StevenJayIsakoffMDPhD

Oncology • Boston, MA

Breast Cancer

Assistant Professor in Medicine, Massachusetts General Hospital

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Office
55 Fruit St
Yawkey 9A
Boston, MA 02114
Phone+1 617-726-6500

Fax+1 617-643-0589
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 2002 - 2006
Brigham and Women's HospitalResidency, Internal Medicine, 2000 - 2002
New York University School of MedicineClass of 2000, MD, PhD
Princeton UniversityAB, Molecular Biology, Cum Laude, 1987 - 1991

Certifications & Licensure

MA State Medical License 2003 - 2024
American Board of Internal Medicine Medical Oncology

Clinical Trials

Platinum for Triple-Negative Metastatic Breast Cancer and Evaluation of p63/p73 as a Biomarker of Response Start of enrollment: 2007 Jun 01
Completed
Phase 2
TOBI to Monitor Response to Neoadjuvant Therapy in Breast Cancer Start of enrollment: 2008 Aug 01
Completed
Not Applicable
ABT-888 and Temozolomide for Metastatic Breast Cancer and BRCA1/2 Breast Cancer Start of enrollment: 2009 Nov 01
Active, not recruiting
Phase 2
Trastuzumab and Vinorelbine in Advanced Breast Cancer Start of enrollment: 2010 Nov 01
Terminated
Phase 2
PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast Cancer Start of enrollment: 2010 Nov 01
Completed
Phase 1
A Phase II Clinical Trial of PM01183 in BRCA 1/2-Associated or Unselected Metastatic Breast Cancer Start of enrollment: 2012 Jun 13
Completed
Phase 2
Cisplatin vs. Doxorubicin/Cyclophosphamide in BrCa Start of enrollment: 2012 Oct 01
Active, not recruiting
Phase 2
A Phase 1 Study of MM-141 in Patients With Advanced Solid Tumors Start of enrollment: 2012 Nov 01
Completed
Phase 1
T-DM1 vs Paclitaxel/Trastuzumab for Breast (ATEMPT Trial) Start of enrollment: 2013 May 01
Active, not recruiting
Phase 2
Phase II Study of Eribulin Mesylate, Trastuzumab, and Pertuzumab in Women With Metastatic, Unresectable Locally Advanced, or Locally Recurrent HER2-Positive Breast Cancer Start of enrollment: 2013 Sep 01
Terminated
Phase 2
Cabozantinib +/- Trastuzumab In Breast Cancer Patients w/ Brain Metastases Start of enrollment: 2014 Nov 01
Completed
Phase 2
Adjuvant PVX-410 Vaccine and Durvalumab in Stage II/III Triple Negative Breast Cancer Start of enrollment: 2016 Aug 01
Active, not recruiting
Phase 1
An Open Label, Phase II Trial of Continuous Low-Irradiance Photodynamic Therapy (CLIPT) Using Verteporfin (Visudyne®) for the Treatment of Cutaneous Metastases of Breast Cancer Start of enrollment: 2016 Oct 01
Unknown status
Phase 2
Multi-epitope Folate Receptor Alpha Peptide Vaccine, GM-CSF, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer Start of enrollment: 2017 Mar 31
Active, not recruiting
Phase 2
PVX-410 Vaccine Plus Pembrolizumab in HLA-A2+ Metastatic Triple Negative Breast Cancer Start of enrollment: 2017 Dec 12
Active, not recruiting
Phase 1
A Pilot Study of Tomographic Optical Breast Imaging (DBT-TOBI) to Monitor Response to Neoadjuvant Therapy Start of enrollment: 2019 Feb 01
Active, not recruiting
Not Applicable
Onvansertib + Paclitaxel In TNBC Start of enrollment: 2022 Sep 30
Recruiting
Phase 1, Phase 2
Roles: Contact, Principal Investigator
Niraparib + Dostarlimab In BRCA Mutated Breast Cancer Start of enrollment: 2020 Dec 18
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Radiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast Cancer Start of enrollment: 2021 Jul 21
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Genomic spectrum of actionable alterations in serial cell free DNA (cfDNA) analysis of patients with metastatic breast cancer.
Yael Bar, Jennifer C Keenan, Andrzej Niemierko, Arielle J Medford, Steven J Isakoff, Leif W Ellisen, Aditya Bardia, Neelima Vidula> ;NPJ Breast Cancer. 2024 Apr 11
1 citations
First-Line Ipatasertib, Atezolizumab, and Taxane Triplet for Metastatic Triple-Negative Breast Cancer: Clinical and Biomarker Results.
Schmid, P., Turner, N., Barrios, C., Isakoff, S., Kim, S., Sablin, M., Saji, S., Savas, P., Vidal, G., Oliveira, M., O'Shaughnessy, J., Italiano, A., Espinosa, E., Bon...> ;Clinical Cancer Research. 2024 Feb 16
Searching for the "Holy Grail" of breast cancer recurrence risk: a narrative review of the hunt for a better biomarker and the promise of circulating tumor DNA (ctDNA).
Gao, L., Spring, L., Bar, Y., Hu, B., Jimenez, R., Peppercorn, J., Medford, A., Isakoff, S., Bardia, A.> ;Breast Cancer Research and Treatment. 2024 Feb 15
3 citations
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.
Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E Martin, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom,...> ;Cancer Discovery. 2024 Feb 8
Virtual Molecular and Precision Medicine Clinic to Improve Access to Clinical Trials for Patients With Metastatic Breast Cancer: An Academic/Community Collaboration.
Laura M Spring, Lindsey Mortensen, Elizabeth Abraham, Jennifer Keenan, Arielle Medford, Annie Ma, Sarah Padden, Elyssa Denault, Lianne Ryan, A John Iafrate, Jochen Len...> ;JCO Oncology Practice. 2024 Jan 1
6 citations
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment.
Yufeng Wang, David L Drum, Ruochuan Sun, Yida Zhang, Feng Chen, Fengfei Sun, Emre Dal, Ling Yu, Jingyu Jia, Shahrzad Arya, Lin Jia, Song Fan, Steven J Isakoff, Allison...> ;Nature Communications. 2023 Sep 15
Feasibility of introducing a smartphone navigation application into the care of breast cancer patients (The FIONA Study).
Steven J Isakoff, Maya R Said, Agnes H Kwak, Eva Glieberman, Emily A O'Rourke, Amanda Stroiney, Laura M Spring, Beverly Moy, Aditya Bardia, Nora Horick, Jeffrey M Pepp...> ;Breast Cancer Research and Treatment. 2023 Jun 1
Utilizing cell-free DNA to predict risk of developing brain metastases in patients with metastatic breast cancer.
Neelima Vidula, Andrzej Niemierko, Katherine Hesler, Lianne Ryan, Beverly Moy, Steven Isakoff, Leif Ellisen, Dejan Juric, Aditya Bardia> ;NPJ Breast Cancer. 2023 Apr 19
4 citations
Therapeutic Role of Tamoxifen for Triple-Negative Breast Cancer: Leveraging the Interaction Between ERβ and Mutant p53.
Lauren Scarpetti, Chetan C Oturkar, Dejan Juric, Maria Shellock, Giuliana Malvarosa, Kathryn Post, Steven Isakoff, Nancy Wang, Brian Nahed, Kevin Oh, Gokul M Das, Adit...> ;The Oncologist. 2023 Apr 6
Adjuvant trastuzumab and vinorelbine for early-stage HER2+ breast cancer.
Shannon McLaughlin, Erika Nakajima, Yael Bar, Jennifer A Hutchinson, Jennifer Shin, Beverly Moy, Steven J Isakoff, Aditya Bardia, Irene Kuter, Laura M Spring> ;Therapeutic Advances in Medical Oncology. 2023 Jan 1
4 citations
Treatment discontinuation, patient-reported toxicities and quality-of-life by age following trastuzumab emtansine or paclitaxel/trastuzumab (ATEMPT).
Tal Sella, Yue Zheng, Nabihah Tayob, Kathryn J Ruddy, Rachel A Freedman, Chau Dang, Denise Yardley, Steven J Isakoff, Vicente Valero, Michelle DeMeo, Harold J Burstein...> ;NPJ Breast Cancer. 2022 Nov 30
3 citations
Breast Medical Oncologists' Perspectives of Telemedicine for Breast Cancer Care: A Survey Study.
Eleni Stavrou, Jeanna Qiu, Affan Zafar, Angela C Tramontano, Steven Isakoff, Eric Winer, Deborah Schrag, Christopher Manz> ;JCO Oncology Practice. 2022 Sep 1
1 citations
Author Correction: Neoadjuvant study of niraparib in patients with HER2-negative, BRCA-mutated, resectable breast cancer.
Laura M Spring, Hyo Han, Minetta C Liu, Erika Hamilton, Hanna Irie, Cesar A Santa-Maria, James Reeves, Peng Pan, Ming Shan, Yongqiang Tang, Julie R Graham, Sebastien H...> ;Nature Cancer. 2022 Sep 1
10 citations
Neoadjuvant study of niraparib in patients with HER2-negative, BRCA-mutated, resectable breast cancer.
Laura M Spring, Hyo Han, Minetta C Liu, Erika Hamilton, Hanna Irie, Cesar A Santa-Maria, James Reeves, Peng Pan, Ming Shan, Yongqiang Tang, Julie R Graham, Sebastien H...> ;Nature Cancer. 2022 Aug 1
4 citations
Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network.
Dora Dias-Santagata, Rebecca S Heist, Adam Z Bard, Annacarolina F L da Silva, Ibiayi Dagogo-Jack, Valentina Nardi, Lauren L Ritterhouse, Laura M Spring, Nicholas Jesso...> ;The Oncologist. 2022 Nov 3
303 citations
Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Elias, A., Savur Moran, M. S., William J Gradishar, Meena S Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H Allison, Bethany Anderson, Harold J Burstein, H...> ;Journal of the National Comprehensive Cancer Network. 2022 Jun 1
19 citations
The Evolving Role of Neoadjuvant Therapy for Operable Breast Cancer.
Laura M Spring, Yael Bar, Steven J Isakoff> ;Journal of the National Comprehensive Cancer Network. 2022 Jun 1
6 citations
Pilot study to assess prolonged overnight fasting in breast cancer survivors (longfast).
Elizabeth O'Donnell, Yael Shapiro, Amy Comander, Steven Isakoff, Beverly Moy, Laura Spring, Seth Wander, Irene Kuter, Jennifer Shin, Michelle Specht, Chryssanthi Kourn...> ;Breast Cancer Research and Treatment. 2022 Jun 1
8 citations
Local Therapy Outcomes and Toxicity From the ATEMPT Trial (TBCRC 033): A Phase II Randomized Trial of Adjuvant Trastuzumab Emtansine Versus Paclitaxel in Combination W...
Jennifer R Bellon, Nabihah Tayob, David D Yang, Jordan Tralins, Chau T Dang, Steven J Isakoff, Michelle DeMeo, Harold J Burstein, Ann H Partridge, Eric P Winer, Ian E ...> ;International Journal of Radiation Oncology, Biology, Physics. 2022 May 1
16 citations
Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer.
Zhen Shi, Julia Wulfkuhle, Malgorzata Nowicka, Rosa I Gallagher, Cristina Saura, Paolo G Nuciforo, Isabel Calvo, Jay Andersen, José Luis Passos-Coelho, Miguel J Gil-Gi...> ;Clinical Cancer Research. 2022 Mar 1
8 citations
Cardiac outcomes of subjects on adjuvant trastuzumab emtansine vs paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT) study (TB...
Romualdo Barroso-Sousa, Paolo Tarantino, Nabihah Tayob, Chau Dang, Denise A Yardley, Steven J Isakoff, Vicente Valero, Meredith Faggen, Therese Mulvey, Ron Bose, Jiani...> ;NPJ Breast Cancer. 2022 Feb 16
2 citations
Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer.
Elyssa Denault, Erika Nakajima, Vivek Naranbhai, Jennifer A Hutchinson, Lindsey Mortensen, Elizabeth Neihoff, Caroline Barabell, Amy Comander, Dejan Juric, Irene Kuter...> ;Therapeutic Advances in Medical Oncology. 2022 Jan 1
1 citations
An Initial Evaluation of Human Plasma cMLC-1: A Potential Protein Biomarker for Trastuzumab-Induced Cardiotoxicity, Breast Cancer Screening and Progression.
Ling Yu, Read Allen, Lin Jia, Ting Sun, Steven J Isakoff, Marielle Scherrer-Crosbie, Allison M Kehlmann, Hui Zheng, Amy Ly, Charlotte S Walmsley, Katherine Hesler, Ava...> ;Frontiers in Oncology. 2022 Jan 1
29 citations
Ipatasertib plus paclitaxel for PIK3CA/AKT1/PTEN-altered hormone receptor-positive HER2-negative advanced breast cancer: primary results from cohort B of the IPATunity...
Nicholas C. Turner, Rebecca Dent, Joyce O'Shaughnessy, Sung-Bae Kim, Steven J. Isakoff, Carlos H. Barrios, Shigehira Saji, Igor Bondarenko, Zbigniew Nowecki, Qinshu Li...> ;Breast Cancer Research and Treatment. 2021 Dec 3
59 citations
Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study.
Vivek Naranbhai, Claire A. Pernat, Alexander Gavralidis, Kerri St. Denis, Evan C. Lam, Laura Spring, Steven J. Isakoff, Jocelyn R. Farmer, Leyre Zubiri, Gabriela S. Ho...> ;Journal of Clinical Oncology. 2021 Nov 9
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Press Mentions

When to Get First Mammogram? Doctor Explains Latest AdviceMay 12th, 2023
Neoadjuvant Niraparib Demonstrates Promising Antitumour Activity and Safety in Patients with Localised HER2-Negative, BRCA-Mutated Breast CancerAugust 10th, 2022
Ribociclib Dose Modifications Do Not Affect OS in Patients with Hr+/her2 Advanced Breast CancerJune 21st, 2022
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