KristinaAColeMDPhD

Pediatric Hematology & Oncology • Philadelphia, PA

Associate Professor of Pediatrics, Perelman School of Medicine

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Office
3401 Civic Center Blvd
Children's Hospital Of Philadelphia - Hem/Onc
Philadelphia, PA 19104
Phone+1 215-590-3535

Fax+1 215-590-3992
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Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 2004 - 2007
Children's Hospital of PhiladelphiaResidency, Pediatrics, 2001 - 2004
University of Maryland School of MedicineClass of 2001

Certifications & Licensure

PA State Medical License 2001 - 2024
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT Start of enrollment: 2017 Feb 22
Completed
Phase 1
Roles: Contact
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Start of enrollment: 2015 Sep 01
Active, not recruiting
Phase 4
Roles: Contact

Publications & Presentations

PubMed

Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil C...> ;The Lancet. Oncology. 2024 Mar 26
1 citations
Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.
Jung Kim, Zalman Vaksman, Laura E Egolf, Rebecca Kaufman, J Perry Evans, Karina L Conkrite, Arnavaz Danesh, Gonzalo Lopez, Michael P Randall, Maiah H Dent, Lance M Far...> ;Journal of the National Cancer Institute. 2024 Jan 10
7 citations
OpenPBTA: The Open Pediatric Brain Tumor Atlas.
Joshua A Shapiro, Krutika S Gaonkar, Stephanie J Spielman, Candace L Savonen, Chante J Bethell, Run Jin, Komal S Rathi, Yuankun Zhu, Laura E Egolf, Bailey K Farrow, Da...> ;Cell Genomics. 2023 Jul 12
1 citations
Germline pathogenic variants in 786 neuroblastoma patients.
Jung Kim, Zalman Vaksman, Laura E Egolf, Rebecca Kaufman, J Perry Evans, Karina L Conkrite, Arnavaz Danesh, Gonzalo Lopez, Michael P Randall, Maiah H Dent, Lance M Far...> ;Medrxiv. 2023 Jan 25
5 citations
Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics.
Kee Kiat Yeo, Sanda Alexandrescu, Jennifer A Cotter, Jayne Vogelzang, Varun Bhave, Marilyn M Li, Jianling Ji, Jamal K Benhamida, Marc K Rosenblum, Tejus A Bale, Nancy ...> ;Neuro-Oncology. 2023 Jan 5
4 citations
Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatc...
Jennifer L Stundon, Heba Ijaz, Krutika S Gaonkar, Rebecca S Kaufman, Run Jin, Anastasios Karras, Zalman Vaksman, Jung Kim, Ryan J Corbett, Matthew R Lueder, Daniel P M...> ;Neuro-Oncology. 2023 Jul 6
50 citations
Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.
Anirban Das, Sumedha Sudhaman, Daniel Morgenstern, Ailish Coblentz, Jiil Chung, Simone C Stone, Noor Alsafwani, Zhihui Amy Liu, Ola Abu Al Karsaneh, Shirin Soleimani, ...> ;Nature Medicine. 2022 Jan 1
35 citations
DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.
Jiil Chung, Yosef E. Maruvka, Sumedha Sudhaman, Jacalyn Kelly, Nicholas J. Haradhvala, Vanessa Bianchi, Melissa Edwards, Victoria J. Forster, Nuno Miguel Nunes, Meliss...> ;Cancer Discovery. 2021 May 1
20 citations
Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns.
Andrew Dodgshun, Kohei Fukuoka, Melissa Edwards, Vanessa Bianchi, Anirban Das, Alexandra Sexton-Oates, Valerie Larouche, Magimairajan Issai Vanan, Scott Lindhorst, Mic...> ;Acta Neuropathologica. 2020 Sep 8
1 citations
A germline PALB2 pathogenic variant identified in a pediatric high-grade glioma.
Yiming Zhong, Jeffrey Schubert, Jinhua Wu, Feng Xu, Fumin Lin, Kajia Cao, Kristin Zelley, Minjie Luo, Jessica B. Foster, Kristina A. Cole, Suzanne P. MacFarland, Adam ...> ;Cold Spring Harbor Molecular Case Studies. 2020 Aug 25
243 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
16 citations
Intracranial growing teratoma syndrome (iGTS): an international case series and review of the literature
George Michaiel, Douglas Strother, Nicholas G. Gottardo, Ute Bartels, Hallie Coltin, Juliette Hukin, Beverly Wilson, Shayna Zelcer, Jordan R. Hansford, Tim Hassall, Mo...> ;Journal of Neuro-Oncology. 2020 Apr 15
1 citations
Targeting ATRX Loss through Inhibition of the Cell-Cycle Checkpoint Mediator WEE1.
Kristina A. Cole> ;Cancer Research. 2020 Feb 1
22 citations
Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium
Heba Ijaz, Mateusz Koptyra, Krutika S. Gaonkar, Jo Lynne Rokita, Valerie Baubet, Lamiya Tauhid, Yuankun Zhu, Miguel A. Brown, Gonzalo Lopez, Bo Zhang, Sharon J. Diskin...> ;Neuro-Oncology. 2020 Jan 11
37 citations
Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312)
Kristina A. Cole, Sharmistha Pal, Rachel A. Kudgus, Heba Ijaz, Xiaowei Liu, Charles G. Minard, Bruce R. Pawel, John M. Maris, Daphne A. Haas-Kogan, Stephan D. Voss, St...> ;Clinical Cancer Research. 2020 Mar 15
24 citations
Immunotherapy for pediatric brain tumors: past and present.
Jessica B. Foster, Peter J. Madsen, Meenakshi Hegde, Nabil Ahmed, Kristina A. Cole, John M. Maris, Adam C. Resnick, Phillip B. Storm, Angela Waanders> ;Neuro-Oncology. 2019 Oct 9
13 citations
Risk of brainstem necrosis in pediatric patients with central nervous system malignancies after pencil beam scanning proton therapy
J. Vogel, A. Grewal, Shannon O'Reilly, Robert A. Lustig, G. Kurtz, Jane E. Minturn, Amish C. Shah, Angela J. Waanders, Jean B. Belasco, Kristina A. Cole, Michael Fishe...> ;Acta Oncologica. 2019 Sep 12
50 citations
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Caitlin D. Lowery, Michele Dowless, Matthew Renschler, Wayne Blosser, Alle B VanWye, Jennifer R. Stephens, Philip W. Iversen, Aimee Bence Lin, Richard P. Beckmann, Kat...> ;Clinical Cancer Research. 2019 Apr 1
12 citations
Endoscopic third ventriculostomy prior to resection of posterior fossa tumors in children
Fabio Frisoli, Michael Kakareka, Kristina A. Cole, Angela J. Waanders, Phillip B. Storm, Shih-Shan Lang> ;Child's Nervous System. 2019 Mar 20
24 citations
Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue
Andrew Y. Shuen, Stella Lanni, Gagan B. Panigrahi, Melissa Edwards, Lisa Yu, Brittany Campbell, Ariane Mandel, Cindy Zhang, Nataliya Zhukova, Musa Alharbi, Mark L. Ber...> ;Journal of Clinical Oncology. 2019 Jan 4
505 citations
Comprehensive Analysis of Hypermutation in Human Cancer
Brittany Campbell, Nicholas Light, David Fabrizio, Matthew Zatzman, Fabio Fuligni, Richard de Borja, Scott Davidson, Melissa Edwards, Julia A. Elvin, Karl P. Hodel, Wa...> ;Cell. 2017 Nov 16
44 citations
The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma
Mario Capasso, Lee D. McDaniel, Flora Cimmino, Andrea Cirino, Daniela Formicola, Mike R. Russell, Pichai Raman, Kristina A. Cole, Sharon J. Diskin> ;Journal of Cellular and Molecular Medicine. 2017 Jun 30
56 citations
Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma
Lori S. Hart, JulieAnn Rader, Pichai Raman, Vandana Batra, Mike R. Russell, Matthew Tsang, Maria Gagliardi, Lucy Chen, Daniel Martinez, Yimei Li, Andrew Wood, Sunkyu K...> ;Clinical Cancer Research. 2017 Apr 1
10 citations
Carboplatin Rechallenge After Hypersensitivity Reactions in Pediatric Patients With Low-Grade Glioma
Amish C. Shah, Jane E. Minturn, Yimei Li, Jean B. Belasco, Peter C. Phillips, Tammy I. Kang, Kristina A. Cole, Angela J. Waanders, Rosanna Pollack, Concetta DiDomenico...> ;Pediatric Blood & Cancer. 2016 Jan 1
119 citations
CASC15-S is a tumor suppressor lncRNA at the 6p22 neuroblastoma susceptibility locus
Mike R. Russell, Annalise Penikis, Derek A. Oldridge, Juan R. Alvarez-Dominguez, Lee D. McDaniel, Maura Diamond, Olivia Padovan, Pichai Raman, Yimei Li, Jun Wei, Shile...> ;Cancer Research. 2015 Aug 1
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