AlexanderRalphCobitzMD

PubMed

• 2 citations
  Analysis of on-treatment cancer safety events with daprodustat versus conventional erythropoiesis-stimulating agents-post hoc analyses of the ASCEND-ND and ASCEND-D tr...
  Ajay K Singh, Finnian R McCausland, Brian L Claggett, Christoph Wanner, Andrzej Wiecek, Michael B Atkins, Kevin Carroll, Vlado Perkovic, John J V McMurray, Janet Witte...> ;Nephrology, Dialysis, Transplantation. 2023 Jul 31
• 8 citations
  The ASCEND-NHQ randomized trial found positive effects of daprodustat on hemoglobin and quality of life in patients with non-dialysis chronic kidney disease.
  Kirsten L Johansen, Alexander R Cobitz, Ajay K Singh, Iain C Macdougall, Renato D Lopes, Gregorio T Obrador, Csaba P Kovesdy, Rubeen Israni, Vivekanand Jha, Tony Okoro...> ;Kidney International. 2023 Jun 1
• Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D).
  Iain C Macdougall, Amy M Meadowcroft, Allison Blackorby, Borut Cizman, Alexander R Cobitz, Sergio Godoy, Vivekanand Jha, Kirsten L Johansen, Gearoid McMahon, Gregorio ...> ;American Journal of Nephrology. 2023 Jan 1
• 1 citations
  Safety of daprodustat in patients with anemia of chronic kidney disease: A pooled analysis of phase 3 studies in Japan.
  Masaomi Nangaku, Tadao Akizawa, Takashi Nagakubo, Taeko Yonekawa, Toshifumi Kimura, Yukihiro Endo, Alexander Cobitz> ;Therapeutic Apheresis and Dialysis. 2022 Dec 1
• 1 citations
  The ASCEND-ND trial: study design and participant characteristics.
  Vlado Perkovic, Allison Blackorby, Borut Cizman, Kevin Carroll, Alexander R Cobitz, Rich Davies, Tara L DiMino, Vivekanand Jha, Kirsten L Johansen, Renato D Lopes, Lat...> ;Nephrology, Dialysis, Transplantation. 2022 Oct 19
• 11 citations
  Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients: ASCEND-TD: A Phase 3 Randomized, Double-Blind, N...
  Daniel W Coyne, Renato D Lopes, Christine K Bailey, Tara L DiMino, Chun Huang, Jeffrey Connaire, Anjay Rastogi, Sung-Gyun Kim, Marcelo Orias, Sapna Shah, Vickas Patel,...> ;Clinical Journal of the American Society of Nephrology. 2022 Sep 1
• 20 citations
  Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial.
  Ajay K Singh, Borut Cizman, Kevin Carroll, John J V McMurray, Vlado Perkovic, Vivekanand Jha, Kirsten L Johansen, Renato D Lopes, Iain C Macdougall, Gregorio T Obrador...> ;JAMA Internal Medicine. 2022 Jun 1
• 4 citations
  Pharmacokinetics of Daprodustat and Metabolites in Individuals with Normal and Impaired Hepatic Function.
  Kelly M Mahar, Bonnie C Shaddinger, Bandi Ramanjineyulu, Susan Andrews, Stephen Caltabiano, Alistair C Lindsay, Alexander R Cobitz> ;Clinical Pharmacology in Drug Development. 2022 May 1
• Challenges of Conducting Clinical Trials during the SARS-CoV-2 Pandemic: The ASCEND Global Program Experience.
  Kirsten L Johansen, Anjali Acharya, Borut Cizman, Alexander R Cobitz, Ricardo Correa-Rotter, Indranil Dasgupta, Vijay Kher, Renato D Lopes, Leonardo Matsumoto, Amy M M...> ;Kidney360. 2022 Apr 28
• 6 citations
  Clinical Pharmacokinetics of Daprodustat: Results of an Absorption, Distribution, and Excretion Study With Intravenous Microtracer and Concomitant Oral Doses for Bioav...
  Kelly M. Mahar, Stephen Caltabiano, Susan Andrews, Bandi Ramanjineyulu, Liangfu Chen, Graeme Young, Adrian Pereira, Alistair C. Lindsay, Frans van den Berg, Alexander ...> ;Clinical Pharmacology in Drug Development. 2021 Oct 28
• 10 citations
  Efficacy and safety of daprodustat in Japanese peritoneal dialysis patients
  Hidetoshi Kanai, Masaomi Nangaku, Reiko Nagai, Nobuhiko Okuda, Kyo Kurata, Takashi Nagakubo, Yukihiro Endo, Alexander R. Cobitz> ;Therapeutic Apheresis and Dialysis. 2021 May 8
• 7 citations
  Study design and baseline characteristics of patients on dialysis in the ASCEND-D trial.
  Ajay K. Singh, Allison Blackorby, Borut Cizman, Kevin Carroll, Alexander R. Cobitz, Rich Davies, Vivekanand Jha, Kirsten L. Johansen, Renato D. Lopes, Lata Kler, Iain ...> ;Nephrology, Dialysis, Transplantation. 2021 Mar 21
• 32 citations
  Daprodustat Compared with Epoetin Beta Pegol for Anemia in Japanese Patients Not on Dialysis: A 52-Week Randomized Open-Label Phase 3 Trial.
  Masaomi Nangaku, Takayuki Hamano, Tadao Akizawa, Yoshiharu Tsubakihara, Reiko Nagai, Nobuhiko Okuda, Kyo Kurata, Takashi Nagakubo, Nigel P. Jones, Yukihiro Endo, Alexa...> ;American Journal of Nephrology. 2021 Feb 9
• 63 citations
  Efficacy and Safety of Daprodustat Compared with Darbepoetin Alfa in Japanese Hemodialysis Patients with Anemia: A Randomized, Double-Blind, Phase 3 Trial.
  Tadao Akizawa, Masaomi Nangaku, Taeko Yonekawa, Nobuhiko Okuda, Shinya Kawamatsu, Tomohiro Onoue, Yukihiro Endo, Katsutoshi Hara, Alexander R. Cobitz> ;Clinical Journal of the American Society of Nephrology. 2020 Aug 7
• 32 citations
  A 24-Week Anemia Correction Study of Daprodustat in Japanese Dialysis Patients
  Yoshiharu Tsubakihara, Tadao Akizawa, Masaomi Nangaku, Tomohiro Onoue, Taeko Yonekawa, Hideki Matsushita, Yukihiro Endo, Alexander R. Cobitz> ;Therapeutic Apheresis and Dialysis. 2020 Apr 1
• 24 citations
  A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat, administered three times weekly in patients with anemia on hemodialysis
  Christine K Bailey, Stephen Caltabiano, Alexander R. Cobitz, Chun Huang, Kelly M. Mahar, Vickas V. Patel> ;BMC Nephrology. 2019 Oct 16
• 20 citations
  Cardiovascular Event Rates Among Hemodialysis Patients Across Geographical Regions-A Snapshot From The Dialysis Outcomes and Practice Patterns Study (DOPPS).
  Heide A. Stirnadel-Farrant, Angelo Karaboyas, Borut Cizman, Brian Bieber, Lata Kler, Delyth Jones, Alexander R. Cobitz, Bruce M. Robinson> ;Kidney International Reports. 2019 Mar 28
• 15 citations
  Effect of renal function and dialysis modality on daprodustat and predominant metabolite exposure
  Stephen Caltabiano, Borut Cizman, Olivia Burns, Kelly M. Mahar, Brendan M Johnson, Bandi Ramanjineyulu, Gulyeter Serbest, Alexander R. Cobitz> ;Clinical Kidney Journal. 2019 Feb 18
• 80 citations
  Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis
  Amy M Meadowcroft, Borut Cizman, Louis Holdstock, Nandita Biswas, Brendan M Johnson, Delyth Jones, A Kaldun Nossuli, John J. Lepore, Michael Aarup, Alexander R. Cobitz> ;Clinical Kidney Journal. 2019 Feb 1
• 58 citations
  Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease
  Louis Holdstock, Borut Cizman, Amy M Meadowcroft, Nandita Biswas, Brendan M Johnson, Delyth Jones, Sung Gyun Kim, Steven Zeig, John J. Lepore, Alexander R. Cobitz> ;Clinical Kidney Journal. 2019 Feb 1
• 22 citations
  An Exploratory Study of Daprodustat in Erythropoietin-Hyporesponsive Subjects.
  Borut Cizman, Andy P. Sykes, Gitanjali Paul, Steven Zeig, Alexander R. Cobitz> ;Kidney International Reports. 2018 Mar 3
• 7 citations
  Anemia and mortality in patients with nondialysis-dependent chronic kidney disease.
  Heide A. Stirnadel-Farrant, Jiacong Luo, Lata Kler, Borut Cizman, Delyth Jones, Steven M. Brunelli, Alexander R. Cobitz> ;BMC Nephrology. 2018 Jun 11
• 15 citations
  The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects.
  Stephen Caltabiano, Kelly M. Mahar, Karyn Lister, David Tenero, Ramiya Ravindranath, Borut Cizman, Alexander R. Cobitz> ;Pharmacology Research & Perspectives. 2018 Apr 1
• 9 citations
  A Randomized, Placebo- and Positive-Controlled, Single-Dose, Crossover Thorough QT/QTc Study Assessing the Effect of Daprodustat on Cardiac Repolarization in Healthy S...
  Stephen Caltabiano, Jon L. Collins, Gul Serbest, Lisa A. Morgan, Deborah A. Smith, Ramiya Ravindranath, Alexander R. Cobitz> ;Clinical Pharmacology in Drug Development. 2017 Nov 1
• 74 citations
  Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects
  Tadao Akizawa, Yoshiharu Tsubakihara, Masaomi Nangaku, Yukihiro Endo, Hiromu Nakajima, Tomoko Kohno, Yukiko Imai, Natsumi Kawase, Katsutoshi Hara, John J. Lepore, Alex...> ;American Journal of Nephrology. 2017 Jan 1
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