Saman Nazarian MD PhD

Cardiac Electrophysiology, Interventional Cardiology

Professor of Medicine, Penn Heart and Vascular Center, University of Pennsylvania Perelman School of Medicine

3400 Civic Center BlvdPhiladelphia, PA 19104
Phone+1 215-615-4949
Fax+1 215-615-0829

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Summary

Dr. Nazarian serves as Professor in the Cardiac Electrophysiology section of the Department of Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Nazarian obtained his Doctor of Medicine degree from the Stanford University School of Medicine. He completed his residency training in internal medicine at the Brigham and Women’s Hospital of Harvard Medical School. He then completed serial fellowships in Cardiology and Cardiac Electrophysiology at the Johns Hopkins University School of Medicine, joining the faculty upon completion. He went on to earn a Doctorate of Philosophy in Clinical Epidemiology at the Johns Hopkins Bloomberg School of Public Health. Dr. Nazarian served on the Johns Hopkins School of Medicine Cardiac Electrophysiology faculty for over 9 years before joining the Perelman School of Medicine faculty. Dr. Nazarian’s research and clinical interests include:
•    Imaging the anatomy of atrial and ventricular arrhythmia substrates
•    Optimal catheter ablation strategies for complex arrhythmia
•    Arrhythmia risk in patients with neurologic disease
Dr. Nazarian is an active investigator in the field of cardiac electrophysiology and is particularly interested in integration of advanced imaging modalities for optimization of procedural success for ablation of complex ventricular arrhythmia in structural heart disease. He has published extensively on the anatomy of the ventricular arrhythmia substrate. He oversees a team of individuals dedicated to facilitating ventricular arrhythmia research and clinical care. In 2013, he was awarded a National Institutes of Health to characterize the substrate for malignant arrhythmia. He is an appointed member of the Heart Rhythm Journal editorial board, the official journal of the Heart Rhythm Society. He is also a fellow of the American Heart Association, American College of Cardiology, and the Heart Rhythm Society.

Education & Training

Johns Hopkins Bloomberg School of Public HealthPhD, Clinical Epidemiology, 2008 - 2012
Johns Hopkins Bloomberg School of Public HealthPh.D., Clinical Epidemiology, 2008 - 2012
Johns Hopkins UniversityFellowship, Clinical Cardiac Electrophysiology, 2006 - 2007
Johns Hopkins UniversityFellowship, Cardiovascular Disease, 1999 - 2005
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 1999 - 2002

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Certifications & Licensure

PA State Medical License 2004 - 2026
MD State Medical License 2007 - 2017
MA State Medical License 2001 - 2008
VA State Medical License 2003 - 2008
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Clinical Cardiac Electrophysiology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2014, 2016-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2014, 2016-2017

Clinical Trials

Anti-arrhythmic Medication v. MRI-Merge Ablation in the Treatment of Ventricular Tachycardia
WITHDRAWN
NA
Clinically Indicated Magnetic Resonance Imaging in Patients With Cardiac Devices
COMPLETED
Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial Start of enrollment: 2018 Aug 18
COMPLETED
NA

Publications & Presentations

PubMed

Value of Left Ventricular Low Voltage Area and Ejection Fraction in Predicting End-Stage Heart Failure Outcomes After Ventricular Tachycardia Ablation in Patients With...
Arian Afzalian, Alireza Oraii, Corentin Chaumont, Oriol Rodriguez-Queralto, Yuichiro Sagawa
Circulation. Arrhythmia and Electrophysiology. 2026-10-08
Ventricular Arrhythmia Location Corresponds More Closely With Myocardial Scar Than Active Inflammation in Treated Cardiac Sarcoidosis.
William Ohley, Ahmad S M Alhamshari, Tejas Bhogale, Lee R Goldberg, Mahesh K Vidula
Journal of Nuclear Cardiology. 2026-10-01
Programmed Ventricular Stimulation for Risk Stratification in Nonischemic Cardiomyopathy With Preserved or Mildly Reduced LVEF.
Piotr Gardziejczyk, Yuichiro Sagawa, Arian Afzalian, Alireza Oraii, Michael Stuckey
JACC. Clinical Electrophysiology. 2026-09-23

Journal Articles

Sex Hormones and the Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA)
Saman Nazarian, MD, Endocrine
Arrhythmia and Electrophysiological Effects of Chemotherapy: A Review
Markman TM, Nazarian S, Oncology, 1/1/2016
Implantable Electronic Cardiac Devices and Compatibility With Magnetic Resonance Imaging
Miller JD, Nazarian S, Halperin HR, J Am Coll Cardiol, 1/1/2016

Books/Book Chapters

Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy
Chapter: Electromagnetic Interference and CIEDs
Page 1004 - 1007Kasazala K, Nazarian S, Halperin HEditors: Ellenbogen KA, Wilkoff BL, Kay GN, Lau CK.Elsevier-SaundersEdition 4th,2011
Atlas of Cardiac MR: Imaging Companion to Braunwald’s Heart Disease
Chapter: Atria and Pulmonary Veins
Nazarian S, Bluemke DA, Calkins H, and Halperin HREditors: Kramer CM, Hundley WG.Saunders Elsevier2010
Novel Techniques for Imaging the Heart: Cardiac MR and CT
Chapter: Safety Considerations of Current and Evolving CMR Techniques and Hardware
Nazarian S, Halperin HR, and Bluemke DAEditors: Di Carli, M.F., and Kwong, R.Y. Series Editor Antman, E.Wiley Blackwell2009

Lectures

The Utility of Advanced Imaging for Ablation of Complex Arrhythmia Circuits
Toronto, Ontario, Canada - 1/31/2016
Critical insights from CT/MRI visualization of lesions - applications to atrial ablation: Lesion Creation and Assessment
Rome, Italy - 1/18/2016
Atrial Fibrosis in Paroxysmal versus Persistent AF
Park City, UT - 1/27/2015

Other

Treatment Options for Ventricular Tachycardia
Nazarian S, Johns Hopkins CME Webinar
1/20/2011
Use of MR Imaging in the Electrophysiology Laboratory
Nazarian S, Journal of Atrial Fibrillation. Atrial Fibrillation Knowledge Treasure Chest Webcast
1/26/2010
MRI-Safe Pacemakers: Should they be used in all eligible patients?
Nazarian S, Gimbel RJ, Medscape Educational Cardiology Debate Webcast
1/3/2010

Press Mentions

The Next Big Think: Artificial Intelligence Arrives at Penn GastroenterologyOctober 7th, 2025
6 Things to Know About Migraines and Cluster HeadachesAugust 10th, 2019
MRIs Proven Safe for Patients with FDA-Unapproved Implantable DevicesJanuary 9th, 2018

Grant Support

Elucidating 3D Constructs of Reentrant Circuits via a Novel Noninvasive Hybrid-AI SystemROCHESTER INSTITUTE OF TECHNOLOGY2019–2030
Elucidating 3D Constructs of Reentrant Circuits via a Novel Noninvasive Hybrid-AI SystemROCHESTER INSTITUTE OF TECHNOLOGY2019–2030
Elucidating 3D Constructs of Reentrant Circuits via a Novel Noninvasive Hybrid-AI SystemROCHESTER INSTITUTE OF TECHNOLOGY2019–2030
LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIAUNIVERSITY OF PENNSYLVANIA2024–2029