Mark Andrew Frye MD

Chair of the Department of Psychology and Psychiatry at the Mayo Clinic and Director of the Mayo Clinic Depression Center in Rochester

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200 1st St SwRochester, MN 55905
Phone+1 507-284-2511

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Education & Training

National Institutes of Health Clinical CenterResidency, Psychiatry, 1994 - 1996
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Psychiatry, 1990 - 1994
University of Minnesota Medical SchoolClass of 1990
Luther CollegeBA, Biology, Cum Laude, 1981 - 1985

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Certifications & Licensure

MN State Medical License 2007 - 2027
AZ State Medical License 2015 - 2023
AK State Medical License 2013 - 2021
CA State Medical License 1991 - 2021
WI State Medical License 2018 - 2021
FL State Medical License 2010 - 2020
DC State Medical License 1994 - 1998
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

CMS Meaningful Use Stage 2 Certification Centricity Patient Online, GE Healthcare, 2014-2017
CMS Meaningful Use Stage 2 Certification Centricity Enterprise (CE), GE Healthcare, 2014-2017
CMS Meaningful Use Stage 1 Certification Centricity Patient Online, GE Healthcare, 2014-2017

Clinical Trials

Can Additional Drug Therapy Accelerate Response Time to Antidepressants
WITHDRAWN
PHASE4
Bipolar Depression Before and After Lamotrigine Treatment
COMPLETED
PHASE3
Ketamine for Depression and Suicide Risk
COMPLETED
PHASE2

Publications & Presentations

PubMed

Accelerated biological aging in bipolar disorder as determined by artificial intelligence-based electrocardiographic assessment.
Alessandro Miola, Betsy J Medina-Inojosa, Alfredo B Cuellar-Barboza, Miguel L Prieto, Rob J Morgan
Journal of Affective Disorders. 2026-10-01
The American Society of Clinical Psychopharmacology task force consensus statement on the deprescribing of stimulant medications in adults with ADHD.
David W Goodman, Rajnish Mago, Leslie Citrome, Holly A Swartz, Roger S McIntyre
European Neuropsychopharmacology. 2026-10-01
Prescription Trends for Bipolar Disorder With and Without Comorbid Substance Use and Anxiety Disorders: A Global Bipolar Cohort Collaborative Study.
Anastasia K Yocum, Martin Alda, Bruno Aouizerate, Valerie Aubin, Frank Bellivier
Bipolar Disorders. 2026-09-01

Journal Articles

Research Paper Sex-Specific Effects of Gain-of-Function P2RX7 Variation on Bipolar Disorder
William V Bobo, Mark A Frye, ScienceDirect
More pernicious course of bipolar disorder in the United States than in many European countries: Implications for policy and treatment
Post RM, Altshuler L, Kupka R, McElroy S, Frye MA, Rowe M, Leverich GS, Grunze H, Suppes T, Keck PE Jr, Nolen WA, J Affect Disord, 1/1/2014
More medical comorbidities in patients with bipolar disorder from the United States than from the Netherlands and Germany
Post RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M, J Nerv Ment Dis, 1/1/2014

Abstracts/Posters

Association between nicotine dependence, alcohol craving and high-risk situations to relapse in patients with alcohol use disorders
Hitschfeld M, Schneekloth T, Ebbert J, Hall-Flavin D, Karpyak V, Geske M, Frye M, 167th American Psychiatric Association (APA) Annual Meeting, New York, NY, 1/3/2014
Impact of smoking cessation on alcohol relapse after residential alcoholism treatment
Hitschfeld M, Schneekloth T, Ebbert J, Hall-Flavin D, Karpyak V, Geske M, Frye M, 167th American Psychiatric Association (APA) Annual Meeting, New York, NY, 1/3/2014
Use of a novel adjunctive clinical trial design to examine efficacy, safety of armodafinil for the treatment of bipolar I depression
Frye MA, New Clinical Drug Evaluation Unit (NCDEU), Hollywood, FL, 1/28/2013

Lectures

Bipolar Disorder: Think Global—Treat Local
Medellin, Colombia - 1/22/2014
Bio-Banking Bipolar Disorder
Hanover, NH - 1/20/2014
Novel Treatment Options for Bipolar Depression
Seoul, South Korea - 1/18/2014

Press Mentions

University of Cincinnati to Join Bipolar Research NetworkMarch 13th, 2025
UC Joins Novel Bipolar Research and Clinical Care NetworkMarch 12th, 2025
Baszucki Group & Mayo Clinic Collaborate on Bipolar Disorder Ketogenic Therapy TrialMarch 5th, 2025

Grant Support

Olfactory neuromodulation of visual circuits and behaviorUNIVERSITY OF CALIFORNIA LOS ANGELES2021–2026
Neural circuits for visual feature detectionUNIVERSITY OF CALIFORNIA LOS ANGELES2016–2025