JohnJLetterioMD

PubMed

• Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of...
  Sung Hee Choi, Emily C. Barker, Kyle J. Gerber, John J. Letterio, Byung-Gyu Kim> ;OncoImmunology. 2020 Dec 3
• Analyzing the Metabolic Phenotype of Bone Marrow-Derived Dendritic Cells by Assessing Their Oxygen Consumption and Extracellular Acidification.
  Wei, H., Letterio, J. J., Pareek, T. K.> ;Methods in molecular biology (Clifton, N.J.). 2020 Aug 19
• Estimating the prevalence and risk of COVID-19 among international travelers and evacuees of Wuhan through modeling and case reports.
  Luo, G., McHenry, M. L., Letterio, J. J.> ;PloS one. 2020 Jun 24
• Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia.
  Wei, H., Gupta, A., Kao, W., Almudallal, O., Letterio, J. J., Pareek, T. K.> ;Journal of autoimmunity. 2018 Jul 22
• Development and Functional Characterization of Murine Tolerogenic Dendritic Cells.
  Wei, H., Letterio, J. J., Pareek, T. K.> ;Journal of visualized experiments : JoVE. 2018 Jun 5
• Response to "GHB concentration in breast milk of narcoleptic women treated with sodium oxybate. How important it is to be careful when interpreting values." (Letter to...
  Barker, E. C., Puchowicz, M. A., Letterio, J. J., Higgins, K., Sharkey, K. M.> ;Sleep medicine. 2017 Oct 20
• 2 citations
  GHB levels in breast milk of women with narcolepsy with cataplexy treated with sodium oxybate.
  Barker, E. C., Puchowicz, M. A., Letterio, J. J., Higgins, K., Sharkey, K. M.> ;Sleep medicine. 2017 Jul 3
• Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice.
  David Askew, Tej K. Pareek, Saada Eid, Sudipto Ganguly, Megan Tyler, Alex Yee-Chen Huang, John J. Letterio, Kenneth R. Cooke> ;Blood. 2017 Jan 12
• 7 citations
  Myeloid-derived suppressor cells: The green light for myeloma immune escape
  Ehsan Malek, Marcos de Lima, John J. Letterio, Byung-Gyu Kim, James H. Finke, James J. Driscoll, Sergio Giralt> ;Blood Reviews. 2016 Sep 1
• Development and Validation of a Small Animal Immobilizer and Positioning System for the Study of Delivery of Intracranial and Extracranial Radiotherapy Using the Gamma...
  Awan, M. J., Dorth, J., Mani, A., Kim, H., Zheng, Y., Mislmani, M., Welford, S. M., Yuan, J., Wessels, B. W., Lo, S. S., Letterio, J. J., Machtay, M., Sloan, A. E., So...> ;Technology in cancer research & treatment. 2016 Jul 23
• The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region.
  Woo Kwang Jeon, Jiyeon Choi, Seong Ji Park, Eun Ji Jo, Young Kyung Lee, Seunghwan Lim, Jae-Hong Kim, John J. Letterio, Fang Liu, Seong Jin Kim, Byung Chul Kim> ;Oncotarget. 2015 Oct 19
• 8 citations
  Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727.
  Lam, E., Choi, S. H., Pareek, T. K., Kim, B., Letterio, J. J.> ;Molecular immunology. 2015 Jul 23
• 60 citations
  Alex's Lemonade stand foundation infant and childhood primary brain and central nervous system tumors diagnosed in the United States in 2007-2011
  Quinn T. Ostrom, Peter de Blank, Carol Kruchko, Claire M. Petersen, Peter Liao, Jonathan L. Finlay, Duncan Stearns, Johannes Wolff, Yingli Wolinsky, John J. Letterio, ...> ;Neuro-oncology. 2015 Jan 1
• 5 citations
  Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review.
  Owusu-Ansah, A., Choi, S. H., Petrosiute, A., Letterio, J. J., Huang, A. Y.> ;Frontiers of medicine. 2014 Dec 17
• 7 citations
  Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer.
  Lim, S., Yoo, B. K., Kim, H., Gilmore, H. L., Lee, Y., Lee, H., Kim, S., Letterio, J. J., Lee, H.> ;BMC cancer. 2014 Dec 11
• Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
  Choi, S. H., Kim, B., Robinson, J., Fink, S., Yan, M., Sporn, M. B., Markowitz, S. D., Letterio, J. J.> ;The Journal of clinical investigation. 2014 May 20
• Disruption of Smad4 Expression in T Cells Leads to IgA Nephropathy-Like Manifestations
  Hiroyuki Inoshita, Byung-Gyu Kim, Michifumi Yamashita, Sung Hee Choi, Yasuhiko Tomino, John J. Letterio, Steven N. Emancipator> ;PLOS ONE. 2013 Nov 4
• 1 citation
  Cdk5: An Emerging Kinase in Pain Signaling.
  Pareek, T. K., Zipp, L., Letterio, J. J.> ;Brain disorders & therapy. 2013 Jul 1
• 8 citations
  TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor.
  Lim, S., Bae, E., Kim, H., Kim, T., Byun, K., Kim, B., Hong, S., Im, J. P., Yun, C., Lee, B., Lee, B., Park, S. H., Letterio, J. J., Kim, S.> ;PloS one. 2012 Mar 20
• 1 citation
  Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.
  Pareek, T. K., Belkadi, A., Kesavapany, S., Zaremba, A., Loh, S. L., Bai, L., Cohen, M. L., Meyer, C. J., Liby, K. T., Miller, R. H., Sporn, M. B., Letterio, J. J.> ;Scientific reports. 2012 Feb 23
• Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis
  Tej K. Pareek, Eric Lam, Xiaojing Zheng, David Askew, Ashok B. Kulkarni, Mark R. Chance, Alex Yee-Chen Huang, Kenneth R. Cooke, John J. Letterio> ;Journal of Experimental Medicine. 2010 Oct 25
• 12 citations
  The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.
  Auletta, J. J., Alabran, J. L., Kim, B., Meyer, C. J., Letterio, J. J.> ;Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2010 Jul 16
• Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages.
  Emily C. Barker, Tonibelle N. Gatbonton-Schwager, Yong Han, Jennifer E. Clay, John J. Letterio, Gregory P. Tochtrop> ;Journal of Natural Products. 2010 Jun 25
• 39 citations
  Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
  Do, J., Fink, P. J., Li, L., Spolski, R., Robinson, J., Leonard, W. J., Letterio, J. J., Min, B.> ;Journal of immunology (Baltimore, Md. : 1950). 2010 Jan 12
• 35 citations
  Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.
  Nolting, J., Daniel, C., Reuter, S., Stuelten, C. H., Li, P., Sucov, H. M., Kim, B., Letterio, J. J., Kretschmer, K., Kim, H., von Boehmer, H.> ;The Journal of experimental medicine. 2009 Sep 10
• Join now to see all

Abstracts/Posters

• Preclinical Studies and Phase I Trial of Vactosertib in Combination with Pomalidomide in Relapsed Multiple Myeloma: A Corticosteroid-Free Approach By Targeting TGF-_ S...
  John Letterio, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• Vactosertib, a TGF-ß Receptor I Kinase/ALK5 Inhibitor, Diminishes Tumor Progression and Bone Disease in a Mouse Model of Multiple Myeloma and Overcomes Resistance to P... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Preclinical Studies and a Phase I Trial of the TGF-β Receptor Inhibitor, Vactosertib (TEW-7197), in Combination with Pomalidomide in Patients with Multiple Myeloma Ref... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018