MatthewClayCaveMD

Gastroenterology • Louisville, KY

Advanced Endoscopic Interventional, Hepatology & Liver Transplantation

Assistant Professor University of Louisville

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Office
401 E Chestnut St
Suite 310
Louisville, KY 40202
Phone+1 502-584-8563

Fax+1 502-589-5093
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Education & Training

University of Louisville School of MedicineFellowship, Gastroenterology, 2004 - 2007
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 2001 - 2004
University of Kentucky College of MedicineClass of 2001

Certifications & Licensure

KY State Medical License 2004 - 2025
American Board of Internal Medicine Gastroenterology
American Board of Internal Medicine Transplant Hepatology

Clinical Trials

Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis Start of enrollment: 2013 Aug 01
Completed
Phase 2
Technology-Based Application To Improve The Triple Therapy Adherence Rate In Subjects With Hepatitis C Infection Start of enrollment: 2014 Apr 01
Withdrawn
Not Applicable
Zinc Supplementation in Alcoholic Cirrhosis Start of enrollment: 2010 Feb 01
Completed
Not Applicable

Publications & Presentations

PubMed

Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease.
Kellianne M Piell, Belinda J Petri, Jason Xu, Lu Cai, Shesh N Rai, Ming Li, Daniel W Wilkey, Michael L Merchant, Carolyn M Klinge, Matthew C Cave> ;Environmental Toxicology and Pharmacology. 2024 Apr 1
ALT poorly predicts Nonalcoholic Fatty Liver Disease (NAFLD) and liver fibrosis as determined by vibration-controlled transient elastography in adult National Health a...
Sally Condon, Huirong Hu, Maiying Kong, Matthew C Cave, Craig J McClain> ;The American Journal of the Medical Sciences. 2024 May 1
Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis.
Jingjing Zhao, Ngozi Adiele, Daniel Gomes, Marina Malovichko, Daniel J Conklin, Abigail Ekuban, Jianzhu Luo, Tyler Gripshover, Walter H Watson, Mayukh Banerjee, Meliss...> ;Toxicological Sciences. 2024 Mar 26
7 citations
Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis.
Hassanein, T., McClain, C., Vatsalya, V., Stein, L., Flamm, S., Martin, P., Cave, M., Mitchell, M., Barton, B., Nagy, L., Szabo, G., McCullough, A., Dasarathy, S., Sha...> ;The American Journal of Gastroenterology. 2024 Jan 1
A hypothesis: Potential contributions of metals to the pathogenesis of pulmonary artery hypertension.
C Danielle Hopkins, Caitlin Wessel, Oscar Chen, Karim El-Kersh, Dakotah Cathey, Matthew C Cave, Lu Cai, Jiapeng Huang> ;Life Sciences. 2024 Jan 1
2 citations
Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease.
Belinda J Petri, Kellianne M Piell, Banrida Wahlang, Kimberly Z Head, Eric C Rouchka, Juw Won Park, Jae Yeon Hwang, Mayukh Banerjee, Matthew C Cave, Carolyn M Klinge> ;Environmental Toxicology and Pharmacology. 2023 Oct 1
Investigating the Acute Metabolic Effects of the N-Methyl Carbamate Insecticide, Methomyl, on Mouse Liver.
Amy M Groswald, Tyler C Gripshover, Walter H Watson, Banrida Wahlang, Jianzhu Luo, Loretta L Jophlin, Matthew C Cave> ;Metabolites. 2023 Aug 1
1 citations
A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data.
Rance Nault, Matthew C Cave, Gabriele Ludewig, Hunter N B Moseley, Kelly G Pennell, Tim Zacharewski> ;Environmental Health Perspectives. 2023 Jun 1
2 citations
Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.
Kellianne M Piell, Belinda J Petri, Kimberly Z Head, Banrida Wahlang, Raobo Xu, Xiang Zhang, Jianmin Pan, Shesh N Rai, Kalpani de Silva, Julia H Chariker, Eric C Rouch...> ;Environmental Toxicology and Pharmacology. 2023 Jun 1
3 citations
Western diet unmasks transient low-level vinyl chloride-induced tumorigenesis; potential role of the (epi-)transcriptome.
Silvia Liu, Liqing He, Olivia B Bannister, Jiang Li, Regina D Schnegelberger, Charis-Marie Vanderpuye, Andrew D Althouse, Francisco J Schopfer, Banrida Wahlang, Matthe...> ;Toxicology and Applied Pharmacology. 2023 Jun 1
5 citations
Associations between residential volatile organic compound exposures and liver injury markers: The role of biological sex and race.
Banrida Wahlang, Hong Gao, Shesh N Rai, Rachel J Keith, Craig J McClain, Sanjay Srivastava, Mathew C Cave, Aruni Bhatnagar> ;Environmental Research. 2023 Mar 15
Potential Roles of Metals in the Pathogenesis of Pulmonary and Systemic Hypertension.
C Danielle Hopkins, Caitlin Wessel, Oscar Chen, Karim El-Kersh, Matthew C Cave, Lu Cai, Jiapeng Huang> ;International Journal of Biological Sciences. 2023 Jan 1
1 citations
Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.
Kimberly Z Head, Oluwanifemi E Bolatimi, Tyler C Gripshover, Min Tan, Yan Li, Timothy N Audam, Steven P Jones, Carolyn M Klinge, Matthew C Cave, Banrida Wahlang> ;Frontiers in Gastroenterology. 2023 Jan 1
4 citations
Metallomics in pulmonary arterial hypertension patients.
Karim El-Kersh, C Danielle Hopkins, Xiaoyong Wu, Shesh N Rai, Matthew C Cave, M Ryan Smith, Young-Mi Go, Dean P Jones, Lu Cai, Jiapeng Huang> ;Pulmonary Circulation. 2023 Jan 1
6 citations
Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease.
Belinda J Petri, Kellianne M Piell, Banrida Wahlang, Kimberly Z Head, Kalina Andreeva, Eric C Rouchka, Matthew C Cave, Carolyn M Klinge> ;Environmental Research. 2023 Jan 1
2 citations
Illustration of Gut-Thyroid Axis in Alcohol Use Disorder: Interplay of Gut Dysfunction, Pro-Inflammatory Responses, and Thyroid Function.
Manasa Sagaram, Amor J Royer, Huirong Hu, Abhas Rajhans, Ranganathan Parthasarathy, Sathya Sridevi Krishnasamy, Sri Prakash Mokshagundam, Maiying Kong, Melanie L Schwa...> ;Cells. 2022 Oct 1
3 citations
Corrigendum to "Obesity II: Establishing causal links between chemical exposures and obesity" [Biochem. Pharmacol. 199 (2022) 115015].
Jerrold J Heindel, Sarah Howard, Keren Agay-Shay, Juan P Arrebola, Karine Audouze, Patrick J Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C Cave, Saurab...> ;Biochemical Pharmacology. 2022 Aug 1
8 citations
Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model.
Belinda J Petri, Kellianne M Piell, Banrida Wahlang, Kimberly Z Head, Kalina Andreeva, Eric C Rouchka, Jianmin Pan, Shesh N Rai, Matthew C Cave, Carolyn M Klinge> ;Environmental Toxicology and Pharmacology. 2022 Aug 1
50 citations
Obesity II: Establishing causal links between chemical exposures and obesity.
Jerrold J Heindel, Sarah Howard, Keren Agay-Shay, Juan P Arrebola, Karine Audouze, Patrick J Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C Cave, Saurab...> ;Biochemical Pharmacology. 2022 May 1
50 citations
Obesity I: Overview and molecular and biochemical mechanisms.
Robert H Lustig, David Collier, Christopher Kassotis, Troy A Roepke, Min Ji Kim, Etienne Blanc, Robert Barouki, Amita Bansal, Matthew C Cave, Saurabh Chatterjee, Mahua...> ;Biochemical Pharmacology. 2022 May 1
7 citations
Whole life exposure to low dose cadmium alters diet-induced NAFLD.
Jamie L Young, Matthew C Cave, Qian Xu, Maiying Kong, Jianxiang Xu, Qian Lin, Lu Cai, Yi Tan> ;Toxicology and Applied Pharmacology. 2022 Feb 1
11 citations
Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey.
Matthew C Cave, Christina M Pinkston, Shesh N Rai, Banrida Wahlang, Marian Pavuk, Kimberly Z Head, Gleta K Carswell, Gail M Nelson, Carolyn M Klinge, Douglas A Bell, L...> ;Environmental Health Perspectives. 2022 Jan 1
11 citations
Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II).
Michael C. Petriello, M. Abdul Mottaleb, Tara C. Serio, Bharat Balyan, Matthew C. Cave, Marian Pavuk, Linda S. Birnbaum, Andrew J. Morris> ;Environment International. 2022 Jan 1
11 citations
A Comprehensive Survey of Statistical Approaches for Differential Expression Analysis in Single-Cell RNA Sequencing Studies
Samarendra Das, Anil Rai, Michael L. Merchant, Matthew C. Cave, Shesh N. Rai> ;Genes. 2021 Dec 1
1 citations
Resolution of Autoimmune Hepatitis Following Total Colectomy in Severe Ulcerative Colitis: A Rare Presentation Associated With Leaky Gut
Matthew A. Heckroth, Mohamed Eisa, Matthew Cave> ;Cureus. 2021 Nov 5
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Press Mentions

UofL and Robley Rex VA Medical Center Partnership Leads to New State-of-the-Art Multiphoton Microscopes for Exposure StudiesNovember 22nd, 2022
Training the Next Generation of Cancer ResearchersApril 20th, 2017