MylesABrownMD

PubMed

• Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes.
  Varadha Balaji Venkadakrishnan, Adam G Presser, Richa Singh, Matthew A Booker, Nicole A Traphagen, Kenny Weng, Nathaniel C Voss, Navin R Mahadevan, Kei Mizuno, Loredan...> ;Research Square. 2024 Mar 4
• Thio-2 inhibits key signaling pathways required for the development and progression of castration resistant prostate cancer.
  Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M Jiménez-Vacas, Victor Gourain, Irene I Lee, Rebecca Seeger, Claudia Muhle-Goll, Bora Gurel...> ;Molecular Cancer Therapeutics. 2024 Feb 27
• Heterogeneity and transcriptional drivers of triple-negative breast cancer.
  Bojana Jovanović, Daniel Temko, Laura E Stevens, Marco Seehawer, Anne Fassl, Katherine Murphy, Jayati Anand, Kodie Garza, Anushree Gulvady, Xintao Qiu, Nicholas W Harp...> ;Cell Reports. 2023 Dec 26
• Cistrome Data Browser: integrated search, analysis and visualization of chromatin data.
  Len Taing, Ariaki Dandawate, Sehi L'Yi, Nils Gehlenborg, Myles Brown, Clifford A Meyer> ;Nucleic Acids Research. 2024 Jan 5
• 1 citations
  TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
  Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla B Heavican-Foral, Elisa Mandato, Huiyun Liu, Geoffrey M Nelson, Lu Yang, Renee Chen, Katherine...> ;Science Translational Medicine. 2023 Sep 20
• Multi-batch single-cell comparative atlas construction by deep learning disentanglement.
  Allen W Lynch, Myles Brown, Clifford A Meyer> ;Nature Communications. 2023 Jul 12
• 2 citations
  MetaTiME integrates single-cell gene expression to characterize the meta-components of the tumor immune microenvironment.
  Yi Zhang, Guanjue Xiang, Alva Yijia Jiang, Allen Lynch, Zexian Zeng, Chenfei Wang, Wubing Zhang, Jingyu Fan, Jiajinlong Kang, Shengqing Stan Gu, Changxin Wan, Boning Z...> ;Nature Communications. 2023 May 6
• Cistrome Explorer: an interactive visual analysis tool for large-scale epigenomic data.
  Sehi L'Yi, Mark S Keller, Ariaki Dandawate, Len Taing, Chen-Hao Chen, Myles Brown, Clifford A Meyer, Nils Gehlenborg> ;Bioinformatics. 2023 Feb 3
• 8 citations
  Machine learning on syngeneic mouse tumor profiles to model clinical immunotherapy response.
  Zexian Zeng, Shengqing Stan Gu, Cheryl J Wong, Lin Yang, Nofal Ouardaoui, Dian Li, Wubing Zhang, Myles Brown, X Shirley Liu> ;Science Advances. 2022 Oct 14
• 6 citations
  Hippo Signaling Pathway Regulates Cancer Cell-Intrinsic MHC-II Expression.
  Zexian Zeng, Shengqing Stan Gu, Nofal Ouardaoui, Carly Tymm, Lin Yang, Cheryl J Wong, Dian Li, Wubing Zhang, Xiaoqing Wang, Jason L Weirather, Scott J Rodig, F Stephen...> ;Cancer Immunology Research. 2022 Dec 2
• 15 citations
  MIRA: joint regulatory modeling of multimodal expression and chromatin accessibility in single cells.
  Allen W Lynch, Christina V Theodoris, Henry W Long, Myles Brown, X Shirley Liu, Clifford A Meyer> ;Nature Methods. 2022 Sep 1
• 3 citations
  A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway.
  Nane C Kuznik, Valeria Solozobova, Irene I Lee, Nicole Jung, Linxiao Yang, Karin Nienhaus, Emmanuel A Ntim, Jaice T Rottenberg, Claudia Muhle-Goll, Amrish Rajendra Kum...> ;Iscience. 2022 May 20
• 43 citations
  MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.
  Xintao Qiu, Nadia Boufaied, Tarek Hallal, Avery Feit, Anna de Polo, Adrienne M Luoma, Walaa Alahmadi, Janie Larocque, Giorgia Zadra, Yingtian Xie, Shengqing Gu, Qin Ta...> ;Nature Communications. 2022 May 13
• 9 citations
  p16-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.
  Jing Ni, Sheheryar Kabraji, Shaozhen Xie, Yanzhi Wang, Peichen Pan, Xiaofang He, Zongming Liu, Jose Palbo Leone, Henry W Long, Myles A Brown, Eric P Winer, Deborah A R...> ;Nature Communications. 2022 Mar 18
• 17 citations
  Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.
  Yiji Liao, Chen-Hao Chen, Tengfei Xiao, Bárbara de la Peña Avalos, Eloise V Dray, Changmeng Cai, Shuai Gao, Neel Shah, Zhao Zhang, Avery Feit, Pengya Xue, Zhijie Liu, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Jan 18
• David M. Livingston 1941-2021.
  James A DeCaprio, Myles Brown> ;Nature Cancer. 2021 Dec 1
• 19 citations
  FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance.
  Yihao Li, Xintao Qiu, Xiaoqing Wang, Hui Liu, Renee C. Geck, Alok K. Tewari, Tengfei Xiao, Alba Font-Tello, Klothilda Lim, Kristen L Jones, Murry Morrow, Raga Vadhi, P...> ;Nature Cell Biology. 2021 Nov 1
• 47 citations
  Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer.
  Paloma Cejas, Yingtian Xie, Alba Font-Tello, Klothilda Lim, Sudeepa Syamala, Xintao Qiu, Alok K. Tewari, Neel Shah, Holly M. Nguyen, Radhika A. Patel, Lisha G. Brown, ...> ;Nature Communications. 2021 Oct 1
• 62 citations
  In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
  Xiaoqing Wang, Collin Tokheim, Shengqing Stan Gu, Binbin Wang, Qin Tang, Yihao Li, Nicole Traugh, Zexian Zeng, Yi Zhang, Ziyi Li, Boning Zhang, Jingxin Fu, Tengfei Xia...> ;Cell. 2021 Oct 14
• 41 citations
  TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response.
  Zexian Zeng, Cheryl J Wong, Lin Yang, Nofal Ouardaoui, Dian Li, Wubing Zhang, Shengqing Gu, Yi Zhang, Yang Liu, Xiaoqing Wang, Jingxin Fu, Liye Zhou, Boning Zhang, Sar...> ;Nucleic Acids Research. 2021 Sep 17
• 19 citations
  Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer.
  Alok K. Tewari, Alexander T. M. Cheung, Jett Crowdis, Jake Conway, Sabrina Y. Camp, Stephanie A. Wankowicz, Dimitri Livitz, Jihye Park, Rosina T. Lis, Alice Bosma-Mood...> ;Cell Reports. 2021 Sep 7
• 13 citations
  CoBRA: Containerized Bioinformatics Workflow for Reproducible ChIP/ATAC-seq Analysis
  Xintao Qiu, Avery S. Feit, Ariel Feiglin, Yingtian Xie, Nikolas Kesten, Len Taing, Joseph Perkins, Shengqing Gu, Yihao Li, Paloma Cejas, Ningxuan Zhou, Rinath Jeselsoh...> ;Genomics, Proteomics & Bioinformatics. 2021 Jul 17
• 12 citations
  Androgen receptor splice variant 7 functions independently of the full length receptor in prostate cancer cells.
  Jiaqian Liang, LiYang Wang, Larysa Poluben, Mannan Nouri, Seiji Arai, Lisha Xie, Olga Voznesensky, Laura Cato, Xin Yuan, Joshua W. Russo, Henry W. Long, Myles Brown, S...> ;Cancer Letters. 2021 Jul 10
• 9 citations
  Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.
  Shengqing Gu, Stephanie Lheureux, Azin Sayad, Paulina Cybulska, Liat Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy R. Parulekar, Matthew Nankivell, Sean Kehoe, Dennis S...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Jun 22
• 35 citations
  Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.
  Zhong Wu, Jin Zhou, Xiaoyang Zhang, Zhouwei Zhang, Yingtian Xie, Jie Bin Liu, Zandra V. Ho, Arpit Panda, Xintao Qiu, Paloma Cejas, Israel Cañadas, Fahire G Akarca, Jam...> ;Nature Genetics. 2021 May 10
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Journal Articles

• Article KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance  
  Nikhil Wagle, Myles Brown, Rinath Jeselsohn, ScienceDirect

Lectures

• Meet-the-Scientist: CRISPR, RNAi, and shRNA Screens 
  ENDO 2019 - New Orleans, LA - 3/24/2019
• Signatures of T Cell Dysfunction and Exclusion Predict Cancer Immunotherapy Response 
  ENDO 2019 - New Orleans, LA - 3/24/2019