DavidYuan-SouChenMDPhD

PubMed

• Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
  David Y. Chen, Ian M. Ferguson, Krista A. Braun, Leslie A. Sutton, Nichole M. Helton, Sai Mukund Ramakrishnan, Amanda Smith, Christopher A. Miller, Timothy J. Ley> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 20
• Successful administration of sequential TVEC and pembrolizumab followed by Temozolomide in immunotherapy refractory intracranial metastatic melanoma with acquired B2M ...
  Karam Khaddour, Joshua L. Dowling, Jiayi Huang, David Y. Chen, Lynn A. Cornelius, Tanner M. Johanns, Sonika Dahiya, George Ansstas> ;Oncotarget. 2020 Dec 29
• Pemphigus foliaceus in a patient with gastrointestinal stromal tumor treated with adjuvant imatinib mesylate.
  Hal A. Lewis, David Y. Chen, Ilana S. Rosman, Joel Picus, Milan J. Anadkat> ;Dermatology Online Journal. 2020 Jun 15
• Neutrophil-predominant bullous pemphigoid induced by checkpoint inhibitors: A case series
  Lisa M. Morris, Hal A. Lewis, Lynn A. Cornelius, David Y. Chen, Ilana S. Rosman> ;Journal of Cutaneous Pathology. 2020 Mar 20
• Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.
  Shamika Ketkar, Angela M. Verdoni, Amanda Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Feb 11
• A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing
  Allegra A. Petti, Stephen R. Williams, Christopher A. Miller, Ian T. Fiddes, Sridhar Nonavinkere Srivatsan, David Y. Chen, Catrina Fronick, Robert S. Fulton, Deanna M....> ;Nature Communications. 2019 Aug 14
• DNMT3AR882-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3AR882C OCI-AML3 leukemia cell line.
  David Y. Chen, Matthew J. Christopher, Nichole M. Helton, Ian Ferguson, Timothy J. Ley, David H. Spencer> ;Blood Cancer Journal. 2018 Apr 4
• 30 citations
  A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.
  Gregory R. Bean, Jeff Kremer, Bethany C. Prudner, Aaron D. Schenone, Juo-Chin Yao, Matthew Schultze, David Y. Chen, Munir R. Tanas, Douglas Adkins, John S. Bomalaski, ...> ;Cell Death and Disease. 2016 Oct 13
• Extensive tumoral melanosis associated with ipilimumab-treated melanoma.
  Karl Staser, David Y. Chen, Jason F. Solus, Ilana S. Rosman, Andras Schaffer, Lynn A. Cornelius, Gerald P. Linette, Ryan C. Fields> ;British Journal of Dermatology. 2016 Mar 18
• Physicians judging medical negligence: a conflict of values.
  David Y. Chen, Kenneth Vuylsteke, Ira J. Kodner, Douglas Brown, Shuddhadeb Ray> ;Surgery. 2015 Apr 1
• 25 citations
  A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth
  David Y. Chen, Yishan Lee, Brian A. Van Tine, Adam C. Searleman, Todd D. Westergard, Han Liu, Ho-Chou Tu, Shugaku Takeda, Yiyu Dong, David Piwnica-Worms, Kyoung J. Oh,...> ;Cancer Research. 2012 Feb 1
• Design, syntheses, and evaluation of Taspase1 inhibitors.
  Lee JT, Chen DY, Yang Z, Ramos AD, Hsieh JJ, Bogyo M> ;Bioorg Med Chem Lett. 2009 Sep 1
• 63 citations
  The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage
  Ho-Chou Tu, Decheng Ren, Gary X. Wang, David Y. Chen, Todd D. Westergard, Hyungjin Kim, Satoru Sasagawa, James J. Hsieh, Emily H. Cheng> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Jan 27
• 96 citations
  Proteolysis of MLL family proteins is essential for Taspase1-orchestrated cell cycle progression
  Shugaku Takeda, David Y. Chen, Todd D. Westergard, Jill K. Fisher, Jeffrey A. Rubens, Satoru Sasagawa, Jason T. Kan, Stanley J. Korsmeyer, Emily H. Cheng, James J. Hsieh> ;Genes & Development. 2006 Sep 1
• 170 citations
  Proteomic Analysis Reveals Hyperactivation of the Mammalian Target of Rapamycin Pathway in Neurofibromatosis 1–Associated Human and Mouse Brain Tumors
  Biplab Dasgupta, Yijun Yi, David Y. Chen, Jason D. Weber, David H. Gutmann> ;Cancer Research. 2005 Apr 1
• 533 citations
  The SLUG Zinc-Finger Protein Represses E-Cadherin in Breast Cancer
  Karen M. Hajra, David Y. Chen, Eric R. Fearon> ;Cancer Research. 2002 Mar 15
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Books/Book Chapters

• Washington Manual of Dermatology Diagnostics 
  Chapter: Malignant Skin Lesions 
  Chen, D.Y., Musiek, A., Cornelius, L.2016
• Washington Manual of Oncology 
  Chapter: Malignant Melanoma and Non-melanoma Skin Cancer 
  Levine, L.S., Chen, D.Y., Cornelius, L., Linette, G.2015