DwightCLookIIIMD

Pulmonology • Saint Louis, MO

Critical Care Medicine, Pleural Disease

Physician

Join to view full profile

Dr. Look is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Look's full profile

Already have an account?

Office
915 N Grand Blvd
Saint Louis, MO 63106
Phone+1 314-652-4100
Is this information wrong?

Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Pulmonary Disease and Critical Care Medicine, 1989 - 1992
Carle Foundation HospitalResidency, Internal Medicine, 1988 - 1989
University of ColoradoResidency, Internal Medicine, 1985 - 1988
University of Missouri Kansas City School of MedicineClass of 1985

Certifications & Licensure

MO State Medical License 2011 - 2024
IA State Medical License 2001 - 2011
IL State Medical License 1987 - 1990
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Clinical Trials

Symbicort in Airway Predominant Chronic Obstructive Pulmonary Disease (COPD) Start of enrollment: 2012 Apr 01
Completed
Phase 4

Publications & Presentations

PubMed

88 citations
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
Carlos H. Martinez, Ya Hong Chen, Phillip M. Westgate, Lyrica X. Liu, Susan Murray, Jeffrey L. Curtis, Barry J. Make, Ella A. Kazerooni, David A. Lynch, Nathaniel Marc...> ;Thorax. 2012 May 1
82 citations
Genome-wide association study of smoking behaviours in patients with COPD.
Mateusz Siedlinski, Michael H. Cho, Per Bakke, Amund Gulsvik, David A. Lomas, Wayne H. Anderson, Xiangyang Kong, Stephen I. Rennard, Terri H. Beaty, John E. Hokanson, ...> ;Thorax. 2011 Oct 1
27 citations
Inhibition by Cigarette Smoke of Nuclear Factor-κB–Dependent Response to Bacteria in the Airway
Lori J. Manzel, Lei Shi, Patrick T. O'Shaughnessy, Peter S. Thorne, Dwight C. Look> ;American Journal of Respiratory Cell and Molecular Biology. 2011 Feb 1
40 citations
Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke
Modestos A Modestou, Lori J. Manzel, Sherif El-Mahdy, Dwight C. Look> ;Respiratory Research. 2010 May 26
30 citations
Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia
Audra A Winder, Christine L. Wohlford-Lenane, Todd E. Scheetz, Brie N Nardy, Lori J. Manzel, Dwight C. Look, Paul B. McCray> ;Respiratory Research. 2009 Oct 16
232 citations
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
Hongpeng Jia, Dwight C. Look, Ping Tan, Lei Shi, Melissa Hickey, Lokesh Gakhar, Mark C. Chappell, Christine L. Wohlford-Lenane, Paul B. McCray> ;American Journal of Physiology-lung Cellular and Molecular Physiology. 2009 Jul 1
22 citations
Recognizing the importance of respiratory syncytial virus in chronic obstructive pulmonary disease.
Murali Ramaswamy, Dayna J. Groskreutz, Dwight C. Look> ;COPD: Journal of Chronic Obstructive Pulmonary Disease. 2009 Jul 2
11 citations
Regulation of Bacteria-Induced Intercellular Adhesion Molecule-1 by CCAAT/Enhancer Binding Proteins
Lori J. Manzel, Cecilia L. Chin, Mark A. Behlke, Dwight C. Look> ;American Journal of Respiratory Cell and Molecular Biology. 2009 Feb 1
39 citations
Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication.
Dayna J. Groskreutz, Martha M. Monick, Ellen C. Babor, Toru Nyunoya, Steven M. Varga, Dwight C. Look, Gary W. Hunninghake> ;American Journal of Respiratory Cell and Molecular Biology. 2009 Jan 8
390 citations
Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense
Sif Hansdottir, Martha M. Monick, Sara L. Hinde, Nina Lovan, Dwight C. Look, Gary W. Hunninghake> ;Journal of Immunology. 2008 Nov 15
20 citations
Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins.
Deborah M. Cholon, David Cutter, Stephen K. Richardson, Sanjay Sethi, Timothy F. Murphy, Dwight C. Look, Joseph W. St. Geme> ;Infection and Immunity. 2008 Oct 1
10 citations
Human adenovirus modulates surfactant phospholipid trafficking.
Olga L. Miakotina, Diann M. McCoy, Lei Shi, Dwight C. Look, Rama K. Mallampalli> ;Traffic. 2007 Dec 1
54 citations
Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells.
Dayna J. Groskreutz, Martha M. Monick, Timur O. Yarovinsky, Linda S. Powers, Dawn E. Quelle, Steven M. Varga, Dwight C. Look, Gary W. Hunninghake> ;Journal of Immunology. 2007 Sep 1
17 citations
Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus.
Lei Shi, Murali Ramaswamy, Lori Manzel, Dwight C. Look> ;American Journal of Respiratory Cell and Molecular Biology. 2007 Jul 19
37 citations
Paracellular Permeability Restricts Airway Epithelial Responses to Selectively Allow Activation by Mediators at the Basolateral Surface
Alicia L. Humlicek, Lori J. Manzel, Cecilia L. Chin, Lei Shi, Katherine J. D. A. Excoffon, Michael C. Winter, D. Michael Shasby, Dwight C. Look> ;Journal of Immunology. 2007 May 15
23 citations
Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR.
Sumit Bhattacharyya, Dwight C. Look, Joanne K. Tobacman> ;Clinica Chimica Acta. 2007 May 1
113 citations
Nonstructural Proteins of Respiratory Syncytial Virus Suppress Premature Apoptosis by an NF-κB-Dependent, Interferon-Independent Mechanism and Facilitate Virus Growth
Vira Bitko, Olena Shulyayeva, Barsanjit Mazumder, Alla Musiyenko, Murali Ramaswamy, Dwight C. Look, Sailen Barik> ;Journal of Virology. 2007 Feb 15
568 citations
Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus
Paul B. McCray, Lecia L. Pewe, Christine L. Wohlford-Lenane, Melissa Hickey, Lori Manzel, Lei Shi, Jason Netland, Hongpeng Jia, Carmen M. Halabi, Curt D. Sigmund, Davi...> ;Journal of Virology. 2007 Jan 15
8 citations
Modulation of Airway Inflammation by Haemophilus influenzae Isolates Associated with Chronic Obstructive Pulmonary Disease Exacerbation
Dwight C. Look, Cecilia L. Chin, Lori Manzel, Erin E. Lehman, Alicia L. Humlicek, Lei Shi, Timothy D. Starner, Gerene M. Denning, Timothy F. Murphy, Sanjay Sethi> ;Proceedings of the American Thoracic Society. 2006 Aug 1
184 citations
Respiratory Syncytial Virus Induces TLR3 Protein and Protein Kinase R, Leading to Increased Double-Stranded RNA Responsiveness in Airway Epithelial Cells
Dayna J. Groskreutz, Martha M. Monick, Linda S. Powers, Timur O. Yarovinsky, Dwight C. Look, Gary W. Hunninghake> ;Journal of Immunology. 2006 Feb 1
126 citations
Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction.
Murali Ramaswamy, Lei Shi, Steven M. Varga, Sailen Barik, Mark A. Behlke, Dwight C. Look> ;Virology. 2006 Jan 20
4 citations
A SARS-CoV-specific protein enhances virulence of an attenuated strain of mouse hepatitis virus.
Lecia L. Pewe, Haixia Zhou, Jason Netland, Chandra Tangadu, Heidi Olivares, Lei Shi, Dwight C. Look, Tom Gallagher, Stanley Perlman> ;Advances in Experimental Medicine and Biology. 2006 Jan 1
18 citations
Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization.
Hongpeng Jia, Dwight C. Look, Melissa Hickey, Lei Shi, Lecia L. Pewe, Jason Netland, Michael Farzan, Christine L. Wohlford-Lenane, Stanley Perlman, Paul B. McCray> ;Advances in Experimental Medicine and Biology. 2006 Jan 1
522 citations
ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia
Hongpeng Jia, Dwight C. Look, Lei Shi, Melissa Hickey, Lecia L. Pewe, Jason Netland, Michael Farzan, Christine L. Wohlford-Lenane, Stanley Perlman, Paul B. McCray> ;Journal of Virology. 2005 Dec 15
50 citations
Pyocyanin and its precursor phenazine-1-carboxylic acid increase IL-8 and intercellular adhesion molecule-1 expression in human airway epithelial cells by oxidant-depe...
Dwight C. Look, Lynn L. Stoll, Sara A. Romig, Alicia L. Humlicek, Bradley E. Britigan, Gerene M. Denning> ;Journal of Immunology. 2005 Sep 15
Join now to see all

Grant Support

Induction Of COPD Exacerbation By Haemophilus InfluenzaeNational Heart, Lung, And Blood Institute2005–2009
RSV Inhibition Of Interferon-Dependent Airway ImmunityNational Heart, Lung, And Blood Institute2004–2007
Epithelial Cell Response To H.Influenzae In The AirwayNational Heart, Lung, And Blood Institute2001–2003
Modification Of ICAM 1 Expression In Lung EpitheliumNational Heart, Lung, And Blood Institute2001
Epithelial Cell Response To H.Influenzae In The AirwayNational Heart, Lung, And Blood Institute2000
Modification Of ICAM 1 Expression In Lung EpitheliumNational Heart, Lung, And Blood Institute1997–2000
Regulation Of The ICAM-1 Gene In The Pulmonary AirwayNational Heart, Lung, And Blood Institute1993–1997

Hospital Affiliations

Phelps HealthRolla, Missouri
Veterans Affairs St. Louis Health Care SystemSaint Louis, Missouri

DwightCLookIIIMD

Dr. Look is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Grant Support

Hospital Affiliations

Viewing the full profile is available to verified healthcare professionals only.