HarryEdwardGruberMD

PubMed

• 9 citations
  PD-L1 checkpoint blockade delivered by retroviral replicating vector confers anti-tumor efficacy in murine tumor models.
  Leah Mitchell, Kader Yagiz, Andrew Hofacre, Sophie Viaud, Anthony W. Munday, Fernando Lopez Espinoza, Daniel Mendoza, Maria Rodriguez-Aguirre, Simon Bergqvist, Ali Hag...> ;Oncotarget. 2019 Mar 19
• 21 citations
  A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
  Kader Yagiz, Maria Rodriguez-Aguirre, Fernando Lopez Espinoza, Tiffany T. Montellano, Daniel Mendoza, Leah Mitchell, Carlos E. Ibanez, Noriyuki Kasahara, Harry E. Grub...> ;Molecular Therapy Oncolytics. 2018 Mar 30
• 15 citations
  Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models
  Kader Yagiz, Tiffany T. Huang, Fernando Lopez Espinoza, Daniel Mendoza, Carlos E. Ibanez, Harry E. Gruber, Douglas J. Jolly, Joan M. Robbins> ;Neuro-Oncology. 2016 Oct 1
• 2 citations
  Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation E...
  Amy H. Lin, Yanzheng Liu, Cynthia Burrascano, Kathrina Cunanan, Christopher R. Logg, Joan M. Robbins, Noriyuki Kasahara, Harry E. Gruber, Carlos E. Ibanez, Douglas J. ...> ;Human Gene Therapy Methods. 2016 Jan 26
• 44 citations
  Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model.
  Tiffany T. Huang, Shraddha Parab, Ryan Burnett, Oscar Diago, Derek Ostertag, Florence M. Hofman, Fernando Lopez Espinoza, Bryan Martin, Carlos E. Ibanez, Noriyuki Kasa...> ;Human Gene Therapy. 2015 Feb 1
• 24 citations
  Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
  Masamichi Takahashi, Gilmer Valdes, Kei Hiraoka, Akihito Inagaki, Shuichi Kamijima, Ewa D. Micewicz, Harry E. Gruber, Joan M. Robbins, Douglas J. Jolly, William H. McB...> ;Cancer Gene Therapy. 2014 Oct 1
• 18 citations
  Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity
  Amy H. Lin, Cindy Burrascano, Pär L. Pettersson, Carlos E. Ibanez, Harry E. Gruber, Douglas J. Jolly> ;Journal of Virology. 2014 Sep 1
• 3 citations
  MicroRNA 142-3p Attenuates Spread of Replicating Retroviral Vector in Hematopoietic Lineage-Derived Cells While Maintaining an Antiviral Immune Response
  Amy H. Lin, Nina Timberlake, Christopher R. Logg, Yanzheng Liu, Shuichi Kamijima, Oscar Diago, Kenneth Wong, Dawn Gammon, Derek Ostertag, Katrin Hacke, Emily Yang, Har...> ;Human Gene Therapy. 2014 May 13
• 41 citations
  Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model
  T T Huang, Juraj Hlavaty, Derek Ostertag, Fernando Lopez Espinoza, Bryan Martin, Helga Petznek, Maria Rodriguez-Aguirre, Carlos E. Ibanez, Noriyuki Kasahara, Walter H....> ;Cancer Gene Therapy. 2013 Aug 23
• 17 citations
  Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model.
  Dali Yin, Yuying Zhai, Harry E. Gruber, Carlos E. Ibanez, Joan M. Robbins, Adrian P. Kells, Noriyuki Kasahara, John Forsayeth, Douglas J. Jolly, Krystof S. Bankiewicz> ;Cancer Gene Therapy. 2013 Jun 1
• 92 citations
  Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression
  Omar D. Perez, Christopher R. Logg, Kei Hiraoka, Oscar Diago, Ryan Burnett, Akihito Inagaki, Dawn Jolson, Karin K. Amundson, Taylor Buckley, Daniel L. Lohse, Amy Lin, ...> ;Molecular Therapy. 2012 Sep 1
• 95 citations
  Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
  Derek Ostertag, Karin K. Amundson, Fernando Lopez Espinoza, Bryan Martin, Taylor Buckley, Ana Paula Galvão Da Silva, Amy H. Lin, David T. Valenta, Omar D. Perez, Carlo...> ;Neuro-Oncology. 2012 Feb 1
• 15 citations
  Retroviral replicating vectors in cancer
  Christopher R. Logg, Joan M. Robbins, Douglas J. Jolly, Harry E. Gruber, Noriyuki Kasahara> ;Methods in Enzymology. 2012 Jan 1
• Clinical and demographic prognostic indicators for human disc cell proliferation in vitro: pilot study.
  Gruber HE, Norton HJ, Leslie K, Hanley EN> ;Spine. 2001-11-01
• Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro.
  Gruber HE, Norton HJ, Hanley EN> ;Spine. 2000-09-01
• Effects of very high antibiotic concentrations on human intervertebral disc cell proliferation, viability, and metabolism in vitro.
  Hoelscher GL, Gruber HE, Coldham G, Grigsby JH, Hanley EN> ;Spine. 2000-08-01
• Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers.
  David SM, Gruber HE, Meyer RA, Murakami T, Tabor OB, Howard BA, Wozney JM, Hanley EN> ;Spine. 1999-10-01
• Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog.
  Meyer RA, Gruber HE, Howard BA, Tabor OB, Murakami T, Kwiatkowski TC, Wozney JM, Hanley EN> ;Spine. 1999-04-15
• Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls.
  Gruber, H. E.,Hanley, E. N.> ;Spine. 1998 May 01
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