BrigitteCWidemannMD

Pediatric Hematology & Oncology • Bethesda, MD

Physician

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Office
8906 Bradmoor Dr
Bethesda, MD 20817
Phone+1 301-496-7387

Fax+1 301-480-8871
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Summary

Dr. Brigitte Widemann, MD is a pediatric hematologist/oncologist in Bethesda, Maryland. She is currently licensed to practice medicine in Maryland.

Education & Training

National Capital ConsortiumFellowship, Pediatric Hematology/Oncology, 1992 - 1995
Medizinische Fakultät Universität zu KölnClass of 1988

Certifications & Licensure

MD State Medical License 1999 - 2025

Clinical Trials

Study of Plexiform Neurofibromas in Neurofibromatosis Type 1 Start of enrollment: 2001 May 18
Completed
Phase I Trial of Tariquidar (XR9576) in Combination With Doxorubicin, Vinorelbine, or Docetaxel in Pediatric Patients With Solid Tumors Start of enrollment: 2001 Feb 15
Completed
Phase 1
Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate Start of enrollment: 1993 Nov 01
Completed
Not Applicable
Tipifarnib in Treating Young Patients With Refractory Leukemia Start of enrollment: 2001 Jun 01
Completed
Phase 1
Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas Start of enrollment: 2002 Dec 01
Completed
Phase 1
Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas Start of enrollment: 2004 Jul 21
Completed
Phase 2
PEG-Interferon Alfa-2b in Treating Young Patients With Plexiform Neurofibroma Start of enrollment: 2005 Sep 01
Completed
Phase 1
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors Start of enrollment: 2005 Dec 01
Completed
Phase 2
AZD2171 to Treat Children and Adolescents With Solid Tumors or Acute Myelogenous Leukemia Start of enrollment: 2006 May 01
Completed
Phase 1
Ixabepilone in Treating Young Patients With Refractory Solid Tumors Start of enrollment: 2006 Apr 01
Completed
Phase 2
Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development Start of enrollment: 2004 Sep 07
Completed
A Phase I/II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (BAY 43-9006, NSC# 724772, IND# 69896) in Children With Refractory Solid Tumors or Refractory Leukemias Start of enrollment: 2006 May 01
Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer Start of enrollment: 2007 Jul 20
Completed
Phase 1, Phase 2
A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas Start of enrollment: 2008 Mar 01
A Phase II Trial of Peginterferon Alpha-2b (Pegintron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas Start of enrollment: 2008 May 01
Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas Start of enrollment: 2008 Jul 08
Completed
Phase 1
A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1 Start of enrollment: 2009 Jul 01
Completed
Phase 2
Natural History Study of Patients With Neurofibromatosis Type I Start of enrollment: 2008 Feb 25
Active, not recruiting
Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas Start of enrollment: 2010 Jul 10
Completed
Phase 2
Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors Start of enrollment: 2010 Dec 03
Completed
Phase 1
AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors Start of enrollment: 2011 Sep 21
Active, not recruiting
Phase 1, Phase 2
Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia Start of enrollment: 2006 May 30
Completed
Phase 1, Phase 2
Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients With Solid Tumors Start of enrollment: 2011 Dec 01
Completed
Phase 1
Mithramycin for Children and Adults With Solid Tumors or Ewing Sarcoma Start of enrollment: 2012 May 10
Terminated
Phase 1, Phase 2
Natural History Study of Children and Adults With Medullary Thyroid Cancer Start of enrollment: 2012 Jul 30
Recruiting
SARC016: Study of Everolimus With Bevacizumab to Treat Refractory Malignant Peripheral Nerve Sheath Tumors Start of enrollment: 2012 Sep 01
Completed
Phase 2
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors Start of enrollment: 2012 Nov 14
Completed
Phase 1
Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Start of enrollment: 2013 May 15
Completed
Phase 2
SARC023: Ganetespib and Sirolimus in Patients With MPNST (Malignant Peripheral Nerve Sheath Tumors) Start of enrollment: 2013 Dec 01
Completed
Phase 1, Phase 2
Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors Start of enrollment: 2013 Dec 14
Completed
Phase 2
MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1 Start of enrollment: 2014 Jun 01
Completed
Phase 2
Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults Start of enrollment: 2014 Jun 01
Completed
Phase 2
VEGF Receptor Tyrosine Kinase Inhibitor Axitinib in Children With Recurrent or Refractory Solid Tumors Start of enrollment: 2014 Sep 01
Completed
Phase 1
Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Start of enrollment: 2014 Dec 08
Completed
Phase 1
A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors Start of enrollment: 2015 Dec 11
Completed
Phase 1
http://clinicaltrials.gov/ct2/show/NCT02644512
Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma Start of enrollment: 2017 Aug 26
Completed
Phase 2
Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Start of enrollment: 2017 Apr 07
Withdrawn
Phase 2
SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors Start of enrollment: 2019 Oct 02
Completed
Phase 2
SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients Start of enrollment: 2021 Jan 05
Active, not recruiting
Phase 1, Phase 2
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Publications & Presentations

PubMed

Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics.
R Taylor Sundby, Jeffrey J Szymanski, Alexander Pan, Paul A Jones, Sana Z Mahmood, Olivia H Reid, Divya Srihari, Amy E Armstrong, Stacey Chamberlain, Sanita Burgic, Ka...> ;Medrxiv. 2024 Mar 11
Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors.
James L Rogers, Thomas Wall, Alvina A Acquaye-Mallory, Lisa Boris, Yeonju Kim, Kenneth Aldape, Martha M Quezado, John A Butman, James G Smirniotopoulos, Huma Chaudhry,...> ;Journal of Neuro-Oncology. 2024 Apr 1
Selumetinib for children with neurofibromatosis type 1 and plexiform neurofibromas: A plain language summary of SPRINT.
Andrea M Gross, Colette Achée, Sarah E Hart, Lindsay Brewer, Andrea Baldwin, Pamela L Wolters, Brigitte C Widemann> ;Future Oncology. 2024 May 1
Imaging as an early biomarker to predict sensitivity to everolimus for progressive NF2-related vestibular schwannoma.
Phioanh Leia Nghiemphu, Jeremie Vitte, Eva Dombi, Thien Nguyen, Naveed Wagle, Akira Ishiyama, Ali R Sepahdari, David Cachia, Brigitte C Widemann, Derald E Brackmann, J...> ;Journal of Neuro-Oncology. 2024 Apr 1
1 citations
Written language achievement in children and adolescents with neurofibromatosis type 1 and Plexiform Neurofibromas.
Siegel, A., Toledo-Tamula, M., Martin, S., Gillespie, A., Goodwin, A., Widemann, B., Wolters, P.> ;Child Neuropsychology. 2024 Feb 6
Longitudinal Natural History Study of Children and Adults with Rare Solid Tumors: Initial Results for First 200 Participants.
Ahmed, S., Wedekind, M., Del Rivero, J., Raygada, M., Lockridge, R., Glod, J., Flowers, C., Thomas, B., Bernstein, D., Kapustina, O., Jain, A., Miettinen, M., Raffeld,...> ;Cancer Research Communications. 2023 Dec 6
1 citations
Childhood cancer data initiative: Status report.
Subhashini Jagu, Elaine R Mardis, Mary F Wedekind, Brigitte C Widemann, Rena K Kingery, Samantha L Gonzalez, Jack F Shern, Gregory H Reaman> ;Pediatric Blood & Cancer. 2024 Feb 1
Development and pilot validation of a novel disfigurement severity scale for plexiform neurofibromas in children with neurofibromatosis type 1.
Liny John, Gurbani Singh, Eva Dombi, Pamela L Wolters, Staci Martin, Andrea Baldwin, Seth M Steinberg, Jessica Bernstein, Patricia Whitcomb, Dominique C Pichard, Anne ...> ;Clinical Trials. 2024 Apr 1
The Landscape of US and Global Rare Tumor Research Programs: A Systematic Review.
Christina Vivelo, Karlyne M Reilly, Brigitte C Widemann, Mary Frances Wedekind, Corrie Painter, Allison F O'Neill, Sabine Mueller, Olivier Elemento, Andrea M Gross, Ab...> ;The Oncologist. 2024 Feb 2
3 citations
Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Michael R Sargen, Jung Kim, Thomas P Potjer, Mary E Velthuizen, Arelis E Martir-Negron, Yazmin Odia, Hildur Helgadottir, Jessica N Hatton, Jeremy S Haley, Gretchen Tho...> ;JAMA Dermatology. 2023 Oct 1
Advancing neurofibromatosis and schwannomatosis clinical trial design: Consensus recommendations from the Response Evaluation in Neurofibromatosis and Schwannomatosis ...
Vanessa L Merker, Andrea M Gross, Brigitte C Widemann, Scott R Plotkin> ;Clinical Trials. 2024 Feb 1
3 citations
Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.
Srivandana Akshintala, R Taylor Sundby, Donna Bernstein, John W Glod, Rosandra N Kaplan, Marielle E Yohe, Andrea M Gross, Joanne Derdak, Haiyan Lei, Alexander Pan, Eva...> ;Clinical Cancer Research. 2023 Sep 1
1 citations
The NIH pediatric/young adult chordoma clinic and natural history study: Making advances in a very rare tumor.
Liny John, Hannah Smith, Maran Ilanchezhian, Robin Lockridge, Karlyne M Reilly, Margarita Raygada, Eva Dombi, Abby Sandler, Barbara J Thomas, John Glod, Markku Miettin...> ;Pediatric Blood & Cancer. 2023 Jun 22
NCI intramural program approach to rare tumors: Natural history study of rare solid tumors in children and adults: A longitudinal, comprehensive data and biospecimen c...
Mary Frances Wedekind, Karlyne M Reilly, Jaydira Del Rivero, Robin Lockridge, Taryn Allen, Margarita Raygada, Donna Bernstein, Barbara J Thomas, Christina Vivelo, Jaso...> ;Pediatric Blood & Cancer. 2023 Jun 21
9 citations
The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer.
Joseph A Flores-Toro, Subhashini Jagu, Gregory T Armstrong, David F Arons, Gregory J Aune, Stephen J Chanock, Douglas S Hawkins, Allison Heath, Lee J Helman, Katherine...> ;Journal of Clinical Oncology. 2023 Aug 20
Perspectives of adolescents with neurofibromatosis 1 and cutaneous neurofibromas: Implications for clinical trials.
Ashley Cannon, Kavita Y Sarin, Andrea K Petersen, Dominique C Pichard, Pamela L Wolters, Gregg Erickson, Andrés J Lessing, Peng Li, Claas Röhl, Tena Rosser, Brigitte C...> ;Clinical Trials. 2024 Feb 1
Retrospective Cohort Analysis of the Impact of Puberty on Plexiform Neurofibroma Growth in Patients with Neurofibromatosis Type 1.
Chelsea Kotch, Eva Dombi, Amish C Shah, Katherine Smith, Symone Brown, Yimei Li, Brigitte C Widemann, Michael J Fisher> ;The Journal of Pediatrics. 2023 Sep 1
6 citations
Long-term safety and efficacy of selumetinib in children with neurofibromatosis type 1 on a phase 1/2 trial for inoperable plexiform neurofibromas.
Andrea M Gross, Eva Dombi, Pamela L Wolters, Andrea Baldwin, Anne Dufek, Kailey Herrera, Staci Martin, Joanne Derdak, Kara S Heisey, Patricia M Whitcomb, Seth M Steinb...> ;Neuro-Oncology. 2023 Oct 3
2 citations
Surgery and proton radiation therapy for pediatric base of skull chordomas: Long-term clinical outcomes for 204 patients.
Myrsini Ioakeim-Ioannidou, Andrzej Niemierko, Daniel W Kim, Athena Tejada, Tobias Urell, Shannon Leahy, Judy Adams, Barbara Fullerton, G Petur Nielsen, Yin P Hung, Ang...> ;Neuro-Oncology. 2023 Sep 5
The Perceived Influence of Neurofibromatosis Type 1(NF1) on the Parents' Relationship.
Lori Wiener, Sima Zadeh Bedoya, Archita Goyal, Mallorie Gordon, Natalie Deuitch, Brigitte Widemann> ;Children. 2023 Feb 25
3 citations
MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors.
Dana C Borcherding, Neha V Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A Pratilas, Ka...> ;Clinical Cancer Research. 2023 Apr 14
Longitudinal association between executive function and academic achievement in children with neurofibromatosis type 1 and plexiform neurofibromas.
Yang Hou, Xian Wu, Taryn Allen, Mary Anne Toledo-Tamula, Staci Martin, Andy Gillespie, Anne Goodwin, Brigitte C Widemann, Pamela L Wolters> ;Journal of the International Neuropsychological Society. 2023 Nov 1
Outcome of Patients With Malignant Peripheral Nerve Sheath Tumors Enrolled on Sarcoma Alliance for Research Through Collaboration (SARC) Phase II Trials.
Srivandana Akshintala, Yao Lu, Karla V Ballman, Scott M Schuetze, Rashmi Chugh, Robert G Maki, Denise K Reinke, Brigitte C Widemann, AeRang Kim, Mallory, N.> ;The Oncologist. 2023 May 8
Advances, challenges and progress in pediatric hematology and oncology.
Brigitte C Widemann> ;Current Opinion in Pediatrics. 2023 Feb 1
Development and psychometric testing of a pediatric chronic graft-versus-host disease symptom scale: protocol for a two-phase, mixed methods study.
Mitchell, S., Hunter, R., Fry, A., Wiener, L., Pavletic, S., Widemann, B.> ;Frontiers in Psychology. 2023 Jan 1
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Press Mentions

NCI Launches Program to Offer Molecular Characterization of Childhood CancersMarch 21st, 2022
IU Researcher Leads National Work Focused on Developing Treatments for Inherited Childhood CancersNovember 18th, 2021
AstraZeneca : SPRINT Phase II Trial Showed Koselugo Reduced Tumour Volume, Reducing Pain and Improving Quality of Life (Form 6-K)June 24th, 2021
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Grant Support

Development Of Therapies For Neurofibromatosis Type 1 Related Tumors And Other GNational Cancer Institute2010–2011
Clinical Development Of Novel Drugs For Children With Refractory CancersNational Cancer Institute2010–2011
Clinical Development Of Novel Drugs For Children With Refractory CancersDivision Of Clinical Sciences - Nci2009
Development Of Therapies For Neurofibromatosis Type 1 Related Tumors And Other GDivision Of Basic Sciences - Nci2009
Development Of Therapies For Neurofibromatosis Type 1 Related Tumors And Other GNational Cancer Institute2008
Clinical Development Of Novel Drugs For Children With Refractory CancersNational Cancer Institute2007–2008
Clinical Development Of Therapies For Neurofibromatosis Type 1-Related TumorsNational Cancer Institute2007
Clinical Development Of Novel Drugs For Children With CADivision Of Clinical Sciences - Nci2002–2006
Clinical Development Of Drugs For Children With Cancer &Division Of Clinical Sciences - Nci2004
Novel Drugs For Children With Cancer /NeurofibromatosisDivision Of Clinical Sciences - Nci2001
Novel Drugs For Children With Cancer &NeurofibromatosisDivision Of Clinical Sciences - Nci2000

Professional Memberships

American Society of Clinical Oncology - ASCO
Member