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James Elder, MD, Dermatology, Ann Arbor, MI, Veterans Affairs Ann Arbor Healthcare System

JamesTilfordElderMDPhD

Dermatology • Ann Arbor, MI

Kirk D. Wuepper Professor of Molecular Genetic Dermatology; Physician, Ann Arbor Veterans Affairs Hospital

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Summary

  • I am a physician-scientist-educator in the Department of Dermatology at the University of Michigan. I have a joint appointment at the Ann Arbor VA Hospital. My clinical practice mainly involves medical Dermatology, with a focus on psoriasis and psoriatic arthritis. My research laboratory uses genetics, immunology, and cell biology to learn more about the pathogenesis of psoriasis and psoriatic arthritis. I’m particularly interested in the nature of innate and acquired immune responses in psoriasis, and how the immune system activates the epidermal hyperproliferative response in psoriasis. I also have a long-standing in keratinocyte biology, particularly regarding autocrine signaling through the EGF receptor. Currently, these interests extend to the role of EGF receptor ligands in carcinomas of epithelial origin, including keratinocyte carcinomas, breast cancer, and head and neck squamous cell carcinoma.

Education & Training

  • University of Michigan Health System
    University of Michigan Health SystemResidency, Dermatology, 1986 - 1988
  • University of Washington
    University of WashingtonResidency, Dermatology, 1983 - 1986
  • University of Washington
    University of WashingtonInternship, Internal Medicine, 1982 - 1983
  • The Graduate School of Yale University
    The Graduate School of Yale UniversityPh.D., Molecular Biophysics and Biochemistry, 1974 - 1982
  • Yale School of Medicine
    Yale School of MedicineClass of 1981
  • Northwestern University
    Northwestern UniversityB.S., Biomedical Engineering, with Highest Distinction, 1970 - 1974

Certifications & Licensure

  • MI State Medical License
    MI State Medical License 1987 - 2025
  • American Board of Dermatology Dermatology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
  • League of Research Excellence University of Michigan, 2011
  • Fine Lecturer in Dermatology Emory University, Atlanta, GA, 2010
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Publications & Presentations

PubMed

Journal Articles

  • Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture  
    Ward NL, Bhagathavula N, Johnston A, Dawes SM, Fu W, Lambert S, Gudjonsson JE, Varani J, Elder JT, Journal of Investigative Dermatology, 10/1/2014
  • Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis  
    Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Elder JT, Modlin RL, Pellegrini M, Journal of Investigative Dermatology, 9/18/2014
  • Fine mapping of eight psoriasis susceptibility loci  
    Das S, Stuart PE, Ding J, Tejasvi T, Li Y, Tsoi LC, Chandran V, Fischer J, Helms C, Callis Duffin K, Voorhees JJ, Bowcock, AM, Krueger GG, Lathrop GM, Nair RP, Rahman ..., European Journal of Human Genetics, 9/3/2014
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Books/Book Chapters

  • Emery and Rimoin's Principles and Practice of Medical Genetics 
    Chapter: Chapter 150: Psoriaisis. 
    Gudjonsson JE, Elder JTEdition 6th,2013
  • Fitzpatrick’s Dermatology in General Medicine 
    Chapter: Psoriasis. 
    Page 169 - 193Gudjonsson J, Elder JTEditors: Wolff K, Goldsmith LE, Katz S, Gilchrest B, Paller A, Lefell D.Mc Graw-Hill, New York, NYEdition 7th,2008
  • Clinics in Dermatology 
    Chapter: Psoriasis: Epidemiology. 
    Page 535 - 546Gudjonsson JE, Elder JTElsevier, New York, NY2007
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Abstracts/Posters

  • Genome-wide serum miRNA expression profiles identify serum miRNAs as potential biomarkers for human psoriatic arthritis.
    Han L, Weiland M, Yin C, Lu C, Nair RP, Zhou L, Lim HW, Elder JT, Mi Q, J Invest Dermatol, 1/1/2014
  • Genome wide association study of psoriasis in India.
    Nair, RP, Tsoi LC, Ghosh M, Kabra M, Tejasvi T, Stuart PE, Zawistowski MS, Voorhees JJ, Abecasis GR, Sharma VK, Elder JT, J Invest Dermatol, 1/1/2014
  • Microanatomy of psoriasis: Sebaceous gland atrophy contributes to downregulation of lipid metabolism genes.
    Rittie L, Tejasvi T, Tsoi LC, Swindell WR, Nair RP, Elder JT, J Invest Dermatol, 1/1/2014
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Lectures

  • Genetics of Psoriasis and Psoriatic Arthritis: What's at the End of the Rainbow? 
    Detroit, MI - 10/2/2014
  • Genetics of Skin Disease: From EGF Receptors to Psoriasis and Back 
    Valdecilla Hospital, Santander, Spain - 9/23/2014
  • Omics: From Genomics to Skinomics 
    Paris, France - 9/20/2014
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Press Mentions

  • Refinement of Genetic Signals for Psoriasis by Combining European-Origin and South Asian Populations
    Refinement of Genetic Signals for Psoriasis by Combining European-Origin and South Asian PopulationsDecember 1st, 2021
  • Research Techniques Made Simple: Itch Measurement in Clinical Trials
    Research Techniques Made Simple: Itch Measurement in Clinical TrialsJuly 19th, 2018
  • What Causes Psoriasis (And How to Stop It Naturally)
    What Causes Psoriasis (And How to Stop It Naturally)June 7th, 2017

Grant Support

  • Identification Of Psoriatic Arthritis GenesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2011
  • Combined Analysis Of Gene Expression And DNA Variation In PsoriasisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2011
  • Training Grant In Cell And Molecular DermatologyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002–2011
  • Linkage Analysis Of Familial PsoriasisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1994–2011
  • Design Approaches For Sequencing Disease-Associated Regions In PsoriasisNational Human Genome Research Institute2010
  • Genotyping The NPF Biobank For Psoriasis Susceptibility GenesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2010
  • Amphiregulin In Psoriatic Epidermal HyperplasiaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2006–2010
  • Identification Of Psoriatic Arthritis Genes In Major Histocompatibility ComplexNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2008
  • Genetic Analysis Of Psoriasis And Psoriatic ArthritisNational Center For Research Resources2006–2007
  • Identification Of Psoriatic Arthritis Genes In The MHCNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2004–2006
  • Organ Culture Of Basal Cell CarcinomaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2001–2002
  • Linkage Analysis Of Familial Psoriasis(Supplement)National Institute Of Arthritis And Musculoskeletal And Skin Diseases2001
  • Linkage Analysis Of Familial PsoriasisNational Center For Research Resources1996–2000
  • Positional Cloning Of Epidermal Differentiation GenesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1993–1996
  • Tgf-Alpha And Tyrosine Kinase Activation In PsoriasisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1989–1993

Professional Memberships

Hospital Affiliations

Dr. James Elder, Dr. James Elder, MD, Dr. J Elder, Dr. James Tilford Elder