KristopherBosseMD

Pediatric Hematology & Oncology • Philadelphia, PA

Physician

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Office
34th St. & Civic Center Blvd
The Children's Hospital Of Philadelphia, Room 9nw55
Philadelphia, PA 19104
Phone+1 215-590-2437

Fax+1 215-590-2768
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Education & Training

Children's Hospital of PhiladelphiaResidency, Pediatrics, 2010 - 2013
Perelman School of Medicine at the University of PennsylvaniaClass of 2010

Certifications & Licensure

PA State Medical License 2010 - 2024
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Publications & Presentations

PubMed

3 citations
Targeting of intracellular oncoproteins with peptide-centric CARs.
Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S T...> ;Nature. 2023 Nov 1
Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S T...> ;Nature. 2023 Nov 1
1 citations
Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.
Jung Kim, Zalman Vaksman, Laura E Egolf, Rebecca Kaufman, J Perry Evans, Karina L Conkrite, Arnavaz Danesh, Gonzalo Lopez, Michael P Randall, Maiah H Dent, Lance M Far...> ;Journal of the National Cancer Institute. 2024 Jan 10
BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma.
Michael P Randall, Laura E Egolf, Zalman Vaksman, Minu Samanta, Matthew Tsang, David Groff, J Perry Evans, Jo Lynne Rokita, Mehdi Layeghifard, Adam Shlien, John M Mari...> ;Journal of the National Cancer Institute. 2024 Jan 10
A MYCN-independent mechanism mediating secretome reprogramming and metastasis in-amplified neuroblastoma.
Hai-Feng Zhang, Alberto Delaidelli, Sumreen Javed, Busra Turgu, Taylor Morrison, Christopher S Hughes, Xiaqiu Yang, Manideep Pachva, Michael M Lizardo, Gurdeep Singh, ...> ;Science Advances. 2023 Aug 25
2 citations
germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma.
Michael P Randall, Laura E Egolf, Zalman Vaksman, Minu Samanta, Matthew Tsang, David Groff, J Perry Evans, Jo Lynne Rokita, Mehdi Layeghifard, Adam Shlien, John M Mari...> ;Biorxiv. 2023 Feb 3
1 citations
Germline pathogenic variants in 786 neuroblastoma patients.
Jung Kim, Zalman Vaksman, Laura E Egolf, Rebecca Kaufman, J Perry Evans, Karina L Conkrite, Arnavaz Danesh, Gonzalo Lopez, Michael P Randall, Maiah H Dent, Lance M Far...> ;Medrxiv. 2023 Jan 25
12 citations
Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma.
Kristopher R Bosse, Anna Maria Giudice, Maria V Lane, Brendan McIntyre, Patrick M Schürch, Guillem Pascual-Pasto, Samantha N Buongervino, Sriyaa Suresh, Alana Fitzsimm...> ;Cancer Discovery. 2022 Dec 2
2 citations
GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies.
Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Samantha N Buongervino, Amy K Erbe, Doncho V Zhelev, Shakhnozakhon Sadirova, Anna M Giudice, Daniel Martinez, La...> ;Journal for Immunotherapy of Cancer. 2022 Dec 1
12 citations
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors.
Jessica B Foster, Crystal Griffin, Jo Lynne Rokita, Allison Stern, Cameron Brimley, Komal Rathi, Maria V Lane, Samantha N Buongervino, Tiffany Smith, Peter J Madsen, D...> ;Journal for Immunotherapy of Cancer. 2022 Sep 1
18 citations
Epigenetic state determines inflammatory sensing in neuroblastoma.
Adam J Wolpaw, Liron D Grossmann, Jessica L Dessau, May M Dong, Bailey J Aaron, Patricia A Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Feb 8
57 citations
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
Sabine Heitzeneder, Kristopher R Bosse, Zhongyu Zhu, Doncho Zhelev, Robbie G Majzner, Molly T Radosevich, Shaurya Dhingra, Elena Sotillo, Samantha Buongervino, Guillem...> ;Cancer Cell. 2022 Jan 10
73 citations
Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Mark Yarmarkovich, Quinlen F. Marshall, John M. Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno Di Marco, Erin Runbeck, Hau Truong, Jugmohit S...> ;Nature. 2021 Nov 3
8 citations
Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
Samantha Buongervino, Maria Lane, Emily Garrigan, Doncho V. Zhelev, Dimiter S. Dimitrov, Kristopher R. Bosse> ;Molecular Cancer Therapeutics. 2021 Aug 31
12 citations
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
Swetha Raman, Samantha Buongervino, Maria Lane, Doncho V. Zhelev, Zhongyu Zhu, Hong Cui, Benjamin Martinez, Daniel Martinez, Yanping Wang, Kristen A. Upton, Khushbu Pa...> ;Cell Reports. Medicine. 2021 Jul 20
Correction to: Genetic susceptibility to neuroblastoma: current knowledge and future directions.
Laura E. Ritenour, Michael P Randall, Kristopher R. Bosse, Sharon J. Diskin> ;Cell and Tissue Research. 2021 Feb 1
21 citations
LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase.
Dongdong Chen, Julie Cox, Jayabhargav Annam, Melanie Weingart, Grace Essien, Komal S. Rathi, Jo Lynne Rokita, Priya Khurana, Selma M. Cuya, Kristopher R. Bosse, Adeiye...> ;Neoplasia. 2020 Jun 1
240 citations
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Lim, K., Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, ...> ;Cell. 2020 Apr 16
6 citations
Immune-Based Approaches for the Treatment of Pediatric Malignancies.
Kristopher R. Bosse, Robbie G. Majzner, Crystal L. Mackall, John M. Maris> ;Annual Review of Cancer Biology. 2020 Mar 9
10 citations
CAMKV Is a Candidate Immunotherapeutic Target in MYCN Amplified Neuroblastoma
Robyn T. Sussman, Jo Lynne Rokita, Kevin Huang, Pichai Raman, Komal S. Rathi, Daniel Martinez, Kristopher R. Bosse, Maria Lane, Lori S. Hart, Tricia R. Bhatti, Bruce R...> ;Frontiers in Oncology. 2020 Mar 6
39 citations
Genetic susceptibility to neuroblastoma: current knowledge and future directions.
Laura E. Ritenour, Michael Randall, Kristopher R. Bosse, Sharon J. Diskin> ;Cell and Tissue Research. 2018 Mar 27
121 citations
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.
Kristopher R. Bosse, Pichai Raman, Zhongyu Zhu, Maria Lane, Daniel Martinez, Sabine Heitzeneder, Komal S. Rathi, Nathan M. Kendsersky, Michael Randall, Laura K. Donova...> ;Cancer Cell. 2017 Sep 11
22 citations
Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes
Yang Feng, Yanping Wang, Zhongyu Zhu, Wei Li, Robyn T. Sussman, Michael Randall, Kristopher R. Bosse, John M. Maris, Dimiter S. Dimitrov> ;Mabs. 2016 Feb 24
149 citations
Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations.
Kristopher R. Bosse, John M. Maris> ;Cancer. 2016 Jan 1
8 citations
Improving Patient Outcomes With Cancer Genomics: Unique Opportunities and Challenges in Pediatric Oncology
Robert W. Schnepp, Kristopher R. Bosse, John M. Maris> ;JAMA. 2015 Sep 1
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Press Mentions

Children’s Hospital of Philadelphia Licenses a CAR-T Therapy to Biotech Venture TmunityOctober 2nd, 2019
Tmunity Announces Exclusive License and Research Collaboration with Children’s Hospital of Philadelphia to Advance GPC2 CAR-T Cell Therapy for NeuroblastomaOctober 1st, 2019
Cell Surface Protein May Offer Big Target in Treating High-Risk Childhood CancersSeptember 7th, 2017
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