David M Holtzman MD
Dementia & Geriatrics
Andrew B. and Gretchen P. Jones Professor of Neurology Charlotte and Paul Hagemann Professor of Neurology Chairman, Department of Neurology Professor, Molecular Biology and Pharmacology Neurologist-in-Chief, Barnes-Jewish Hospital
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4921 Parkview Pl# DvSaint Louis, MO 63110
Phone+1 314-362-1408
Fax+1 314-286-1985
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Education & Training
University of California (San Francisco)Residency, Neurology, 1989 - 1990- University of California (San Francisco)Residency, Neurology, 1986 - 1989
- University of California (San Francisco)Internship, Internal Medicine, 1985 - 1986
Northwestern University The Feinberg School of MedicineClass of 1985
Certifications & Licensure
CA State Medical License 1986 - Present
MO State Medical License 1995 - 2026
American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
- Elected Member Institute of Medicine, 2008
- Elected Member The American Society for Clinical Investigation, 2004
Publications & Presentations
PubMed
- Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, ...Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford
The Lancet. Neurology. 2025-04-01 - Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer's disease.Kanta Horie, Gemma Salvadó, Rama K Koppisetti, Shorena Janelidze, Nicolas R Barthélemy
Nature Medicine. 2025-03-31 - The night's watch: Exploring how sleep protects against neurodegeneration.Samira Parhizkar, David M Holtzman
Neuron. 2025-03-19
Journal Articles
- Interplay Between Innate Immunity and Alzheimer Disease: APOE and TREM2 in the SpotlightDavid Holtzman, MD, Nature
- Trisomy of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently of an Extra Copy of APPDavid Holtzman, MD, Brain
- Lack of BACE1 S-palmitoylation Reduces Amyloid Burden and Mitigates Memory Deficits in Transgenic Mouse Models of Alzheimer’s DiseaseDavid Holtzman, MD, Proceedings of the National Academy of Sciences
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Press Mentions
Novel Blood Test Could Help Diagnose, Track Alzheimer’sApril 9th, 2025- HMN 2025: Xenon Gas May Protect Against Alzheimer’s Disease: Mouse StudyJanuary 17th, 2025
- Xenon Gas Offers Potential Neuroprotective Effects for Alzheimer's PatientsJanuary 15th, 2025
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Grant Support
- Role of T cells in tau-mediated neurodegenerationWASHINGTON UNIVERSITY2024–2029
- Perturbing the LXR/SREBP axis to decipher protective and pathogenic AD/ADRD microglial phenotypesUNIVERSITY OF CALIFORNIA, SAN DIEGO2024–2027
- Biology and pathobiology of apoE in aging and Alzheimer's diseaseMAYO CLINIC JACKSONVILLE2021–2026
- Alzheimer's Disease Research CenterWASHINGTON UNIVERSITY2020–2025
- Effect of APOE on CNS Neurons: Role of LRPWASHINGTON UNIVERSITY1996–2025
- Antecedent Biomakers Of AD In CSF And PlasmaNational Institute On Aging2009–2012
- Proteomic Analysis Of Human Cerebrospinal FluidNational Center For Research Resources2009–2011
- Washington University Center For Translational NeuroscienceNational Institute Of Neurological Disorders And Stroke2006–2011
- Effect Of APOE On CNS Neurons: Role Of LRPNational Institute On Aging2004–2011
- Nervous System Development And InjuryNational Institute Of Neurological Disorders And Stroke2004–2011
- LC-MS/MS Analysis Of CSF And Antecedent Biomarkers Of ADNational Institute On Aging2009–2010
- Pathogenesis Of Caa-Induced Neurovascular DysfunctionNational Institute Of Neurological Disorders And Stroke2006–2010
- Effects Of Polyphenols On Neonatal HI Brain InjuryNational Institute Of Neurological Disorders And Stroke2008
- Novel Biomarkers To Predict Alzheimer DiseaseNational Institute On Aging2004–2008
- Healthy Aging And Senile DementiaNational Center For Research Resources2006–2007
- Functional Analysis Of Astrocyte-Derived APOE3 And APOE4National Center For Research Resources2005
- Cns/Plasma Abeta Clearance Of Anti-Abeta AntibodyNational Institute On Aging2001–2003
- APOE Effect On CNS Neurons--Role Of LRPNational Institute On Aging1996–2003
- Caspase Dependent And Independent InjuryNational Institute Of Neurological Disorders And Stroke2002
- Core--Transgenic Mouse Facility And Morphometric CenterNational Institute On Aging2000–2002
- CNS Apolipoprotein J--Role In A Beta DepositionNational Institute On Aging2000–2002
- Core--StereologyNational Institute Of Neurological Disorders And Stroke2000–2002
- Functional Analysis Of Astrocyte Derived APOE3 And APOE4National Center For Research Resources2000–2002
- Mechanisms Of Neonatal Ischemic Brain InjuryNational Institute Of Neurological Disorders And Stroke1997–2001
- Creatine Kinase And Brain EnergeticsNational Institute Of Neurological Disorders And Stroke1997–1999
- Creatine Kinase &Mouse Brain EnergeticsNational Center For Research Resources1997
- Creatine Kinase And Brain EnergeticsNational Institute Of Neurological Disorders And Stroke1993–1996
- Trisomy 16 And Ngf--Effects On CNS Gene ExpressionNational Institute On Aging1989–1993
- Cellular Energy Metabolism In Mature And Developing BrainNational Center For Research Resources1989–1993
- Maturation Of Brain Energetics By NMR SpectroscopyNational Institute Of Neurological Disorders And Stroke1986–1987
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