EdwardVProchownikMD

Hematology • Pittsburgh, PA

Hematologic Oncology

Professor, Pediatrics, University of Pittsburgh School of Medicine

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Office
3705 5th Ave
Room 4b385
Pittsburgh, PA 15213
Phone+1 412-692-5055
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Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1980 - 1983
Children's Hospital/Boston Medical CenterResidency, Pediatrics, 1978 - 1980
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1978

Certifications & Licensure

PA State Medical License 1992 - 2018
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1989

Publications & Presentations

PubMed

The Myc-Like Mlx Network Impacts Aging and Metabolism.
Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V Prochownik> ;Biorxiv. 2023 Nov 27
A Novel Transgenic Mouse Model Implicatesas a Promoter of Hepatocellular Carcinoma.
Alexandra V Schmidt, Satdarshan P Monga, Edward V Prochownik, Eric S Goetzman> ;International Journal of Molecular Sciences. 2023 Aug 9
9 citations
Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation.
Huabo Wang, Jie Lu, Taylor Stevens, Alexander Roberts, Jordan Mandel, Raghunandan Avula, Bingwei Ma, Yijen Wu, Jinglin Wang, Clinton Van't Land, Toren Finkel, Jerry E ...> ;Cell Reports. 2023 Aug 29
4 citations
Phosphomevalonate Kinase Controls β-Catenin Signaling via the Metabolite 5-Diphosphomevalonate.
Zhiqiang Chen, Xinyi Zhou, Xiaojun Zhou, Yi Tang, Mingzhu Lu, Jianhong Zhao, Chenhui Tian, Mingzhi Wu, Yanliang Liu, Edward V Prochownik, Fubing Wang, Youjun Li> ;Advanced Science. 2023 Apr 1
5 citations
p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression.
Jianhong Zhao, Xiaojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang, Nagarajan Elumalai, Chenhui Tian, Jinmiao Zhang, Yanliang Liu, Zhiqiang Chen, Xinyi Zhou, Mingzhi ...> ;Cell Death & Disease. 2023 Feb 7
Cholesterol esterification and p53-mediated tumor suppression.
Youjun Li, Michael Karin, Prochownik, E.> ;Exploration of Targeted Anti-Tumor Therapy. 2023 Jan 1
3 citations
Lessons in aging from Myc knockout mouse models.
Edward V Prochownik, Huabo Wang> ;Frontiers in Cell and Developmental Biology. 2023 Jan 1
4 citations
Disruption of Multiple Overlapping Functions Following Stepwise Inactivation of the Extended Myc Network.
Huabo Wang, Taylor Stevens, Jie Lu, Merlin Airik, Rannar Airik, Edward V Prochownik> ;Cells. 2022 Dec 16
7 citations
Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network.
Edward V Prochownik> ;Cells. 2022 Dec 8
7 citations
Posttranslational control of lipogenesis in the tumor microenvironment.
Yahui Zhu, Xingrong Lin, Xiaojun Zhou, Edward V Prochownik, Fubing Wang, Youjun Li> ;Journal of Hematology & Oncology. 2022 Aug 29
26 citations
P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis.
Yahui Zhu, Li Gu, Xi Lin, Xinyi Zhou, Bingjun Lu, Cheng Liu, Yajun Li, Edward V Prochownik, Michael Karin, Fubing Wang, Youjun Li> ;Hepatology. 2023 May 1
Correction: Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation.
Laura E Jackson, Sucheta Kulkarni, Huabo Wang, Jie Lu, James M Dolezal, Sivakama S Bharathi, Sarangarajan Ranganathan, Mulchand S Patel, Rahul Deshpande, Frances Alenc...> ;Cancer Research. 2022 Mar 1
12 citations
Normal and Neoplastic Growth Suppression by the Extended Myc Network.
Edward V Prochownik, Huabo Wang> ;Cells. 2022 Feb 21
16 citations
Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice.
Yahui Zhu, Li Gu, Xi Lin, Jinmiao Zhang, Yi Tang, Xinyi Zhou, Bingjun Lu, Xingrong Lin, Cheng Liu, Edward V Prochownik, Youjun Li> ;JCI Insight. 2022 Feb 8
11 citations
Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia.
Huabo Wang, Jie Lu, Frances Alencastro, Alexander Roberts, Julia Fiedor, Patrick Carroll, Robert N Eisenman, Sarangarajan Ranganathan, Michael Torbenson, Andrew W Dunc...> ;Cellular and Molecular Gastroenterology and Hepatology. 2022 Jan 1
14 citations
USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1.
Yahui Zhu, Li Gu, Xi Lin, Xinyi Zhou, Bingjun Lu, Cheng Liu, Caoqi Lei, Feng Zhou, Qiu Zhao, Edward V Prochownik, Youjun Li> ;Cell Reports. 2021 Dec 28
Editorial Expression of Concern: Dynamic in vivo interactions among Myc network members.
Xiao Ying Yin, Melanie F. Landay, Weiping Han, Edwin S. Levitan, Simon C. Watkins, Richard M. Levenson, Daniel L. Farkas, Edward V. Prochownik> ;Oncogene. 2021 Jul 29
5 citations
Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity.
Edward V. Prochownik> ;Cancers. 2021 Apr 21
47 citations
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells.
Edward V. Prochownik, Huabo Wang> ;Cells. 2021 Mar 30
13 citations
Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas
Huabo Wang, Jie Lu, Jordan A. Mandel, Weiqi Zhang, Marie Schwalbe, Joanna E. Gorka, Brady Marburger, Jinglin Wang, Sarangarajan Ranganathan, Edward V. Prochownik> ;Cellular and Molecular Gastroenterology and Hepatology. 2021 Jan 1
17 citations
FBXL6 degrades phosphorylated p53 to promote tumor growth.
Yajun Li, Kaisa Cui, Qiang Zhang, Xu Li, Xingrong Lin, Yi Tang, Edward V. Prochownik, Youjun Li> ;Cell Death and Differentiation. 2021 Feb 10
6 citations
Acquired deficiency of peroxisomal dicarboxylic acid catabolism is a metabolic vulnerability in hepatoblastoma.
Huabo Wang, Jie Lu, Xiaoguang Chen, Marie Schwalbe, Joanna E. Gorka, Jordan A. Mandel, Jinglin Wang, Eric S. Goetzman, Sarangarajan Ranganathan, Steven F. Dobrowolski,...> ;The Journal of Biological Chemistry. 2021 Jan 1
57 citations
The IKKβ‐USP30‐ACLY Axis Controls Lipogenesis and Tumorigenesis
Li Gu, Yahui Zhu, Xi Lin, Bingjun Lu, Xinyi Zhou, Feng Zhou, Qiu Zhao, Edward V. Prochownik, Youjun Li> ;Hepatology. 2021 Jan 1
5 citations
Sequential analysis of transcript expression patterns improves survival prediction in multiple cancers
Jordan A. Mandel, Raghunandan Avula, Edward V. Prochownik> ;BMC Cancer. 2020 Apr 7
63 citations
Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis
Yahui Zhu, Li Gu, Xi Lin, Cheng Liu, Bingjun Lu, Kaisa Cui, Feng Zhou, Qiu Zhao, Edward V. Prochownik, Chengpeng Fan, Youjun Li> ;Molecular Cell. 2020 Jan 2
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Press Mentions

V Foundation Grant Goes Toward Children’s Cancer Research at UPMC Children’sFebruary 10th, 2021

Grant Support

Structure-Based Design Of Novel Low Molecular Weight C-MYC InhibitorsNational Cancer Institute2009–2011
C-N-, And L-MYC Effects On Hematopoietic CellsNational Cancer Institute2009
C-N-, And L-MYC Effects On Hematopoietic CellsNational Cancer Institute2005–2008
Regulation Of And By The MYC OncoproteinNational Cancer Institute2004–2008
C-, N-, And L-MYC Effects On Hematopoietic CellsNational Cancer Institute1999–2003
Molecular Biology Of Hematopoietic DifferentiationNational Heart, Lung, And Blood Institute1992–2000
Signaling Pathways Of Transforming OncogenesNational Cancer Institute1992–1996
Signaling Pathways Of Transforming OncogenesNational Cancer Institute1992
Molecular Biology Of Hematopoietic DifferentiationNational Heart, Lung, And Blood Institute1988–1991
Human Atiii Genes &Coagulopathy Of Atiii DeficiencyNational Heart, Lung, And Blood Institute1987
Human Antithrombin IIINational Heart, Lung, And Blood Institute1985–1986

Hospital Affiliations

UPMC Children's Hospital of PittsburghPittsburgh, Pennsylvania
UPMC Magee-Womens HospitalPittsburgh, Pennsylvania