GregoryAnthonyYanikMD

Pediatric Hematology & Oncology • Ann Arbor, MI

Professor, Pediatrics & Communicable Diseases, University of Michigan Medical School

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Office
1540 E Hospital Dr
Ann Arbor, MI 48109
Phone(734) 936-9814
Fax(734) 232-7580
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Education & Training

Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Hematology/Oncology, 1988 - 1991
William Beaumont HospitalResidency, Internal Medicine, 1984 - 1987
William Beaumont HospitalInternship, Transitional Year, 1983 - 1984
Wayne State University School of MedicineClass of 1983

Certifications & Licensure

OH State Medical License 1988 - 1992
MI State Medical License 1984 - 2023
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinistat Start of enrollment: 2014 Jul 01Marachelian, A.,Twist, C.,Yanik, G.,Park, J.,Matthay, K.,Goldsmith, K.,Macy, M.,Granger, M.,Roberts, S.,DuBois, S.,Cohn, S.L.,Shusterman, S.,Baruchel, S.,Mosse, Y.
N2012-01: Phase 1 Study of Difluoromethylornithine (DFMO) and Celecoxib With Cyclophosphamide/Topotecan Start of enrollment: 2013 Dec 01Marachelian, A.,Marchelian, A.,Weiss, B.,Twist, C.,Yanik, G.,Park, J.R.,Matthay, K.,Goldsmith, K.,Macy, M.,Granger, M.,Kreissman, S.,Cohn, S.L.,Shusterman, S.-.,Mosse, Y.
A Phase I Study of Lenalidomide and Anti-GD2 Mab Ch14.18 +/- Isotretinoin in Patients With Refractory/Recurrent Neuroblastoma Start of enrollment: 2013 Feb 01Macy, M.,Park, J.R.,Matthay, K.K.,Granger, M.M.,Twist, C.,Mosse, Y.P.,Marachelian, A.,Weiss, B.D.,Roberts, S.S.,Yanik, G.A.,Shusterman, S.,Cohn, S.L.
Vorinostat With 131-I MIBG Therapy for Resistant/Relapsed Neuroblastoma: A Phase I Study IND# 105,744 Start of enrollment: 2010 Mar 01Cohn, S.L.,DuBois, S.,Granger, M.,Katzenstein, H.,Kreissman, S.,Marachelian, A.,Matthay, K.K.,Mosse, Y.,Park, J.R.,Shusterman, S.,Twist, C.,Weiss, B.,Yanik, G.,Zage, P.
A Phase I Study of Bevacizumab With Bolus and Metronomic Cyclophosphamide and Zoledronic Acid in Children With Recurrent or Refractory Neuroblastoma Start of enrollment: 2009 Dec 01Baruchel, S.,Cohn, S.L.,Glade-Bender, J.,Glade-Bender, J.L.,Granger, M.,Katzenstein, H.,Kreissman, S.,Marachelian, A.,Matthay, K.K.,Mosse, Y.,Park, J.R.,Shusterman, S.,Teira, P.,Twist, C.,Weiss, B.,Yanik,...
A Randomized Double-Blind, Placebo-Controlled Trial of Soluble Tumor Necrosis Factor Receptor: Enbrel (Etanercept) for the Treatment of Acute Non-Infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Cell Transplantation (B Start of enrollment: 2007 Aug 01Afessa, B.,Bolanos-Meade, J.,Castro-Malaspina, H.,Giralt, S.,Hayes-Lattin, B.,Ho, V.,Jansen, J.,Lazarus, H.,Long, G.,Madtes, D.,McClune, B.,Schwartz, J.,Stadtmann, E.,Wingard, J.,Yanik, G.
Hematopoietic Stem Cell Transplantation for the Treatment of Older Patients With Acute Myelogenous Leukemia Start of enrollment: 2007 Mar 01Line, C.A.,Yanik, G.
Soluble Tumor Necrosis Factor Receptor: Enbrel (Etanercept) for the Treatment of Acute Non-Infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Stem Cell Transplantation Start of enrollment: 2006 Apr 01Barnette, P.E.,Baruchel, S.,Cooke, K.R.,Estrada, J.,Fox, E.,Goldman, S.,Hale, G.A.,Katzenstein, H.M.,Kelly, M.E.,Maloney, K.W.,Marina, N.M.,Mascarenhas, L.,McNall-Knapp, R.Y.,Megason, G.C.,Ozkaynak, M.F.,...
I-Metaiodobenzylguanidine (MIBG) With Intensive Chemotherapy and Autologous Stem Cell Rescue for High-Risk Neuroblastoma Start of enrollment: 2005 Sep 01Maris, J.M.,Matthay, K.K.,Yanik, G.
I-MIBG Escalating Dose Rapid Sequence Double Infusion Followed By Autologous Stem Cell Infusion For Refractory Neuroblastoma Start of enrollment: 2004 Mar 01Maris, J.M.,Matthay, K.K.,Yanik, G.
Soluble Tumor Necrosis Factor Receptor: Enbrel (Etanercept) for the Treatment of Sub-Acute Pulmonary Dysfunction Following Allogeneic Stem Cell Transplantation. A Phase II Study Start of enrollment: 2003 Oct 01Yanik, G.A.
Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS) Gregory Yanik, MD
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Publications & Presentations

PubMed

A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation.
Muna Qayed, Kwang Woo Ahn, Carrie L. Kitko, Mariam H Johnson, Nirali N. Shah, Christopher C. Dvorak, Karin Mellgren, Brian D. Friend, Michael R. Verneris, Wing Leung, ...> ;Blood. 2020 Nov 18
Concurrent Reductions in Spirometry Predict Mortality and Bronchiolitis Obliterans in Chronic Graft versus Host Disease.
O'Dwyer, D. N., Wang, Y., Myers, D., Moore, B. B., Murray, S., Yanik, G. A.> ;Annals of the American Thoracic Society. 2020 Nov 5
Chimeric Antigen Receptor T-Cell Therapy-Associated Cardiomyopathy in Patients With Refractory or Relapsed Non-Hodgkin Lymphoma.
Sarju Ganatra, Robert A. Redd, Salim S. Hayek, Rohan Parikh, Tariq U. Azam, Gregory A. Yanik, Lauren Spendley, Sarah Nikiforow, Caron A. Jacobson, Anju Nohria> ;Circulation. 2020 Oct 27
Response to Maccio et al., "Multifactorial Pathogenesis of COVID-19-related Coagulopathy: Can defibrotide have a role in the early phases of coagulation disorders?"
Edward Richardson, Carmelo Carlo-Stella, Ruben Jara, Israel Vlodavsky, Massimo Iacobelli, Jawed Fareed, Clifton C. Mo, Peter O'Gorman, Gregory A. Yanik, Marta Palomo, ...> ;Journal of Thrombosis and Haemostasis. 2020 Aug 28
Veno-occlusive disease after high-dose busulfan-melphalan in neuroblastoma.
Tal Schechter, Evelio Perez-Albuerne, Tiffany F. Lin, Meredith S. Irwin, Mohammed Al Essa, Ami V. Desai, Haydar Frangoul, Gregory A. Yanik, L. Lee Dupuis, David A. Jac...> ;Bone Marrow Transplantation. 2020 Mar 1
Priorities for Improving Outcomes for Nonmalignant Blood Diseases: A Report from the Blood and Marrow Transplant Clinical Trials Network.
Levine, J. E., Antin, J. H., Allen, C. E., Burroughs, L. M., Cooke, K. R., Devine, S., Heslop, H., Nakamura, R., Talano, J. A., Yanik, G., DiFronzo, N.> ;Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2020 Feb 9
Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.
Cheng, G., Selwa, K. E., Hatt, C., Ram, S., Fortuna, A. B., Guerriero, M., Himelhoch, B., McAree, D., Hoffman, T. C., Brisson, J., Nazareno, R., Bloye, K., Johnson, T....> ;American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Feb 9
Disease risk and GVHD biomarkers can stratify patients for risk of relapse and nonrelapse mortality post hematopoietic cell transplant.
Aziz, M. D., Shah, J., Kapoor, U., Dimopoulos, C., Anand, S., Augustine, A., Ayuk, F., Chaudhry, M., Chen, Y., Choe, H. K., Etra, A., Gergoudis, S., Hartwell, M. J., H...> ;Leukemia. 2020 Feb 6
Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Brown, P., Inaba, H., Annesley, C., Beck, J., Colace, S., Dallas, M., DeSantes, K., Kelly, K., Kitko, C., Lacayo, N., Larrier, N., Maese, L., Mahadeo, K., Nanda, R., N...> ;Journal of the National Comprehensive Cancer Network : JNCCN. 2020 Jan 8
How Should We Determine the Value of CAR T-Cell Therapy?
Silbert, S., Yanik, G. A., Shuman, A. G.> ;AMA journal of ethics. 2019 Oct 28
Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a globa...
Laetsch, T. W., Myers, G. D., Baruchel, A., Dietz, A. C., Pulsipher, M. A., Bittencourt, H., Buechner, J., De Moerloose, B., Davis, K. L., Nemecek, E., Driscoll, T., M...> ;The Lancet. Oncology. 2019 Oct 14
Assessment of Individual versus Composite Endpoints of Acute Graft-versus-Host Disease in Determining Long-Term Survival after Allogeneic Transplantation.
John M. Magenau, Thomas M. Braun, Erin Gatza, Tracey Churay, Amanda Mazzoli, Grant Chappell, Joseph Brisson, Lyndsey Runaas, Sarah Anand, Monalisa Ghosh, Mary M. Riwes...> ;Biology of Blood and Marrow Transplantation. 2019 Aug 1
First-Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation
Xiaofeng Zhou, David N O'Dwyer, Meng Xia, Holly K. Miller, Paul R Chan, Kelsey Trulik, Mathew M Chadwick, Timothy Hoffman, Camille Bulte, Kevin Sekerak, Carol A. Wilke...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Jul 1
Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children
Matt S. Zinter, Christopher C. Dvorak, Madeline Y Mayday, Kensho Iwanaga, Ngoc P. Ly, Meghan E. McGarry, Gwynne D. Church, Lauren E Faricy, Courtney M. Rowan, Janet R....> ;Clinical Infectious Diseases. 2019 May 17
Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation: RDSafe Peds Results.
Michael A. Pulsipher, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, Susan F. Leitman, James W. Varni, H...> ;Biology of Blood and Marrow Transplantation. 2019 May 1
Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors
Michael A. Pulsipher, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, O’Susan F. Leitman, Hati Kobusingye...> ;Haematologica. 2019 Apr 1
Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study
Michael A. Pulsipher, Brent R. Logan, Pintip Chitphakdithai, Deidre M. Kiefer, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, Susan F. Leitman, James W. Varni, H...> ;Biology of Blood and Marrow Transplantation. 2019 Apr 1
Respiratory Tract Colonization by <i>Candida</i> species Portends Worse Outcomes in Immunocompromised Patients.
Pendleton, K. M., Dickson, R. P., Newton, D. W., Hoffman, T. C., Yanik, G. A., Huffnagle, G. B.> ;Clinical pulmonary medicine. 2019 Mar 27
Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma
Steven G. DuBois, Yael P. Mosse, Elizabeth Fox, Rachel A. Kudgus, Joel M. Reid, Renee M. McGovern, S. Groshen, Rochelle Bagatell, John M. Maris, Clare J. Twist, Kelly ...> ;Clinical Cancer Research. 2018 Dec 15
Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma.
Elizabeth A. Sokol, Roger Engelmann, Wenjun Kang, Navin Pinto, Adam Starkey, Hollie Lai, Helen Nadel, Barry L. Shulkin, Yonglin Pu, Daniel Appelbaum, Gregory A. Yanik,...> ;Pediatric Blood & Cancer. 2018 Dec 1
23 citations
An early-biomarker algorithm predicts lethal graft-versus-host disease and survival.
Hartwell, M. J., Özbek, U., Holler, E., Renteria, A. S., Major-Monfried, H., Reddy, P., Aziz, M., Hogan, W. J., Ayuk, F., Efebera, Y. A., Hexner, E. O., Bunworasate, U...> ;JCI insight. 2018 Aug 24
Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.
Shernan G. Holtan, Todd E. DeFor, Angela Panoskaltsis-Mortari, Nandita Khera, John E. Levine, Mary E.D. Flowers, Stephanie J. Lee, Yoshihiro Inamoto, George L. Chen, S...> ;Blood Advances. 2018 Aug 14
Treosulfan, Fludarabine, and Low-Dose Total Body Irradiation for Children and Young Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Allogenei...
Eneida R. Nemecek, Ralf A. Hilger, Alexia Adams, Bronwen E. Shaw, Deidre M. Kiefer, Jennifer Le-Rademacher, John E. Levine, Gregory A. Yanik, Wing Leung, Julie-An Tala...> ;Biology of Blood and Marrow Transplantation. 2018 Aug 1
1 citation
MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD
Hannah Major-Monfried, Anne S. Renteria, Attaphol Pawarode, Pavan Reddy, Francis Ayuk, Ernst Holler, Yvonne A. Efebera, William J. Hogan, Matthias Wölfl, Muna Qayed, E...> ;Blood. 2018 Jun 21
Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation.
O'Dwyer, D. N., Zhou, X., Wilke, C. A., Xia, M., Falkowski, N. R., Norman, K. C., Arnold, K. B., Huffnagle, G. B., Murray, S., Erb-Downward, J. R., Yanik, G. A., Moore...> ;American journal of respiratory and critical care medicine. 2018 Jun 8
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Abstracts/Posters

Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World E...
Gregory Yanik, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

Molecular Detection of Minimal Residual Disease Precedes Morphological Relapse and Could be Used to Identify Relapse in Pediatric and Young Adult B-Cell Acute Lymphobl...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

U-M Rogel Cancer Center First in Michigan to Offer All FDA Approved Car T-cell TherapiesMay 24, 2018 17:48
Mott Poised to Be Among First in the Nation to Offer Groundbreaking CAR-T Cell Therapy for Childhood LeukemiaSeptember 01, 2017 11:03

Grant Support

MIBG W/ Intensive Chemotheryapy &Autologous Stem Cell Rescue For NeuroblastemaNational Center For Research Resources2007
Etanercept For Treatment Of Sub-Acute Pulm Dysfunction After Allogeneic BMTNational Center For Research Resources2007
(MIBG) With Intensive Chemotheryapy And Autologous Stem Cell Rescue For NeuroblaNational Center For Research Resources2006
131-I-Metaiodobenzylguanidine (131i-Mibg) Therapy For Refractory NeuroblastomaNational Center For Research Resources2004–2006
131-1 MIBG In Combination With Chemotherapy For NeuroblastomaNational Center For Research Resources2000–2002