R. ScottHarrisMD

Pulmonology • Boston, MA

Critical Care Medicine, Pleural Disease

Associate Professor, Medicine-Massachusetts General Hospital, Harvard Medical School

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Office
55 Fruit St
Cox 2
Boston, MA 02114
Phone+1 617-726-1721

Fax+1 617-726-6878
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Education & Training

Massachusetts General Hospital/BIDMC/Harvard Medical SchoolFellowship, Pulmonary Disease and Critical Care Medicine, 1995 - 2000
Tufts Medical CenterResidency, Internal Medicine, 1991 - 1994
University of Massachusetts Medical SchoolClass of 1991

Certifications & Licensure

MA State Medical License 1993 - 2024
FL State Medical License 2014 - 2019

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

Evaluation of Pulmonary Perfusion Heterogeneity and Compliance in Patients With Pulmonary Hypertension Using Positron Emission Tomography Imaging Start of enrollment: 2013 Feb 01
Completed
Not Applicable
Imaging Study of the Lungs During an Allergic Asthma Attack Start of enrollment: 2012 May 01
Completed
Not Applicable
T Cell Effector and Regulatory Mechanisms in Asthma Start of enrollment: 2012 Sep 01
Completed
Phase 1
EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures Start of enrollment: 2012 Oct 31
Completed
Not Applicable
Impact of PAV Versus NAVA on Patient-Ventilator Synchrony and Respiratory Muscle Unloading Start of enrollment: 2010 Apr 01
Withdrawn
Not Applicable
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Publications & Presentations

PubMed

1 citations
Perfusion imaging heterogeneity during NO inhalation distinguishes pulmonary arterial hypertension (PAH) from healthy subjects and has potential as an imaging biomarker.
Tilo Winkler, Puja Kohli, Vanessa J Kelly, Ekaterina G Kehl, Alison S Witkin, Josanna M Rodriguez-Lopez, Kathryn A Hibbert, Mamary T Kone, David M Systrom, Aaron B Wax...> ;Respiratory Research. 2022 Dec 1
2 citations
Smoking and Human Immunodeficiency Virus 1 Infection Promote Retention of CD8+ T Cells in the Airway Mucosa.
Björn Corleis, Josalyn L. Cho, Samantha J Gates, Alice H Linder, Amy Dickey, Antonella C Lisanti-Park, Abigail E Schiff, Musie Ghebremichael, Puja Kohli, Tilo Winkler,...> ;American Journal of Respiratory Cell and Molecular Biology. 2021 Nov 1
3 citations
PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking
Puja Kohli, Vanessa J. Kelly, Kathryn A. Hibbert, Björn Corleis, Mamary Kone, Josalyn L. Cho, Doreen DeFaria-Yeh, Douglas S. Kwon, Benjamin D. Medoff, R. Scott Harris,...> ;Journal of Nuclear Medicine. 2021 Mar 1
8 citations
Plasma Soluble Suppression of Tumorigenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure.
Jehan Alladina, Sean D. Levy, Josalyn L. Cho, Kelsey Brait, Sowmya R. Rao, Alexander Camacho, Kathryn A. Hibbert, R. Scott Harris, Benjamin D. Medoff, James L. Januzzi...> ;American Journal of Respiratory and Critical Care Medicine. 2021 May 20
13 citations
A phase 3, double-blind, parallel-group study to evaluate the efficacy and safety of tezacaftor in combination with ivacaftor in participants 6 through 11 years of age...
Jane C. Davies, Isabelle Sermet-Gaudelus, Lutz Naehrlich, R. Scott Harris, Daniel Campbell, Neil Ahluwalia, Christopher Short, Eric L. Haseltine, Paul Panorchan, Clare...> ;Journal of Cystic Fibrosis. 2021 Jan 1
1 citations
Endogenous Carbon Monoxide Production and Diffusing Capacity of the Lung for Carbon Monoxide in Sepsis-Induced Acute Respiratory Distress Syndrome.
Yao-Wen Kuo, R. Scott Harris, Dean R. Hess, Paul B. Dieffenbach, Augustine M.K. Choi, Laura E. Fredenburgh, Tilo Winkler> ;Critical Care Explorations. 2020 Dec 2
4 citations
Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects.
Dexter P. Mendoza, Puja Kohli, John W. Nance, Ramandeep Singh, Josalyn L. Cho, Jason W. Griffith, R. Scott Harris, Vanessa J. Kelly, Andrew D. Luster, Benjamin D. Medo...> ;Annals of Translational Medicine. 2020 Jul 20
9 citations
Quantification of the Pulmonary Vascular Response to Inhaled Nitric Oxide Using Noncontrast Computed Tomography Imaging.
Farbod N. Rahaghi, Tilo Winkler, Puja Kohli, Pietro Nardelli, Berta Marti-Fuster, James C. Ross, Ramya Radhakrishnan, Tyler Blackwater, Samuel Y. Ash, Isaac de La Brue...> ;Circulation. Cardiovascular Imaging. 2019 Dec 1
38 citations
A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11 years with cystic fibrosis.
Seth Walker, Patrick A. Flume, John McNamara, Melinda Solomon, Mark A. Chilvers, James Chmiel, R. Scott Harris, Eric L. Haseltine, David Stiles, Chonghua Li, Neil Ahlu...> ;Journal of Cystic Fibrosis. 2019 Sep 1
7 citations
Perfusion Imaging Distinguishes Exercise Pulmonary Arterial Hypertension at Rest.
Puja Kohli, Vanessa J. Kelly, Ekaterina G Kehl, Josanna Rodriguez-Lopez, Kathryn A. Hibbert, Mamary Kone, David M. Systrom, Aaron B. Waxman, Jose G. Venegas, Richard N...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Jun 1
18 citations
Quantitative assessment of airway remodelling and response to allergen in asthma.
David C. Adams, Alyssa J. Miller, Matthew B. Applegate, Josalyn L. Cho, Daniel L. Hamilos, Alex Chee, Jasmin A. Holz, Margit V. Szabari, Lida P. Hariri, R. Scott Harri...> ;Respirology. 2019 Mar 7
4 citations
Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction.
Juan Sebastian Osorio-Valencia, Chanikarn Wongviriyawong, Tilo Winkler, Vanessa J. Kelly, R. S. Harris, Jose G. Venegas> ;Plos One. 2018 Dec 19
63 citations
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;JCI Insight. 2018 Dec 6
49 citations
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Gabriel Casulari Motta-Ribeiro, Soshi Hashimoto, Tilo Winkler, Rebecca M. Baron, K. S. Grogg, Luis Felipe Paula, Arnoldo Santos, Congli Zeng, Kathryn A. Hibbert, R. S....> ;American Journal of Respiratory and Critical Care Medicine. 2018 Oct 1
3 citations
The effect of emphysema on readmission and survival among smokers with heart failure
Puja Kohli, Pedro V. Staziaki, Sumbal Janjua, Daniel Addison, Travis R. Hallett, Orla Hennessy, Richard A.P. Takx, Michael T. Lu, Florian J. Fintelmann, Marc J. Semigr...> ;Plos One. 2018 Jul 30
1 citations
Reply to Dorrington et al. and to Swenson: “Hypercapnic Pulmonary Vasoconstriction Contributes to Regional Perfusion Distribution: Relevance to Asthma” and “Hypercapni...
Vanessa J. Kelly, Tilo Winkler, R. Scott Harris> ;American Journal of Respiratory and Critical Care Medicine. 2017 Oct 26
21 citations
Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma.
Vanessa J. Kelly, Kathryn A. Hibbert, Puja Kohli, Mamary Kone, Elliot Greenblatt, Jose G. Venegas, Tilo Winkler, R. Scott Harris> ;American Journal of Respiratory and Critical Care Medicine. 2017 Sep 29
20 citations
Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity.
Tyler J. Wellman, Nicolas de Prost, Mauro R. Tucci, Tilo Winkler, Rebecca M. Baron, Piotr T. Filipczak, Benjamin A. Raby, Jen-Hwa Chu, R. Scott Harris, Guido Musch, Lu...> ;Anesthesiology. 2016 Nov 1
67 citations
Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo
David C. Adams, Lida P. Hariri, Alyssa J. Miller, Yan Wang, Josalyn L. Cho, Martin Villiger, Jasmin A. Holz, Margit V. Szabari, Daniel L. Hamilos, R. Scott Harris, Jas...> ;Science Translational Medicine. 2016 Oct 5
37 citations
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation
Josalyn L. Cho, Morris Ling, David C. Adams, Lucas Faustino, Sabina A. Islam, Roshi Afshar, Jason W. Griffith, R. S. Harris, Aylwin Ng, Giorgia Radicioni, Amina A. For...> ;Science Translational Medicine. 2016 Oct 5
20 citations
Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With...
Jehan Alladina, Sean D. Levy, Kathryn A. Hibbert, James L. Januzzi, R. Scott Harris, Michael A. Matthay, B. Taylor Thompson, Ednan K. Bajwa> ;Critical Care Medicine. 2016 Sep 1
1 citations
CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 17-2016. A 60-Year-Old Woman with Increasing Dyspnea.
Sydney B. Montesi, John W. Nance, R. Scott Harris, Eugene J. Mark> ;The New England Journal of Medicine. 2014 Mar 20
35 citations
High-flow oxygen therapy and other inhaled therapies in intensive care units
Sean D. Levy, Jehan Alladina, Kathryn A. Hibbert, R. Scott Harris, Ednan K. Bajwa, Dean R. Hess> ;Lancet. 2016 Apr 30
4 citations
A method for mapping regional oxygen and CO2 transfer in the lung.
Troels Johansen, Tilo Winkler, Vanessa J. Kelly, Juan Sebastian Osorio-Valencia, Elliot Greenblatt, R. S. Harris, Jose G. Venegas> ;Respiratory Physiology & Neurobiology. 2016 Feb 1
1 citations
Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge.
Vanessa J. Kelly, Tilo Winkler, Jose G. Venegas, Mamary Kone, Daniel L. Hamilos, Roshi Afshar, Josalyn L. Cho, Andrew D. Luster, Benjamin D. Medoff, R. Scott Harris> ;Plos One. 2015 Dec 7
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Hospital Affiliations

Mount Auburn HospitalCambridge, Massachusetts
Encompass Health Rehabilitation Hospital of BraintreeBraintree, Massachusetts