LeslieASpikesMD

Pulmonology • Kansas City, KS

Critical Care Medicine, Pleural Disease

Assistant Professor, Internal Medicine, University Kansas School of Medicine

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Office
3901 Rainbow Blvd
Kansas City, KS 66160
Phone+1 913-588-5000

Fax+1 913-888-8814
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Education & Training

University of Kansas School of MedicineFellowship, Pulmonary Disease and Critical Care Medicine, 2007 - 2010
University of Kansas School of MedicineResidency, Internal Medicine, 2004 - 2007
University of Kansas School of MedicineClass of 2004

Certifications & Licensure

MO State Medical License 2021 - 2025
KS State Medical License 2007 - 2024
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Patient-Centered Specialty Practice Recognition Program National Committee for Quality Assurance, 2014-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument Start of enrollment: 2013 Apr 01
Completed
Phase 3
Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER Start of enrollment: 2017 Apr 18
Terminated
Phase 3
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH Start of enrollment: 2018 Jul 15
Terminated
Phase 2
Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004 Start of enrollment: 2019 Apr 10
Terminated
Phase 2
Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Start of enrollment: 2020 Jul 15
Terminated
Phase 2
COVID-19 Biorepository Start of enrollment: 2020 Apr 15
Recruiting
A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension (ELEVATE 2) Start of enrollment: 2021 Mar 15
Completed
Phase 2
Post COVID-19 Biorepository Start of enrollment: 2021 Feb 08
Recruiting
Roles: Principal Investigator
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Publications & Presentations

PubMed

33 citations
Persistent circulation of soluble and extracellular vesicle-linked Spike protein in individuals with postacute sequelae of COVID-19.
Vaughn Craddock, Aatish Mahajan, Leslie Spikes, Balaji Krishnamachary, Anil K Ram, Ashok Kumar, Ling Chen, Prabhakar Chalise, Dhillon, N.> ;Journal of Medical Virology. 2023 Feb 1
3 citations
Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design.
Raymond L Benza, Veronica Franco, Mandar A Aras, Leslie Spikes, Daniel Grinnan, Carol Satler> ;Respiratory Research. 2022 Dec 17
9 citations
BREEZE: Open-label clinical study to evaluate the safety and tolerability of treprostinil inhalation powder as Tyvaso DPI™ in patients with pulmonary arterial hyperten...
Leslie A Spikes, Abubakr A Bajwa, Charles D Burger, Sapna V Desai, Michael S Eggert, Karim A El-Kersh, Micah R Fisher, Shilpa Johri, Joanna M Joly, Jinesh Mehta, Harol...> ;Pulmonary Circulation. 2022 Apr 1
53 citations
Extracellular vesicle-mediated endothelial apoptosis and EV-associated proteins correlate with COVID-19 disease severity.
Balaji Krishnamachary, Christine Cook, Ashok Kumar, Leslie Spikes, Prabhakar Chalise, Navneet K. Dhillon> ;Journal of Extracellular Vesicles. 2021 Jul 1
33 citations
The Potential Role of Extracellular Vesicles in COVID-19 Associated Endothelial injury and Pro-inflammation
Balaji Krishnamachary, Christine Cook, Leslie Spikes, Prabhakar Chalise, Navneet K. Dhillon> ;Medrxiv. 2020 Sep 1
1 citations
A 29-Year-Old Woman With Severe Sepsis and Hemoptysis
Allison Aripoli, Lucas Meek, Steven Lemons, Leslie Spikes> ;Chest. 2016 Aug 1
21 citations
Effect of Cocaine on Pulmonary Vascular Remodeling and Hemodynamics in Human Immunodeficiency Virus–Transgenic Rats
Pranjali Dalvi, Leslie Spikes, Julie Allen, Vijayalaxmi Gupta, Himanshu Sharma, Marion Gillcrist, Jamison Montes de Oca, Amy O'Brien-Ladner, Navneet K. Dhillon> ;American Journal of Respiratory Cell and Molecular Biology. 2016 Aug 1
4 citations
Macitentan for the treatment of pulmonary arterial hypertension.
Leslie Spikes, Timothy Williamson, Lewis Satterwhite> ;Drugs of Today. 2014 Jun 1
51 citations
Enhanced pulmonary arteriopathy in simian immunodeficiency virus-infected macaques exposed to morphine.
Leslie Spikes, Pranjali Dalvi, Ossama Tawfik, Haihua Gu, Norbert F. Voelkel, Paul Cheney, Amy O'Brien-Ladner, Navneet K. Dhillon> ;American Journal of Respiratory and Critical Care Medicine. 2012 Dec 14
22 citations
Hantavirus Pulmonary Syndrome
Steven Q. Simpson, Leslie Spikes, Saurin Patel, Ibrahim Faruqi> ;Infectious Disease Clinics of North America. 2010 Mar 1
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Press Mentions

United Therapeutics Announces the Publication of Tyvaso DPI™ BREEZE Clinical and Long-Term Data in the Journal Pulmonary CirculationApril 6th, 2022
KC Doctors Worried About Number of COVID Deaths, Long-Hauler SymptomsJanuary 13th, 2022
United Therapeutics Presents Tyvaso DPI™ BREEZE Clinical Data at the European Respiratory Society International Congress 2021September 7th, 2021
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