JohnJLeporeMD

PubMed

• 4 citations
  A Randomized, Placebo-Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High-Density Lipoprotein Choles...
  Eric Olson, Kelly M. Mahar, Thomas F Haws, Michael J. Fossler, Feng Gao, Anne-Charlotte de Gouville, Dennis L. Sprecher, John J. Lepore> ;Clinical Pharmacology in Drug Development. 2019 Oct 1
• 79 citations
  Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis
  Amy M Meadowcroft, Borut Cizman, Louis Holdstock, Nandita Biswas, Brendan M Johnson, Delyth Jones, A Kaldun Nossuli, John J. Lepore, Michael Aarup, Alexander R. Cobitz> ;Clinical Kidney Journal. 2019 Feb 1
• 58 citations
  Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease
  Louis Holdstock, Borut Cizman, Amy M Meadowcroft, Nandita Biswas, Brendan M Johnson, Delyth Jones, Sung Gyun Kim, Steven Zeig, John J. Lepore, Alexander R. Cobitz> ;Clinical Kidney Journal. 2019 Feb 1
• 1 citations
  Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury
  Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning F Kramer, Robert S. ...> ;Skeletal Muscle. 2018 Dec 10
• 18 citations
  HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury.
  Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning F Kramer, Robert S. ...> ;Skeletal Muscle. 2018 Nov 13
• 26 citations
  The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits
  Jin Zhou, Jie Li, Daniel M. Rosenbaum, Jian Zhuang, Carrie Poon, Pu Qin, Katrina Rivera, John J. Lepore, Robert N. Willette, Erding Hu, Frank C. Barone> ;Plos One. 2017 Sep 7
• 74 citations
  Effects of Daprodustat, a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Anemia Management in Japanese Hemodialysis Subjects
  Tadao Akizawa, Yoshiharu Tsubakihara, Masaomi Nangaku, Yukihiro Endo, Hiromu Nakajima, Tomoko Kohno, Yukiko Imai, Natsumi Kawase, Katsutoshi Hara, John J. Lepore, Alex...> ;American Journal of Nephrology. 2017 Jan 1
• 92 citations
  Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and ...
  John J. Lepore, Eric Olson, Laura Demopoulos, Thomas F Haws, Zixing Fang, April M. Barbour, Michael J. Fossler, Victor G. Davila-Roman, Stuart D. Russell, Robert J. Gr...> ;JACC. Heart Failure. 2016 Jul 1
• 158 citations
  Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.
  Michelle L. O'Donoghue, Ruchira Glaser, Matthew A. Cavender, Philip E. Aylward, Marc P. Bonaca, Andrzej Budaj, Richard Davies, Mikael Dellborg, Keith A.A. Fox, Jorge A...> ;JAMA. 2016 Apr 19
• 147 citations
  Four-Week Studies of Oral Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia
  Louis Holdstock, Amy M Meadowcroft, Rayma Maier, Brendan M. Johnson, Delyth Jones, Anjay Rastogi, Steven Zeig, John J. Lepore, Alexander R. Cobitz> ;Journal of the American Society of Nephrology. 2016 Apr 1
• 32 citations
  Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart
  Karpagam Aravindhan, Weike Bao, Mark R. Harpel, Robert N. Willette, John J. Lepore, Beat M. Jucker> ;Plos One. 2015 Jun 22
• 31 citations
  Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited periphe...
  Eric Olson, Laura Demopoulos, Thomas F Haws, Erding Hu, Zixing Fang, Kelly M. Mahar, Pu Qin, John J. Lepore, Timothy A. Bauer, William R. Hiatt> ;Vascular Medicine. 2014 Nov 6
• 107 citations
  Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
  L. Kristin Newby, Michael S. Marber, Chiara Melloni, Lea Sarov-Blat, Laura H. Aberle, Philip E. Aylward, Gengqian Cai, Robbert J. de Winter, Christian W. Hamm, John F....> ;Lancet. 2014 Sep 27
• 138 citations
  Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy
  Kinya Seo, Peter P. Rainer, Virginia S. Hahn, Dong Ik Lee, Su Hyun Jo, Asger Andersen, Ting Liu, Xiaoping Xu, Robert N. Willette, John J. Lepore, Joseph P. Marino, Lut...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Jan 28
• 18 citations
  Platelet Aggregation Unchanged by Lipoprotein-Associated Phospholipase A2 Inhibition: Results from an In Vitro Study and Two Randomized Phase I Trials
  Bonnie C. Shaddinger, Yanmei Xu, James H. Roger, Colin H. Macphee, Malcolm Handel, Charlotte A. Baidoo, Mindy Magee, John J. Lepore, Dennis L. Sprecher> ;Plos One. 2014 Jan 27
• 42 citations
  Ephrin-B2 controls PDGFRβ internalization and signaling
  Akiko Nakayama, Masanori Nakayama, Christopher J. Turner, Susanne Höing, John J. Lepore, Ralf H. Adams> ;Genes & Development. 2013 Dec 1
• 51 citations
  Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart.
  Ronald J. Vagnozzi, Gatto Gregory J, Lara S. Kallander, Nicholas E. Hoffman, Karthik Mallilankaraman, Victoria L. T. Ballard, Brian G. Lawhorn, Patrick Stoy, Joanne Ph...> ;Science Translational Medicine. 2013 Oct 16
• 38 citations
  Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat
  Weike Bao, Lucy J Holt, Rob D Prince, Gavin C. Jones, Karpagam Aravindhan, Mathew Szapacs, April M. Barbour, Larry J. Jolivette, John J. Lepore, Robert N. Willette, El...> ;Cardiovascular Diabetology. 2013 Oct 14
• 116 citations
  Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.
  Christine Y. Ivashchenko, Gordon C. Teg Pipes, Irina M. Lozinskaya, Zuojun Lin, Xu Xiaoping, Saul Needle, Eugene T. Grygielko, Erding Hu, John R. Toomey, John J. Lepor...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2013 Sep 15
• 231 citations
  An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
  Kevin S. Thorneloe, Mui Cheung, Weike Bao, Hasan Alsaid, Stephen C. Lenhard, Ming-Yuan Jian, Melissa H. Costell, Kristeen Maniscalco-Hauk, John A. Krawiec, Alan R. Olz...> ;Science Translational Medicine. 2012 Nov 7
• 105 citations
  Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.
  Maysoon Elkhawad, James H.F. Rudd, Lea Sarov-Blat, Gengqian Cai, Richard J.B. Wells, L. Ceri Davies, David Collier, Michael S. Marber, Robin P. Choudhury, Zahi A. Faya...> ;JACC. Cardiovascular Imaging. 2012 Sep 1
• 42 citations
  Comparison of Soluble Guanylate Cyclase Stimulators and Activators in Models of Cardiovascular Disease Associated with Oxidative Stress
  Melissa H. Costell, Nicolas Ancellin, Roberta E. Bernard, Shu Fang Zhao, John J. Upson, Lisa A. Morgan, Kristeen Maniscalco, Alan R. Olzinski, Victoria L. T. Ballard, ...> ;Frontiers in Pharmacology. 2012 Jul 5
• 56 citations
  Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature
  Huansheng Xu, B. Alexander Yi, Hao Wu, Christoph Bock, Hongcang Gu, Kathy O. Lui, Joo Hye C. Park, Ying Shao, Alyssa K. Riley, Ibrahim J. Domian, Erding Hu, Robert N. ...> ;Cell Research. 2012 Jan 1
• 39 citations
  Aortic Aneurysm Generation in Mice With Targeted Deletion of Integrin-Linked Kinase in Vascular Smooth Muscle Cells
  Dongxiao Shen, Jian Li, John J. Lepore, Thomas J.T. Anderson, Sumita Sinha, Alexander Y. Lin, Lan Cheng, Ethan D. Cohen, Jesse D. Roberts, Shoukat Dedhar, Michael S. P...> ;Circulation Research. 2011 Sep 2
• 77 citations
  Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Effici...
  Weike Bao, Karpagam Aravindhan, Hasan Alsaid, Thimmaiah P Chendrimada, Matthew Szapacs, David Richard Citerone, Mark R. Harpel, Robert N. Willette, John J. Lepore, Bea...> ;Plos One. 2011 Aug 26
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