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Donald Siegel, MD, Pathology, Philadelphia, PA, Penn Presbyterian Medical Center

DonaldLSiegelMDPhD

Pathology • Philadelphia, PA

Blood Banking & Transfusion Medicine, Clinical Pathology

Professor, Pathology & Laboratory Medicine, Perelman School of Medicine

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Education & Training

  • University of Pennsylvania Health System
    University of Pennsylvania Health SystemFellowship, Blood Banking/Transfusion Medicine, 1990 - 1991
  • University of Pennsylvania Health System
    University of Pennsylvania Health SystemResidency, Pathology-Anatomic and Clinical, 1987 - 1991
  • Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of PennsylvaniaClass of 1987
  • Harvard University
    Harvard UniversityPhD, Biophysics, 1977 - 1983
  • Brown University
    Brown UniversityB.Sc., Biophysics, with Honors, 1973 - 1977

Certifications & Licensure

  • PA State Medical License
    PA State Medical License 1989 - 2024
  • American Board of Pathology Clinical Pathology

Awards, Honors, & Recognition

  • Elected Fellow College of American Pathologists, 2013
  • Elected to The Academy of Master Clinicians Penn Medicine, 2013
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
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Publications & Presentations

PubMed

Journal Articles

  • Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array  
    Gao, C., Liu, Y., Zhang, H., Zhang, Y., Fukuda, M.N., Palma, A.S., Kozak, R.P., Childs, R.A., Nonaka, M., Li, Z., Siegel, D.L., Hanfland, P., Peehl, D.M., Chai, W., Gr..., J Biol Chem, 1/1/2014
  • Persistence of anti-desmoglein 3 IgG+ B-cell clones in pemphigus patients over years  
    Hammers, C., Chen, J., Lin, C., Kacir, S., Siegel, D.L., Payne, A.S., Stanley, J.R., J Invest Dermatol, 1/1/2014
  • Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody  
    Kouno M., Lin C., Schechter N., Siegel D.L., Stanley J.R., J Invest Dermatol, 1/1/2013
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Books/Book Chapters

  • The Intensive Care Unit Manual 
    Chapter: Transfusion reactions. 
    O’Doherty U., Siegel D.L.Editors: Lanken, P.N., Manaker S., Kohl B.A., Hanson C.W..Elsevier Saunders, Philadelphia, PAEdition 2nd,2014
  • Bacteriophages in Health and Disease 
    Chapter: Clinical applications of phage display-derived peptides and proteins. 
    Siegel D.L.Editors: Hyman P., Abedon S..CABI Press, Cambridge, U.K.2012
  • American Society for Hematology Self-Assessment Program 
    Chapter: Chapter 11, Transfusion Medicine. 
    Siegel D.L., Quillen K.Editors: Gregory S.A. and McCrae K.R..2010
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Abstracts/Posters

  • Successful red blood cell gemotyping from leukoreduced packed red blood cell segments.
    Azzato E., Gentile C., Carpenter H., Siegel D., Watt C., Annual Meeting of the Association for Molecular Pathology, National Harbor, MD, 1/1/2014
  • Transfusions modulate the host inflammatory response and prime the endothelium for subsequent injury through the receptor for advanced glycation end products.
    Mangalmurti N.S., Qing D., Siegel D., Lee J.S., Worthen G.S., Albelda S.M., Transfusion, 1/1/2013
  • Prospective monitoring of cryoprecipitate resulting in decreased product waste.
    Azzato E., Carpenter H., Miszczanczuk M., Dinh L-H., DeMuth F., Magee D., Aqui N., Siegel D., Sachais B.S., Transfusion, 1/1/2013
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Lectures

  • High-Performance Hematology: Elite Athletes and Weekend Warriors 
    60th American Society of Hematology Annual Meeting - 12/3/2018
  • High-Performance Hematology: Elite Athletes and Weekend Warriors 
    60th American Society of Hematology Annual Meeting - 12/1/2018
  • Update on Hematopoietic Stem Cell Transplantation 
    San Diego, CA - 1/1/2014
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Other

  • Methods for Isolation of Antibody Binding to Cells. 
    Siegel D.L., United States Patent Office, #8,623,594 B2
    1/7/2014
  • Drug Delivery to Human Tissues by Single Chain Variable Region Antibody Fragments Cloned by Phage Display. 
    Stanley J.R., Amagai M., Siegel D.L., United States Patent Office, #8,470,323 B2
    1/25/2013
  • Compositions, Methods, and Kits for Detection of an Antigen on a Cell and in a Biological Mixture. 
    Siegel D.L., United States Patent Office, #8,586,293 B2
    1/19/2013
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Press Mentions

  • Glioblastoma Multiforme Translational Center of Excellence
    Glioblastoma Multiforme Translational Center of ExcellenceMarch 1st, 2019

Grant Support

  • Transfusion Medicine Research Training ProgramNational Heart, Lung, And Blood Institute2001–2011
  • Phage Display Tools For Automated Blood TypingNational Heart, Lung, And Blood Institute2006–2007
  • Phage Display Tools For Automated Blood TypingNational Heart, Lung, And Blood Institute2003–2004
  • Monoclonal ITP Autoantibodies--Paradigm For AutoimmunityNational Heart, Lung, And Blood Institute1998–2002
  • Cellular And Humoral Aspects Of ImmunomodulationNational Heart, Lung, And Blood Institute2000
  • Characterization Of The Anti-Rh Alloimmune ResponseNational Heart, Lung, And Blood Institute1996–2000
  • Biology Of Human Warm Autoimmune Hemolytic AnemiaNational Heart, Lung, And Blood Institute1991–1993

Hospital Affiliations

Dr. Donald Siegel, Dr. Donald Siegel, MD, Dr. D Siegel, Dr. Donald L Siegel