Kenneth Ber Margulies MD

Heart Failure & Transplantation, Interventional Cardiology, Cardiac Critical Care

Professor, Medicine, Perelman School of Medicine

3400 Civic Center Blvd# EPhiladelphia, PA 19104
Phone+1 215-615-4949
Fax+1 215-615-0829

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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 1989 - 1993
Mayo Clinic College of Medicine and Science (Rochester)Internship, Internal Medicine, 1986 - 1987
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1986
Princeton UniversityAB, Summa Cum Laude, 1978 - 1982
Princeton UniversityAB, Summa Cum Laude, 1978 - 1982

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A self-designated specialty, subspecialty, or practice area neither implies nor is equivalent to ABMS board certification or the existence of specialized training by or competence of a physician or medical specialist.

Certifications & Licensure

FL State Medical License 2022 - Present
PA State Medical License 1993 - 2026
MN State Medical License 1987 - 1994
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2012, 2014, 2016-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012, 2014, 2016-2017
CMS Meaningful Use Stage 2 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2012, 2014, 2016-2017

Clinical Trials

Study of Anginera in Adults With a Left Ventricular Assist Device (LVAD) as Bridge to Transplant
UNKNOWN
PHASE1
Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)
COMPLETED
PHASE2
Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction
COMPLETED
PHASE2

Publications & Presentations

PubMed

Single nucleus RNA sequencing identifies PLXNA4 upregulation in end-stage arrhythmogenic right ventricular cardiomyopathy.
Bridget Simonson, Mark Chaffin, Yasmine Guedira, Talita Z Choudhury, Ling Xiao
Iscience. 2026-10-16
Immunologically Active Cardiac Fibroblasts Expressing Major Histocompatibility Complex-II Promote Doxorubicin Cardiotoxicity.
Maria Antonia Zambrano, Abraham L Bayer, Ramon Bossardi Ramos, Constanza Stortini, Kuljeet Kaur
The American Journal of Pathology. 2026-09-21
Mechano-sensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology.
Stanley J Stachelek, Emily J Hauber, Xiaoqiu Yang, Devin W Laurence, Vitali Rusinkevich
Cardiovascular Research. 2026-09-03

Journal Articles

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction
Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA
Suppression of Detyrosinated Microtubules Improves Cardiomyocyte Function in Human Heart Failure
Kenneth Margulies, MD, Nature

Abstracts/Posters

A Novel Needleless Liquid Jet Injection System for Heart Failure Gene Therapy: Feasibility Study Demonstrates Enhanced Myocardial Distribution and Safety Profile in th...
Fargnoli AS, Mu A, Katz MG, Williams RD, Dvorak J, Walling T, Margulies KB, Bridges CR, J Cardiac Fail, 1/1/2013
A Novel Anti-Inflammatory Formulation Approach To Enhance Myocardial Gene Transfer: An In-Vitro Assessment of Aspirin Loaded Poly-Lactic Glycolic Acid Nanoparticles
Fargnoli AS, Mu A, Katz MG, Williams, Sumaroka, MV, Levy R,Weiner, DB, Diamond SL, Margulies KB, Yang S, Bridges, CR, Mol Therapy, 1/1/2013
Patients with Obesity and Type-2 Diabetes Present Cardiac IAPP Accumulation: A Source of Cardiomyocyte Ca2+ Dysregulation
Despa S, Margulies KB, Bers D, Despa F, Circulation, 1/1/2011

Lectures

Takutsobo's Cardiomyopathy: Diagnosis and Recovery
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Generation of 3D Myocardial Tissue from Stem Cells
11/17/2013
Reverse Myocardial Remodeling Following LVAD: Where to We Stand?
1/13/2013

Press Mentions

FDA Expands Mavacamten Indication to Pediatric Obstructive HCM PatientsOctober 1st, 2026
High-Quality Heart Failure Care Is Easy to Find for Many Americans—but Care Gaps RemainSeptember 24th, 2026
New National Report Maps U.S. Heart Failure Clinic Landscape, Reveals Major Care GapsSeptember 23rd, 2026

Grant Support

Mechanical Stress-Dependent Remodeling of the Cardiac Microtubule NetworkUNIVERSITY OF PENNSYLVANIA2020–2031
Cardiotropic nanocarriers: from discovery to understandingUNIVERSITY OF PENNSYLVANIA2026–2030
Cardiac delivery of RNA to treat contractile disorderUNIVERSITY OF PENNSYLVANIA2024–2028
Cardiac delivery of RNA to treat contractile disorderUNIVERSITY OF PENNSYLVANIA2024–2028
Computer-Assisted Histologic Evaluation of Cardiac Allograft RejectionUNIVERSITY OF PENNSYLVANIA2020–2025