HowardScottBoswellJr.MD

Oncology • Indianapolis, IN

Professor, Medicine, IN Univ Sch of Med

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Office
1044 W Walnut St
R4202
Indianapolis, IN 46202
Phone+1 317-944-5000

Fax+1 317-554-0178
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Summary

Dr. Howard Boswell Jr., MD is an oncologist in Indianapolis, Indiana. He is currently licensed to practice medicine in Indiana. He is affiliated with Indiana University Health University Hospital and Richard L. Roudebush Veterans Affairs Medical Center.

Education & Training

University of Virginia Medical CenterResidency, Internal Medicine, 1980 - 1984
University of Virginia School of MedicineClass of 1977

Certifications & Licensure

IN State Medical License 1983 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Publications & Presentations

PubMed

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Dani...> ;Nature Communications. 2020 Jul 28
7 citations
Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in acute myeloid leukaemia: Therapeutic implications.
Fangli Chen, Xue Wu, Cristina Mariana Niculite, Marilena Gilca, Daniela N. Petrusca, Adriana L. Rogozea, Susan Rice, Bin Guo, Shawn Griffin, George A. Calin, H. Scott ...> ;Journal of Cellular and Molecular Medicine. 2020 Jul 1
61 citations
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway.
Sisi Chen, Qiang Wang, Hao Yu, Maegan L. Capitano, Sasidhar Vemula, Sarah C. Nabinger, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Zhuangzhuang Geng, Aidan Fahey, Dani...> ;Nature Communications. 2019 Dec 11
11 citations
Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development
Sarah C. Nabinger, Sisi Chen, Rui Gao, Chonghua Yao, Michihiro Kobayashi, Sasidhar Vemula, Aidan Fahey, Christine Y. Wang, Cecil Daniels, H. Scott Boswell, George E. S...> ;Leukemia. 2019 Jan 23
11 citations
Combination of sorafenib, vorinostat and bortezomib for the treatment of poor-risk AML: report of two consecutive clinical trials.
Hamid Sayar, Larry D. Cripe, Antoine N. Saliba, Mohammad Abu Zaid, Heiko Konig, H. Scott Boswell> ;Leukemia Research. 2019 Feb 1
3 citations
Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML
Hamid Sayar, Yan Liu, Rui Gao, Mohammad Abu Zaid, Larry D. Cripe, Jill Weisenbach, Katie J. Sargent, Mehdi Nassiri, Lang Li, Heiko Konig, Attaya Suvannasankha, Feng Pa...> ;Oncotarget. 2015 Nov 7
Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53.
Chen, S.,Gao, R.,Yao, C.,Kobayashi, M.,Liu, S. Z.,Yoder, M. C.,Broxmeyer, H.,Kapur, R.,Boswell, H. S.,Mayo, L. D.,Liu, Y.> ;Leukemia. 2017 Dec 22
Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia.
Kobayashi, M.,Chen, S.,Bai, Y.,Yao, C.,Gao, R.,Sun, X. J.,Mu, C.,Twiggs, T. A.,Yu, Z. H.,Boswell, H. S.,Yoder, M. C.,Kapur, R.,Mulloy, J. C.,Zhang, Z. Y.,Liu, Y.> ;Leukemia. 2017 Feb 22
11 citations
Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-bindin...
Padmaja Gade, Amy S. Kimball, Angela C. DiNardo, Priyamvada Gangwal, Douglas D. Ross, H. Scott Boswell, Susan Keay, Dhananjaya V. Kalvakolanu> ;The Journal of Biological Chemistry. 2016 Oct 14
Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia.
Richine, B. M.,Virts, E. L.,Bowling, J. D.,Ramdas, B.,Mali, R.,Naoye, R.,Liu, Z.,Zhang, Z. Y.,Boswell, H. S.,Kapur, R.,Chan, R. J.> ;Leukemia. 2016 Jun 04
49 citations
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis
Anindya Chatterjee, Joydeep Ghosh, Baskar Ramdas, Raghuveer Singh Mali, Holly Martin, Michihiro Kobayashi, Sasidhar Vemula, Victor Hugo Canela, Emily R. Waskow, Valeri...> ;Cell Reports. 2014 Nov 20
146 citations
Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner
Lin Wang, Huajia Zhang, Sonia Rodríguez, Liyun Cao, Jonathan Parish, Christen L. Mumaw, Amy Zollman, Malgorzata M. Kamoka, Jian Mu, Danny Z. Chen, Edward F. Srour, Bra...> ;Cell Stem Cell. 2014 Jul 3
The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Nabinger, S. C.,Li, X. J.,Ramdas, B.,He, Y.,Zhang, X.,Zeng, L.,Richine, B.,Bowling, J. D.,Fukuda, S.,Goenka, S.,Liu, Z.,Feng, G. S.,Yu, M.,Sandusky, G. E.,Boswell, H. ...> ;Leukemia. 2013 Feb
17 citations
Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells
Tareq Al Baghdadi, Rafat Abonour, H. Scott Boswell> ;Clinical Lymphoma, Myeloma & Leukemia. 2012 Apr 1
28 citations
A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia.
Rajasubramaniam Shanmugam, Padmaja Gade, Annique Wilson-Weekes, Hamid Sayar, Attaya Suvannasankha, Chirayu P. Goswami, Lang Li, Sushil Gupta, Angelo A. Cardoso, Tareq ...> ;Clinical Cancer Research. 2012 Jan 15
79 citations
Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL
Raghuveer Singh Mali, Baskar Ramdas, Peilin Ma, Jianjian Shi, Veerendra Munugalavadla, Emily Sims, Lei Wei, Sasidhar Vemula, Sarah C. Nabinger, Charles B. Goodwin, Reb...> ;Cancer Cell. 2011 Sep 13
38 citations
Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3.
Seiji Fukuda, Pratibha Singh, Akira Moh, Mariko Abe, Edward M. Conway, H. Scott Boswell, Seiji Yamaguchi, Xin-Yuan Fu, Louis M. Pelus> ;Blood. 2009 Jul 9
33 citations
Antimyeloma Effects of a Sesquiterpene Lactone Parthenolide
Attaya Suvannasankha, Colin D. Crean, Rajasubramaniam Shanmugam, Sherif S. Farag, Rafat Abonour, H. Scott Boswell, Harikrishna Nakshatri> ;Clinical Cancer Research. 2008 Mar 15
20 citations
MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB–dependent promoters
Edward M. Chan, Rebecca J. Chan, Elisha M. Comer, Robert J. Goulet, Colin D. Crean, Zachary D. Brown, Amy M. Fruehwald, Zhenyun Yang, H. Scott Boswell, Harikrishna Nak...> ;Experimental Hematology. 2007 Dec 1
29 citations
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.
Amy D. Hartman, Annique Wilson-Weekes, Attaya Suvannasankha, Burgess Gs, Carissa A. Phillips, Katie J. Hincher, Larry D. Cripe, H. Scott Boswell> ;Experimental Hematology. 2006 Oct 1
P21waf-1-Chk1 pathway monitors G1 phase microtubule integrity and is crucial for restriction point transition.
Mantel, C.R., Gelfano, V.M., Kim, Y., McDaniel, A., Lee, Y., Boswell, H.S., Broxmeyer, H.E.> ;Cell Cycle. 2002-09-01
Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation.
Cripe LD, Gelfanov VM, Smith EA, Spigel DR, Phillips CA, Gabig TG, Jung S, Fyffe J, Hartman AD, Kneebone P, Mercola D, Burgess GS, Boswell HS> ;Leukemia. 2002-05-01
30 citations
Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapop...
Vasily M. Gelfanov, Burgess Gs, Litz-Jackson S, Alastair J. King, Mark S. Marshall, Harikrishna Nakshatri, H. Scott Boswell> ;Blood. 2001 Oct 15
55 citations
Induction of Apoptosis by Arachidonic Acid in Chronic Myeloid Leukemia Cells
M. T. Rizzo, E. Regazzi, D. Garau, Luke P. Akard, Michael J. Dugan, H. Scott Boswell, Vittorio Rizzoli, Carmelo Carlo-Stella> ;Cancer Research. 1999 Oct 1
38 citations
Regulation of the c-jun Gene in p210 BCR-ABL Transformed Cells Corresponds With Activity of JNK, the c-jun N-Terminal Kinase
Burgess Gs, Elizabeth A. Williamson, Larry D. Cripe, Litz-Jackson S, Jay A. Bhatt, Kurt Stanley, Mark J. Stewart, Andrew S. Kraft, Harikrishna Nakshatri, H. Scott Boswell> ;Blood. 1998 Oct 1
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Hospital Affiliations

Richard L. Roudebush Veterans Affairs Medical CenterIndianapolis, Indiana
Indiana University Health University HospitalIndianapolis, Indiana