LarsMWagnerMD

Pediatric Hematology & Oncology • Durham, NC

Pediatric Hematologic Oncology, Pediatric Sarcoma Oncology, Pediatric Solid Tumor Oncology

Chief, Division of Pediatric Hematology/Oncology, Duke University

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Office
330 Trent Drive
Durham, NC 27710
Phone+1 919-681-1634
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Education & Training

University of TennesseeFellowship, Pediatric Hematology/Oncology, 1998 - 2001
University of TennesseeResidency, Pediatrics, 1991 - 1994
University of Kentucky College of MedicineClass of 1991

Certifications & Licensure

NC State Medical License 2018 - 2024
KY State Medical License 1996 - 2019
OH State Medical License 2003 - 2013
UT State Medical License 2001 - 2004
TN State Medical License 1993 - 2001
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

N2003-01: Irinotecan, Temozolomide, and Cefixime in Treating Young Patients With Recurrent or Resistant Neuroblastoma Start of enrollment: 2004 May 01
Completed
Phase 1
Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors Start of enrollment: 2005 Oct 01
Completed
Phase 1
Combination Chemotherapy and Radiation Therapy in Treating Younger Patients Who Are Undergoing an Autologous Stem Cell Transplant for Newly Diagnosed Gliomas Start of enrollment: 2005 Aug 01
Completed
Not Applicable
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
A Pilot Study of the Addition of Bevacizumab to VOIT Regimen for Relapsed/Refractory Pediatric Solid Tumors Start of enrollment: 2008 Oct 01
Completed
Phase 1
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Brentuximab Vedotin and Gemcitabine Hydrochloride in Treating Younger Patients With Relapsed or Refractory Hodgkin Lymphoma Start of enrollment: 2013 Jan 31
Completed
Phase 1, Phase 2
Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas Start of enrollment: 2013 Jun 17
Active, not recruiting
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Completed
Phase 2
Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma Start of enrollment: 2014 Aug 01
Completed
Phase 2
Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Start of enrollment: 2014 Oct 04
Active, not recruiting
Phase 3
Use of Propranolol to Reduce FDG Uptake in Brown Adipose Tissue in Pediatric Cancer Patients PET Scans Start of enrollment: 2014 Jul 01
Completed
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Start of enrollment: 2014 Jul 11
Active, not recruiting
Phase 2, Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma Start of enrollment: 2016 Oct 25
Active, not recruiting
Phase 2
Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2019 Jul 08
Active, not recruiting
Phase 2
Evolutionary Therapy for Rhabdomyosarcoma Start of enrollment: 2020 Sep 27
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Comparison of oral aprepitant and intravenous fosaprepitant for prevention of chemotherapy-induced nausea and vomiting in pediatric oncology patients: a randomized pha...
Yu, L., Wang, Z., Han, Y., Zhou, F., Zhang, S., Li, Z., Gao, Y., Wagner, L.> ;Translational Pediatrics. 2024 Jan 29
5 citations
Thyroid Nodules on Ultrasound in Children and Young Adults: Comparison of Diagnostic Performance of Radiologists' Impressions, ACR TI-RADS, and a Deep Learning Algorithm.
Jichen Yang, Laura C Page, Lars Wagner, Benjamin Wildman-Tobriner, Logan Bisset, Donald Frush, Maciej A Mazurowski> ;AJR. American Journal of Roentgenology. 2023 Mar 1
9 citations
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues.
Lyndsay E A Young, Lindsey R Conroy, Harrison A Clarke, Tara R Hawkinson, Kayli E Bolton, William C Sanders, Josephine E Chang, Madison B Webb, Warren J Alilain, Craig...> ;EMBO Molecular Medicine. 2022 Nov 8
1 citations
Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry.
Allison L Bartlett, Adam Lane, Brooklyn Chaney, Nancy Yanez Escorza, Katie Black, Anne Cochrane, Jane Minturn, Ute Bartels, Kathy Warren, Jordan Hansford, David Ziegle...> ;Neuro-Oncology. 2022 Dec 1
7 citations
Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry.
Margot A Lazow, Christine E. Fuller, Mariko DeWire, Adam Lane, Pratiti Bandopadhayay, Ute Bartels, Eric Bouffet, Sylvia Cheng, Kenneth J. Cohen, Tabitha Cooney, Scott ...> ;Neuro-Oncology. 2021 Oct 20
Addressing Barriers to Fertility Preservation for Cancer Patients: The Role of Oncofertility Patient Navigation
Caroline S. Dorfman, Juliann M Stalls, Coleman Mills, Shannon Voelkel, Mallori Thompson, Kelly S. Acharya, Karen C. Baker, Lars M. Wagner, Nolan Miller, Amy Boswell, C...> ;Journal of Oncology Navigation & Survivorship. 2021 Oct 1
7 citations
Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors
Andrew J. Bellantoni, Lars M. Wagner> ;Cancers. 2021 Jul 14
10 citations
Receptor tyrosine kinase inhibitors for the treatment of osteosarcoma and Ewing sarcoma.
Marissa A. Just, David Van Mater, Lars M. Wagner> ;Pediatric Blood & Cancer. 2021 Apr 24
13 citations
Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.
Javier Oesterheld, Damon R. Reed, Bhuvana A. Setty, Michael S. Isakoff, Patrick A. Thompson, Hong Yin, Masanori Hayashi, David M. Loeb, Tiffany Smith, Rikesh J Makanji...> ;Pediatric Blood & Cancer. 2020 Jul 1
25 citations
An evolutionary framework for treating pediatric sarcomas
Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, Masanori Hayashi, Michael S. Isakoff, David M. Loeb, Rikesh J Makanji, Ryan D. Roberts, Matteo Truc...> ;Cancer. 2020 Jun 1
1 citations
Imaging of childhood urologic cancers: current approaches and new advances.
Joseph T. Davis, Lars M. Wagner> ;Translational Andrology and Urology. 2020 May 15
Case 4: Gynecomastia in a 15-year-old Boy
Claci A. Walls, John M. Draus, Lars M. Wagner> ;Pediatrics in Review. 2020 Apr 1
1 citations
Sarcoma as the Prototype Disease for Adolescent and Young Adult Programs.
Lars M. Wagner> ;Journal of Oncology Practice. 2019 May 10
51 citations
Management of recurrent Ewing sarcoma: challenges and approaches.
David Van Mater, Lars M. Wagner> ;Oncotargets and Therapy. 2019 Mar 27
48 citations
Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma
Steven G. DuBois, Yael P. Mosse, Elizabeth Fox, Rachel A. Kudgus, Joel M. Reid, Renee M. McGovern, S. Groshen, Rochelle Bagatell, John M. Maris, Clare J. Twist, Kelly ...> ;Clinical Cancer Research. 2018 Dec 15
8 citations
Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry.
Craig Erker, Adam Lane, Brooklyn Chaney, Nancy Yanez Escorza, Christine Fuller, Raya Saab, Mark W. Kieran, Roger J. Packer, Javad Nazarian, Jane E. Minturn, Andrew Dod...> ;Neuro-Oncology. 2018 Jun 22
97 citations
Immunotherapy for osteosarcoma: Where do we go from here?
Mary Frances Wedekind, Lars M. Wagner, Timothy P. Cripe> ;Pediatric Blood & Cancer. 2018 Jun 19
10 citations
Targeted therapy for infants with diencephalic syndrome: A case report and review of management strategies
Lars M. Wagner, John S. Myseros, Douglas E. Lukins, Christi M. Willen, Roger J. Packer> ;Pediatric Blood & Cancer. 2018 May 1
29 citations
National cancer database analysis of outcomes in pediatric glioblastoma
Meng Liu, Jigisha P. Thakkar, Catherine R. Garcia, Therese A. Dolecek, Lars M. Wagner, Emily V. Dressler, John L. Villano> ;Cancer Medicine. 2018 Mar 13
56 citations
Consensus and controversies regarding the treatment of rhabdomyosarcoma.
Scott C. Borinstein, Diana Steppan, Masanori Hayashi, David M. Loeb, Michael S. Isakoff, Odion Binitie, Andrew S. Brohl, Julia A. Bridge, Mark J. Stavas, Eric T. Shino...> ;Pediatric Blood & Cancer. 2018 Feb 1
48 citations
SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors
Christine Higham, Seth M. Steinberg, Eva Dombi, Arie Perry, Lee J. Helman, Scott M. Schuetze, Joseph A. Ludwig, Arthur P. Staddon, Mohammed M. Milhem, Daniel A. Rushin...> ;Sarcoma. 2017 Sep 12
26 citations
Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapy
Talal Hilal, Mary Nakazawa, Jacob Hodskins, John L. Villano, Aju Mathew, Gaurav Goel, Lars M. Wagner, Susanne M. Arnold, Philip A. DeSimone, Lowell Anthony, Peter J. H...> ;BMC Cancer. 2017 Aug 30
9 citations
Pilot study of propranolol premedication to reduce FDG uptake in brown adipose tissue on PET scans of adolescent and young adult oncology patients.
Anil P. George, Partha Sinha, Gary R. Conrad, Aum A Memon, Emily V. Dressler, Lars M. Wagner> ;Pediatric Hematology and Oncology. 2017 Jul 20
98 citations
Treatment Pathway of Bone Sarcoma in Children, Adolescents, and Young Adults
Damon R. Reed, Masanori Hayashi, Lars M. Wagner, Odion Binitie, Diana Steppan, Andrew S. Brohl, Eric T. Shinohara, Julia A. Bridge, David M. Loeb, Scott C. Borinstein,...> ;Cancer. 2017 Jun 15
39 citations
Targeting the PD-1 pathway in pediatric solid tumors and brain tumors.
Lars M. Wagner, Val R. Adams> ;Oncotargets and Therapy. 2017 Apr 12
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Hospital Affiliations

UK HealthCare Good Samaritan HospitalLexington, Kentucky
Duke Childrens Hospital And Health CenterDurham, North Carolina