NaokoTakebeMDPhD

PubMed

• The effect of liver dysfunction on the pharmacokinetic disposition of belinostat and its five metabolites in patients with advanced cancers.
  Allison Dunn, Naoko Takebe, Alice Chen, Shivaani Kummar, Richard Piekarz, Brian Kiesel, Nancy Moore, James Doroshow, Jan H Beumer, Jogarao V S Gobburu> ;Cancer Chemotherapy and Pharmacology. 2024 Mar 14
• The novel ATR inhibitor M1774 induces replication protein overexpression and broad synergy with DNA-targeted anticancer drugs.
  Ukhyun Jo, Yashuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M Jenkins, Tapan Maity, Suresh Kumar, Frank T Zenke, Naoko Takebe, Yves Pommier> ;Molecular Cancer Therapeutics. 2024 Mar 11
• Phase 1/2 study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors.
  Corcoran, R., Do, K., Kim, J., Cleary, J., Parikh, A., Yeku, O., Xiong, N., Weekes, C., Veneris, J., Ahronian, L., Mauri, G., Tian, J., Norden, B., Michel, A., Van Sev...> ;Clinical Cancer Research. 2024 Mar 8
• Influence ofComutation on the Tumor Immune Microenvironment and Clinical Outcomes With Immune Checkpoint Inhibitors in-Mutant Non-Small-Cell Lung Cancer.
  Naqash, A., Floudas, C., Aber, E., Maoz, A., Nassar, A., Adib, E., Choucair, K., Xiu, J., Baca, Y., Ricciuti, B., Alessi, J., Awad, M., Kim, C., Judd, J., Raez, L., Lo...> ;JCO Precision Oncology. 2024 Feb 1
• Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort.
  Emiloju, O., Yin, J., Koubek, E., Reid, J., Borad, M., Lou, Y., Seetharam, M., Edelman, M., Sausville, E., Jiang, Y., Kaseb, A., Posey, J., Davis, S., Gores, G., Rober...> ;Investigational New Drugs. 2024 Feb 1
• Blood-based multi-cancer detection: A state-of-the-art update.
  Farooq, M., Leevan, E., Shin, S., De Souza, A., Ahmed, J., Ko, B., Takebe, N.> ;Current Problems in Cancer. 2024 Feb 1
• 12 citations
  The NCI-MATCH trial: lessons for precision oncology.
  Peter J O'Dwyer, Robert J Gray, Keith T Flaherty, Alice P Chen, Shuli Li, Victoria Wang, Lisa M McShane, David R Patton, James V Tricoli, P Mickey Williams, A John Iaf...> ;Nature Medicine. 2023 Jun 1
• 8 citations
  Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C.
  Susan N Chi, Joanna S Yi, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent D Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey L Be...> ;Journal of the National Cancer Institute. 2023 Nov 8
• 2 citations
  Rethinking Oncologic Treatment Strategies with Interleukin-2.
  Brian Ko, Naoko Takebe, Omozusi Andrews, Monish Ram Makena, Alice P Chen> ;Cells. 2023 May 5
• 2 citations
  ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-0449.
  Andrew E Sloan, Charles J Nock, Xiaobu Ye, Robert Buerki, Susan Chang, Glenn Lesser, Andrew Norden, Timothy Cloughesy, Jeffrey Olson, Amber Kerstetter-Fogle, Jeremy Ri...> ;Journal of Neuro-Oncology. 2023 Jan 1
• 4 citations
  Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma.
  James Nguyen, Naoko Takebe, Shivaani Kummar, Albiruni Razak, Sant P Chawla, Suzanne George, Shreyaskumar R Patel, Mary Louise Keohan, Sujana Movva, Geraldine O'Sulliva...> ;Clinical Cancer Research. 2023 Apr 3
• 10 citations
  Early drug development in solid tumours: analysis of National Cancer Institute-sponsored phase 1 trials.
  Dai Chihara, Ruitao Lin, Christopher R Flowers, Shanda R Finnigan, Lisa M Cordes, Yoko Fukuda, Erich P Huang, Larry V Rubinstein, Loretta J Nastoupil, S Percy Ivy, Jam...> ;Lancet. 2022 Aug 13
• 3 citations
  Trends in Grade 5 Toxicity and Response in Phase I Trials in Hematologic Malignancy: 20-Year Experience From the Cancer Therapy Evaluation Program at the National Canc...
  Dai Chihara, Erich P Huang, Shanda R Finnigan, Lisa M Cordes, Nebojsa Skorupan, Yoko Fukuda, Larry V Rubinstein, S Percy Ivy, James H Doroshow, Loretta J Nastoupil, Ch...> ;Journal of Clinical Oncology. 2022 Jun 10
• 18 citations
  A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma.
  Mrinal M Gounder, Evan Rosenbaum, Nian Wu, Mark A Dickson, Tahir N Sheikh, Sandra P D'Angelo, Ping Chi, Mary Lou Keohan, Joseph P Erinjeri, Cristina R Antonescu, Naras...> ;Clinical Cancer Research. 2022 Apr 14
• 17 citations
  Phase II Study of Selumetinib in Children and Young Adults With Tumors Harboring Activating Mitogen-Activated Protein Kinase Pathway Genetic Alterations: Arm E of the ...
  Olive S Eckstein, Carl E Allen, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey ...> ;Journal of Clinical Oncology. 2022 Jul 10
• Population Pharmacokinetics of Z-Endoxifen in Patients With Advanced Solid Tumors.
  Emily J Koubek, Andrew T Ralya, Thomas R Larson, Renee M McGovern, Sarah A Buhrow, Joseph M Covey, Alex A Adjei, Naoko Takebe, Matthew M Ames, Matthew P Goetz, Joel M ...> ;Journal of Clinical Pharmacology. 2022 Sep 1
• 37 citations
  Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients With Refractory Cancers in the National Cancer Institute-Children'...
  D Williams Parsons, Katherine A Janeway, David R Patton, Cynthia L Winter, Brent Coffey, P Mickey Williams, Sinchita Roy-Chowdhuri, Gregory J Tsongalis, Mark Routbort,...> ;Journal of Clinical Oncology. 2022 Jul 10
• 13 citations
  Crizotinib in patients with tumors harboring ALK or ROS1 rearrangements in the NCI-MATCH trial.
  A S Mansfield, Z Wei, R Mehra, A T Shaw, C H Lieu, P M Forde, A E Drilon, E P Mitchell, J J Wright, N Takebe, E Sharon, D Hovelson, S Tomlins, J Zeng, K Poorman, N Mal...> ;NPJ Precision Oncology. 2022 Mar 1
• SLFN11's surveillance role in protein homeostasis.
  Yasuhisa Murai, Ukhyun Jo, Yasuhiro Arakawa, Naoko Takebe, Yves Pommier> ;Oncoscience. 2022 Jan 1
• 2 citations
  Advances in Oncology in US and Japan: Focusing on Cancer and Infectious Diseases.
  Hiroto Nakano, Takuto Miyamoto, Yelena Y Janjigian, Sohtaro Mine, Hiroaki Mitsuya, Naoto T Ueno, Elad Sharon, Shunsuke Sakai, William C Timmer, Shuichiro Nakabo, Tomok...> ;World Journal of Oncology. 2021 Dec 1
• 5 citations
  Clinical activity of single-agent cabozantinib (XL184), a multi-receptor tyrosine kinase inhibitor, in patients with refractory soft tissue sarcomas.
  Geraldine O'Sullivan Coyne, S. Kummar, James C. Hu, Kristen N. Ganjoo, Warren A. Chow, Khanh T. Do, Jennifer Zlott, Ashley Bruns, Larry Rubinstein, Jared C. Foster, La...> ;Clinical Cancer Research. 2021 Oct 29
• 4 citations
  Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway
  Yasuhisa Murai, Ukhyun Jo, Junko Murai, Shinsaku Fukuda, Naoko Takebe, Yves Pommier> ;Iscience. 2021 Oct 22
• 11 citations
  Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11.
  Ukhyun Jo, Yasuhisa Murai, Naoko Takebe, Anish Thomas, Yves Pommier> ;Cancers. 2021 Sep 14
• 6 citations
  Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA.
  Carter K. Fairchild, Konstantinos V. Floros, Sheeba Jacob, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Hisashi Harada, Mikhail G. Dozmorov, Jennifer E. Koblinski, Ste...> ;Cancers. 2021 May 12
• 17 citations
  SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.
  Yasuhisa Murai, Ukhyun Jo, Junko Murai, Lisa M. Miller Jenkins, Shar-yin N. Huang, Sirisha Chakka, Ken Cheng, Shinsaku Fukuda, Naoko Takebe, Yves Pommier> ;Cancer Research. 2021 Jun 1
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Lectures

• Safety, tolerability, and antitumor activity of once-daily Wee-1 inhibitor AZD1775. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
• Phase I trial of z-endoxifen with estrogen receptor imaging in adults with advanced hormone receptorâ€positive solid tumors including desmoid and gynecologic tumors. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018