referral.
Elizaveta Makarova, Katrina Bakhl, Seyma Demirsoy, Kevin Xu, Grace Ryu
Urologic Oncology. 2025-08-13
Revisiting Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma: Real-World Evidence of Survival Benefit with First-Line Immunotherapy and Targeted Therapy Reg...
Sri Saran Manivasagam, Alireza Aminsharifi, Jay D Raman
Journal of Clinical Medicine. 2025-08-06
Oncologic and survival outcomes in patients undergoing radical nephroureterectomy with preoperative or iatrogenic dialysis dependence.
Matthew S Lee, Patrick J Hensley, Daniel Igel, Roger Li, Roderick K Clark
Urologic Oncology. 2025-08-02

Journal Articles

Original Contribution Mitotic Activity in Non-Invasive Papillary Urothelial Carcinoma: Its Value in Predicting Tumor Recurrence, and Comparison to the Contemporary Two...
Augustyna Gogoj, Suzanne B Merrill, Monika Joshi, Sheldon Holder, Joshua I Warrick, Matthew Kaag, Jay D Raman, Joseph Drabick, ScienceDirect
Predicted Versus Observed 30-Day Perioperative Outcomes Using the ACS NSQIP Surgical Risk Calculator in Patients Undergoing Partial Nephrectomy for Renal Cell Carcinoma
Brian M Blair, Jay D Raman, Matthew G Kaag, International Urology and Nephrology
TALL score for prediction of oncological outcomes after radical nephroureterectomy for high-grade upper tract urothelial carcinoma
Youssef RF, Krabbe LM, Shariat SF, Lotan Y, Sagalowsky AI, Raman J, Wood CG, Weizer A, Roscigno M, Montorsi F, Bolenz C, Remzi M, Bensalah K, Kassouf W, Margulis V, World J Urol, 1/1/2015
Lynch syndrome: a primer for urologists
Mork M, Hubosky SG, Roupret M, Margulis V, Raman J, Lotan Y, O'Brien T, You N, Sharait SF, Matin SF, J Urol, 1/1/2015
Volumetric changes following partial nephrectomy
Raman JD, Can J Urol, 1/1/2015
Systemic chemotherapy and radical nephroureterectomy
Jafri S and Raman JD, Int Urol Nephrol, 1/1/2015
Hospital readmission following urologic surgery
Raman JD, Can J Urol, 1/1/2015
Multi-Institutional Validation of the Predictive Value of KI-67 in Patients with High-Grade Urothelial Carcinoma of the Upper Urinary Tract
Krabbe LM, Bagrodia A, Haddad AQ, Kapur P, Khalil D, Hynan LS, Wood CG, Karam JA, Weizer AZ, Raman JD, Remzi M, Rioux-Leclercq N, Haitel A, Roscigno M, Bolenz C, Bensa..., J Urol, 1/1/2014
Peri-procedural povidone-iodine rectal preparation reduces microorganism counts and infections complications following ultrasound-guided needle biopsy of the prostate
Gyorfi JR, Otteni C, Brown K, Patel A, Lehman K, Phillips BE, Dewan K, Kirimanjeswara G, Raman JD, World J Urol, 1/1/2014
Insulin-like Growth Factor Messenger RNA-binding Protein 3 Expression Helps Prognostication in Patients with Upper Tract Urothelial Carcinoma
Lee DJ, Xylinas E, Rieken M, Khani F, Klatte T, Wood CG, Karam JA, Weizer AZ, Raman JD, Remzi M, Guo CC, Rioux-Leclercq N, Haitel A, Bolenz C, Bensalah K, Sagalowsky A..., Eur Urol, 1/1/2014
BAP1 Immunohistochemistry Predicts Outcomes in a Multi-Institutional Cohort with Clear Cell Renal Cell Carcinoma
Kapur P, Christie A, Raman JD, Then MT, Nuhn P, Buchner A, Bastian P, Seitz C, Shariat SF, Bensalah K, Rioux-Leclercq N, Xie XJ, Lotan Y, Margulis V, Brugarolas J, J Urol, 1/1/2014
Prediction of intravesical recurrence after radical nephroureterectomy: development of a clinical decision-making tool
Xylinas E, Kluth L, Passoni N, Trinh QD, Rieken M, Lee RK, Fajkovic H, Novara G, Margulis V, Raman JD, Lotan Y, Roupret M, Aziz A, Fritsche HM, Weizer A, Martinez-Sala..., Eur Urol, 1/1/2014
Predictors of survival in patients with disease recurrence following radical nephroureterectomy
Kluth LA, Xylinas E, Kent M, Hagiwara M, Kikuchi E, Matsumoto K, Ikeda M, Dalpiaz O, Zigeuner R, Aziz A, Fritsche HM, Deliere A, Raman JD, Bensalah K, Al-Matar B, Gaki..., BJU Int, 1/1/2014
Upper Tract Urothelial Carcinoma Collaboration Impact of Distal Ureter Management on Oncologic Outcomes Following Radical Nephroureterectomy for Upper Tract Urothelial...
Xylinas E, Rink M, Cha EK, Clozel T, Lee RK, Fajkovic H, Comploj E, Novara G, Margulis V, Raman JD, Lotan Y, Kassouf W, Fritsche HM, Weizer A, Martinez-Salamanca JI, M..., Eur Urol, 1/1/2014
Considerations regarding active surveillance for small renal masses
Raman JD, Can J Urol, 1/1/2014
Editorial Comment from Dr Kaag and Dr Raman to Obesity and prognosis in muscle-invasive bladder cancer: the continuing controversy
Kaag MG, Raman JD, Int J Urol, 1/1/2014
Editorial Comment to Retreatment after percutaneous nephrolithotomy in the computed tomography era: long-term follow-up
Reynolds CR, Raman JD, Urology, 1/1/2014
Empiric antibiotics for an elevated prostate-specific antigen (PSA) level: a randomized, prospective, controlled multi-institutional trial
Eggener SE, Large MC, Gerber GS, Pettus J, Yossepowitch O, Smith ND, Kundu S, Kunnavakkam R, Zorn K, and Raman JD, BJU Int, 1/1/2013
Upper Tract Urothelial Carcinoma Collaboration (UTUCC) Gender-specific effect of smoking on upper tract urothelial carcinoma outcomes
Rink M, Xylinas E, Trinh QD, Lotan Y, Margulis V, Raman JD, Fisch M, Lee RK, Chun FK, Abdennabi J, Seitz C, Pycha A, Zlotta AR, Karakiewicz PI, Babjuk M, Scherr DS, Sh..., BJU Int, 1/1/2013
UTUC Collaboration Impact of renal function on eligibility for chemotherapy and survival in patients who have undergone radical nephro-ureterectomy
Xylinas E, Rink M, Margulis V, Clozel T, Lee RK, Comploj E, Novara G, Raman JD, Lotan Y, Weizer A, Roupret M, Pycha A, Scehrr DS, Seitz C, Ficarra V, Trinh QD, Karakie..., BJU Int, 1/1/2013
Conservative nephron-sparing treatment of upper-tract tumors
Smith P, Mandel J, and Raman JD, Curr Urol Reports, 1/1/2013
Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to...
Lin YK, Gettle L, and Raman JD, BJU Int, 1/1/2013
UTUC Collaboration Prediction of true nodal status in patients with pathologic lymph node negative upper tract urothelial carcinoma at radical nephroureterectomy
Xylinas E, Rink M, Margulis V, Faison T, Comploj E, Novara G, Raman JD, Lotan Y, Guillonneau B, Weizer A, Pycha A, Scherr DS, Seitz C, Sun M, Trinh QD, Karakiewicz PI,..., J Urol, 1/1/2013
French National Database on Upper Tract Tumors and the Upper Tract Urothelial Carcinoma Collaboration (UTUCC) Prediction of cancer-specific survival after radical neph...
Roupret M, Hupertan V, Seisen T, Colin P, Xylinas E, Yates DR, Fajkovic H, Lotan Y, Raman JD, Zigeuner R, Remzi M, Bolenz C, Novara G, Kassouf W, Ouzzane A, Rozet F, C..., J Urol, 1/1/2013
Upper Tract Urothelial Carcinoma Collaboration Impact of Smoking on Oncologic Outcomes of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy
Rink M, Xylinas E, Margulis V, Cha EK, Ehdaie B, Raman JD, Chun FK, Matsumoto K, Lotan Y, Furberg H, Babjuk M, Pycha A, Wood CG, Karakiewicz PI, Fisch M, Scherr DS, Sh..., Eur Urol, 1/1/2013
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Books/Book Chapters

Prostate Cancer
Chapter: Indications for pelvic lymphadenectomy
Raman JD and Gherezghihir AElsevier-SaundersEdition 2nd,2015
Campbell-Walsh Urology
Chapter: Hematuria: Diagnosis and Management
Boorjian SA, Raman JD, Barocas DAElsevier-SaundersEdition 11th,2014
Clinical Management of Urolithiasis
Chapter: Acute Flank Pain
Rippel C and Raman JDSpringer-Verlag, Heidelberg, Berlin, Germany2012
Scar-LESS surgery
Chapter: Single port laparoscopy: Issues and Complications
Raman JDSpringer-Verlag, NY2012
Smith's Textbook of Endourology
Chapter: Physiologic effects of pneumoperitoneum
Raman JD and Cadeddu JAJohn Wiley and Sons, UKEdition 3rd,2010
AUA Update Series
Chapter: Management of stones in anomalous kidneys
Page 210 - 219Elliott VL, Clements T, Gettle L, and Raman JD2010
Evidence-based Urology
Chapter: Surgical management of ureteral stone disease
Raman JD and Pearle MSEditors: Dahm P and Dmochowski R.John Wiley and Sons, UK2010
Urinary Tract Stone Disease
Chapter: Shock wave lithotripsy for ureteral calculi
Raman JD and Pearle MSEditors: Rao NP, Preminger GM, and Kavanagh JP.2010
Cancer of the Testis
Chapter: Post-chemotherapy retroperitoneal lymph node dissection
Raman JD and Sheinfeld JEditors: Laguna MP, Albers P, Richie J, and Bokemeyer, C.Springer London Ltd,, UK2010
AUA Update Series
Chapter: Natural orifice transluminal endoscopic surgery: potential applications in urology
Page 150 - 155Messer J, Raman JD, Tracy CR, and Cadeddu JA2009
Last Minute Internal Medicine Review Book
Chapter: Urologic Disorders
Raman JD and Scherr DSEditors: Miksad R, DeLaMora P, and Meyer G.McGraw-Hill, NY2008
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Lectures

Evaluation and management of urinary tract bleeding: from asymptomatic microhematuria to intractable hemorrhagic cystitis
1/1/2015
Upper-tract Urothelial Carcinoma: controversies and considerations
Washington, DC - 1/1/2015
Surgical management of urothelial carcinoma with squamous differentiation
1/1/2014
Robotic surgery
Hershey, PA - 1/1/2014
Twenty-five years of urothelial cancer in Pennsylvania
Hershey, PA - 1/1/2014
Kidney Cancer, Reducing Cancer in our Community
Hershey, PA - 1/1/2014
Lasers, Laparoscopes, and Lithotvriptors: The science behind minimally invasive surgery
Charlottesville, VA - 1/1/2013
Contemporary outcomes of renal thermal ablation
Penn State Hershey Medical Center, Hershey, PA - 1/1/2013
Creating an infrastructure for comprehensive care of urologic diseases
Washington, DC - 1/1/2013
Prostate Cancer Take Home Highlights
San Diego, CA - 1/1/2013
Lasers, laparoscopes, and lithotripters: the science of minimally invasive surgery
Charlottesville, VA - 1/1/2013
Best of the American Urologic Association (AUA)
San Jose, CR - 1/1/2013
Infectious complications following prostate needle biopsy: an increasing problem with need for solutions
White Sulfur Springs, WV - 1/1/2013
Strategies to reduce infections following prostate needle biopsy
Penn State University, University Park, PA - 1/1/2013
Single port laparoscopic surgery in urology: setting Started
North Shore Center for Simulation and Innovation, Evanston, IL - 1/1/2011
Pitfalls for single site laparoscopic surgery
Washington, DC - 1/1/2011
Management of a rising PSA following surgery or radiotherapy for localized prostate cancer
State College, PA - 1/1/2011
Changes in urinary biomarkers of kidney injury following partial nephrectomy
Oakland, CA - 1/1/2011
Prostate cancer screening - making (some) sense out of the controversy
State College, PA - 1/1/2011
Invasive and non-invasive access considerations for robotic assisted urologic surgery
Penn State Hershey Medical Center, Hershey, PA - 1/1/2010
Single site laparoscopic surgery: fad or future
University of Miami School of Medicine, Miami, FL - 1/1/2010
Surveillance for management of the small renal mass
Farmington, PA - 1/1/2010
Why should we pursue LESS?
Chicago, IL - 1/1/2010
Access for LESS nephrectomy
Chicago, IL - 1/1/2010
LESS: Challenges, complications, and how to avoid them
San Francisco, CA - 1/1/2010
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Authored Content

Highlights from AUA 2023May 2023
AUA Hybrid Format SuccessMay 2022
Multi-Institutional Evaluation of the Prognostic Significance of EZH2 Expression in High-Grade Upper Tract Urothelial CarcinomaMay 2018
Multi-Institutional Evaluation of the Prognostic Significance of EZH2 Expression in High-Grade Upper Tract Urothelial CarcinomaMay 2018
Multi-Institutional Evaluation of the Prognostic Significance of EZH2 Expression in High-Grade Upper Tract Urothelial CarcinomaMay 2018
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Press Mentions

Biden’s Prostate Cancer Diagnosis Should Serve as Reminder to Men to Get ScreenedMay 19th, 2025
Penn State Health Offers Innovative Aquablation Therapy to Treat Enlarged ProstateJuly 15th, 2024
College of Medicine Researchers Discover Different Types of Bladder Cancer Cells Share Common Genetic AncestryMarch 29th, 2023
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Grant Support

The Efficacy and Safety of UGN-102 as a Primary Chemoablation Therapy in Patients With LG NMIBC at Intermediate Risk of RecurrenceUrogen Pharma Ltd2019–2021
The CXBladder Hematuria Clinical Utility StudyPacific Edge Biotechnologies2019–2021
A Phase 3 Multicenter Trial Evaluating the Efficacy and Safety of Instillation of Mitogel on Ablation of Urothelial Carcinoma Lesions in the Upper Urinary TractUrogen Pharma Ltd2017–2020
Multi-Institutional Study To Evaluate DNA Methylation Markers For Detection Of Primary Bladder Cancers In Urine Samples From a Cohort Of Patients With HematuriaMDXHealth Inc.2017–2019
Association of metabolic syndrome with pathologic characteristics of kidney cancerPenn State Kidney Cancer Fund2015–2019
Impact of low dose naltrexone on in vitro and in vivo prostate cancer growthKen and Bonnie Shockey Fund2014–2019
Molecular profiling of high risk bladder cancer to predict BCG responsivenessAlbert Foundation2016–2018
Nanojacket delivery of novel antibioticsPenn State Clinical Translational Science Institute (CTSI)2015–2017