JosephASparanoMD

Breast Cancer

Ezra M Greenspan MD Professor of Clinical Cancer Therapeutics; Chief, Division of Hematology and Medical Oncology; Deputy Director, Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai, NY, NY

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Office
1425 Madison Avenue
New York, NY 10029
Phone+1 212-659-6754
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Education & Training

Montefiore Medical Center/Albert Einstein College of Medicine (Moses and Weiler Campuses)Fellowship, Hematology and Medical Oncology, 1986 - 1987
New York Medical College at St Vincent's Hospital and Medical Center of New YorkResidency, Internal Medicine, 1982 - 1985
New York Medical CollegeClass of 1982

Certifications & Licensure

NY State Medical License 1985 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

New York Magazine: Top Doctors Castle Connolly, 2002, 2006, 2018
Top Doctors: New York Metro Area Castle Connolly, 2003-2008, 2010-2014
Super Doctor SuperDoctors.com

Clinical Trials

Marimastat or No Further Therapy in Treating Women With Metastatic Breast Cancer That Is Responding or Stable Following Chemotherapy Start of enrollment: 1997 Dec 02
Completed
Phase 3
Combination Chemotherapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Has Spread to the Lymph Nodes Start of enrollment: 1999 Nov 16
Completed
Phase 3
Combination Chemotherapy and Rituximab in Treating Patients With HIV-Associated Stage I, Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma Start of enrollment: 2003 Mar 01
Completed
Phase 2
Tipifarnib, Doxorubicin, and Cyclophosphamide in Treating Women With Locally Advanced Breast Cancer Start of enrollment: 2003 Feb 01
Completed
Phase 2
Capecitabine and Tipifarnib in Treating Women With Taxane-Resistant Metastatic Breast Cancer Start of enrollment: 2004 May 01
Completed
Phase 2
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) Start of enrollment: 2006 Apr 07
Active, not recruiting
Phase 3
Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Start of enrollment: 2007 Feb 28
Completed
Phase 2
Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Start of enrollment: 2006 Sep 01
Completed
Phase 2
Phase I-II Study of Vorinostat, Paclitaxel, and Bevacizumab in Metastatic Breast Cancer Start of enrollment: 2006 Jul 01
Completed
Phase 1, Phase 2
Tipifarnib and Combination Chemotherapy in Treating Patients With Stage II or Stage III Breast Cancer Start of enrollment: 2007 Apr 01
Completed
Phase 1, Phase 2
Trial for Locally Advanced Breast Cancer Using Vorinostat Plus Chemotherapy Start of enrollment: 2007 Dec 01
Completed
Phase 1, Phase 2
Identifying Genes That Predict Recurrence in Women With Breast Cancer Treated With Chemotherapy Start of enrollment: 2005 Oct 07
Completed
Fulvestrant With or Without Bortezomib in Patients With Inoperable Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer Start of enrollment: 2010 May 26
Completed
Phase 2
Veliparib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer or Metastatic Breast Cancer Start of enrollment: 2010 Jun 01
Completed
Phase 1
Veliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer Start of enrollment: 2010 Jun 30
Active, not recruiting
Phase 2
Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell Lymphomas Start of enrollment: 2010 Oct 06
Completed
Phase 1, Phase 2
Veliparib and Carboplatin in Treating Patients With HER2-Negative Metastatic Breast Cancer Start of enrollment: 2010 Nov 16
Completed
Phase 1
MK2206 in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer Start of enrollment: 2011 Apr 01
Terminated
Phase 2
Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer Start of enrollment: 2011 Apr 21
Active, not recruiting
Phase 2
Cyclophosphamide and Veliparib in Treating Patients With Locally Advanced or Metastatic Breast Cancer Start of enrollment: 2011 May 02
Active, not recruiting
Phase 1
A Phase II Study Of Imtox-25 In Adults With Refractory/Relapsed Cd25 Positive Adult T Cell Leukemia/Lymphoma Start of enrollment: 2010 Sep 01
Terminated
Phase 2
Alisertib, Bortezomib, and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or B-cell Low Grade Non-Hodgkin Lymphoma Start of enrollment: 2012 Aug 31
Active, not recruiting
Phase 1
PTX-200, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer Start of enrollment: 2012 Jan 01
Terminated
Phase 1, Phase 2
Pilot Study to Evaluate Safety & Biological Effects of Orally Administered Reparixin in Early Breast Cancer Start of enrollment: 2013 Feb 01
Terminated
Phase 2
Chemotherapy Before Surgery and Tissue Sample Collection in Patients With Stage IIA-IIIC Breast Cancer Start of enrollment: 2013 Jun 01
Active, not recruiting
Not Applicable
Study of Efficacy and Safety of LEE011 in Postmenopausal Women With Advanced Breast Cancer.(MONALEESA-2) Start of enrollment: 2013 Dec 17
Completed
Phase 3
Endocrine Response in Women With Invasive Lobular Breast Cancer Start of enrollment: 2015 Sep 30
Active, not recruiting
Phase 2
Roles: Contact
Study of Efficacy of Ribociclib After Progression on CDK4/6 Inhibition in Patients With HR+ HER2- Advanced Breast Cancer Start of enrollment: 2016 Mar 01
Active, not recruiting
Phase 2
TMEM-MRI: A Pilot Feasibility Study of MRI for Imaging of TMEM in Patients With Operable Breast Cancer Start of enrollment: 2018 Dec 12
Recruiting
Not Applicable
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Publications & Presentations

PubMed

Lumpectomy without radiation for ductal carcinoma in situ of the breast: 20-year results from the ECOG-ACRIN E5194 study.
Gray, R., Comstock, C., Wolff, A., Wright, J., Rahbar, H., Tjoe, J., Badve, S., Recht, A., Sparano, J., Davidson, N.> ;NPJ Breast Cancer. 2024 Feb 24
Adjuvant platinum versus capecitabine for residual, invasive, triple-negative breast cancer: Patient-reported outcomes in ECOG-ACRIN EA1131.
Smith, K., Zhao, F., Mayer, I., Tevaarwerk, A., Garcia, S., Arteaga, C., Symmans, W., Park, B., Burnette, B., Makower, D., Block, M., Morley, K., Jani, C., Mescher, C....> ;Cancer. 2024 Jan 18
Phase I Trial of the Multi-kinase Inhibitor Cabozantinib, a CYP3A4 Substrate, plus CYP3A4-Interacting Antiretroviral Therapy in People Living with HIV and Cancer (AMC-...
Missak Haigentz, Jeannette Y Lee, Elizabeth Y Chiao, Ronald T Mitsuyasu, Michelle A Rudek, Aboulafia, D., Ratner, L., Ambinder, R., Baiocchi, R., Wachsman, W., Sparano...> ;Clinical Cancer Research. 2023 Dec 15
1 citations
Assessment of the safety of nivolumab in people living with HIV with advanced cancer on antiretroviral therapy: the AIDS Malignancy Consortium 095 Study.
Lakshmi Rajdev, Chia-Ching Jackie Wang, Himanshu Joshi, Shelly Lensing, Jeannette Lee, Juan Carlos Ramos, Robert Baiocchi, Lee Ratner, Paul G Rubinstein, Richard Ambin...> ;Cancer. 2024 Mar 15
Importance of Low- and Moderate-Grade Adverse Events in Patients' Treatment Experience and Treatment Discontinuation: An Analysis of the E1912 Trial.
Nathaniel S O'Connell, Fengmin Zhao, Ju-Whei Lee, Edward H Ip, John Devin Peipert, Noah Graham, Mary Lou Smith, Ilana F Gareen, Ruth C Carlos, Samilia Obeng-Gyasi, Jos...> ;Journal of Clinical Oncology. 2024 Jan 20
3 citations
Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy.
Gina Kim, Burcu Karadal-Ferrena, Jiyue Qin, Ved P Sharma, Isabelle S Oktay, Yu Lin, Xianjun Ye, Saeed Asiry, Jessica M Pastoriza, Esther Cheng, Nurfiza Ladak, John S C...> ;NPJ Breast Cancer. 2023 Jun 13
8 citations
Racial and Ethnic Disparities in Locoregional Recurrence Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer: A Post Hoc Analysis of the TAILORx...
Olga Kantor, Tari A King, Rachel A Freedman, Erica L Mayer, Mariana Chavez-MacGregor, Larissa A Korde, Joseph A Sparano, Elizabeth A Mittendorf> ;JAMA Surgery. 2023 Jun 1
16 citations
An emerging generation of endocrine therapies in breast cancer: a clinical perspective.
Rima Patel, Paula Klein, Amy Tiersten, Joseph A Sparano> ;NPJ Breast Cancer. 2023 Apr 5
The ESC Cardio-Oncology Guidelines: A Roadmap for Clinical Practice and Generating Needed Evidence.
Joseph A Sparano, Gagan Sahni> ;JACC. Cardiooncology. 2023 Feb 1
2 citations
Reply to B. Ulaş Kahya et al and A. Soran et al.
Seema Ahsan Khan, Fengmin Zhao, Lori Goldstein, Joseph Sparano, George Sledge> ;Journal of Clinical Oncology. 2022 Nov 20
3 citations
Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy.
George S Karagiannis, Anthony Bianchi, Luis Rivera Sanchez, Kamal Ambadipudi, Min-Hui Cui, Jesus M Anampa, Saeed Asiry, Yarong Wang, Allison S Harney, Jessica M Pastor...> ;NPJ Breast Cancer. 2022 Sep 2
3 citations
Correlation of the Ki67 Working Group prognostic risk categories with the Oncotype DX Recurrence Score in early breast cancer.
Rima Patel, Malin Hovstadius, Melanie W Kier, Erin L Moshier, Brittney S Zimmerman, Krystal Cascetta, Shabnam Jaffer, Joseph A Sparano, Amy Tiersten> ;Cancer. 2022 Oct 1
Safety and Tolerability of Carboplatin and Paclitaxel in Cancer Patients with HIV (AMC-078), an AIDS Malignancy Consortium (AMC) Study.
Missak Haigentz, Page Moore, Milan Bimali, Joseph Sparano, Michelle Rudek, Lee Ratner, David Henry, Juan Ramos, John Deeken, Paul Rubinstein, Elizabeth Chiao, Timothy ...> ;The Oncologist. 2022 Aug 5
ASO Visual Abstract: Expanding Staging Criteria in T1-2N0 Hormone Receptor-Positive Breast Cancer Patients Enrolled in TAILORx.
Olga Kantor, Harold J Burstein, Tari A King, Steven Shak, Christy A Russell, Armando E Giuliano, Gabriel N Hortobagyi, Eric P Winer, Larissa A Korde, Joseph A Sparano,...> ;Annals of Surgical Oncology. 2022 Dec 1
Expanding the Staging Criteria for T1-2N0 Hormone-Receptor Positive Breast Cancer Patients Enrolled in TAILORx.
Olga Kantor, Harold J Burstein, Tari A King, Steven Shak, Christy A Russell, Armando E Giuliano, Gabriel N Hortobagyi, Eric P Winer, Larissa A Korde, Joseph A Sparano,...> ;Annals of Surgical Oncology. 2022 Dec 1
102 citations
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Joel M Palefsky, Jeannette Y Lee, Naomi Jay, Stephen E Goldstone, Teresa M Darragh, Hillary A Dunlevy, Isabella Rosa-Cunha, Abigail Arons, Julia C Pugliese, Don Vena, ...> ;The New England Journal of Medicine. 2022 Jun 16
2 citations
Plasma extracellular vesicles bearing PD-L1, CD40, CD40L or TNF-RII are significantly reduced after treatment of AIDS-NHL.
Laura E Martínez, Shelly Lensing, Di Chang, Larry I Magpantay, Ronald Mitsuyasu, Richard F Ambinder, Joseph A Sparano, Otoniel Martínez-Maza, Marta Epeldegui> ;Scientific Reports. 2022 Jun 2
Erratum to "Gene expression signatures for tailoring adjuvant chemotherapy of luminal breast cancer: stronger evidence, greater trust": [Annals of Oncology 32 (2021) 1...
M J Piccart, K Kalinsky, R Gray, W E Barlow, C Poncet, F Cardoso, E Winer, J Sparano> ;Annals of Oncology. 2022 Jun 1
3 citations
Racial disparities in neutrophil counts among patients with metastatic breast cancer during treatment with CDK4/6 inhibitors.
Ashley Schreier, Laura Munoz-Arcos, Alvaro Alvarez, Joseph A Sparano, Jesus D Anampa> ;Breast Cancer Research and Treatment. 2022 Jul 1
8 citations
Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project...
Gina Kim, Jessica M Pastoriza, Jiyue Qin, Juan Lin, George S Karagiannis, John S Condeelis, Greg Yothers, Stewart Anderson, Thomas Julian, David Entenberg, Thomas E Ro...> ;Cancer. 2022 Jul 15
3 citations
Association Between Surgery Preference and Receipt in Ductal Carcinoma In Situ After Breast Magnetic Resonance Imaging: An Ancillary Study of the ECOG-ACRIN Cancer Res...
Soudabeh Fazeli, Bradley S Snyder, Ilana F Gareen, Constance D Lehman, Seema A Khan, Justin Romanoff, Constantine A Gatsonis, Ralph L Corsetti, Habib Rahbar, Derrick W...> ;JAMA Network Open. 2022 May 2
24 citations
Assessment of Racial Disparity in Survival Outcomes for Early Hormone Receptor-Positive Breast Cancer After Adjusting for Insurance Status and Neighborhood Deprivation...
Gelareh Sadigh, Robert J Gray, Joseph A Sparano, Betina Yanez, Sofia F Garcia, Lava R Timsina, Samilia Obeng-Gyasi, Ilana Gareen, George W Sledge, Timothy J Whelan, Da...> ;JAMA Oncology. 2022 Apr 1
64 citations
Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (EA2108).
Seema A Khan, Fengmin Zhao, Lori J Goldstein, David Cella, Mark Basik, Mehra Golshan, Thomas B Julian, Barbara A Pockaj, Christine A Lee, Wajeeha Razaq, Joseph A Spara...> ;Journal of Clinical Oncology. 2022 Mar 20
Systemic therapy for triple-negative breast cancer: A changing landscape.
Alaina J Kessler, Joseph A Sparano> ;Critical Reviews in Oncology/hematology. 2022 Mar 1
10 citations
Inflammatory cytokines and distant recurrence in HER2-negative early breast cancer.
Joseph A Sparano, Anne O'Neill, Noah Graham, Donald W Northfelt, Chau T Dang, Antonio C Wolff, George W Sledge, Kathy D Miller> ;NPJ Breast Cancer. 2022 Feb 8
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Journal Articles

Deconstructing Racial and Ethnic Disparities in Breast Cancer
Joseph A Sparano, Otis W Brawley, JAMA Oncology
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer
Matthew P Goetz, Thomas J Saphner, Joseph A Sparano, Lynne I Wagner, Peter M Ravdin, Daniel F Hayes, Adam M Brufsky, Della F Makower, Sunil S Badve, Robert J Gray, Wil..., The New England Journal of Medicine

Abstracts/Posters

A Randomized Trial of EPOCH-Based Chemotherapy with Vorinostat for Highly Aggressive HIV-Associated Lymphomas: Updated Results Evaluating Impact of Diagnosis-to-Treatm...
Joseph Sparano, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Response-Adapted Therapy with Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma
Joseph Sparano, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

Impact of clinical risk category on prognosis and prediction of chemotherapy benefit in early breast cancer (EBC) by age and the 21-gene recurrence score (RS) in TAILORx.
2019 ASCO Annual Meeting - 6/1/2019
Selected Updates in Breast Cancer
2007 Annual Meeting, Chicago, Illinois, USA

Press Mentions

TAILORx Update: 12-Year Recurrence and Survival Outcomes for Patients with Early-Stage Breast CancerDecember 13th, 2022
SABCS: Updated Analysis Confirms Endocrine Therapy Effective With/Without ChemoDecember 12th, 2022
Global Cardio-Oncology Viewpoints ‘Contextualize’ ESC GuidelinesDecember 12th, 2022
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Grant Support

Albert Einstein Core SiteNational Cancer Institute2010–2011
Centralized Protocol And Data Management UnitNational Cancer Institute2007–2011
Eastern Cooperative Oncology GroupNational Cancer Institute2004–2011
Montefiore Medical Center / Albert Einstein School Of MedicineNational Cancer Institute2006
AIDS Malignancy ConsortiumNational Cancer Institute1999–2005
Eastern Cooperative Oncology GroupNational Cancer Institute2002–2003