LeeRatnerMD

PubMed

• Phase I Trial of the Multi-kinase Inhibitor Cabozantinib, a CYP3A4 Substrate, plus CYP3A4-Interacting Antiretroviral Therapy in People Living with HIV and Cancer (AMC-...
  Missak Haigentz, Jeannette Y Lee, Elizabeth Y Chiao, Ronald T Mitsuyasu, Michelle A Rudek, Aboulafia, D., Ratner, L., Ambinder, R., Baiocchi, R., Wachsman, W., Sparano...> ;Clinical Cancer Research. 2023 Dec 15
• 20 citations
  Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma.
  Thomas, N., Dreval, K., Gerhard, D., Hilton, L., Abramson, J., Ambinder, R., Barta, S., Bartlett, N., Bethony, J., Bhatia, K., Bowen, J., Bryan, A., Cesarman, E., Casp...> ;Blood. 2023 Feb 23
• 22 citations
  Defactinib, Pembrolizumab, and Gemcitabine in Patients with Advanced Treatment Refractory Pancreatic Cancer: A Phase I Dose Escalation and Expansion Study.
  Andrea Wang-Gillam, Kian-Huat Lim, Robert McWilliams, Rama Suresh, Albert C Lockhart, Amberly Brown, Marcus Breden, Jad I Belle, John Herndon, Savannah J Bogner, Katri...> ;Clinical Cancer Research. 2022 Dec 15
• Adult T-Cell Leukemia-Lymphoma Presenting Concurrently with Myelopathy.
  Ancy Joseph, John C Harding, Hemalatha Sundaramoorthi, Neha Mehta-Shah, Patrick Green, Anjum Hassan, Daniel A Rauch, Lee Ratner, Sneha Poondru> ;Case Reports in Oncology. 2022 Nov 8
• Safety and Tolerability of Carboplatin and Paclitaxel in Cancer Patients with HIV (AMC-078), an AIDS Malignancy Consortium (AMC) Study.
  Missak Haigentz, Page Moore, Milan Bimali, Joseph Sparano, Michelle Rudek, Lee Ratner, David Henry, Juan Ramos, John Deeken, Paul Rubinstein, Elizabeth Chiao, Timothy ...> ;The Oncologist. 2022 Aug 5
• 1 citations
  Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy.
  Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C Martin, Bruce A Rosa, Makedonka Mitreva, Lee Ratner> ;Microbiology Spectrum. 2022 Aug 31
• 12 citations
  Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19.
  Jingyu Xiang, Mijia Lu, Min Shi, Xiaogang Cheng, Kristin A Kwakwa, Jennifer L Davis, Xinming Su, Suzanne J Bakewell, Yuexiu Zhang, Francesca Fontana, Yalin Xu, Deborah...> ;Journal of Virology. 2022 Apr 13
• 4 citations
  Phase 1b trial of anti-VEGF/PDGFR vorolanib combined with immune checkpoint inhibitors in patients with advanced solid tumors.
  Nusayba A Bagegni, Haeseong Park, Katlyn Kraft, Maura O-Toole, Feng Gao, Saiama N Waqar, Lee Ratner, Daniel Morgensztern, Siddhartha Devarakonda, Manik Amin, Maria Q B...> ;Cancer Chemotherapy and Pharmacology. 2022 Apr 1
• 6 citations
  The Past, Present, and Future of a Human T-Cell Leukemia Virus Type 1 Vaccine.
  Joshua J Tu, Victoria Maksimova, Lee Ratner, Amanda R Panfil> ;Frontiers in Microbiology. 2022 Jan 1
• 4 citations
  A role for an HTLV-1 vaccine?
  Lee Ratner> ;Frontiers in Immunology. 2022 Jan 1
• 3 citations
  Epigenetic Regulation of Human T-Cell Leukemia Virus Gene Expression.
  Lee Ratner> ;Microorganisms. 2021 Dec 31
• 7 citations
  Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma
  Daniel Rauch, John C. S. Harding, Lee Ratner, Samuel A. Wickline, Hua Pan> ;Nanomaterials. 2021 Jun 16
• 6 citations
  Germinal epimutation of Fragile Histidine Triad (FHIT) gene is associated with progression to acute and chronic adult T-cell leukemia diseases.
  Marcia Bellon, Izabela Bialuk, Veronica Galli, Xue Tao Bai, Lourdes Farre, Achiléa L. Bittencourt, Ambroise Marçais, Michael N. Petrus, Lee Ratner, Thomas A. Waldmann,...> ;Molecular Cancer. 2021 Jun 6
• 8 citations
  Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF.
  Xiaogang Cheng, Ancy Joseph, Victor Castro, Alice Chen-Liaw, Zachary L. Skidmore, Takaharu Ueno, Jun-ichi Fujisawa, Daniel Rauch, Grant A. Challen, Michael P. Martinez...> ;Plos Pathogens. 2021 May 21
• 28 citations
  Impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH and outcomes with vorinostat (AMC-075 trial)
  Juan Carlos Ramos, Joseph A. Sparano, Amy Chadburn, Erin Reid, Richard F. Ambinder, Eric R. Siegel, Page C. Moore, Paul G. Rubinstein, Christine M. Durand, Ethel Cesar...> ;Blood. 2020 Sep 10
• 8 citations
  Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma.
  Daniel Rauch, Sydney L. Olson, John C. S. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant A. Challen, Lee Ratner> ;Retrovirology. 2020 Aug 28
• 1 citations
  Predicting the future: adult T-cell leukemia.
  Lee Ratner> ;Blood. 2020 Jun 4
• 12 citations
  Molecular biology of human T cell leukemia virus.
  Lee Ratner> ;Seminars in Diagnostic Pathology. 2020 Mar 1
• 8 citations
  Response-adapted therapy with infusional EPOCH chemotherapy plus rituximab in HIV-associated, B-cell non-Hodgkin's lymphoma.
  Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David M. Aboulafia, Ariela Noy, David H. Henry, Lee ...> ;Haematologica. 2020 Feb 27
• 18 citations
  HTLV-1 CTCF-binding site is dispensable for in vitro immortalization and persistent infection in vivo.
  Michael P. Martinez, Xiaogang Cheng, Ancy Joseph, Jacob Al-Saleem, Amanda R. Panfil, Marilly Palettas, Wessel P. Dirksen, Lee Ratner, Patrick L. Green> ;Retrovirology. 2019 Dec 21
• 12 citations
  The Dual-Specificity Kinase DYRK1A Modulates the Levels of Cyclin L2 To Control HIV Replication in Macrophages.
  Javan K. Kisaka, Lee Ratner, George B. Kyei> ;Journal of Virology. 2020 Feb 28
• 73 citations
  Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade
  Daniel Rauch, Kevin C. Conlon, Murali Janakiram, Jonathan E. Brammer, John C. S. Harding, B. Hilda Ye, Xingxing Zang, Xiaoxin Ren, Sydney L. Olson, Xiaogang Cheng, Mil...> ;Blood. 2019 Oct 24
• 10 citations
  HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia
  Jingyu Xiang, Daniel Rauch, Devra Huey, Amanda R. Panfil, Xiaogang Cheng, Alison K. Esser, Xinming Su, John C. S. Harding, Yalin Xu, Gregory C. Fox, Francesca Fontana,...> ;JCI Insight. 2019 Oct 3
• 2 citations
  Biomarkers and Preclinical Models for Adult T-Cell Leukemia-Lymphoma Treatment
  Lee Ratner> ;Frontiers in Microbiology. 2019 Sep 18
• 4 citations
  The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instabil...
  Aditi Malu, Tetiana Hutchison, Lacin Yapindi, Katie Smith, Katherine Nelson, Rachel Bergeson, Jordan Pope, Megan Romeo, Carolyn K. Harrod, Lee Ratner, Carine Van Lint,...> ;Virology. 2019 Jul 3
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Journal Articles

• V1 and V2 Domains of HIV Envelope Contribute to CCR5 Antagonist Resistance  
  Lee Ratner, MD, mBio
• Outcome of patients with relapsed/refractory AIDS-related lymphoma diagnosed 1999-2008 in the AIDS Malignancy Consortium  
  Bayraktar UD, Peetrich A, Gupta N, Lensing S, Moore P, Reid EG, Aboulafia DM, Ratner L, Mitsuyasu R, Stier E, Henry DH, Barr P, Noy A, Leukemia & Lymphoma, 1/1/2013
• Cytolytic nanoparticles attenuate HIV-1 infectivity  
  Hood JL, Jallouk AP, Campbell N, Ratner L, Wickline SA, Antiviral Therapy, 1/1/2013
• Treatment factors affecting outcomes in HIV associated non-Hodgkin’s lymphomas: a pooled analysis of 1546 patients  
  Barta SK, Xue X, Wang D, Tamari R, Lee JY, Mounier N, Kaplan LD, Ribera J-M, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Wilson W, Wyen C, Oriol A, Navarro J-T, D..., Blood, 1/1/2013
• IFN-alpha restricts HTLV-1 and HTLV-2 infection through PKR activation  
  Cachat A, Chevalier S, Alais S, Ko NL, Ratner L, Journo C, Dutarre H, Mahieux R, J Virology, 1/1/2013
• The SMAC mimetic RMT52652HCL induces apoptosis in EBV AND HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C a...  
  Ramachandiran S, Cain J, Liao A, He Y, Guo, X, Boise L, Fu H, Ratner L, Khoury HJ, and Bernal-Mizrachi L, Leukemia Research, 1/1/2012
• Vpx is critical for SIVmne infection of pigtail macaques  
  Belshan M, Kimata J, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L, Retrovirology, 1/1/2012
• HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection  
  McCulley A, Ratner L, Virology, 1/1/2012
• Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis  
  Zane L, Yasunaga J, Mitagami Y, Matsuoka M, Yedavalli V, Tan S-W, Ratner L, Liu X, and Jeang KT, Retrovirology, 1/1/2012
• Liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone (DR-COP) in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047  
  Levine AM, Noy A, Lee J, Cesarman E, Ramos JC, Henry D, Sparano J, Reid E, Mitsuyasu R, Dezube B, Ratner L, Tulpule A, Journal of Clinical Oncology, 1/1/2012
• The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30II mRNA  
  Choudhary G, Ratner L, Virology, 1/1/2011
• Adjustable post-formulation drug loading of nanostructures for metered control of NF-kB signaling  
  Pan H, Ivashyna O, Sinha B, Lanza GM, Ratner L, Schlesinger PH, Wickline SA, Biomaterials, 1/1/2011
• Integrase inhibitors effective againt human T-cell leukemia virus type 1  
  Seegulam, ME, Ratner L, Antimicrobial Agents and Chemotherapy, 1/1/2011
• Targeting HTLV-1 activation of NFkB in mouse models and ATLL patients  
  Rauch DA, Ratner L, Viruses, 1/1/2011
• Molecular determinants of human T-lymphotropic virus type 1 transmission and spread  
  Lairmore MD, Anupam R, Bowden N, Haines R, Haynes RA, Ratner L, Green PL, Viruses, 1/1/2011
• HIV-1 determinants of thrombocytopenia at the stage of CD34+ progenitor cell differentiation in vivo lie in the viral envelop gp120 V3 loop region  
  Zhang M, Evans S, Yuan J, Ratner L, and Koka PS, Virology, 1/1/2010
• Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step  
  Harmon B, Campbell N, Ratner L, PLoS Pathogens, 1/1/2010
• Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective without excessive toxicity in HIV-associated, B-cell non-Hodgkin's lymphoma  
  Sparano JA, Lee J, Kaplan LD, Levine A, Harrington W, Ambinder R, Wachsman W, Aboulafia D, Noy A, Henry D, Von Roenn J, Dezube B, Remick S, Shah M, Leichman L, Ratner ..., Blood, 1/1/2010
• The Arf tumor suppressor regulates bone remodeling and osteosarcoma development  
  Rauch DA, Hurchla MA, Harding JC, Deng H, Shea L, Eagleton MC, Niewiesk S, Lairmore M, Piwnica-Worms D, Rosol T, Weber JD, Ratner L, Weilbaecher K, PLOS One, 1/1/2010
• Bioluminescence imaging of myeloperoxidase activity in vivo  
  Gross S, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D, Nature Medicine, 1/1/2009
• Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors  
  Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L, Blood, 1/1/2009
• Mutation of critical serine residues in HIV-1 matrix result in an envelope incorporation defect which can be rescued by truncation of the gp41 cytoplasmic tail  
  Bhatia A, Kaushik R, Pontow S, Vander Heyden N, Ratner L, Virology, 1/1/2009
• Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma  
  Ratner L, Harrington W, Feng X, Grant C, Jacobson S, Noy A, Sparano J, Lee J, Ambinder R, Campbell N, Lairmore M, for the AIDS Malignancy Consortium, PLOS One, 1/1/2009
• A novel role for IL2R-Jak signaling in retrovirus virion maturation and infectivity  
  Taylor JM, Brown M, Nejmeddine M, Kim KJ, Ratner L, Lairmore M, Bangham C, Nicot C, J Virology, 1/1/2009
• T-cell activation promotes tumorigenesis in inflammation associated cancer  
  Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L, Retrovirology, 1/1/2009
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Abstracts/Posters

• Response-Adapted Therapy with Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma
  Lee Ratner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Safety and Efficacy of Brentuximab Vedotin in Combination with AVD in Stage II-IV HIV-Associated Classical Hodgkin Lymphoma: Results of the Phase 2 Study, AMC 085
  Lee Ratner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• A Randomized Trial of EPOCH-Based Chemotherapy with Vorinostat for Highly Aggressive HIV-Associated Lymphomas: Updated Results Evaluating Impact of Diagnosis-to-Treatm...
  Lee Ratner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019