Alfred T Look Jr. MD

PubMed

• Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation.
  Joana R Costa, Yang Li, Nurkaiyisah Zaal Anuar, David O'Connor, Sunniyat Rahman
  Cell Reports. 2025-05-27
• Accurate Measurement of Cell Number-Normalized Differential Gene Expression in Cells Treated With Retinoic Acid.
  Nina Weichert-Leahey, Mark W Zimmerman, Alla Berezovskaya, A Thomas Look, Brian J Abraham
  Bio-Protocol. 2024-11-05
• 7 citations
  Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
  Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch
  The Journal of Clinical Investigation. 2024-04-15

Journal Articles

• Selective Gene Dependencies in MYCN-Amplified Neuroblastoma Include the Core Transcriptional Regulatory Circuitry  
  William C Hahn, Todd R Golub, A Thomas Look, Adam D Durbin, Neekesh V Dharia, Kimberly Stegmaier, Nature
• The MCL1-Specific Inhibitor S63845 Acts Synergistically with venetoclax/ABT-199 to Induce Apoptosis in T-cell Acute Lymphoblastic Leukemia Cells  
  Alfred Look Jr., MD, Nature
• NOTCH2 Links Protein Kinase C Delta to the Expression of CD23 in Chronic Lymphocytic Leukaemia (CLL) Cells  
  Hubmann R, Duchler M, Schnabl S, Hilgarth M, Demirtas D, Mitteregger D, Holbl A, Vanura K, Le T, Look T, Schwarzmeier JD, Valent P, Jager U, Shehata M, Br. J. Haematol, 1/1/2010

Books/Book Chapters

• Oncology of Infancy and Childhood 
  Page 331.0 - 402.0Clark JJ, Berman JN, Look ATEditors: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG.W.B. Saunders, Philadelphia, PA2009
• Molecular Biology of B Cells 
  Chapter: Chromosomal Translocations in B Cell Leukemias and Lymphomas 
  Page 1891. - 1900.Ferrando A. and Look ATEditors: Honjo T, Alt FW, Neuberger M.Elsevier Academic Press, London, UK2004
• Hematology of Infancy and Childhood 
  Chapter: Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children 
  Page 1167. - 1209.Bennett CM, Hsu K and Look ATEditors: Nathan DG, Orkin SH, Ginsburg D, Look AT.W.B. Saunders, Philadelphia, PAEdition 6th,2003

Abstracts/Posters

• Therapy of Childhood Leukemia -understanding Success and Failure
  Simone JV, Rivera GK, Look AT, Crist WM, Proc of 20th Anniversary Symposium, Children's Cancer Association of Japan, 1/1/1989

Lectures

• Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Emerging features of Super-Enhancers in T-Cell acute Leukemia 
  Boston University School of Medicine - 1/1/2015
• Inherited and Somatically Acquired Super-Enhancers in Development Cancers 
  Denver, Colorado - 1/1/2015