JohnRotrosenMD

Psychiatry • New York, NY

Professor, Psychiatry, New York University School of Medicine

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Office
One Park Avenue
Department of Psychiatry 8th Floor
New York, NY 10016
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Education & Training

NYU Grossman School of MedicineInternship, Transitional Year, 1973 - 1974
New York University School of MedicineClass of 1972

Certifications & Licensure

NY State Medical License 1976 - 2025
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1 Start of enrollment: 1996 Apr 01
Completed
Phase 3
Modeling Impaired Judgement in Cocaine Abusers - 6 Start of enrollment: 1997 Mar 01
Completed
Phase 4
Prepulse Inhibition of Startle in Cocaine Dependence - 7 Start of enrollment: 1997 Feb 01
Completed
Phase 1
Buprenorphine and Naloxone Combination Study - 10 Start of enrollment: 1996 Nov 01
Completed
Phase 1
Impact of Exercise and Affirmations (IntenSati) on Addiction-related Cognitive and Psychosocial Deficits Start of enrollment: 2010 Jul 01
Completed
Not Applicable
Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment Start of enrollment: 2014 Jan 29
Completed
Phase 4
A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence Start of enrollment: 2014 Jun 01
Completed
Phase 2
TAU Opioid Use Outcomes Following Discharge From Detoxification and Short Term Residential Programs Affiliated With CTN-0051 Start of enrollment: 2016 Jun 01
Completed
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Publications & Presentations

PubMed

Discontinuation of medication treatment for opioid use disorder after a successful course: The discontinuation phase of the CTN-0100 (RDD) trial.
Scott Provost, Kaitlyn Ohrtman, Patricia Novo, Sarah Meyers-Ohki, Paul Van Veldhuisen, Neal Oden, Michael Otterstatter, Genie L Bailey, David Liu, Edward V Nunes, Roge...> ;Contemporary Clinical Trials. 2024 Apr 23
Target trial emulation for comparative effectiveness research with observational data: Promise and challenges for studying medications for opioid use disorder.
Sara Lodi, Shapei Yan, Dana Bernson, Patricia Novo, Joshua D Lee, Paul J Christine, Heather E Hsu, Benjamin Bovell-Ammon, John Rotrosen, Jane Liebschutz, Alexander Y W...> ;Addiction. 2024 Mar 22
Optimizing the use of ketamine to reduce chronic postsurgical pain in women undergoing mastectomy for oncologic indication: study protocol for the KALPAS multicenter r...
Wang, B., Park, H., Edwards, R., Perez, R., , Wang, J., Doan, L., Axelrod, D., Rotrosen, J., Curatolo, M., Jackman, C.> ;Trials. 2024 Jan 19
3 citations
Individual-Level Risk Prediction of Return to Use During Opioid Use Disorder Treatment.
Castillo, F., Sean X Luo, Daniel J Feaster, Ying Liu, Raymond R Balise, Mei-Chen Hu, Layla Bouzoubaa, Gabriel J Odom, Laura Brandt, Yue Pan, Yih-Ing Hser, Paul VanVeld...> ;JAMA Psychiatry. 2024 Jan 1
2 citations
Retention and critical outcomes among new methadone maintenance patients following extended take-home reforms: a retrospective observational cohort study.
Williams, A., Krawczyk, N., Hu, M., Harpel, L., Aydinoglo, N., Cerda, M., Nunes, E., Rotrosen, J.> ;Lancet Regional Health. Americas. 2023 Dec 1
Implementation of substance use screening in rural federally-qualified health center clinics identified high rates of unhealthy alcohol and cannabis use among adult pr...
Jennifer McNeely, Bethany McLeman, Trip Gardner, Noah Nesin, Vijay Amarendran, Sarah Farkas, Aimee Wahle, Seth Pitts, Margaret Kline, Jacquie King, Carmen Rosa, Lisa M...> ;Addiction Science & Clinical Practice. 2023 Sep 20
Clinical and psychosocial outcomes by sex among individuals prescribed buprenorphine-naloxone (BUP-NX) or extended-release naltrexone (XR-NTX) for opioid use disorder.
Margaret Paschen-Wolff, Shelly F Greenfield, R Kathryn McHugh, Kathleen Burlew, Martina Pavlicova, Tse-Hwei Choo, Celestina Barbosa-Leiker, Lesia M Ruglass, Sarah Menn...> ;The American Journal on Addictions. 2023 Nov 1
Risks of returning to opioid use at treatment entry and early in opioid use disorder treatment: Role of non-opioid substances.
Felipe Castillo, Mei-Chen Hu, Ying Liu, Raymond R Balise, Roger D Weiss, John Rotrosen, Edward V Nunes, Andrew J Saxon, Daniel J Feaster, Sean X Luo> ;Drug and Alcohol Dependence. 2023 Oct 1
1 citations
Misclassification of overdose events in the X:BOT study - Authors' reply.
Joshua D Lee, Edward V Nunes, Paul Van Veldhuisen, Robert Lindblad, John Rotrosen> ;Lancet. 2023 Aug 12
2 citations
Impact of Medication-Based Treatment on Health Care Utilization Among Individuals With Opioid Use Disorder.
Manesh Gopaldas, Kevin Wenzel, Aimee N C Campbell, Ali Jalali, Marc Fishman, John Rotrosen, Edward V Nunes, Sean M Murphy> ;Psychiatric Services. 2023 Dec 1
2 citations
Implementing Programs to Initiate Buprenorphine for Opioid Use Disorder Treatment in High-Need, Low-Resource Emergency Departments: A Nonrandomized Controlled Trial.
Ryan P McCormack, John Rotrosen, Phoebe Gauthier, Gail D'Onofrio, David A Fiellin, Lisa A Marsch, Patricia Novo, David Liu, E Jennifer Edelman, Sarah Farkas, Abigail G...> ;Annals of Emergency Medicine. 2023 Sep 1
Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT): A stepped wedge hybrid type 1 effectiveness-implementation study.
Greiner, M., Shulman, M., Opara, O., Potter, K., Voronca, D., Tafessu, H., Hefner, K., Hamilton, A., Scheele, C., Ho, R., Dresser, L., Jelstrom, E., Fishman, M., Ghitz...> ;Contemporary Clinical Trials. 2023 May 1
1 citations
Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.
Annabelle M Belcher, Thomas O Cole, Ebonie Massey, Amy S Billing, Michael Wagner, William Wooten, David H Epstein, Stephen W Hoag, Emerson M Wickwire, Aaron D Greenbla...> ;JAMA Network Open. 2023 Apr 3
Rudolph et al. Respond to "Mathematization of Epidemiology".
Kara E Rudolph, Nicholas T Williams, Iván Díaz, Sean X Luo, John Rotrosen, Edward V Nunes> ;American Journal of Epidemiology. 2023 May 5
1 citations
Trajectories of depression among patients in treatment for opioid use disorder: A growth mixture model secondary analysis of the XBOT trial.
Noel Vest, Kevin Wenzel, Tse-Hwei Choo, Martina Pavlicova, John Rotrosen, Edward Nunes, Joshua D Lee, Marc Fishman> ;The American Journal on Addictions. 2023 May 1
Optimally Choosing Medication Type for Patients With Opioid Use Disorder.
Kara E Rudolph, Nicholas T Williams, Iván Díaz, Sean X Luo, John Rotrosen, Edward V Nunes> ;American Journal of Epidemiology. 2023 May 5
Time-lagged association between counseling and/or 12-Step attendance with subsequent opioid use in a secondary analysis from a randomized, clinical trial of medication...
Kathryn Hefner, Tse-Hwei Choo, Dikla Shmueli-Blumberg, Martina Pavlicova, Jacquie King, Marc Fishman, Aimee Campbell, Miranda Greiner, Jennifer Scodes, Sarah Meyers-Oh...> ;Drug and Alcohol Dependence Reports. 2022 Dec 1
5 citations
Specific polysubstance use patterns predict relapse among patients entering opioid use disorder treatment.
Yue Pan, Daniel J Feaster, Gabriel Odom, Laura Brandt, Mei-Chen Hu, Roger D Weiss, John Rotrosen, Andrew J Saxon, Sean X Luo, Raymond R Balise> ;Drug and Alcohol Dependence Reports. 2022 Dec 1
8 citations
Polysubstance use before and during treatment with medication for opioid use disorder: Prevalence and association with treatment outcomes.
Amanda M Bunting, Noa Krawczyk, Tse-Hwei Choo, Martina Pavlicova, Jennifer McNeely, Babak Tofighi, John Rotrosen, Edward Nunes, Joshua D Lee> ;Journal of Substance Abuse Treatment. 2022 Dec 1
1 citations
Psilocybin for alcohol use disorder: Rationale and design considerations for a randomized controlled trial.
Kelley C O'Donnell, Sarah E Mennenga, Lindsey T Owens, Samantha K Podrebarac, Tara Baron, John Rotrosen, Stephen Ross, Alyssa A Forcehimes, Michael P Bogenschutz> ;Contemporary Clinical Trials. 2022 Dec 1
2 citations
Buprenorphine & methadone dosing strategies to reduce risk of relapse in the treatment of opioid use disorder.
Kara E Rudolph, Nicholas T Williams, Alicia T Singham Goodwin, Marc Fishman, Iván Díaz, Sean Luo, John Rotrosen, Edward V Nunes, Shulman, M.> ;Drug and Alcohol Dependence. 2022 Oct 1
4 citations
Under-representation of key demographic groups in opioid use disorder trials.
Kara E Rudolph, Matthew Russell, Sean X Luo, John Rotrosen, Edward V Nunes> ;Drug and Alcohol Dependence Reports. 2022 Sep 1
154 citations
Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Cli...
Michael P Bogenschutz, Stephen Ross, Snehal Bhatt, Tara Baron, Alyssa A Forcehimes, Eugene Laska, Sarah E Mennenga, Kelley O'Donnell, Lindsey T Owens, Samantha Podreba...> ;JAMA Psychiatry. 2022 Oct 1
7 citations
A neuroeconomic signature of opioid craving: How fluctuations in craving bias drug-related and nondrug-related value.
Kathryn Biernacki, Silvia Lopez-Guzman, John C Messinger, Nidhi V Banavar, John Rotrosen, Paul W Glimcher, Anna B Konova> ;Neuropsychopharmacology. 2022 Jul 1
1 citations
Methamphetamine/amphetamine use over time among persons with opioid use disorders treated with buprenorphine/naloxone versus extended-release naltrexone.
Judith I Tsui, Aimee N C Campbell, Martina Pavlicova, Tse-Hwei Choo, Joshua D Lee, Ryan R Cook, Edward V Nunes, John Rotrosen, Shulman, M.> ;Drug and Alcohol Dependence. 2022 Jul 1
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Journal Articles

Cost-Effectiveness of Buprenorphine–Naloxone Versus Extended-Release Naltrexone to Prevent Opioid Relapse
Joshua D Lee, John Rotrosen, Edward V Nunes, Annals of Internal Medicine
American Psychiatric Association Publishing
John Rotrosen, MD, PubMed

Press Mentions

Open-Label Placebo Improved Outcomes for People in Treatment for Opioid Use DisorderApril 12th, 2023
Psychedelic Drug Therapy May Help Treat Alcohol AddictionAugust 24th, 2022
Study Shows Two Addiction Medications Similar but Drop Out Rates High: Three Possible RemediesNovember 27th, 2017
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