MarioCastroMDMPH

Pulmonology • Kansas City, KS

Asthma & COPD, Critical Care Medicine, Interventional Pulmonology, Pleural Disease

Professor, Chief, Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine

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Office
4000 Cambridge St
MSN 3007
Kansas City, KS 66160
Phone+1 913-588-7529

Fax+1 913-535-2200
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Summary

Dr. Mario Castro is a pulmonologist in Kansas City, KS and is affiliated with The University of Kansas Health System. He received his medical degree from University of Missouri - Kansas City School of Medicine and has been in practice 29 years. He specializes in asthma & copd, critical care medicine, interventional pulmonology, and pleural disease and is experienced in asthma, chronic obstructive pulmonary disease, lymphangioleiomyomatosis, sarcoidosis, and airway remodeling.

Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Pulmonary Disease and Critical Care Medicine, 1991 - 1994
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1988 - 1991
University of Missouri Kansas City School of MedicineClass of 1988

Certifications & Licensure

MO State Medical License 1994 - 2025
KS State Medical License 2019 - 2024
IA State Medical License 1991 - 1994
MN State Medical License 1989 - 1994
FL State Medical License 1990 - 1994
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012

Clinical Trials

Asthma Clinical Research Network (ACRN) Trial - Long-Acting Beta Agonist Response by Genotype (LARGE) Start of enrollment: 2004 Dec 01
Completed
Phase 3
Asthma Clinical Research Network (ACRN) Trial - Macrolides in Asthma (MIA) Start of enrollment: 2006 Jun 01
Completed
Phase 3
Asthma Clinical Research Network (ACRN) Trial - Best Adjustment Strategy for Asthma in Long Term (BASALT) Start of enrollment: 2007 Jun 01
Completed
Phase 3
Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC) Start of enrollment: 2008 May 01
Completed
Phase 3
Long-term Oxygen Treatment Trial Start of enrollment: 2009 Jan 01
Completed
Phase 3
Effects of cKit Inhibition by Imatinib in Patients With Severe Refractory Asthma (KIA) Start of enrollment: 2010 Nov 01
Completed
Phase 2
A Prospective Observational Study of Biopredictors of Bronchial Thermoplasty Response in Patients With Severe Refractory Asthma (BTR Study) Start of enrollment: 2010 Aug 01
Completed
Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma Start of enrollment: 2011 Apr 01
Completed
Phase 3
Long-acting Beta Agonist Step Down Study Start of enrollment: 2012 Mar 01
Completed
Phase 4
Severe Asthma Research Program Start of enrollment: 2012 Oct 01
Active, not recruiting
Washington University Severe Asthma Research Program III Start of enrollment: 2012 Oct 01
Active, not recruiting
Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol, in Mild Asthma Start of enrollment: 2013 Mar 01
Unknown status
Phase 2
Efficacy and Safety of Βeta-adrenoceptor Inverse Agonist and Biased Ligand, Nadolol, In Smoking Cessation of Patients With Chronic Cough With or Without Airflow Obstruction Start of enrollment: 2014 Mar 01
Completed
Phase 2
Bronchial Thermoplasty for Severe Asthmatics Guided by HXe MRI Start of enrollment: 2013 Mar 01
Completed
Phase 2, Phase 3
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Publications & Presentations

PubMed

Use of Quantitative CT Imaging to Identify Bronchial Thermoplasty Responders.
Maanasi Samant, James G Krings, Daphne Lew, Charles W Goss, Tammy Koch, Mary Clare McGregor, Jonathan Boomer, Chase S Hall, Ken B Schechtman, Ajay Sheshadri, Samuel Pe...> ;Chest. 2024 Apr 1
Dupilumab sustains lung function improvements in patients with moderate-to-severe asthma.
Alberto Papi, Mario Castro, Jonathan Corren, Ian D Pavord, Yuji Tohda, Arman Altincatal, Nami Pandit-Abid, Elizabeth Laws, Bolanle Akinlade, Leda P Mannent, Rebecca Ga...> ;Respiratory Medicine. 2024 Apr 1
1 citations
Cluster Analysis to Identify Long COVID Phenotypes UsingXe Magnetic Resonance Imaging: A Multi-centre Evaluation.
Rachel L Eddy, David Mummy, Shuo Zhang, Haoran Dai, Aryil Bechtel, Alexandra Schmidt, Bradie Frizzell, Firoozeh V Gerayeli, Jonathon A Leipsic, Janice M Leung, Bastiaa...> ;The European Respiratory Journal. 2024 Feb 8
1 citations
Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma.
Brendan K Huang, Brett M Elicker, Travis S Henry, Kimberly G Kallianos, Lewis D Hahn, Monica Tang, Franklin Heng, Charles E McCulloch, Nirav R Bhakta, Sharmila Majumda...> ;JCI Insight. 2024 Feb 8
Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma.
Hastie, A., Bishop, A., Khan, M., Bleecker, E., Castro, M., Denlinger, L., Erzurum, S., Fahy, J., Israel, E., Levy, B., Mauger, D., Meyers, D., Moore, W., Ortega, V., ...> ;Clinical and Experimental Allergy. 2024 Jan 22
Azithromycin therapy in infants hospitalized for respiratory syncytial virus bronchiolitis: Airway matrix metalloproteinase-9 levels and subsequent recurrent wheeze.
Beigelman, A., Goss, C., Wang, J., Boomer, J., Zhou, Y., Casper, T., Coverstone, A., Kanchongkittiphon, W., Storch, G., Schechtman, K., Srinivasan, M., Bram, S., Kukli...> ;Annals of Allergy, Asthma & Immunology. 2024 Jan 17
A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.
Leung, C., Tang, M., Huang, B., Fain, S., Hoffman, E., Choi, J., Dunican, E., Mauger, D., Denlinger, L., Jarjour, N., Israel, E., Levy, B., Wenzel, S., Sumino, K., Has...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Dec 19
Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach.
Njira Lugogo, Maeve O'Connor, Maureen George, Rajan Merchant, Greg Bensch, Jay Portnoy, John Oppenheimer, Mario Castro> ;Current Allergy and Asthma Reports. 2023 Nov 1
1 citations
Acute HDM exposure shows time-of-day and sex-based differences in the severity of lung inflammation and circadian clock disruption.
Ashokkumar Srinivasan, Allan Giri, Santhosh Kumar Duraisamy, Alexander Alsup, Mario Castro, Isaac Kirubakaran Sundar> ;The Journal of Allergy and Clinical Immunology. Global. 2023 Nov 1
2 citations
Association of Preoperative Lung Function with Complications after Lobectomy Using Race-Neutral and Race-Specific Normative Equations.
Ajay Sheshadri, Ravi Rajaram, Aaron Baugh, Mario Castro, Felipe Soto, Liang Li, Scott E Evans, Burton F Dickey, Ara A Vaporciyan, David E Ost, Correa, A., Daniel, C.> ;Annals of the American Thoracic Society. 2024 Jan 1
2 citations
Genetic analyses of chr11p15.5 region identify-associated with asthma-related phenotypes.
Kaminski, N., Xingnan Li, Huashi Li, Stephanie A Christenson, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin M Gaston, Elliot Israel, Nizar N...> ;The Journal of Asthma. 2023 Oct 1
Bronchial Thermoplasty in the Biologic Era.
Joseph Johnstone, Mario Castro> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Oct 1
2 citations
Chronic HDM exposure shows time-of-day and sex-based differences in inflammatory response associated with lung circadian clock disruption.
Ashokkumar Srinivasan, Allan Giri, Santhosh Kumar Duraisamy, Alexander Alsup, Mario Castro, Isaac Kirubakaran Sundar> ;Iscience. 2023 Sep 15
Impact of exacerbation history on long-term efficacy of dupilumab in patients with asthma.
Jonathan Corren, Constance H Katelaris, Mario Castro, Jorge F Maspero, Marc Humbert, David M G Halpin, Arman Altincatal, Nami Pandit-Abid, Xavier Soler, Amr Radwan, Ju...> ;ERJ Open Research. 2023 Sep 1
5 citations
Eosinophils and tissue remodeling: Relevance to airway disease.
Salman Siddiqui, Claus Bachert, Leif Bjermer, Kathleen M Buchheit, Mario Castro, Yimin Qin, Hitasha Rupani, Hironori Sagara, Peter Howarth, Camille Taillé> ;The Journal of Allergy and Clinical Immunology. 2023 Oct 1
Beginning to Address an Implementation Gap in Asthma: Clinicians' Views of Prescribing Reliever Budesonide-Formoterol Inhalers and SMART in the United States.
James G Krings, Tejas C Sekhar, Vanessa Chen, Kathryn V Blake, Kaharu Sumino, Aimee S James, Amber K Clover, Eric J Lenze, Ross C Brownson, Mario Castro> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Sep 1
2 citations
The Fungal Microbiome of the Upper Airway Is Associated With Future Loss of Asthma Control and Exacerbation Among Children With Asthma.
Hanshu Yuan, Zhongmao Liu, Jinhong Dong, Leonard B Bacharier, Daniel Jackson, David Mauger, Homer Boushey, Mario Castro, Juliana Durack, Yvonne J Huang, Robert F Leman...> ;Chest. 2023 Aug 1
1 citations
Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes.
Huashi Li, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin Gaston, Elliot Israel, Nizar N Jarjour, Bruce D Levy, David T Mauger, Wendy C Moore...> ;The Journal of Asthma. 2023 Oct 1
3 citations
A single-breath-hold protocol for hyperpolarizedXe ventilation and gas exchange imaging.
Peter J Niedbalski, Matthew M Willmering, Robert P Thomen, John P Mugler 3rd, Jiwoong Choi, Chase Hall, Mario Castro> ;NMR in Biomedicine. 2023 Aug 1
6 citations
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma.
Marc Gauthier, Sagar Laxman Kale, Timothy B Oriss, Michael Gorry, Richard P Ramonell, Kathryn Dalton, Prabir Ray, John V Fahy, Max A Seibold, Mario Castro, Nizar Jarjo...> ;The Journal of Allergy and Clinical Immunology. 2023 Jul 1
Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.
Aparna Balasubramanian, Janet T Holbrook, Brendan J Canning, Loretta G Que, Mario Castro, Barry J Make, Linda Rogers, Michael F Busk, Alexis Rea, Ashley A McCook-Veal,...> ;ERJ Open Research. 2023 Mar 1
24 citations
Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial.
Susanna Naggie, David R Boulware, Christopher J Lindsell, Thomas G Stewart, Alex J Slandzicki, Stephen C Lim, Jonathan Cohen, David Kavtaradze, Arch P Amon, Ahab Gabri...> ;JAMA. 2023 Mar 21
12 citations
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Xingnan Li, Stefano Guerra, Julie G Ledford, Monica Kraft, Huashi Li, Annette T Hastie, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin Gaston...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Feb 15
Mucus Plugging: A New Phenotype for Your Practice.
Jorge Cedano, Jiwoong Choi, Mario Castro> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Feb 1
30 citations
Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
Matthew W McCarthy, Susanna Naggie, David R Boulware, Christopher J Lindsell, Thomas G Stewart, G Michael Felker, Dushyantha Jayaweera, Mark Sulkowski, Nina Gentile, C...> ;JAMA. 2023 Jan 24
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Press Mentions

Ivermectin Shown Ineffective in Treating COVID-19, According to Multi-Site Study Including KU Medical CenterDecember 1st, 2022
American College of Chest Physicians, Oct. 16-19October 31st, 2022
Biologic Dupilumab Shows Sustained Benefit in Asthma PatientsOctober 19th, 2022
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