DouglasScottMicalizziMDPhD

Oncology • Boston, MA

Internal Medicine Intern

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Office
55 Fruit Street
Boston, MA 02114
Phone+1 617-726-2000
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Education & Training

Massachusetts General HospitalInternship, Internal Medicine, 2012
Massachusetts General HospitalResidency, Internal Medicine, 2012 - 2015
University of Colorado School of Medicine Anschutz Medical CampusClass of 2012

Certifications & Licensure

MA State Medical License 2014 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology
Massachusetts Medical BoardTraining

Publications & Presentations

PubMed

Deploying blood-based cancer screening.
Micalizzi, D., Sequist, L., Haber, D.> ;Science. 2024 Jan 26
2 citations
A Gene Panel Associated With Abemaciclib Utility in-Mutated Breast Cancer After Prior Cyclin-Dependent Kinase 4/6-Inhibitor Progression.
Jamie O Brett, Taronish D Dubash, Gabriela N Johnson, Andrzej Niemierko, Veronica Mariotti, Leslie S L Kim, Jing Xi, Apurva Pandey, Siobhan Dunne, Azadeh Nasrazadani, ...> ;JCO Precision Oncology. 2023 May 1
A Pooled Electronic Consultation Program to Improve Access to Genetics Specialists.
Emma K Folkerts, Renée C Pelletier, Daniel C Chung, Susan A Goldstein, Douglas S Micalizzi, Kristen M Shannon, David A Sweetser, Eugene K Wong, Heidi L Rehm, Leland E ...> ;Medrxiv. 2023 Feb 10
5 citations
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody.
Douglas S Micalizzi, Dante Che, Benjamin T Nicholson, Jon F Edd, Niyati Desai, Evan R Lang, Mehmet Toner, Shyamala Maheswaran, David T Ting, Daniel A Haber> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Oct 25
2 citations
Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition.
Karabacak, N., Zheng, Y., Dubash, T., Burr, R., Micalizzi, D., Wittner, B., Lin, M., Wiley, D., Comaills, V., Emmons, E., Niederhoffer, K., Ho, U., Ukleja, J., Che, D....> ;Cancer Research. 2022 Mar 15
19 citations
Translational Regulation of Cancer Metastasis.
Douglas S. Micalizzi, Richard Y. Ebright, Daniel A. Haber, Shyamala Maheswaran> ;Cancer Research. 2021 Jan 21
41 citations
HIF1A signaling selectively supports proliferation of breast cancer in the brain
Richard Y. Ebright, Marcus A. Zachariah, Douglas S. Micalizzi, Ben S. Wittner, Kira L. Niederhoffer, Linda T. Nieman, Brian Chirn, Devon F. Wiley, Benjamin Wesley, Bri...> ;Nature Communications. 2020 Dec 9
168 citations
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
, , , , , , , , , , , , , , , , , , , , , , , > ;Science. 2020 Mar 27
21 citations
A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells
Sooncheol Lee, Douglas S. Micalizzi, Samuel S. Truesdell, Syed I. A. Bukhari, Myriam Boukhali, Jennifer Lombardi-Story, Yasutaka Kato, Min-Kyung Choo, Ipsita Dey-Guha,...> ;Genome Biology. 2020 Feb 10
10 citations
Identification of somatically acquired BRCA1/2 mutations by cfDNA analysis in patients with metastatic breast cancer
Neelima Vidula, Taronish D. Dubash, Michael S. Lawrence, Antoine Simoneau, Andrzej Niemierko, Erica Blouch, Becky Nagy, Whijae Roh, Brian Chirn, Brittany A. Reeves, Gi...> ;Clinical Cancer Research. 2020 Sep 15
On the trail of invasive cells in breast cancer.
Micalizzi, D. S., Maheswaran, S.> ;Nature. 2018 Feb 16
On the trail of invasive cells in breast cancer.
Micalizzi, D. S., Maheswaran, S.> ;Nature. 2018 Feb 1
269 citations
A conduit to metastasis: circulating tumor cell biology.
Douglas S. Micalizzi, Shyamala Maheswaran, Daniel A. Haber> ;Genes & Development. 2017 Sep 15
54 citations
Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells.
Douglas S. Micalizzi, Daniel A. Haber, Shyamala Maheswaran> ;Molecular Oncology. 2017 Jul 1
A Man in His 40s With Headache, Lethargy, and Altered Mental Status.
Kathleen E. McKee, Mark R Etherton, Scott B. Lovitch, Anoopum S. Gupta, Douglas S. Micalizzi, Travis S. Tierney, Martha Wadleigh, Henrikas Vaitkevicus> ;JAMA Neurology. 2015 Sep 1
243 citations
The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer
Anna L Smith, Ritsuko Iwanaga, David J. Drasin, Douglas S. Micalizzi, Rebecca L. Vartuli, Aik Choon Tan, Heide L. Ford> ;Oncogene. 2012 Dec 13
73 citations
Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated k...
Ritsuko Iwanaga, Chu-An Wang, Douglas S. Micalizzi, J. Chuck Harrell, Paul Jedlicka, Carol A. Sartorius, Peter Kabos, Susan M. Farabaugh, Andrew P. Bradford, Heide L. ...> ;Breast Cancer Research. 2012 Jul 5
88 citations
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer
Chu-An Wang, Paul Jedlicka, Aaron N. Patrick, Douglas S. Micalizzi, Kimberly C. Lemmer, Erin Deitsch, Matias Casás-Selves, J. Chuck Harrell, Heide L. Ford> ;The Journal of Clinical Investigation. 2012 May 1
99 citations
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties.
Susan M. Farabaugh, Douglas S. Micalizzi, Paul Jedlicka, Rui Zhao, Heide L. Ford> ;Oncogene. 2012 Feb 2
84 citations
Homeoprotein Six1 Increases TGF-β Type I Receptor and Converts TGF-β Signaling from Suppressive to Supportive for Tumor Growth
Douglas S. Micalizzi, Chu An Wang, Susan M. Farabaugh, William P. Schiemann, Heide L. Ford> ;Cancer Research. 2010 Dec 15
722 citations
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
Douglas S. Micalizzi, Susan M. Farabaugh, Heide L. Ford> ;Journal of Mammary Gland Biology and Neoplasia. 2010 May 19
117 citations
Epithelial–mesenchymal transition in development and cancer
Douglas S. Micalizzi, Heide L. Ford> ;Future Oncology. 2009 Oct 26
189 citations
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling
Douglas S. Micalizzi, Kimberly L. Christensen, Paul Jedlicka, Ricardo D. Coletta, Anna E. Barón, J. Chuck Harrell, Kathryn B. Horwitz, Dean Billheimer, Karen A. Heichm...> ;The Journal of Clinical Investigation. 2009 Sep 1
81 citations
Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation
Ricardo D. Coletta, Kimberly L. Christensen, Douglas S. Micalizzi, Paul Jedlicka, Marileila Varella-Garcia, Heide L. Ford> ;Cancer Research. 2008 Apr 1
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