LeoCharlesGinnsMD

Pulmonology • Boston, MA

Pleural Disease

Associate Professor of Medicine, Massachusetts General Hospital

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Office
55 Fruit St
White 905
Boston, MA 02114
Phone+1 617-726-1718

Fax+1 617-724-1792
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Education & Training

Massachusetts General HospitalResidency, Internal Medicine, 1977 - 1979
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1972 - 1975
University of Vermont College of MedicineClass of 1972

Certifications & Licensure

MA State Medical License 1975 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Clinical Trials

STX-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF) Start of enrollment: 2012 Jul 16
Completed
Phase 2
Study to Assess the Efficacy and Safety of Simtuzumab (GS-6624) in Adults With Idiopathic Pulmonary Fibrosis (IPF) Start of enrollment: 2013 Jan 31
Terminated
Phase 2

Publications & Presentations

PubMed

Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction.
George A Alba, Iris Y Zhou, Molly Mascia, Michael Magaletta, Francesca L Giacona, Peter Caravan, Jehan W Alladina, Leo C Ginns, Bradley A Maron, Sydney B Montesi> ;Pulmonary Circulation. 2024 Jan 1
2 citations
Dynamic Contrast-enhanced MRI Demonstrates Pulmonary Microvascular Abnormalities Months After SARS-CoV-2 Infection.
Iris Y Zhou, Molly Mascia, George A Alba, Michael Magaletta, Leo C Ginns, Peter Caravan, Sydney B Montesi> ;American Journal of Respiratory and Critical Care Medicine. 2023 Jun 15
25 citations
Exercise performance in patients with post-acute sequelae of SARS-CoV-2 infection compared to patients with unexplained dyspnea.
George A. Alba, David R. Ziehr, Jennifer N. Rouvina, Lida P. Hariri, Rachel S. Knipe, Benjamin D. Medoff, Kathryn A. Hibbert, Alyssa Kowal, Casey Hoenstine, Leo C. Gin...> ;Eclinicalmedicine. 2021 Aug 28
85 citations
Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020).
Chunxue Bai, Sanjay H. Chotirmall, Jordi Rello, George A. Alba, Leo C. Ginns, Jerry A. Krishnan, Robert S. Rogers, Elisabeth Bendstrup, Pierre-Régis Burgel, James D. C...> ;European Respiratory Review. 2020 Sep 30
67 citations
Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy
Bernt van den Blink, Marlous R. Dillingh, Leo C. Ginns, Lake Morrison, Matthijs Moerland, Marlies S. Wijsenbeek, Elizabeth G. Trehu, Brian J. Bartholmai, Jacobus Burgg...> ;The European Respiratory Journal. 2016 Mar 1
3 citations
Case 20-2014: A 65-year-old man with dyspnea and progressively worsening lung disease
Kathleen M. Finn, Leo C. Ginns, Gregory K. Robbins, Carol C. Wu, John A. Branda> ;The New England Journal of Medicine. 2014 Jun 25
50 citations
Outcome of influenza infection managed with oseltamivir in lung transplant recipients.
Michael G. Ison, Amita Sharma, Jo-Anne O. Shepard, John C. Wain, Leo C. Ginns> ;The Journal of Heart and Lung Transplantation. 2008 Mar 1
25 citations
Cutaneous Aspergillus Ustus in a Lung Transplant Recipient : Emergence of a New Opportunistic Fungal Pathogen
Parsia A. Vagefi, A. Benedict Cosimi, Leo C. Ginns, Camille N. Kotton> ;The Journal of Heart and Lung Transplantation. 2008 Jan 1
18 citations
Medical and Psychologic Outcome of Living Lobar Lung Transplant Donors
Laura M. Prager, John C. Wain, David H. Roberts, Leo C. Ginns> ;The Journal of Heart and Lung Transplantation. 2006 Oct 1
45 citations
CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function.
Benjamin D. Medoff, John C. Wain, Edward Seung, Ryan Jackobek, Terry K. Means, Leo C. Ginns, Joshua M. Farber, Andrew D. Luster> ;Journal of Immunology. 2006 Jun 1
17 citations
Pathogenic T-Cell Recruitment into the Airway in Human Disease
Benjamin D. Medoff, Seddon Y. Thomas, Aleena Banerji, John C. Wain, Hui Zhang, Craig M. Lilly, Leo C. Ginns, Andrew D. Luster> ;Annals of the New York Academy of Sciences. 2005 Dec 1
56 citations
BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
Benjamin D. Medoff, Edward Seung, John C. Wain, Terry K. Means, Gabriele S. V. Campanella, Sabina A. Islam, Seddon Y. Thomas, Leo C. Ginns, Nir Grabie, Andrew H. Licht...> ;The Journal of Experimental Medicine. 2005 Jul 4
Concordance of genotypes in pre- and post-lung transplantation DNA samples.
Dawn L. DeMeo, John J. Reilly, Leo C. Ginns, Jody S. Sylvia, Edwin K. Silverman> ;American Journal of Respiratory Cell and Molecular Biology. 2005 Jun 30
46 citations
Donor-recipient gender mismatch in lung transplantation: impact on obliterative bronchiolitis and survival.
David H. Roberts, John C. Wain, Yuchiao Chang, Leo C. Ginns> ;The Journal of Heart and Lung Transplantation. 2004 Nov 1
58 citations
Predictors of Survival in Severe, Early Onset COPD
Craig P. Hersh, Dawn L. DeMeo, Essain Al-Ansari, Vincent J. Carey, John J. Reilly, Leo C. Ginns, Edwin K. Silverman> ;Chest. 2004 Nov 1
48 citations
Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD.
Dawn L. DeMeo, Vincent J. Carey, Harold A. Chapman, John J. Reilly, Leo C. Ginns, Frank E. Speizer, Scott T. Weiss, Edwin K. Silverman> ;Thorax. 2004 May 1
47 citations
Pulmonary Capillary Hemangiomatosis With Atypical Endotheliomatosis: Successful Antiangiogenic Therapy With Doxycycline
Leo C. Ginns, David H. Roberts, Eugene J. Mark, John L. Brusch, Jennifer J. Marler> ;Chest. 2003 Nov 1
26 citations
Left Ventricular Diastolic Function in Patients With Advanced Cystic Fibrosis
Todd M. Koelling, G. William Dec, Leo C. Ginns, Marc J. Semigran> ;Chest. 2003 May 1
118 citations
Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension.
John J. Lepore, Anjli Maroo, Naveen L. Pereira, Leo C. Ginns, G. William Dec, Warren M. Zapol, Kenneth D. Bloch, Marc J. Semigran> ;The American Journal of Cardiology. 2002 Sep 15
51 citations
An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation.
Kelan G. Tantisira, David M. Systrom, Leo C. Ginns> ;American Journal of Respiratory and Critical Care Medicine. 2002 Jun 15
132 citations
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease.
Edwin K. Silverman, Lyle J. Palmer, Jonathan D. Mosley, Matthew J. Barth, Jody M. Senter, Alison Brown, Jeffrey M. Drazen, David J. Kwiatkowski, Harold A. Chapman, Edw...> ;American Journal of Human Genetics. 2002 May 1
86 citations
Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes
Edwin K. Silverman, Jonathan D. Mosley, Lyle J. Palmer, Matthew J. Barth, Jody M. Senter, Alison Brown, Jeffrey M. Drazen, David J. Kwiatkowski, Harold A. Chapman, Edw...> ;Human Molecular Genetics. 2002 Mar 15
32 citations
Association of lung perfusion disparity and mortality in patients with cystic fibrosis awaiting lung transplantation.
Michael L Stanchina, Kelan G. Tantisira, Suzanne L. Aquino, John C. Wain, Leo C. Ginns> ;The Journal of Heart and Lung Transplantation. 2002 Feb 1
24 citations
Clinical status of lung transplantation.
Dawn L. DeMeo, Leo C. Ginns> ;Transplantation. 2001 Dec 15
79 citations
Oxygen Therapy Improves Cardiac Index and Pulmonary Vascular Resistance in Patients With Pulmonary Hypertension
David H. Roberts, John J. Lepore, Anjli Maroo, Marc J. Semigran, Leo C. Ginns> ;Chest. 2001 Nov 1
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