
John C. Byrd MD
Hematologic Oncology, Myeloproliferative Disorder Hematology-Oncology, Clinical Pharmacology
Chair and Professor, Department of Internal Medicine
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5150 Centre AveFl 5Pittsburgh, PA 15232
Phone+1 412-623-3205
Fax+1 513-584-6955
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Summary
- I am currently Chair, Department of Internal Medicine at the University of Cincinnati and also a physician scientist who has done translational and clinical drug development for two decades. Closest to me professional being is performing as an exceptional, empathetic board certified hematologist in care of patients with blood cancers. My laboratory and clinical research has directly resulted in 7 drugs getting FDA approval. This experience bridges close interaction with industry as a consultant to develop and implement a successful development plan (Calistoga, Idelalisib) to performing pre-clinical and clinical work in my University role focused on a single class of drugs that transformed the care of CLL (Ibrutinib, Acalabrutinib) and other B-cell malignancies. My role in the current Leukemia and Lymphoma Society Beat AML Study as Principal and Chief Medical Officer has offered an even larger extension of this by planning, implementing, and running a multi-center umbrella study in AML that brings together academic clinical investigators, diagnostic companies, pharmaceutical companies, clinical research organizations and the FDA to effectively move new therapies forward to the clinic.
Education & Training
National Capital ConsortiumFellowship, Hematology and Medical Oncology, 1994 - 1997
National Capital Consortium (Walter Reed)Residency, Internal Medicine, 1991 - 1994
University of Arkansas For Medical Sciences College of MedicineClass of 1991
Hendrix CollegeB.A., Chemistry, With distinction, 1987
Certifications & Licensure
OH State Medical License 2001 - 2027
PA State Medical License 2025 - 2026
VA State Medical License 1993 - 2020
American Board of Internal Medicine Hematology
Awards, Honors, & Recognition
- Return of the Child Award Leukemia and Lymphoma Society, 2017
- Fellow American College of Physicians, 2017
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012, 2014, 2016-2017
Clinical Trials
- Fludarabine and Monoclonal Antibody Therapy in Treating Patients With Untreated B-cell Chronic Lymphocytic Leukemia
- Monoclonal Antibody Therapy in Treating Patients With Chronic Lymphocytic Leukemia, Lymphocytic Lymphoma, Acute Lymphoblastic Leukemia, or Acute Myeloid Leukemia
- Alvocidib, Fludarabine Phosphate, and Rituximab in Treating Patients With Lymphoproliferative Disorders or Mantle Cell Lymphoma
Publications & Presentations
PubMed
- Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA.Fieke W Hoff, Joshua F Zeidner, Geeta Torlapati, Deedra Nicolet, Krzysztof Mrózek
American Journal of Hematology. 2026-09-01 - Prognostic and therapeutic implications of BRAF mutations in acute myeloid leukemia.Darren Lee, Yazan Abu-Shihab, Kate Plas, Deedra Nicolet, Krzysztof Mrózek
Leukemia. 2026-08-01 - Outcomes of patients with chronic lymphocytic leukemia discontinuing covalent Bruton tyrosine kinase inhibitors due to adverse events.Anthony G Mansour, Ying Huang, J Phillip Pemberton, Aseel Alsouqi, Adam S Kittai
Leukemia. 2026-08-01
Journal Articles
- Non-Hodgkin’s lymphomasZelenetz AD, Abramson JS, Advani RH, Andreadis B, Bartlett N, Bellam N, Byrd JC, Czuczman MS, Fayad LE, Glenn MJ, Gockerman JP, Gordon LI, Harris NL, Hoppe RT, Horwitz..., J Natl Compr Canc Netw, 1/1/2011
- Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitorsLu Q, Yang YT, Chen CS, Davis M, Byrd JC, Etherton MR, Umar A, Chen CS, J Med Chemistry, 1/15/2004
- Coxsackievirus-associated pancreatitis mimicking metastatic carcinomaGooby Toedt DM, Byrd JC, Omori D, South Med J, 1/1/1996
Press Mentions
UPMC Hillman Cancer Center Completes Extensive Renovations Supported by the Lemieux Foundation and Chris and Bob PietrandreaNovember 13th, 2025
Combination Therapy Offers Hope for Ending Lifelong Chronic Lymphocytic Leukemia TreatmentNovember 5th, 2025
John C. Byrd, MDOctober 20th, 2025
Grant Support
- Pharmacodynamically directed targeted therapy for leukemiaUNIVERSITY OF CINCINNATI2025–2030
- ITSC for Leukemia: Novel Molecular strategies for NCTN "Individualized" TherapiesUNIVERSITY OF CINCINNATI2019–2026
- NCI ETCTN Pittsburgh Cancer Consortium (PCC)UNIVERSITY OF PITTSBURGH AT PITTSBURGH2014–2026
- Lenalidomide As An Immune Modulating Agent For Chronic Lymphocytic LeukemiaNational Cancer Institute2009–2011
- Experimental Therapeutics Of LeukemiaNational Cancer Institute2009–2011
Professional Memberships
- Member
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