KaraNoelleMaxwellMDPHD

PubMed

• Neighborhood Deprivation, Race and Ethnicity, and Prostate Cancer Outcomes Across California Health Care Systems.
  Ananta Wadhwa, Charlotte Roscoe, Elizabeth A Duran, Lorna Kwan, Candace L Haroldsen, Jeremy B Shelton, Jennifer Cullen, Beatrice S Knudsen, Mathew B Rettig, Saiju Pyar...> ;JAMA Network Open. 2024 Mar 4
• Toward Application of Polygenic Risk Scores to Both Enhance and Deintensify Breast Cancer Screening.
  Kara N Maxwell, Susan M Domchek> ;Journal of Clinical Oncology. 2024 Feb 29
• Genome-first approach of the prevalence and cancer phenotypes of pathogenic or likely pathogenic germline TP53 variants.
  de Andrade, K., Strande, N., Kim, J., Haley, J., Hatton, J., Frone, M., Khincha, P., Thone, G., Mirshahi, U., Schneider, C., Desai, H., Dove, J., Smelser, D., , , Levi...> ;HGG Advances. 2024 Jan 11
• "Likely Pathogenic Heterozygous ATM Gene Mutation": Not Always What It Seems.
  Vapiwala, N., Maxwell, K.> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Jan 1
• Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer.
  John K Lin, Caleb M Hearn, Emily Getzen, Qi Long, David C Lee, Tony M Keaveny, Ravishankar Jayadevappa, Kyle W Robinson, Yu-Ning Wong, Kara N Maxwell, Vivek Narayan, N...> ;European Urology Oncology. 2023 Nov 3
• Multiple TP53 p.R337H haplotypes and implications for tumor susceptibility.
  Emilia M Pinto, Cintia Fridman, Bonald C Figueiredo, Hector Salvador, Manuel R Teixeira, Carla Pinto, Manuela Pinheiro, Christian P Kratz, Cinzia Lavarino, Edith A M F...> ;HGG Advances. 2024 Jan 11
• In Reply to "Pathogenic/Likely Pathogenic Somatic CDK12 Mutations in Black Men With Prostate Cancer".
  Luca F Valle, Nicholas G Nickols, Kosj Yamoah, Isla P Garraway, Kara N Maxwell, Julie A Lynch> ;The Oncologist. 2023 Nov 2
• 1 citations
  Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.
  Jung Kim, Zalman Vaksman, Laura E Egolf, Rebecca Kaufman, J Perry Evans, Karina L Conkrite, Arnavaz Danesh, Gonzalo Lopez, Michael P Randall, Maiah H Dent, Lance M Far...> ;Journal of the National Cancer Institute. 2024 Jan 10
• 1 citations
  Rates of Intervention and Cancer Detection on Initial versus Subsequent Whole-body MRI Screening in Li-Fraumeni Syndrome.
  Laura A T Kagami, Yun K Du, Conrad J Fernandes, Anh N Le, Madeline Good, Melani M Duvall, Sarah E Baldino, Jacquelyn Powers, Kristin Zelley, Lisa J States, Manoj C Mat...> ;Cancer Prevention Research. 2023 Sep 1
• Uptake of Genetic Research Results and Patient-Reported Outcomes With Return of Results Incorporating Web-Based Predisclosure Education.
  Madison Kilbride, Brian L Egleston, Wendy K Chung, Olufunmilayo Olopade, Kara N Maxwell, Payal Shah, Jane E Churpek, Linda Fleisher, Mary Beth Terry, Dominique Fetzer,...> ;Journal of Clinical Oncology. 2023 Nov 1
• 2 citations
  BiallelicLoss and Homologous Recombination Deficiency in Nonbreast/Ovarian Tumors in GermlineCarriers.
  Dylane Wineland, Anh N Le, Ryan Hausler, Gregory Kelly, Emanuel Barrett, Heena Desai, Bradley Wubbenhorst, John Pluta, Paul Bastian, Heather Symecko, Kurt D'Andrea, Ab...> ;JCO Precision Oncology. 2023 Aug 1
• 2 citations
  Germline Exome Sequencing for Men with Testicular Germ Cell Tumor Reveals Coding Defects in Chromosomal Segregation and Protein-targeting Genes.
  Louise C Pyle, Jung Kim, Jonathan Bradfield, Scott M Damrauer, Kurt D'Andrea, Lawrence H Einhorn, Rama Godse, Hakon Hakonarson, Peter A Kanetsky, Rachel L Kember, Lind...> ;European Urology. 2024 Apr 1
• 2 citations
  Actionable Genomic Alterations in Prostate Cancer Among Black and White United States Veterans.
  Luca F Valle, Nicholas G Nickols, Ryan Hausler, Patrick R Alba, Tori Anglin-Foote, Cristina Perez, Kosj Yamoah, Brent S Rose, Michael J Kelley, Scott L DuVall, Isla P ...> ;The Oncologist. 2023 Jun 2
• Tumor testing and treatment patterns in veterans with metastatic castration-resistant prostate cancer.
  Anna Hung, Danielle Candelieri, Yanhong Li, Patrick Alba, Brian Robison, Fatai Agiri, Cristina Perez, Kyung-Min Lee, Kara N Maxwell, Weiyan Li, Himani Aggarwal, Kathry...> ;Seminars in Oncology. 2023 Mar 15
• 1 citations
  Germline pathogenic variants in 786 neuroblastoma patients.
  Jung Kim, Zalman Vaksman, Laura E Egolf, Rebecca Kaufman, J Perry Evans, Karina L Conkrite, Arnavaz Danesh, Gonzalo Lopez, Michael P Randall, Maiah H Dent, Lance M Far...> ;Medrxiv. 2023 Jan 25
• 9 citations
  Gastric Cancer Risk and Pathogenesis inandCarriers.
  Kole H Buckley, Blake A Niccum, Kara N Maxwell, Bryson W Katona> ;Cancers. 2022 Dec 1
• Reply to Joanne L. Dickinson, Georgea R. Foley, and Liesel M. FitzGerald's Letter to the Editor re: Daniel J. Lee, Ryan Hausler, Anh N. Le, et al. Association of Inher...
  Daniel J Lee, Ryan Hausler, Kara N Maxwell> ;European Urology. 2022 Dec 1
• 7 citations
  Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers.
  Jennifer B Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D'Andrea, Anna P Hubert, Jake S Shilan, Wenting Zhou, Adam A Kraya, Alba Llop Guevara...> ;Nature Communications. 2022 Nov 7
• Reply to Hela Sassi, Olivier Caron, and Etienne Rouleau's Letter to the Editor re: Kara N. Maxwell, Heather H. Cheng, Jacquelyn Powers, et al. Inherited TP53 Variants ...
  Kara N Maxwell, Colin C Pritchard> ;European Urology. 2023 Jan 1
• 12 citations
  Cetuximab-Based vs Carboplatin-Based Chemoradiotherapy for Patients With Head and Neck Cancer.
  Lova Sun, Danielle Candelieri-Surette, Tori Anglin-Foote, Julie A Lynch, Kara N Maxwell, Christopher D'Avella, Aditi Singh, Erin Aakhus, Roger B Cohen, Robert M Brody> ;JAMA Otolaryngology-- Head & Neck Surgery. 2022 Nov 1
• Fanconi anemia caused by biallelic inactivation of BRCA2 can present with an atypical cancer phenotype in adulthood.
  Kara N Maxwell, Vishal Patel, Kevin T Nead, Shana Merrill, Dana Clark, Qinqin Jiang, Bradley Wubbenhorst, Kurt D'Andrea, Roger B Cohen, Susan M Domchek, Jennifer J D M...> ;Clinical Genetics. 2023 Jan 1
• 7 citations
  Association Between Up-front Surgery and Risk of Stroke in US Veterans With Oropharyngeal Carcinoma.
  Lova Sun, Robert Brody, Danielle Candelieri, Tori Anglin-Foote, Julie A Lynch, Kara N Maxwell, Scott Damrauer, Eric Ojerholm, John N Lukens, Roger B Cohen, Kelly D Get...> ;JAMA Otolaryngology-- Head & Neck Surgery. 2022 Aug 1
• 3 citations
  Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra-cellular matrix marker ...
  Moen Sen, Ryan M Hausler, Keely Dulmage, Taylor A Black, William Murphy, Charles H Pletcher Jr, Ling Wang, Chang Chen, Stephanie S Yee, Scott J Bornheimer, Kara N Maxw...> ;Clinical and Translational Medicine. 2022 Jul 1
• 12 citations
  The distinct impacts of race and genetic ancestry on health.
  Timothy R Rebbeck, Brandon Mahal, Kara N Maxwell, Isla P Garraway, Kosj Yamoah> ;Nature Medicine. 2022 May 1
• 6 citations
  A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG-ACRIN Cancer Research Group (EAQ152).
  Angela R Bradbury, Ju-Whei Lee, Jill Bennett Gaieski, Shuli Li, Ilana F Gareen, Keith T Flaherty, Benjamin A Herman, Susan M Domchek, Angela M DeMichele, Kara N Maxwel...> ;Cancer. 2022 Apr 1
• Join now to see all

Journal Articles

• Electronic health record phenotypes for precision medicine: perspectives and caveats from treatment of breast cancer at a single institution  
  Breitenstein MK, Liu H, Maxwell KN, Pathak J, Zhang R, Clinical and Translational Science, 1/1/2018
• The differential diagnosis of a TP53 genetic testing result  
  MacFarland SP, Maxwell KN, Genetics in Medicine, 1/1/2018
• BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers  
  Maxwell KN, Wubbenhorst B, Wenz BM, De Sloover D, Pluta J, Emery L, Barrett A, Kraya AA, Anastopoulos IN, Yu S, Jiang Y, Chen H, Zhang NR, Hackman N, D'Andrea K, Daber..., Nature Communications, 1/1/2017
• Dietary influence on estrogens and cytokines in breast cancer  
  Nian X, Nagai Y, Jeffers C, Maxwell KN, Zhang H, AIMS Molecular Science, 1/1/2017
• Allele-specific copy number estimation by whole exome sequencing  
  Chen H, Jiang Y, Maxwell KN, Nathanson KL, Zhang N, Ann Appl Stat, 1/1/2017
• The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk  
  Slavin TP, Maxwell KN, Lilyquist J, Vijai J, Neuhausen SL, Hart SN, Ravichandran V, Thomas T, Maria A, Villano D, Schrader KA, Moore R, Hu C, Wubbenhorst B, Wenz BM, D..., NPJ Breast Cancer, 1/1/2017
• Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer  
  Maxwell KN, Soucier-Ernst D, Tahirovic E, Troxel AB, Clark C, Feldman M, Colameco C, Kakrecha B, Langer M, Lieberman D, Morrissette JJD, Paul MR, Pan TC, Yee S, Shih N..., Breast Cancer Research and Treatment, 1/1/2017
• Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer  
  Maxwell KN, Hart SN, Vijai J, Schrader KA, Slavin TP, Thomas T, Wubbenhorst B, Ravichandran V, Moore RM, Hu C, Guidugli L, Wenz B, Domchek SM, Robson ME, Szabo C, Neuh..., American Journal of Human Genetics, 1/1/2016
• A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer  
  Vijai J, Topka S, Villano D, Ravichandran V, Maxwell KN, Maria A, Thomas T, Gaddam P, Lincoln A, Kazzaz S, Wenz B, Carmi S, Schrader KA, Hart SN, Lipkin SM, Neuhausen ..., Cancer Discovery, 1/1/2016
• Population Frequency of Germline BRCA1/2 Mutations  
  Maxwell KN, Domchek SM, Nathanson KL, Robson ME, Journal of Clinical Oncology, 1/1/2016
• Collaborative science in the next-generation sequencing era: a viewpoint on how to combine exome sequencing data across sites to identify novel disease susceptibility ...  
  Hart SN, Maxwell KN, Thomas T, Ravichandran V, Wubberhorst B, Klein RJ, Schrader K, Szabo C, Weitzel JN, Neuhausen SL, Nathanson K, Offit K, Couch FJ, Vijai J, Briefings in Bioinformatics, 1/1/2016
• Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations  
  Jean S, Li J, Katsaros D, Wubbenhorst B, Maxwell KN, Fishbein L, McLane MW, Benedetto C, Canuto EM, Mitra N, Zhang L, Nathanson KL, Tanyi JL, Oncotarget, 1/1/2016
• Patient feedback and early outcome data with a novel tiered-binned model for multiplex breast cancer susceptibility testing  
  Bradbury Angela R, Patrick-Miller Linda J, Egleston Brian L, DiGiovanni Laura, Brower Jamie, Harris Diana, Stevens Evelyn M, Maxwell Kara N, Kulkarni Abha, Chavez Tyle..., Genetics in Medicine, 1/1/2015
• Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer  
  Maxwell KN, Wubbenhorst B, D'Andrea Ku, Garman B, Long JM, Powers J, Rathbun K, Stopfer JE, Zhu J, Bradbury AR, Simon MS, DeMichele A, Domchek SM, Nathanson KL, Genetics in Medicine, 1/1/2015
• Common breast cancer risk variants in the post-COGS era: a comprehensive review  
  Maxwell KN, Nathanson KL, Breast Cancer Research, 1/1/2013
• Familial breast cancer risk  
  Maxwell KN, Domchek SM, Current Breast Cancer Reports, 1/1/2013
• A classic presentation of an uncommon leukemia  
  Maxwell KN, Porter DL, American Journal of Hematology, 1/1/2013
• Antibodies to PCSK9: a superior way to lower LDL cholesterol?  
  Maxwell KN, Breslow JL, Circulation Research, 1/1/2012
• Prophylactic Mastectomy and Risk-Reducing Salpingo-oophorectomy in BRCA1/2 Mutation Carriers  
  Maxwell KN, Domchek, SM, Current Breast Cancer Reports, 1/1/2012
• Cancer treatment according to BRCA1 and BRCA2 mutations  
  Maxwell KN, Domchek SM, Nature Reviews Clinical oncology, 1/1/2012
• The incidence of both serious and minor complications in young women undergoing oocyte donation  
  Maxwell KN, Cholst IN, Rosenwaks Z, Fertility and Sterility, 1/1/2008
• Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia  
  Maxwell KN, Breslow JL, Current Opinion in Lipidology, 1/1/2005
• Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment  
  Maxwell KN, Fisher EA, Breslow JL, Proceedings of the National Academy of Sciences of the United States of America, 1/1/2005
• Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endop...  
  Soccio RaE, Adams RM, Maxwell KN, Breslow JL, Journal of Biological Chemistry, 1/1/2005
• Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype  
  Maxwell KN, Breslow JL, Proceedings of the National Academy of Sciences of the United States of America, 1/1/2004
• Join now to see all

Abstracts/Posters

• Genes Everywhere: Germline, Somatic, and Circulation
  Maxwell KN, Cancer Prevention, Genetics and Epidemiology Track at the American Society of Clinical Oncology Annual Meeting, Chicago, IL, 1/1/2017
• Moving Beyond Clinical Risk Prediction Models for Cancer Susceptibility Assessment - Unexpected Results with Multiplex Panel Testing
  Maxwell KN, Clinical Sciences Symposium, American Society of Clinical Oncology Annual Meeting, Chicago, IL, 1/1/2016
• Evidence for diverse mechanisms of tumorigenesis in breast and ovarian tumors of BRCA1/2 carriers
  Maxwell, K.N., DeSloover D., Wubbenhorst, B., Wenz, B., Lunceford, N., Emery, L., D'Andrea, K., Feldman, M., Daber, R., Domchek, S.M., Nathanson, K.L., Cancer Research, 1/1/2015
• Identification of germline variants in cancer susceptibility genes in patients with multiple primary cancers
  Wenz, B., Maxwell, K.N., Wubbenhorst,B., D'Andrea, K.P., Garman, B., Long, J., Powers, J., Stopfer, J., Bradbury, A.R., DeMichele, A., Domchek, S.M., Nathanson, K.L., Cancer Research, 1/1/2015
• The contribution of high and moderate penetrance breast cancer susceptibility genes to familial breast cancer risk in BRCAx families
  Maxwell, K.N., Hart, S.N., Vijai, J, Schrader, K., Slavin, T.P., Thomas, T., Moore, R., Hu,C., Wubbenhorst, B., Domchek, S.M., Robson, M.E., Radice, P., Peterlong, P.,..., 65th Annual Meeting of The American Society of Human Genetics, 1/1/2015
• Join now to see all

Lectures

• Inherited mutations in breast cancer patients with and without multiple primary cancers. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018
• Inherited Genetics in Breast and Ovarian Tumorigenesis and Treatment 
  Multiple Dates and Locations - 1/1/2018
• New challenges in germline cancer risk evaluation - the interaction with advancing tumor testing technologies 
  Chicago, IL - 1/1/2017
• Variant classification and clinical benefit of gene panels for cancer susceptibility 
  1/1/2016
• Genetic Testing Today: What Genes Can Tell Us 
  Philadelphia, PA - 1/1/2016
• Characteristics of high risk breast cancer patients with mutations identified by multiplex panel testing 
  Chicago, IL - 1/1/2015
• Focus on BRCA deficient cancers 
  Philadelphia, PA - 1/1/2015
• When Worlds Collide: Genetic Counseling and Testing Conundrums in Identifying Cancer Risk for the Prenatal, Pediatric and Cancer Genetic Counselor 
  Pittsburgh, PA - 1/1/2015
• Focus on BRCA deficient and triple-negative breast cancers 
  Philadelphia, PA - 1/1/2014
• Prevalence of mutations in a panel of breast cancer susceptibility genes in patients with early onset breast cancer 
  Chicago, IL - 1/1/2014
• An adult cancer patient with biallelic BRCA2 mutations -expanding the clinical paradigm of Fanconi Anemia D1 
  Bethesda, MD - 1/1/2014
• Targeted massively parallel sequencing identifies a limited number of clinically actionable variants in women with early onset breast cancer 
  Washington, DC - 1/1/2013
• PCSK9: From microarray to clinical trial in 10 years 
  Rockefeller University, New York, NY - 1/1/2013
• Pcsk9 regulates LDL receptor function and LDL cholesterol levels 
  Readington Township, NJ - 1/1/2005
• Adenoviral mediated overexpression of the subtilisin protease Pcsk9 increases plasma LDL cholesterol levels in the mouse 
  San Francisco, CA - 1/1/2004
• Overexpression of Pcsk9 leads to the formation of an LDLR-Pcsk9 complex and acceleration of LDLR degradation 
  New Orleans, LA - 1/1/2004
• Join now to see all