ChristopherSheildNabelMD

PubMed

• Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
  Keene L Abbott, Ahmed Ali, Bradley I Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D Landis, Rachel A Hongo, Kirsten L Young, Tenzin Kunchok, Christopher S Nabel, Kayla D ...> ;Biorxiv. 2024 Apr 8
• Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy.
  Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta...> ;Nature Immunology. 2024 Apr 1
• 2 citations
  Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC.
  Hua Zhang, Christopher S Nabel, Dezhi Li, Ruth Í O'Connor, Caroline R Crosby, Sarah M Chang, Yuan Hao, Robyn Stanley, Soumyadip Sahu, Daniel S Levin, Ting Chen, Sittin...> ;Journal of Thoracic Oncology. 2023 Jul 1
• 2 citations
  Brief Report: Declining Rates of SARS-CoV-2 Vaccine Uptake Among Patients With Thoracic Malignancies.
  Catherine B Meador, Vivek Naranbhai, Grace Hambelton, Julia Rivera, Christopher S Nabel, Rebecca Lewinsohn, Mustafa Sakhi, Alejandro B Balazs, A John Iafrate, Justin F...> ;Clinical Lung Cancer. 2023 Jun 1
• 38 citations
  Nucleotide imbalance decouples cell growth from cell proliferation.
  Frances F Diehl, Teemu P Miettinen, Ryan Elbashir, Christopher S Nabel, Alicia M Darnell, Brian T Do, Scott R Manalis, Caroline A Lewis, Matthew G Vander Heiden> ;Nature Cell Biology. 2022 Aug 1
• Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?
  Christopher S. Nabel, Matthew G. Vander Heiden> ;Cancer Research. 2021 Sep 1
• 21 citations
  Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease.
  Sheila K Pierson, Sushila A. Shenoy, Ana B Oromendia, Alexander M. Gorzewski, Ruth-Anne Langan Pai, Christopher S. Nabel, Jason R. Ruth, Sophia A. T. Parente, Daniel J...> ;Blood Advances. 2021 Sep 14
• Bridging the Divide: Student Grand Rounds at the Interface of Basic Science and Clinical Medicine.
  Marie A. Hollenhorst, David A. Braun, Christopher R Burtner, Iahn Cajigas, Amy Cunningham-Bussel, Pinar Ö Eser, Christopher S. Nabel, Frederick D. Tsai, Lachelle D. We...> ;Academic Medicine. 2020 Apr 1
• 76 citations
  Identification of DHODH as a therapeutic target in small cell lung cancer.
  Leanne Li, Sheng Rong Ng, Caterina I. Colón, Benjamin J. Drapkin, Peggy P. Hsu, Zhaoqi Li, Christopher S. Nabel, Caroline A. Lewis, Rodrigo Romero, Kim L. Mercer, Arju...> ;Science Translational Medicine. 2019 Nov 6
• 71 citations
  Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.
  David C. Fajgenbaum, Ruth-Anne Langan, Alberto Sada Japp, Helen L. Partridge, Sheila K Pierson, Amrit Singh, Daniel J. Arenas, Jason R. Ruth, Christopher S. Nabel, Kat...> ;The Journal of Clinical Investigation. 2019 Oct 1
• 11 citations
  Anti‐PD‐1 Immunotherapy‐Induced Flare of a Known Underlying Relapsing Vasculitis Mimicking Recurrent Cancer
  Christopher S. Nabel, Mariano Severgnini, Yin P Hung, Amy Cunningham-Bussel, Evisa Gjini, Katja Kleinsteuber, Lake J. Seymour, Martha Holland, Rachel Cunningham, Krist...> ;The Oncologist. 2019 Aug 1
• 17 citations
  Virome capture sequencing does not identify active viral infection in unicentric and idiopathic multicentric Castleman disease.
  Christopher S. Nabel, Stephen Sameroff, Dustin Shilling, Daisy Alapat, Jason R. Ruth, Mitsuhiro Kawano, Yasuharu Sato, Katie L. Stone, Signe Spetalen, Federico Valdivi...> ;Plos One. 2019 Jun 26
• 117 citations
  Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase.
  Emily K Schutsky, Jamie E. DeNizio, Peng Hu, Monica Yun Liu, Christopher S. Nabel, Emily B. Fabyanic, Young Hwang, Frederic D. Bushman, Hao Wu, Rahul M. Kohli> ;Nature Biotechnology. 2018 Oct 8
• 53 citations
  Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease.
  Sheila K Pierson, Aaron J. Stonestrom, Dustin Shilling, Jason R. Ruth, Christopher S. Nabel, Amrit Singh, Yue Ren, Katie L. Stone, Hongzhe Li, Frits van Rhee, David C....> ;American Journal of Hematology. 2018 Jul 1
• 13 citations
  Canakinumab and Lung Cancer: Intriguing, but Is It Real?
  Bruce A. Chabner, Christopher S. Nabel> ;The Oncologist. 2018 Jun 1
• 48 citations
  APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.
  Emily K Schutsky, Christopher S. Nabel, Amy K. F. Davis, Jamie E. DeNizio, Rahul M. Kohli> ;Nucleic Acids Research. 2017 Jul 27
• 2 citations
  DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia
  Christopher S. Nabel, Jamie E. DeNizio, Martin Carroll, Rahul M. Kohli> ;Biochemistry. 2017 Apr 12
• 299 citations
  International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease
  David C. Fajgenbaum, Thomas S. Uldrick, Adam Bagg, Dale Frank, David Wu, Gordan Srkalovic, David Simpson, Amy Y. Liu, David M. Menke, Shanmuganathan Chandrakasan, Mary...> ;Blood. 2017 Mar 23
• 176 citations
  Idiopathic multicentric Castleman's disease: a systematic literature review
  Amy Y. Liu, Christopher S. Nabel, Brian S. Finkelman, Jason R. Ruth, Razelle Kurzrock, Frits van Rhee, Vera P. Krymskaya, Dermot Kelleher, Arthur H. Rubenstein, David ...> ;The Lancet. Haematology. 2016 Apr 1
• 175 citations
  Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease
  Noriko Iwaki, David C. Fajgenbaum, Christopher S. Nabel, Yuka Gion, Eisei Kondo, Mitsuhiro Kawano, Taro Masunari, Isao Yoshida, Hiroshi Moro, Koji Nikkuni, Kazue Takai...> ;American Journal of Hematology. 2016 Feb 1
• 48 citations
  Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism
  Daniel J. Crawford, Monica Yun Liu, Christopher S. Nabel, Xing Jun Cao, Benjamin A. Garcia, Rahul M. Kohli> ;Journal of the American Chemical Society. 2016 Jan 13
• 211 citations
  HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy.
  David C. Fajgenbaum, Frits van Rhee, Christopher S. Nabel> ;Blood. 2014 May 8
• 176 citations
  Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor
  Zheng Sun, Dan Feng, Bin Fang, Shannon E. Mullican, Seo-Hee You, Hee-Woong Lim, Logan J. Everett, Christopher S. Nabel, Yun Li, Vignesh Selvakumaran, Kyoung-Jae Won, M...> ;Molecular Cell. 2013 Dec 26
• 3 citations
  Molecular targeting of mutagenic AID and APOBEC deaminases.
  Christopher S. Nabel, Emily K Schutsky, Rahul M. Kohli> ;Cell Cycle. 2014 Jan 15
• 26 citations
  Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase
  Christopher S. Nabel, Jae W. Lee, Laura C. Wang, Rahul M. Kohli> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Aug 27
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Abstracts/Posters

• Quantitative Changes in Serum Proteins Including CXCL13 Are Early Indicators of Response to Anti-IL6 Therapy in Idiopathic Multicentric Castleman Disease
  Christopher Sheild Nabel, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019