Defne Audrey Amado MD PhD
Neuromuscular Medicine
Assistant Professor of Neurology
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3400 Civic Center BlvdPhiladelphia, PA 19104
Phone+1 215-662-3397
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Summary
- Dr. Defne Amado is a neurologist in Philadelphia, PA and is affiliated with multiple hospitals in the area, including Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, and Pennsylvania Hospital. She received her medical degree and PhD from Perelman School of Medicine at the University of Pennsylvania and has been in practice 6 years. She specializes in neuromuscular medicine with a particular focus in ALS, and does translational research using gene therapy-based approaches to develop treatments for neurodegenerative diseases.
Education & Training
Penn MedicinePost-Doctoral Fellowship, 2015- Penn MedicineFellowship, 2015 - 2016
- University of Pennsylvania Health SystemResidency, Neurology, 2012 - 2015
- University of Pennsylvania Health SystemInternship, Internal Medicine, 2011 - 2012
Perelman School of Medicine at the University of PennsylvaniaClass of 2011
Certifications & Licensure
PA State Medical License 2011 - 2026
American Board of Psychiatry and Neurology Neurology
Publications & Presentations
PubMed
- Dissecting the relationship between haplotypes around ATXN2 CAG repeats and the number of CAA interruptions by long-read sequencing.Beoung Hun Lee, Joe Chan, Yuk Yee Leung, Corey T McMillan,
Medrxiv. 2026-07-22 - RAN translation as a dominant pathogenic axis in C9ORF72-associated ALS and FTD models.Pegah Masrori, Defne Audrey Amado
Molecular Neurodegeneration. 2026-06-06 - Author Correction: AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice.Defne A Amado, Ashley B Robbins, Katherine R Whiteman, Alicia R Smith, Guillem Chillon
Nature Communications. 2025-10-23
Press Mentions
Gene Therapy May Slow Loss of Motor Function in ALS, Penn and CHOP Research FindsJune 25th, 2025
The Philadelphia Foundation Board of Managers Selects 2016 Brody Fellowship RecipientMarch 28th, 2016
Grant Support
- Identifying Neurodegeneration Along the Path of Intracranial CST in ALS Patients using Combined Metabolic and Microstructural TractometryUNIVERSITY OF PENNSYLVANIA2026–2028
- Viral-based Therapeutic Approaches for Reversal of ALS PathologyUNIVERSITY OF PENNSYLVANIA2020–2025
Professional Memberships
- Member
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