Assistant Professor of Medicine, University of Chicago - Director of Mechanical Circulatory Support - Advanced Heart Failure, Mechanical Circulatory Support and Cardiac Transplantation
Jonathan Grinstein, MD, is an advanced heart failure physician and Director of Mechanical Circulatory Support for the Advanced Heart Failure Group at The University of Chicago. He is an Assistant Professor of Medicine at The University of Chicago and a member of the Alpha Omega Alpha Medical Society and the Gold Humanism Honor Society.
As a specialist in the field of cardiovascular disease and advanced heart failure, Dr. Grinstein treats patients through the use of left ventricular assist devices (LVADs), long-term IV medications or continuous infusion pump medications, and heart transplantation.
Dr. Grinstein received his medical degree from the University of Chicago. He then joined Brigham and Women’s Hospital, associated with Harvard Medical School, for internship and residency training in internal medicine. Finally, he returned to the University of Chicago for a three-year fellowship in cardiology followed by specialty training in advanced heart failure.
Dr. Grinstein participates in novel research involving LVADs. In lieu of a physical examination or an invasive right heart catheterization procedure, Dr. Grinstein has researched, perfected, and currently utilizes an echocardiographic and computed tomography techniques to noninvasively monitor the pressure and volume inside the heart of individuals with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. He is conducting research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics to study and predict blood flow patterns through the LVAD to maximize device performance.
He is board certified in Advanced Heart Failure and Transplant Cardiology, Cardiovascular Disease and Internal Medicine.
Thomas M Cascino, Rebecca Cogswell, Jennifer A Cowger, Keyur B Shah, Jonathan Grinstein, Igor Gosev, Manreet K Kanwar, Shah, P., Molina, E., Wood, K.> ;Journal of Cardiac Failure. 2024 Jan 1
Hidefumi Nishida, Valluvan Jeevanandam, Christopher Salerno, Tae Song, David Onsager, Ann Nguyen, Jonathan Grinstein, Bow Chung, Nitasha Sarswat, Gene Kim, Sean Pinney...> ;Journal of Cardiothoracic Surgery. 2023 Oct 12
Jonathan Grinstein, Brian A Houston, Ann B Nguyen, Bryan A Smith, Annalyse Chinco, Sean P Pinney, Ryan J Tedford, Mark N Belkin> ;Journal of Cardiac Failure. 2023 Nov 1
Jonathan Grinstein, Mark N Belkin, Sara Kalantari, Kevin Bourque, Christopher Salerno, Sean Pinney> ;Journal of the American College of Cardiology. 2023 Jul 4
Jonathan Grinstein, Shashank S Sinha, Rohan M Goswami, Priyesh A Patel, Nicole Cyrille-Superville, Maryam E Neyestanak, Jason P Feliberti, David F Snipelisky, Adam D D...> ;Journal of Cardiac Failure. 2023 Nov 1
Alejandro Plana, Mark N Belkin, Anthony J Kanelidis, William F Parker, Valluvan Jeevanandam, Christopher Salerno, Ann B Nguyen, Bow B Chung, Bryan A Smith, Sara Kalant...> ;Journal of Cardiac Failure. 2023 Jun 1
Anthony J Kanelidis, Umar Siddiqi, Tamari Miller, Mark Belkin, George Li, Bryan Smith, Sara Kalantari, Ann Nguyen, Ben B Chung, Nitasha Sarswat, Gene Kim, Christopher ...> ;Artificial Organs. 2023 Mar 1
Mark N Belkin, Teruhiko Imamura, Daniel Rodgers, Anthony J Kanelidis, Michael P Henry, Takeo Fujino, Viktoriya Kagan, Karen Meehan, Justin Okray, Shana Creighton, Coll...> ;Artificial Organs. 2022 Sep 15
Hidefumi Nishida, Sara Kalantari, Ann Nguyen, Bow Chung, Jonathan Grinstein, Gene Kim, Nitasha Sarswat, Bryan Smith, Sean Pinney, David Onsager, Tae Song, Christopher ...> ;Heart and Vessels. 2022 Dec 1
Hidefumi Nishida, Tae Song, David Onsager, Ann Nguyen, Jonathan Grinstein, Bow Chung, Bryan Smith, Sara Kalantari, Nitasha Sarswat, Gene Kim, Sean Pinney, Valluvan Jee...> ;Annals of Vascular Surgery. 2022 Jul 1
Hidefumi Nishida, Christopher Salerno, David Onsager, Tae Song, Ann Nguyen, Jonathan Grinstein, Bow Chung, Bryan Smith, Sara Kalantari, Nitasha Sarswat, Gene Kim, Sean...> ;ESC Heart Failure. 2022 Aug 1
Jonathan Grinstein, Pablo J Blanco, Carlos A Bulant, Ryo Torii, Christos V Bourantas, Pedro A Lemos, Hector M Garcia-Garcia> ;Frontiers in Cardiovascular Medicine. 2022 Jan 1
Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported with Left Ventricular Assist Devices
Grinstein J, Garan AR, Flatley E, Kim GH, Mai X, Sarswat N, Kalantari S, Adatya S, Raikhelkar J, Sayer G, Oesterle A, Jeevanandam V, Moss J, Uriel N, J Heart Lung Transplant, 1/1/2017
Right Ventricular Pacing Improves Functional Status and Quality of Life Compared to Biventricular Pacing in Left Ventricular Assist Device Patients
Grinstein J, Medvedofsky D, Flatley E, Moss, J, Beiser D, Adatya S, Sayer G, Sarswat N, Raikhelkar J, Kim GH, Kagan V, Lee W, Ota T, Jeevanandam V, Lang R, Uriel N, J Heart Lung Transplant, 1/1/2017
Echocardiographic Predictors of Hemodynamics in Patients Supported with Left Ventricular Assist Devices
Grinstein J, Kruse E, Kalantari Tannenbaum S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raikhelkar J, Kagan V, Costantini H, Burkhoff D, Jeevanandam V, Lang R, ..., J Heart Lung Transplant, 1/1/2017
The Impact of Race on Hemodynamics and Heart Transplant Outcomes
Smith BA, Bassi N, Wright C, Kalantari-Tannenbaum S, Grinstein J, Kim G, Sayer G, Adatya S, Sarswat N, Fedson S, Ota T, Jeevanandam V, Uriel N, J Heart Lung Transplant, 1/1/2017
Reduced PF4 and C6orf25 Gene Copies Prior to LVAD in Patients with Thromboembolic Events
Kim GH, Sayer G, Rodgers D, Woodward R, Arnold P, Sarswat N, Grinstein J, Kalantari S, Adatya S, Yee J, Ota T, Jeevanandam V, Uriel N, J Heart Lung Transplant, 1/1/2017
Management of Cardiac Implantable Electronic Devices (CIEDs) in Patients with Left Ventricular Assist Devices
Grinstein J, Uriel N, Upadhyay GA, 1/22/2016
Discordance between Thermodilution and Indirect Fick Cardiac Outpit Measurements in LVAD Patients
Tehrani DM, Grinstein J, Anyanwu EC, Kim G, Sarswat N, Adatya S, Sayer G, Uriel N, J Car Fail, 1/1/2016
HVAD Waveform as a Surrogate Marker of Cardiac Index and Pulmonary Capillary Wedge Pressure
Grinstein J, Rodgers DE, Tannenbaum SK, Adatya S, Sarswat N, Kim GH, Sayer G, Ota T, Jeevanandam V, Mor-Avi V, Burkhoff D, Uriel N, J Heart Lung Transplant, 1/1/2016
LVAD Outflow Cannula Systolic Slope in Patients with Left Ventricular Assist Devices: A Marker of Myocardial Contractility
Grinstein J, Kruse E, Sayer G, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N, J Heart Lung Transplant, 1/1/2016
The Hemodynamic Effects of Intravenous Inotrope/Vasodilator Therapy in the Beta-Blocker Era
Kalantari S, Grinstein J, Smith B, Sayer G, Adatya S, Sarswat N, Kim G, Burkhoff D, Uriel N, JACC, 1/1/2016
The Hemodynamic Effects of Milrinone in the Beta-Blocker Era
Tannenbaum SK, Grinstein J, Smith B, Marinescu K, Sarswat N, Adatya S, Sayer G, Kim GH, Ota T, Jeevanandam V, Uriel N, J Heart Lung Transplant, 1/1/2016
Discordance Between C4d Staining by Immunohistochemistry and Immunofluorescence and Clinical Outcomes
Tannenbaum SK, Uraizee I, Grinstein J, Smith B, Marinescu K, Sayer G, Sarswat N, Kim GH, Adatya S, Jeevanandam V, Ota T, Husain A, Uriel N, J Heart Lung Transplant, 1/1/2016
Impact of Aortic Insufficiency on Unloading Properties of Continous-Flow Left Ventricular Assist Devices
Sayer G, Kruse E, Addetia K, Grinstein J, Adatya S, Sarswat N, Kim GH, Ota T, Jeevanandam V, Lang R, Uriel N, J Heart Lung Transplant, 1/1/2016
Improved prognostic performance of novel parameters for grading aortic insufficiency severity in patients with left ventricular assist devices
Grinstein J, Kruse E, Collins KA, Sayer G, Fedson S, Kim GH, Jeevanandam V, Lang RM, Uriel N, Circulation, 1/1/2015
Screening for Outflow Cannula Malfunction of Left Ventricular Assist Devices Using Doppler Echocardiography: Establishing New Reference Values
Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Shah A, Paul J, Lang RM, Uriel N, Circulation, 1/1/2015
Novel parameters for grading aortic insufficiency severity in patients with left ventricular assist devices
Grinstein J, Kruse E, Collins KA, Sayer G, Fedson S, Kim GH, Jeevanandam V, Lang RM, Uriel N, JASE, 1/1/2015
Doppler echocardiographic assessment of the left ventricular assist device outflow cannula in the screening of cannula malfunction
Kruse E, Grinstein J, Sayer G, Fedson S, Kim GH, Shah A, Paul J, Uriel N, Lang RM, JASE, 1/1/2015
Quantification of Aortic Insufficiency in Patients With Left Ventricular Assist Devices: A Novel Approach Combining Invasive Hemodynamics and Echocardiography
Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Jorde UP, Juricek C, Ota T, Jeevanandam V, Lang RM, Uriel N, J Heart Lung Transplant, 1/1/2015
Prognostic implications of low-level cardiac troponin elevation using the high-sensitivity assay for cardiac troponin T: Results from EARLY ACS & SEPIA-TIMI 42
Grinstein J, Bonaca M, Sabatine M, Jarolim P, Conrad M, Braunwald E, Giugliano R, Newby LK, Morrow D, J Am Coll Cardiol, 1/1/2013
University of ChicagoFellowship, Advanced Heart Failure and Transplant Cardiology, 2016 - 2017
Brigham and Women's HospitalResidency, Internal Medicine, 2011 - 2013
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 2010
McGill UniversityB.S., Physiology, 2002 - 2006
IL State Medical License 2019 - 2026
DC State Medical License 2017 - 2020
MA State Medical License 2010 - 2013
University of Chicago Medical CenterChicago, Illinois
