DonaldCharlesGoffMD

Psychosomatic Medicine

Marvin Stern Professor of Psychiatry Vice Chair for Research, Department of Psychiatry, NYU School of Medicine Director, Nathan Kline Institute for Psychiatric Research

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Office
1 Park Ave Rm 8-212
NYUMC Psychiatry
New York, NY 10016
Phone+1 646-754-4843

Fax+1 646-754-4781
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Education & Training

Tufts Medical CenterFellowship, Psychosomatic Medicine, 1984 - 1985
Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1981 - 1984
Cedars-Sinai Medical CenterInternship, Internal Medicine, 1980 - 1981
David Geffen School of Medicine at UCLAClass of 1980

Certifications & Licensure

CA State Medical License 1985 - Present
NY State Medical License 2011 - 2025
MA State Medical License 1982 - 2013
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Top Doctors: New York Metro Area Castle Connolly, 2013-2014
America's Top Doctors Castle Connolly, 2008-2014
Boston Magazine Castle Connolly, 2008-2011
Super Doctor SuperDoctors.com
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Clinical Trials

Trial of D-Cycloserine in Schizophrenia Start of enrollment: 1996 Aug 01
Completed
Phase 3
Glycine and D-Cycloserine in Schizophrenia Start of enrollment: 1998 Mar 01
Withdrawn
Phase 3
Trial of Ampakine Added to Clozapine, Olanzapine or Risperidone in Patients With Schizophrenia Start of enrollment: 2002 Feb 01
Completed
Phase 2, Phase 3
Folate Supplementation in Schizophrenia Start of enrollment: 2003 Dec 01
Completed
Phase 4
Risperidone Augmentation in Patients With Schizophrenia Start of enrollment: 2003 Feb 01
Completed
Phase 4
The Partners Genetics Collaborative Study of Schizophrenia Start of enrollment: 2001 Mar 01
Completed
High-Dose Oral Ziprasidone Versus Conventional Dosing in Participants With Residual Schizophrenia Symptoms Start of enrollment: 2006 Jan 01
Completed
Phase 3
Effects of Weekly Dosing of D-cycloserine on Cognitive Function in Individuals With Schizophrenia Start of enrollment: 2004 Jul 01
Completed
Phase 4
A Placebo-Controlled Single-Dose Trial of Sildenafil in Schizophrenia Start of enrollment: 2006 Feb 01
Completed
Phase 4
A Placebo-Controlled Trial of Modafinil (Provigil) Added to Clozapine in Patients With Schizophrenia Start of enrollment: 2003 Sep 01
Completed
Phase 4
Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia Start of enrollment: 2007 Dec 01
Completed
Phase 4
Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia Start of enrollment: 2006 Sep 01
Completed
Phase 4
D-cycloserine Augmentation of Cognitive Remediation in Schizophrenia Start of enrollment: 2009 Aug 01
Completed
Not Applicable
Once Weekly D-cycloserine for Schizophrenia Start of enrollment: 2009 Jul 01
Withdrawn
Phase 4
DECIFER: Depression and Citalopram In First Episode Recovery Start of enrollment: 2010 Jan 01
Completed
Phase 4
D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions Start of enrollment: 2014 Feb 01
Completed
Phase 4
Biomarkers in First Episode Schizophrenia Start of enrollment: 2012 Jul 01
Completed
Levetiracetam in Early Psychosis Start of enrollment: 2017 Aug 18
Completed
Phase 2
Hippocampal Memory Circuits in Delusions Start of enrollment: 2019 Jul 13
Recruiting
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Publications & Presentations

PubMed

1 citations
Another Step Toward the Prediction of Antipsychotic Treatment Response Using Functional Connectivity.
Donald C Goff, Joshua Roffman, Daphne J Holt> ;The American Journal of Psychiatry. 2023 Nov 1
Aberrant resting-state functional connectivity of the globus pallidus interna in first-episode schizophrenia.
Wei Qi, Zhenfu Wen, Jingyun Chen, Gillian Capichioni, Fumika Ando, Zhe Sage Chen, Jijun Wang, Yuliya Yoncheva, Francisco X Castellanos, Mohammed Milad, Donald C Goff> ;Schizophrenia Research. 2023 Nov 1
Levetiracetam effects on hippocampal blood flow and symptoms in medication-free individuals with nonaffective first episode psychosis (letter).
Donald C Goff, Michele Santacatterina, Gillian Capichioni, Fumika Ando, Antonio Convit, Henry Rusinek, Kamber Hart> ;Schizophrenia Research. 2023 Oct 1
Microstructural and Microvascular Alterations in Psychotic Spectrum Disorders: A Three-Compartment Intravoxel Incoherent Imaging and Free Water Model.
Faye McKenna, Pradeep Kumar Gupta, Yu Veronica Sui, Hilary Bertisch, Oded Gonen, Donald C Goff, Mariana Lazar> ;Schizophrenia Bulletin. 2023 Nov 29
Hippocampal Subfield Volumes Predict Disengagement from Maintenance Treatment in First Episode Schizophrenia.
Wei Qi, Julia Marx, Michael Zingman, Yi Li, Eva Petkova, Esther Blessing, Babak Ardekani, Ayse Sakalli Kani, Corinne Cather, Oliver Freudenreich, Daphne Holt, Jingping...> ;Schizophrenia Bulletin. 2023 Jan 3
3 citations
Decreased basal ganglia and thalamic iron in early psychotic spectrum disorders are associated with increased psychotic and schizotypal symptoms.
Yu Veronica Sui, Faye McKenna, Hilary Bertisch, Pippa Storey, Rebecca Anthopolos, Donald C Goff, Alexey Samsonov, Mariana Lazar> ;Molecular Psychiatry. 2022 Dec 1
16 citations
Association Between the Use of Psychotropic Medications and the Risk of COVID-19 Infection Among Long-term Inpatients With Serious Mental Illness in a New York State-w...
Katlyn Nemani, Sharifa Z Williams, Mark Olfson, Emily Leckman-Westin, Molly Finnerty, Jammie Kammer, Thomas E Smith, Daniel J Silverman, Jean-Pierre Lindenmayer, Gilli...> ;JAMA Network Open. 2022 May 2
9 citations
Impairment in acquisition of conditioned fear in schizophrenia
Lauri Tuominen, Liana Romaniuk, Mohammed R. Milad, Donald C. Goff, Jeremy Hall, Daphne J. Holt> ;Neuropsychopharmacology. 2021 Sep 29
21 citations
Association Between Antipsychotic Use and COVID-19 Mortality Among People With Serious Mental Illness.
Katlyn Nemani, Sarah Conderino, Julia Marx, Lorna E. Thorpe, Donald C. Goff> ;JAMA Psychiatry. 2021 Sep 22
115 citations
Association Between Mental Health Disorders and Mortality Among Patients With COVID-19 in 7 Countries: A Systematic Review and Meta-analysis.
Guillaume Fond, Katlyn Nemani, Damien Etchecopar-Etchart, Anderson Loundou, Donald C. Goff, Seung Won Lee, Christophe Lançon, Pascal Auquier, Karine Baumstarck, Pierre...> ;JAMA Psychiatry. 2021 Jul 27
2 citations
Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia.
John Wang, Kamber L. Hart, Wei Qi, Babak A. Ardekani, Chenxiang Li, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne J. Holt, Iruma Bello, Erica D. Diminich, Yi...> ;Journal of Clinical Psychopharmacology. 2021 May 1
2 citations
Effect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial.
Wei Qi, Esther M. Blessing, Chenxiang Li, Babak A. Ardekani, Kamber L. Hart, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne J. Holt, Iruma Bello, Erica D. Dim...> ;Psychiatry Research. Neuroimaging. 2021 Jun 30
6 citations
Quantitative Macromolecular Proton Fraction Mapping Reveals Altered Cortical Myelin Profile in Schizophrenia Spectrum Disorders.
Yu Veronica Sui, Hilary Bertisch, Hong-Hsi Lee, Pippa Storey, James S. Babb, Donald C. Goff, Alexey Samsonov, Mariana Lazar> ;Cerebral Cortex Communications. 2021 Apr 1
214 citations
Association of Psychiatric Disorders With Mortality Among Patients With COVID-19.
Katlyn Nemani, Chenxiang Li, Mark Olfson, Esther M. Blessing, Narges Razavian, Ji Chen, Eva Petkova, Donald C. Goff> ;JAMA Psychiatry. 2021 Apr 1
8 citations
Exposure to Epstein Barr virus and cognitive functioning in individuals with schizophrenia.
Faith Dickerson, Emily Katsafanas, Andrea Origoni, Amalia Squire, Sunil Khushalani, Theresa Newman, Kelly C. Rowe, Cassie Stallings, Christina L.G. Savage, Kevin Sween...> ;Schizophrenia Research. 2021 Jan 12
30 citations
The Pharmacologic Treatment of Schizophrenia-2021.
Donald C. Goff> ;JAMA. 2020 Dec 28
31 citations
Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia.
Huan Huang, Zeng Botao, Yuchao Jiang, Yingying Tang, Tianhong Zhang, Xiaochen Tang, LiHua Xu, Junjie Wang, Jin Li, Zhenying Qian, Xu Liu, Huiling Wang, Cheng Luo, Chun...> ;Brain Imaging and Behavior. 2020 Oct 1
62 citations
Psychiatry and COVID-19.
Dost Öngür, Roy H. Perlis, Donald C. Goff> ;JAMA. 2020 Sep 22
4 citations
Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia
Wenjun Su, Tianyuan Zhu, Lihua Xu, YanYan Wei, Botao Zeng, Tianhong Zhang, HuiRu Cui, Junjie Wang, Yuping Jia, Jinhong Wang, Donald C. Goff, Yingying Tang, Jijun Wang> ;Brain Imaging and Behavior. 2021 Aug 1
5 citations
D-cycloserine augmentation of cognitive behavioral therapy for delusions: A randomized clinical trial.
Erica D. Diminich, Faith Dickerson, Iruma Bello, Corinne Cather, David Kingdon, Pamela Rakhshan Rouhakhtar, Kamber L. Hart, Chenxiang Li, Andrea B. Troxel, Donald C. Goff> ;Schizophrenia Research. 2020 Jun 23
6 citations
Parietal memory network and default mode network in first-episode drug-naïve schizophrenia: Associations with auditory hallucination.
Qian Guo, Yang Hu, Botao Zeng, Yingying Tang, Guanjun Li, Tianhong Zhang, Jinhong Wang, Georg Northoff, Chunbo Li, Donald C. Goff, Jijun Wang, Zhi Yang> ;Human Brain Mapping. 2020 Jun 1
51 citations
Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Thera...
Georgios Schoretsanitis, John M. Kane, Christoph U. Correll, Stephen R. Marder, Leslie Citrome, John W. Newcomer, Delbert G. Robinson, Donald C. Goff, Deanna L. Kelly,...> ;The Journal of Clinical Psychiatry. 2020 May 19
27 citations
Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic sympt...
Joshua T. Kantrowitz, Jack Grinband, Donald C. Goff, Adrienne C. Lahti, Stephen R. Marder, Lawrence S. Kegeles, Ragy R. Girgis, Tarek Sobeih, Melanie M. Wall, Tse-Hwei...> ;Neuropsychopharmacology. 2020 May 13
7 citations
Promising Evidence of Antipsychotic Efficacy without Dopamine D2-Receptor Binding.
Donald C. Goff> ;The New England Journal of Medicine. 2020 Apr 15
5 citations
Reduced Microstructural Lateralization in Males with Chronic Schizophrenia: A Diffusional Kurtosis Imaging Study.
Faye McKenna, James S. Babb, Laura Miles, Donald C. Goff, Mariana Lazar> ;Cerebral Cortex. 2020 Apr 14
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Journal Articles

Association of Psychiatric Disorders with Mortality Among Patients with COVID-19
Mark Olfson, Donald C Goff, JAMA Psychiatry
The Pharmacologic Treatment of Schizophrenia—2021
Donald Goff, MD, JAMA
Psychiatry and COVID-19
Roy Perlis, Donald Goff, JAMA

Press Mentions

Atypical Antipsychotics Linked to Lower Odds of COVIDMay 6th, 2022
COVID-19 Greatly Increases Mortality Risk for Schizophrenia Patients, Research ShowsFebruary 26th, 2021
‘Alarming Finding’ in Schizophrenia Patients with COVID-19February 2nd, 2021
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Grant Support

Citalopram In First Episode SchizophreniaNational Institute Of Mental Health2012
Citalopram In First Episode SchizophreniaNational Institute Of Mental Health2009–2011
New Treatment And Mechanisms In SchizophreniaNational Institute Of Mental Health2001–2011
Folate In SchizophreniaNational Institute Of Mental Health2007–2010
Relapse Prevention: Long-Acting Atypical AntipsychoticsNational Institute Of Mental Health2006–2010
NMDA Receptor Function In SchizophreniaNational Institute Of Mental Health2000–2002
A Trial Of D-Cycloserine In SchizophreniaNational Center For Research Resources1997–2002
Glycine And D-Cycloserine In SchizophreniaNational Institute Of Mental Health1998–2000
Trial Of D-Cycloserine In SchizophreniaNational Institute Of Mental Health1996–1998
Excitatory Amino Acids In SchizophreniaNational Center For Research Resources1997
Lactate/Pyruvate Ratio In Cerebrospinal Fluid--Tardive DyskinesiaNational Center For Research Resources1996
Faculty Scholar Award In SchizophreniaNational Institute Of Mental Health1988–1990