DennisL.SprecherMD

PubMed

• Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo.
  Xiaoping Xu, Navin Goyal, Melissa H. Costell, Theresa J. Roethke, Christian H. James, Kevin S. Thorneloe, Jaclyn R. Patterson, Patrick Stoy, Krista B. Goodman, Dennis ...> ;Journal of Pharmacology and Experimental Therapeutics. 2021 Mar 1
• 6 citations
  Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia.
  Marie E. Faughnan, Johannes J. Mager, Steven W. Hetts, Valerie A. Palda, Kelly Lang-Robertson, Elisabetta Buscarini, Erik Deslandres, Raj S. Kasthuri, Andrea Lausman, ...> ;Annals of Internal Medicine. 2020 Dec 15
• Development of a conceptual model and patient-reported outcome measures for assessing symptoms and functioning in patients with heart failure.
  Olga Moshkovich, Katy Benjamin, Katie Hall, Ryan Murphy, Robyn von Maltzahn, Boris Gorsh, Vanja Sikirica, Rajnish Saini, Dennis Sprecher> ;Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2020 Oct 1
• Correction to: Development of a conceptual model and patient-reported outcome measures for assessing symptoms and functioning in patients with heart failure.
  Olga Moshkovich, Katy Benjamin, Katie Hall, Ryan Murphy, Robyn von Maltzahn, Boris Gorsh, Vanja Sikirica, Rajnish Saini, Dennis Sprecher> ;Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2020 Oct 1
• Assessing the Impact of Losmapimod on Proteinuria in Idiopathic Focal Segmental Glomerulosclerosis.
  Debbie S. Gipson, Michelle A. Hladunewich, Richard A. Lafayette, John R. Sedor, Brad H. Rovin, Sean J. Barbour, Alan W. McMahon, J. Charles Jennette, Patrick H. Nachma...> ;Kidney International Reports. 2020 May 26
• 8 citations
  Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial
  Glenn M. Stewart, Bruce D. Johnson, Dennis L. Sprecher, Yogesh N.V. Reddy, Masaru Obokata, Steven R. Goldsmith, Brad Bart, Anna Oughton, Christina Fillmore, David J. B...> ;European Journal of Heart Failure. 2020 Mar 30
• 8 citations
  The Burden of Congestion in Patients Hospitalized With Acute Decompensated Heart Failure
  Lauren B. Cooper, Steven J. Lippmann, Julia DiBello, Boris Gorsh, Lesley H. Curtis, Vanja Sikirica, Adrian F. Hernandez, Dennis L. Sprecher, Warren K. Laskey, Rajnish ...> ;American Journal of Cardiology. 2019 Aug 15
• A Randomized, Placebo-Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High-Density Lipoprotein Choles...
  Eric Olson, Kelly M. Mahar, Thomas F Haws, Michael J. Fossler, Feng Gao, Anne-Charlotte de Gouville, Dennis L. Sprecher, John J. Lepore> ;Clinical pharmacology in drug development. 2019 Oct 1
• 24 citations
  Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects
  Navin Goyal, Pete Skrdla, Rosemary O. Schroyer, Subramanya Kumar, Disala Fernando, Anna Oughton, Nicola Norton, Dennis L. Sprecher, Joseph Cheriyan> ;American Journal of Cardiovascular Drugs. 2019 Jan 1
• Nosebleeds in hereditary hemorrhagic telangiectasia: Development of a patient-completed daily eDiary.
  Marci Clark, Pamela Berry, Susan A. Martin, Nimanee Harris, Dennis L. Sprecher, Scott E. Olitsky, Jeffrey B. Hoag> ;Laryngoscope investigative otolaryngology. 2018 Nov 14
• 29 citations
  Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia.
  Marie E. Faughnan, James R. Gossage, Murali M. Chakinala, S. Paul Oh, Raj S. Kasthuri, Christopher C.W. Hughes, Justin P. McWilliams, Joseph G. Parambil, Nicholas T. V...> ;Angiogenesis. 2019 Feb 1
• 4 citations
  Development of Focal Segmental Glomerulosclerosis Patient-Reported Outcome Measures: Symptom Diary and Symptom Impact Questionnaire
  Susan D. Mathias, Susan Vallow, Debbie S. Gipson, Kevin S. Thorneloe, Dennis L. Sprecher> ;American Journal of Kidney Diseases. 2017 Oct 1
• Selective Effects of Oral Anti-Angiogenic Tyrosine Kinase Inhibitors on an Animal Model of Hereditary Hemorrhagic Telangiectasia
  Dennis Sprecher, MD> ;Journal of Thrombosis and Haemostasis. 1900 Jan 01
• 4 citations
  Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist.
  Dennis L. Sprecher, Miles Maxwell, Joanne Goodman, Brian H. White, Chi-Man Tang, Valerie Boullay, Anne-Charlotte de Gouville> ;European Journal of Pharmacology. 2015 Jun 5
• 74 citations
  Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
  L. Kristin Newby, Michael S. Marber, Chiara Melloni, Lea Sarov-Blat, Laura H. Aberle, Philip E. Aylward, Gengqian Cai, Robbert J. de Winter, Christian W. Hamm, John F....> ;The Lancet. 2014 Sep 27
• 2 citations
  A Low‐Frequency Variant in MAPK14 Provides Mechanistic Evidence of a Link With Myeloperoxidase: A Prognostic Cardiovascular Risk Marker
  Dawn M. Waterworth, Li Li, Robert A. Scott, Liling Warren, Christopher Gillson, Jennifer L. Aponte, Lea Sarov-Blat, Dennis L. Sprecher, Josée Dupuis, Alex P. Reiner, B...> ;Journal of the American Heart Association. 2014 Aug 21
• 14 citations
  Platelet Aggregation Unchanged by Lipoprotein-Associated Phospholipase A2 Inhibition: Results from an In Vitro Study and Two Randomized Phase I Trials
  Bonnie C. Shaddinger, Yanmei Xu, James H. Roger, Colin H. Macphee, Malcolm Handel, Charlotte A. Baidoo, Mindy Magee, John J. Lepore, Dennis L. Sprecher> ;PLOS ONE. 2014 Jan 27
• 3 citations
  Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers
  April M. Barbour, Lea Sarov-Blat, Gengqian Cai, Michael J. Fossler, Dennis L. Sprecher, Johann Graggaber, Adam McGeoch, Jo Maison, Joseph Cheriyan> ;British Journal of Clinical Pharmacology. 2013 Jul 1
• 15 citations
  The Study of LoSmapimod Treatment on Inflammation and InfarCtSizE (SOLSTICE): Design and Rationale
  Manesh R Patel, L Kristin Newby, Dennis L Sprecher> ;American Heart Journal. 2012 Nov 1
• 38 citations
  Lipid Effects of Peroxisome Proliferator-Activated Receptor-Δ Agonist GW501516 in Subjects With Low High-Density Lipoprotein Cholesterol: Characteristics of Metabolic ...
  Eric Olson, Gregory L. Pearce, Nigel P. Jones, Dennis L. Sprecher> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 Sep 1
• 67 citations
  Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.
  Maysoon Elkhawad, James H.F. Rudd, Lea Sarov-Blat, Gengqian Cai, Richard J.B. Wells, L. Ceri Davies, David Collier, Michael S. Marber, Robin P. Choudhury, Zahi A. Faya...> ;Jacc-cardiovascular Imaging. 2012 Sep 1
• 5 citations
  Apolipoprotein B-100–Containing Lipoprotein Metabolism in Subjects With Lipoprotein Lipase Gene Mutations
  Esther M.M. Ooi, Betsy S. Russell, Eric N. Olson, Sam Z. Sun, Margaret R. Diffenderfer, Alice H. Lichtenstein, Leonard M. Keilson, P. Hugh R. Barrett, Ernst J. Schaefe...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2012 Feb 1
• 47 citations
  Mechanism of Action of a Peroxisome Proliferator-Activated Receptor (PPAR)-δ Agonist on Lipoprotein Metabolism in Dyslipidemic Subjects with Central Obesity
  Esther M.M. Ooi, Gerald F. Watts, Dennis L. Sprecher, Dick C. Chan, P. Hugh R. Barrett> ;The Journal of Clinical Endocrinology and Metabolism. 2011 Aug 3
• 15 citations
  Inhibition of p38 Mitogen-Activated Protein Kinase Improves Nitric Oxide–Mediated Vasodilatation and Reduces Inflammation in Hypercholesterolemia
  Joseph Cheriyan, Andrew J. Webb, Lea Sarov-Blat, Maysoon Elkhawad, Sharon M.L. Wallace, Kaisa M. Mäki-Petäjä, David Collier, John Morgan, Zixing Fang, Robert N. Willet...> ;Circulation. 2011 Feb 8
• 36 citations
  Inhibition of p38 Mitogen-Activated Protein Kinase Reduces Inflammation After Coronary Vascular Injury in Humans
  Lea Sarov-Blat, John M. Morgan, Pedro Fernandez, Rachel James, Zixing Fang, Mark R. Hurle, Charlotte A. Baidoo, Robert N. Willette, John J. Lepore, Svend Eggert Jensen...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2010 Nov 1
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