DavidMHoltzmanMD
Neurology • Saint Louis, MODementia & Geriatrics
Andrew B. and Gretchen P. Jones Professor of Neurology Charlotte and Paul Hagemann Professor of Neurology Chairman, Department of Neurology Professor, Molecular Biology and Pharmacology Neurologist-in-Chief, Barnes-Jewish Hospital
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Office
4921 Parkview Pl
Saint Louis, MO 63110Phone+1 314-286-1967Fax+1 314-286-1985- Is this information wrong?
Education & Training
University of California (San Francisco)Residency, Neurology, 1989 - 1990- University of California (San Francisco)Residency, Neurology, 1986 - 1989
- University of California (San Francisco)Internship, Internal Medicine, 1985 - 1986
Northwestern University The Feinberg School of MedicineClass of 1985
Certifications & Licensure
CA State Medical License 1986 - Present
MO State Medical License 1995 - 2025- American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
- Elected Member Institute of Medicine, 2008
- Elected Member The American Society for Clinical Investigation, 2004
Publications & Presentations
PubMed
- Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model.Jinchao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A L...> ;Science Translational Medicine. 2024 Apr 3
- Use of a Blood Biomarker Test Improves Economic Utility in the Evaluation of Older Patients Presenting with Cognitive Impairment.William J Canestaro, Joel B Braunstein, Randall J Bateman, David M Holtzman, Mark Monane> ;Population Health Management. 2024 Mar 28
- Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.Qingyi Ma, Zhen Zhao, Abhay P Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B Verghese, Joachim Herz, Berislav V Zlokovic, David M Holtzman> ;Molecular Neurodegeneration. 2024 Mar 22
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Journal Articles
- Interplay Between Innate Immunity and Alzheimer Disease: APOE and TREM2 in the SpotlightDavid Holtzman, MD, Nature
- Trisomy of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently of an Extra Copy of APPDavid Holtzman, MD, Brain
- Lack of BACE1 S-palmitoylation Reduces Amyloid Burden and Mitigates Memory Deficits in Transgenic Mouse Models of Alzheimer’s DiseaseDavid Holtzman, MD, Proceedings of the National Academy of Sciences
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Press Mentions
A Scientific Grand Slam – Washington University School of Medicine in St. LouisMarch 10th, 2023- T Cells’ Role in Alzheimer’s Suggests a New Treatment StrategyMarch 10th, 2023
- T Cells Could Represent Therapeutic Target for Alzheimer’s DiseaseMarch 9th, 2023
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Grant Support
- Antecedent Biomakers Of AD In CSF And PlasmaNational Institute On Aging2009–2012
- Proteomic Analysis Of Human Cerebrospinal FluidNational Center For Research Resources2009–2011
- Washington University Center For Translational NeuroscienceNational Institute Of Neurological Disorders And Stroke2006–2011
- Effect Of APOE On CNS Neurons: Role Of LRPNational Institute On Aging2004–2011
- Nervous System Development And InjuryNational Institute Of Neurological Disorders And Stroke2004–2011
- LC-MS/MS Analysis Of CSF And Antecedent Biomarkers Of ADNational Institute On Aging2009–2010
- Pathogenesis Of Caa-Induced Neurovascular DysfunctionNational Institute Of Neurological Disorders And Stroke2006–2010
- Effects Of Polyphenols On Neonatal HI Brain InjuryNational Institute Of Neurological Disorders And Stroke2008
- Novel Biomarkers To Predict Alzheimer DiseaseNational Institute On Aging2004–2008
- Healthy Aging And Senile DementiaNational Center For Research Resources2006–2007
- Functional Analysis Of Astrocyte-Derived APOE3 And APOE4National Center For Research Resources2005
- Cns/Plasma Abeta Clearance Of Anti-Abeta AntibodyNational Institute On Aging2001–2003
- APOE Effect On CNS Neurons--Role Of LRPNational Institute On Aging1996–2003
- Caspase Dependent And Independent InjuryNational Institute Of Neurological Disorders And Stroke2002
- Core--Transgenic Mouse Facility And Morphometric CenterNational Institute On Aging2000–2002
- CNS Apolipoprotein J--Role In A Beta DepositionNational Institute On Aging2000–2002
- Core--StereologyNational Institute Of Neurological Disorders And Stroke2000–2002
- Functional Analysis Of Astrocyte Derived APOE3 And APOE4National Center For Research Resources2000–2002
- Mechanisms Of Neonatal Ischemic Brain InjuryNational Institute Of Neurological Disorders And Stroke1997–2001
- Creatine Kinase And Brain EnergeticsNational Institute Of Neurological Disorders And Stroke1997–1999
- Creatine Kinase &Mouse Brain EnergeticsNational Center For Research Resources1997
- Creatine Kinase And Brain EnergeticsNational Institute Of Neurological Disorders And Stroke1993–1996
- Trisomy 16 And Ngf--Effects On CNS Gene ExpressionNational Institute On Aging1989–1993
- Cellular Energy Metabolism In Mature And Developing BrainNational Center For Research Resources1989–1993
- Maturation Of Brain Energetics By NMR SpectroscopyNational Institute Of Neurological Disorders And Stroke1986–1987
Hospital Affiliations
Barnes-Jewish HospitalSaint Louis, Missouri
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