IanMichaelMcGowanMD

PubMed

• 3 citations
  A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection.
  Angela Wahl, Wenbo Yao, Baolin Liao, Morgan Chateau, Cara Richardson, Lijun Ling, Adrienne Franks, Krithika Senthil, Genevieve Doyon, Fengling Li, Josh Frost, Christop...> ;Nature Biotechnology. 2023 Aug 10
• 5 citations
  Acceptability of a Dapivirine/Placebo Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-026).
  José A. Bauermeister, Ryan C Tingler, Clara Dominguez, Eileen F. Dunne, Craig J. Hoesley, Ken K. Y. Ho, Sherri Johnson, Jonathan Lucas, Nicole Macagna, Elizabeth R. Br...> ;AIDS and Behavior. 2021 Oct 17
• 8 citations
  An Open-Label Pharmacokinetic and Pharmacodynamic Assessment of Tenofovir Gel and Oral Emtricitabine/Tenofovir Disoproxil Fumarate.
  Ian McGowan, Ratiya Pamela Kunjara Na Ayudhya, Rhonda M. Brand, Mark A. Marzinke, Craig W. Hendrix, Sherri Johnson, Jeanna M. Piper, Timothy H. Holtz, Marcel E. Curlin...> ;AIDS Research and Human Retroviruses. 2021 Oct 29
• 5 citations
  A Randomized, Double Blind, Placebo-Controlled, Phase 1 Safety and Pharmacokinetic Study of Dapivirine Gel (0.05%) Administered Rectally to HIV-1 Seronegative Adults (...
  Ross D Cranston, Elizabeth R. Brown, José A. Bauermeister, Eileen F. Dunne, Craig J. Hoesley, Ken K. Y. Ho, Sherri Johnson, Jonathan Lucas, Clara Dominguez-Islas, Holl...> ;AIDS Research and Human Retroviruses. 2021 Sep 9
• 5 citations
  A Randomized, Open-Label, Crossover Phase 1 Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel (the CHARM-03 Study).
  Ian McGowan, Sylvain Chawki, Craig W. Hendrix, Peter A. Anton, Mark A. Marzinke, Rhonda M. Brand, Jarret Engstrom, Lisa C. Rohan, Kaleab Z. Abebe, Nicola Richardson-Ha...> ;AIDS Research and Human Retroviruses. 2021 Sep 14
• 22 citations
  Safety and Pharmacokinetics of a Tenofovir Alafenamide Fumarate-Emtricitabine based Oral Antiretroviral Regimen for Prevention of HIV Acquisition in Women: A Randomize...
  Andrea R. Thurman, Jill L. Schwartz, Mackenzie L. Cottrell, Vivian Brache, Beatrice A. Chen, Leila Cochon, Susan Ju, Ian McGowan, James F. Rooney, Scott McCallister, G...> ;Eclinicalmedicine. 2021 May 23
• 8 citations
  Higher colorectal tissue HIV infectivity in cisgender women compared with MSM before and during oral preexposure prophylaxis.
  Rogers Sekabira, Ian McGowan, Krista Yuhas, Rhonda M. Brand, Mark A. Marzinke, Yukari C. Manabe, Ian Frank, Joseph J. Eron, Raphael J. Landovitz, Peter A. Anton, Ross ...> ;AIDS. 2021 Apr 6
• 4 citations
  Evaluation of the Safety, Acceptability, and Pharmacokinetic Profile of a Gel Formulation of OB-002 in Healthy Volunteers
  Ian McGowan, Niko Tzakis, Beata Kosak, Bozena Korczak, Jarret Engstrom, Monika Tomaszewska-Kiecana, Oliver Hartley> ;AIDS Research and Human Retroviruses. 2021 Apr 30
• 6 citations
  Tofacitinib inhibits inflammatory cytokines from ulcerative colitis and healthy mucosal explants and is associated with pSTAT1/3 reduction in T-cells.
  Rhonda M. Brand, Beverley A. Moore, Ashley Zyhowski, Aaron Siegel, Shikhar Uttam, E. Jeffrey Metter, Jarret Engstrom, Randall E. Brand, Nabanita Biswas, David C. Whitc...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Mar 1
• 4 citations
  Brief Report: Dipyridamole Decreases Gut Mucosal Regulatory T-Cell Frequencies Among People With HIV on Antiretroviral Therapy.
  Christina Mallarino-Haeger, Kaleab Z. Abebe, Edwin K. Jackson, Ashley Zyhowski, Cynthia Klamar-Blain, Joshua C. Cyktor, Diane M. Comer, Rhonda M. Brand, Delbert G. Gil...> ;Journal of Acquired Immune Deficiency Syndromes. 2020 Dec 15
• 10 citations
  Receptive anal sex contributes substantially to heterosexually acquired HIV infections among at-risk women in twenty US cities: Results from a modelling analysis.
  Jocelyn Elmes, Romain Silhol, Kristen L. Hess, Lukyn M. Gedge, Ashley E. Nordsletten, Roisin Staunton, Peter A. Anton, Barbara L. Shacklett, Ian McGowan, Que Dang, Ada...> ;American Journal of Reproductive Immunology. 2020 Jun 9
• 11 citations
  Increases in HIV Incidence Following Receptive Anal Intercourse Among Women: A Systematic Review and Meta-analysis.
  James Stannah, Romain Silhol, Jocelyn Elmes, Branwen N. Owen, Barbara L. Shacklett, Peter A. Anton, Ian McGowan, Ariane van der Straten, Dobromir T. Dimitrov, Rebecca ...> ;AIDS and Behavior. 2020 Mar 1
• 19 citations
  Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women.
  Beatrice A. Chen, Jingyang Zhang, Holly Gundacker, Craig W. Hendrix, Craig J. Hoesley, Robert A. Salata, Charlene S. Dezzutti, Ariane van der Straten, Wayne Hall, Cind...> ;Clinical Infectious Diseases. 2019 Mar 19
• 4 citations
  The Use of Droplet Digital PCR to Quantify HIV-1 Replication in the Colorectal Explant Model
  Ashley Myerski, Aaron Siegel, Jarret Engstrom, Ian McGowan, Rhonda M. Brand> ;AIDS Research and Human Retroviruses. 2019 Mar 5
• 14 citations
  The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing pre-exposure prophylaxis regimens in MSM.
  Ian McGowan, Timothy J. Wilkin, Raphael J. Landovitz, Chunyuan Wu, Ying Q. Chen, Mark A. Marzinke, Craig W. Hendrix, Paul G. Richardson, Susan H. Eshleman, Adriana And...> ;AIDS. 2019 Feb 1
• 16 citations
  Prevalence and determinants of anal human papillomavirus infection in men who have sex with men and transgender women.
  Ross D. Cranston, Alex Carballo-Diéguez, Holly Gundacker, Barbra A. Richardson, Rebecca Giguere, Curtis Dolezal, Aaron Siegel, Ratiya P KunjaraNaAyudhya, Kailazarid Go...> ;International Journal of STD & AIDS. 2019 Feb 1
• The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing PrEP Regimens in Men who have Sex with Men.
  McGowan, I.,Wilkin, T.,Landovitz, R. J.,Wu, C.,Chen, Y.,Marzinke, M. A.,Hendrix, C. W.,Richardson, P.,Eshleman, S. H.,Andrade, A.,Chege, W.,Anderson, P. L.,McCauley, M...> ;AIDS. 2018 Dec 21
• 8 citations
  Immunological responsiveness of intestinal tissue explants and mucosal mononuclear cells to ex vivo stimulation.
  Rhonda M. Brand, Nabanita Biswas, Aaron Siegel, Ashley Myerski, Jarret Engstrom, E. Jeffrey Metter, Randall E. Brand, Ross D. Cranston, Ian McGowan> ;Journal of Immunological Methods. 2018 Dec 1
• 30 citations
  Does per‐act HIV‐1 transmission risk through anal sex vary by gender? An updated systematic review and meta‐analysis
  Rebecca F. Baggaley, Branwen N. Owen, Romain Silhol, Jocelyn Elmes, Peter A. Anton, Ian McGowan, Ariane van der Straten, Barbara L. Shacklett, Que Dang, Edith Swann, D...> ;American Journal of Reproductive Immunology. 2018 Nov 1
• 6 citations
  Ranpirnase reduces HIV-1 infection and associated inflammatory changes in a human colorectal explant model
  Rhonda M. Brand, Aaron Siegel, Ashley Myerski, E. Metter, Jarret Engstrom, Randall E. Brand, Luis Squiquera, Thomas W. Hodge, Jamie Sulley, Ross D. Cranston, Ian McGowan> ;AIDS Research and Human Retroviruses. 2018 Oct 12
• 10 citations
  Pharmacokinetics and Pharmacodynamics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments in Women: A Cross-Compartmental Study With Directly O...
  Jessica Justman, Gonasagrie Nair, Craig W. Hendrix, Jeanna M. Piper, Mark A. Marzinke, James Y. Dai, Zhenyu Pan, Beth Galaska, Lisa Levy, Jill L. Schwartz, Bhavna Bala...> ;Journal of Acquired Immune Deficiency Syndromes. 2018 Jun 1
• 4 citations
  Comparative Assessment of Small and Large Intestine Biopsies for Ex Vivo HIV-1 Pathogenesis Studies
  Julie Elliott, Jonathan Fulcher, F. Javier Ibarrondo, Karen Tanner, Ian McGowan, Peter A. Anton> ;AIDS Research and Human Retroviruses. 2018 Oct 12
• 4 citations
  A Pilot Study of the Immunologic, Virologic, and Pathologic Consequences of Intra-anal 5% Imiquimod in HIV-1-Infected Men With High-Grade Squamous Intraepithelial Lesi...
  Ross D. Cranston, Jonathan Baker, Aaron Siegel, Rhonda M. Brand, Laura Janocko, Ian McGowan> ;Diseases of the Colon and Rectum. 2018 Mar 1
• 6 citations
  Patterns of a Rectal Microbicide Placebo Gel Use in a Preparatory Stage for a Phase I Trial Among Young Men Who Have Sex with Men.
  José A. Bauermeister, Rebecca Giguere, C. S. Leu, Curtis Dolezal, Irma Febo, Ross D. Cranston, Kenneth H. Mayer, Ian McGowan, Alex Carballo-Diéguez> ;AIDS and Behavior. 2018 Feb 1
• 8 citations
  A Pilot Study of the Prevalence of Anal Human Papillomavirus and Dysplasia in a Cohort of Patients With IBD
  Ross D. Cranston, Miguel Regueiro, Jana G. Hashash, Jonathan Baker, Nicola Richardson-Harman, Laura Janocko, Ian McGowan> ;Diseases of the Colon and Rectum. 2017 Dec 1
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Journal Articles

• Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women  
  Craig W Hendrix, Robert A Salata, Mark A Marzinke, Craig J Hoesley, Ian McGowan, Clinical Infectious Diseases
• Does Per‐Act HIV‐1 Transmission Risk Through Anal Sex Vary by Gender? An Updated Systematic Review and Meta‐Analysis  
  Peter Anton, Ian McGowan, American Journal of Reproductive Immunology