JohnTChangMD

PubMed

• 10 citations
  A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy.
  Aaron T Mayer, Derek R Holman, Anav Sood, Utkarsh Tandon, Salil S Bhate, Sunil Bodapati, Graham L Barlow, Jeff Chang, Sarah Black, Erica C Crenshaw, Alexander N Koron,...> ;Science Advances. 2023 Jan 20
• 15 citations
  Small intestine and colon tissue-resident memory CD8T cells exhibit molecular heterogeneity and differential dependence on Eomes.
  Lin, Y., Duong, H., Limary, A., Kim, E., Hsu, P., Patel, S., Wong, W., Indralingam, C., Liu, Y., Yao, P., Chiang, N., Vandenburgh, S., Anderson, T., Olvera, J., Ferry,...> ;Immunity. 2023 Jan 10
• 7 citations
  Preserved SARS-CoV-2 Vaccine Cell-Mediated Immunogenicity in Patients With Inflammatory Bowel Disease on Immune-Modulating Therapies.
  Brigid S Boland, Benjamin Goodwin, Zeli Zhang, Nathaniel Bloom, Yu Kato, Jennifer Neill, Helen Le, Tiffani Tysl, Angelina E Collins, Parambir S Dulai, Siddharth Singh,...> ;Clinical and Translational Gastroenterology. 2022 Apr 1
• 9 citations
  Skin inflammation activates intestinal stromal fibroblasts and promotes colitis
  Tatsuya Dokoshi, Jason S Seidman, Kellen J. Cavagnero, Fengwu Li, Marc C. Liggins, Bryn C. Taylor, Jocelyn G. Olvera, Rob Knight, John T. Chang, Nita H. Salzman, Richa...> ;The Journal of Clinical Investigation. 2021 Nov 1
• 30 citations
  Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.
  Debashis Sahoo, Lee Swanson, Ibrahim M Sayed, Gajanan D. Katkar, Stella-Rita Ibeawuchi, Yash Mittal, Rama F. Pranadinata, Courtney Tindle, MacKenzie Fuller, Dominik St...> ;Nature Communications. 2021 Jul 12
• 23 citations
  Distinct integrin activation pathways for effector and regulatory T cell trafficking and function
  Hao Sun, Frederic Lagarrigue, Hsin Wang, Zhichao Fan, Miguel Alejandro Lopez-Ramirez, John T. Chang, Mark H. Ginsberg> ;The Journal of Experimental Medicine. 2021 Feb 1
• Clone Wars: Survival of the Fittest CD8+ Trm Cells.
  Tiani L. Louis, John T. Chang> ;Immunity. 2021 Jan 12
• 239 citations
  Pathophysiology of Inflammatory Bowel Diseases
  John T. Chang> ;The New England Journal of Medicine. 2020 Dec 30
• 23 citations
  Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity.
  Xin Fang, Yoshiki Vázquez-Baeza, Emmanuel O. Elijah, Fernando Vargas, Gail Ackermann, Gregory Humphrey, Rebecca Lau, Kelly C. Weldon, Jon G. Sanders, Morgan Panitchpak...> ;Inflammatory Bowel Diseases. 2021 Apr 15
• 56 citations
  Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population.
  J. Justin Milner, Hongtuyet Nguyen, Kyla D. Omilusik, Miguel Reina-Campos, Matthew S. Tsai, Clara Toma, Arnaud Delpoux, Brigid S. Boland, Stephen M. Hedrick, John T. C...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 25
• 113 citations
  Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
  Brigid S. Boland, Zhaoren He, Matthew S. Tsai, Jocelyn G. Olvera, Kyla D. Omilusik, Han G. Duong, Eleanor S. Kim, Abigail E. Limary, Wenhao Jin, J. Justin Milner, Bing...> ;Science Immunology. 2020 Aug 21
• 131 citations
  Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
  J. Justin Milner, Clara Toma, Zhaoren He, Nadia S. Kurd, Quynh P. Nguyen, Bryan McDonald, Lauren K. Quezada, Christella E. Widjaja, Deborah A. Witherden, John T. Crowl...> ;Immunity. 2020 May 19
• 106 citations
  Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing
  Nadia S. Kurd, Zhaoren He, Tiani L. Louis, J. Justin Milner, Kyla D. Omilusik, Wenhao Jin, Matthew S. Tsai, Christella E. Widjaja, Jad N. Kanbar, Jocelyn G. Olvera, Ti...> ;Science Immunology. 2020 May 15
• 255 citations
  Global chemical effects of the microbiome include new bile-acid conjugations
  Robert A. Quinn, Alexey V. Melnik, Alison Vrbanac, Ting Fu, Kathryn A. Patras, Mitchell P. Christy, Zsolt Bodai, Pedro Belda-Ferre, Anupriya Tripathi, Lawton K. Chung,...> ;Nature. 2020 Feb 26
• 36 citations
  Development and Validation of Clinical Scoring Tool to Predict Outcomes of Treatment With Vedolizumab in Patients With Ulcerative Colitis.
  Parambir S. Dulai, Siddharth Singh, Niels Vande Casteele, Joseph Meserve, Adam Winters, Shreya Chablaney, Satimai Aniwan, Preeti Shashi, Gursimran Kochhar, A Weiss, Je...> ;Clinical Gastroenterology and Hepatology. 2020 Feb 13
• 3 citations
  Universal Principled Review: A Community-Driven Method to Improve Peer Review
  Matthew F. Krummel, Catherine A. Blish, Michael S. Kuhns, Ken Cadwell, Andrew Oberst, Ananda W. Goldrath, K. Mark Ansel, Hongbo Chi, Ryan M. O'Connell, E. John Wherry,...> ;Cell. 2019 Dec 12
• 72 citations
  Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases?
  Parambir S. Dulai, Siddharth Singh, Niels Vande Casteele, Brigid S. Boland, Jesus Rivera-Nieves, Peter B. Ernst, Lars Eckmann, Kim E. Barrett, John T. Chang, William J...> ;Clinical Gastroenterology and Hepatology. 2019 Dec 1
• 35 citations
  Optimizing sequencing protocols for leaderboard metagenomics by combining long and short reads.
  Jon G. Sanders, Sergey Nurk, Rodolfo A. Salido, Jeremiah J. Minich, Zhenjiang Zech Xu, Qiyun Zhu, Cameron Martino, Marcus W. Fedarko, Timothy D. Arthur, Feng Chen, Bri...> ;Genome Biology. 2019 Oct 31
• 2 citations
  The Autoimmune Protocol Diet Modifies Intestinal RNA Expression in Inflammatory Bowel Disease.
  Anita Chandrasekaran, Bhuvan Molparia, Ehsaan Akhtar, Xiaoyun Wang, James D. Lewis, John T. Chang, Glenn Oliveira, Ali Torkamani, Gauree G. Konijeti> ;Crohn's & Colitis 360. 2019 Oct 1
• 23 citations
  Biomarkers Are Associated With Clinical and Endoscopic Outcomes With Vedolizumab Treatment in Ulcerative Colitis
  Robert Battat, Parambir S. Dulai, Niels Vande Casteele, Elisabeth Evans, Kelly D. Hester, Edvelyn Webster, Anjali Jain, James A. Proudfoot, Ara Mairalles, Jennifer Nei...> ;Inflammatory Bowel Diseases. 2019 Jan 10
• 57 citations
  Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.
  Ricard Garcia-Carbonell, Jerry Wong, Ju Youn Kim, Lisa Abernathy Close, Brigid S. Boland, Thomas L. Wong, Philip A. Harris, Samuel B. Ho, Soumita Das, Peter B. Ernst, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Sep 25
• 79 citations
  Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients With Crohn’s Disease
  Parambir S. Dulai, Brigid S. Boland, Siddharth Singh, Khadija Chaudrey, Jenna L. Koliani-Pace, Gursimran Kochhar, Malav P. Parikh, Eugenia Shmidt, Justin Hartke, Prian...> ;Gastroenterology. 2018 Sep 1
• 25 citations
  Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance
  Jane E. Klann, Stephanie H. Kim, Kelly A. Remedios, Zhaoren He, Patrick J. Metz, Justine Lopez, Tiffani Tysl, Jocelyn G. Olvera, Jailal N. G. Ablack, Joseph M. Cantor,...> ;Journal of Immunology. 2018 Apr 27
• Hyperbaric Oxygen Therapy Is Well Tolerated and Effective for Ulcerative Colitis Patients Hospitalized for Moderate–Severe Flares: A Phase 2A Pilot Multi-Center, Rando...
  John T Chang, Corey A Siegel, Parambir S Dulai, Laura E Raffals, Jason M Swoger, Michael W Gleeson> ;Nature. 2018 Feb 18
• 61 citations
  Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease.
  Ahmed A. Moustafa, Weizhong Li, Ericka L. Anderson, Emily H. M. Wong, Parambir S. Dulai, William J. Sandborn, William H. Biggs, Shibu Yooseph, Marcus B. Jones, J. Crai...> ;Clinical and Translational Gastroenterology. 2018 Jan 18
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Lectures

• Over-detection of colonic abnormalities on CTAP and a decrease with experience: A simulation of machine learning. 
  ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/25/2020