FrancesEJensenMDFACP, FAAN, FANA

Neurology • Philadelphia, PA

Epilepsy, Neurorehabilitation, Neurodegenerative

Chair, Department of Neurology, Perelman School of Medicine Professor of Neurology, University of Pennsylvania

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Office
3400 Spruce Street
3 W Gates Bldg
Philadelphia, PA 19104
Phone+1 215-662-3606

Fax+1 617-738-1542
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 1984 - 1987
Brigham and Women's HospitalInternship, Internal Medicine, 1983 - 1984
Weill Cornell MedicineClass of 1983

Certifications & Licensure

MA State Medical License 1987 - 2025
PA State Medical License 2012 - 2024
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Pilot Study of Bumetanide for Newborn Seizures Start of enrollment: 2010 Jan 01
Completed
Phase 1

Publications & Presentations

PubMed

Posttraumatic Epilepsy and Dementia Risk.
Andrea L C Schneider, Connor A Law, Rebecca F Gottesman, Gregory Krauss, Juebin Huang, Anna Kucharska-Newton, Frances E Jensen, James J Gugger, Ramon Diaz-Arrastia, Em...> ;JAMA Neurology. 2024 Feb 26
Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures.
Xing, B., Barbour, A., Vithayathil, J., Li, X., Dutko, S., Fawcett-Patel, J., Lancaster, E., Talos, D., Jensen, F.> ;The Journal of Clinical Investigation. 2024 Jan 16
Shifting the trajectory of therapeutic development for neurological and psychiatric disorders.
Martin, W., Casey, B., Tishkoff, S., Potter, W., Hyman, S., Krainc, D., Jensen, F.> ;Science Translational Medicine. 2023 Nov 1
Recognizing and Responding to the Needs of Future Child and Adult Neurology Care Through the Evolution of Residency Training.
Justin Charles McArthur, Erika F Augustine, S Thomas Carmichael, Donna M Ferriero, Frances E Jensen, Shafali S Jeste, Lori C Jordan, Rafael H Llinas, Bradley L Schlagg...> ;Annals of Neurology. 2023 Dec 1
1 citations
Anti-seizure efficacy of perampanel in two established rodent models of early-life epilepsy.
Nicholas S Roberts, Marcus J Handy, Yoshimasa Ito, Keisuke Hashimoto, Frances E Jensen, Delia M Talos> ;Epilepsy & Behavior. 2023 Jun 1
Discovery of E2730, a novel selective uncompetitive GAT1 inhibitor, as a candidate for anti-seizure medication.
Kazuyuki Fukushima, Hiroyuki Higashiyama, Yuji Kazuta, Keisuke Hashimoto, Naoto Watanabe, Yoshiaki Furuya, Yoshimasa Ito, Ting Wu, Takashi Kosasa, Delia M Talos, Yeri ...> ;Epilepsia Open. 2023 Sep 1
In Memoriam: Arthur Knight Asbury, MD (1928-2022).
Mark J Brown, Frances E Jensen, Howard Hurtig> ;Annals of Neurology. 2023 Jan 1
1 citations
Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer's Disease.
He N Xu, Sarah Gourmaud, Allison Podsednik, Xiaofan Li, Huaqing Zhao, Frances E Jensen, Delia M Talos, Lin Z Li> ;Metabolites. 2022 Aug 25
13 citations
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
Sarah Gourmaud, David Andrew Stewart, David J. Irwin, Aaron J Barbour, Grace Eberwine, William T. O'Brien, Robert Vassar, Delia M. Talos, Frances E. Jensen> ;Brain. 2021 Jul 15
4 citations
Strengthened through Diversity: A Blueprint for Organizational Change
Allison W. Willis, Lesli E. Skolarus, Roland Faigle, Uma Menon, Hannah Redwine, Amanda Brown, Elizabeth A. Felton, Adys Mendizabal, Avindra Nath, Frances E. Jensen, Ju...> ;Annals of Neurology. 2021 Aug 5
6 citations
Dysregulation of GABAA Receptor-Mediated Neurotransmission during the Auditory Cortex Critical Period in the Fragile X Syndrome Mouse Model.
Yeri J. Song, Bo Xing, Aaron J Barbour, Chengwen Zhou, Frances E. Jensen> ;Cerebral Cortex. 2021 Jul 5
3 citations
Altered hippocampal dendritic spine maturation after hypoxia-induced seizures in neonatal rats.
Jocelyn J. Lippman-Bell, Marcus Handy, Cassidy Nieder, Frances E. Jensen> ;Molecular and Cellular Neurosciences. 2021 May 18
24 citations
Adults with Cerebral Palsy Require Ongoing Neurologic Care: A Systematic Review.
Sarah E. Smith, Mary E. Gannotti, Edward A. Hurvitz, Frances E. Jensen, Linda E. Krach, Michael C. Kruer, Michael E. Msall, Garey Noritz, Deepa S. Rajan, Bhooma R. Ara...> ;Annals of Neurology. 2021 May 1
46 citations
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Janet S. Soul, Ann M. Bergin, Christian Stopp, Breda Hayes, Avantika Singh, Carmen Rosa Fortuno, Deirdre O’Reilly, Kalpathy S. Krishnamoorthy, Frances E. Jensen, Valer...> ;Annals of Neurology. 2021 Feb 1
47 citations
Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research.
Guoping Feng, Frances E. Jensen, Henry T. Greely, Hideyuki Okano, Stefan Treue, Angela C. Roberts, James G. Fox, Sarah J. Caddick, Mu-ming Poo, William T. Newsome, Joh...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 29
58 citations
Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy
Sarah Gourmaud, Haochang Shou, David J. Irwin, Kimberly Sansalone, Leah M. Jacobs, Timothy H. Lucas, Eric D. Marsh, Kathryn A. Davis, Frances E. Jensen, Delia M. Talos> ;Brain. 2020 Jan 1
HASH(0x39ab020)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Dragicevic, M.,Erö, J.,Del Valle, A. E.,Flechl, M.,Frühwirth, R.,Ghete, V. M...> ;Eur Phys J C Part Fields. 2019 Apr 30
HASH(0x55e4668)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Dragicevic, M.,Erö, J.,Del Valle, A. E.,Flechl, M.,Frühwirth, R.,Ghete, V. M...> ;Eur Phys J C Part Fields. 2019 Apr 23
HASH(0x610b500)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö, J.,Del Valle, A. E.,Flechl, M.,Friedl, M.,...> ;Eur Phys J C Part Fields. 2019 Apr 23
HASH(0x3d5f9a0)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Dragicevic, M.,Erö, J.,Del Valle, A. E.,Flechl, M.,Frühwirth, R.,Ghete, V. M...> ;Eur Phys J C Part Fields. 2019 Apr 23
HASH(0x363aa28)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Dragicevic, M.,Erö, J.,Escalante Del Valle, A.,Flechl, M.,Frühwirth, R.,Ghet...> ;Eur Phys J C Part Fields. 2019 Apr 12
36 citations
AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder
Madhumita Yennawar, Rachel S. White, Frances E. Jensen> ;The Journal of Neuroscience. 2019 Jun 12
Observation of Single Top Quark Production in Association with a Z Boson in Proton-Proton Collisions at sqrt[s]=13 TeV.
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Dragicevic, M.,Erö, J.,Escalante Del Valle, A.,Flechl, M.,Frühwirth, R.,Ghet...> ;Phys. Rev. Lett.. 2019 Apr 24
HASH(0x2e47610)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Dragicevic, M.,Erö, J.,Del Valle, A. E.,Flechl, M.,Frühwirth, R.,Ghete, V. M...> ;Eur Phys J C Part Fields. 2019 Mar 16
HASH(0x5107718)
Sirunyan, A. M.,Tumasyan, A.,Adam, W.,Ambrogi, F.,Asilar, E.,Bergauer, T.,Brandstetter, J.,Brondolin, E.,Dragicevic, M.,Erö, J.,Del Valle, A. E.,Flechl, M.,Frühwirth, ...> ;Eur Phys J C Part Fields. 2019 Mar 16
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Press Mentions

A Clearer Picture: State-of-the-Art Imaging Technology at the Pavilion Is Improving Diagnostics and Advancing Medical ResearchJanuary 13th, 2022
Penn’s $1.6 Billion Pavilion Tower, Its Biggest yet, Opens with Massive Patient TransferOctober 30th, 2021
Penn Medicine Launches Region’s First Post-COVID-19 Neurological Care ClinicMay 25th, 2021
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