PatrickJHuMDPhD

Gastrointestinal Cancer, Hematologic Oncology

Associate Professor of Medicine, Cell and Developmental Biology, and Cancer Biology, Vanderbilt University School of Medicine

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Office
1310 24th Ave S
Nashville, TN 37212
Phone+1 615-355-3451
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Education & Training

Massachusetts General Hospital1999 - 2005
Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1998 - 2001
Johns Hopkins UniversityResidency, Internal Medicine, 1995 - 1998
New York University School of MedicineClass of 1995
Harvard UniversityA.B., Biology, cum laude, 1981 - 1985

Certifications & Licensure

TN State Medical License 2016 - 2025
MI State Medical License 2005 - 2018
MA State Medical License 1998 - 2007
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Elected Member The American Society for Clinical Investigation, 2011

Publications & Presentations

PubMed

4 citations
Pearls of wisdom for aspiring physician-scientist residency applicants and program directors.
Emily J Gallagher, Don C Rockey, Christopher D Kontos, Jatin M Vyas, Lawrence F Brass, Patrick J Hu, Carlos M Isales, Olujimi A Ajijola, W Kimryn Rathmell, Paul R Conl...> ;JCI Insight. 2022 Mar 22
Microbiome: Insulin signaling shapes gut community composition.
Patrick J. Hu> ;Current Biology. 2021 Jun 21
Starvation Responses Throughout theLife Cycle.
L Ryan Baugh, Patrick J Hu> ;Genetics. 2020 Dec 1
12 citations
Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles.
Henry H. Le, Chester J J Wrobel, Sarah M Cohen, Jingfang Yu, Heenam Park, Maximilian J. Helf, Brian J Curtis, Joseph C Kruempel, Pedro R Rodrigues, Patrick J. Hu, Paul...> ;Elife. 2020 Oct 16
13 citations
Addressing the physician-scientist pipeline: strategies to integrate research into clinical training programs.
Sallie R. Permar, Rebecca A Ward, Katherine J. Barrett, Stephanie A. Freel, Rasheed Gbadegesin, Christopher D. Kontos, Patrick J. Hu, Katherine E Hartmann, Christopher...> ;The Journal of Clinical Investigation. 2020 Mar 2
16 citations
Requirement for translocon-associated protein (TRAP) α in insulin biogenesis
Xin Li, Omar A. Itani, Leena Haataja, Kathleen J. Dumas, Jing Yang, Jeeyeon Cha, Stephane Flibotte, Hung-Jen Shih, Colin Delaney, Jialu Xu, Ling Qi, Peter Arvan, Ming ...> ;Science Advances. 2019 Dec 1
27 citations
Training the physician-scientist: views from program directors and aspiring young investigators
Christopher S. Williams, Audra N. Iness, Rebecca M. Baron, Olujimi A. Ajijola, Patrick J. Hu, Jatin M. Vyas, Robert A. Baiocchi, Alexander J. Adami, Jeremie M. Lever, ...> ;JCI Insight. 2018 Dec 7
16 citations
A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity
Colin Delaney, Albert Tzong Yang Chen, Jacqueline Graniel, Kathleen J. Dumas, Patrick J. Hu> ;Development. 2017 Jan 1
3 citations
N-ethyl-N-nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in vivo
Omar A. Itani, Stephane Flibotte, Kathleen J. Dumas, Chunfang Guo, Thomas Blumenthal, Patrick J. Hu> ;G3. 2016 Jun 1
12 citations
Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans.
Omar A. Itani, Stephane Flibotte, Kathleen J. Dumas, Donald G. Moerman, Patrick J. Hu> ;G3. 2016 Feb 1
55 citations
Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans.
Albert Tzong Yang Chen, Chunfang Guo, Omar A. Itani, Breane G. Budaitis, Travis W. Williams, Christopher E. Hopkins, Richard C. McEachin, Manjusha Pande, Ana R. Grant,...> ;Genetics. 2015 Oct 1
10 citations
Whole genome sequencing and the transformation of C. elegans forward genetics
Patrick J. Hu> ;Methods. 2014 Aug 1
76 citations
Comparative Metabolomics Reveals Endogenous Ligands of DAF-12, a Nuclear Hormone Receptor, Regulating C. elegans Development and Lifespan
Parag Mahanti, Neelanjan Bose, Axel Bethke, Joshua C. Judkins, Joshua Wollam, Kathleen J. Dumas, Anna M. Zimmerman, Sydney L. Campbell, Patrick J. Hu, Adam Antebi, Fra...> ;Cell Metabolism. 2014 Jan 7
313 citations
Insulin/insulin-like growth factor signaling in C. elegans.
Coleen T. Murphy, Patrick J. Hu> ;Wormbook. 2013 Dec 26
35 citations
TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans
Annabel A. Ferguson, Sudipa Saha Roy, Kaitlyn N. Kormanik, Yongsoon Kim, Kathleen J. Dumas, Vladimir B. Ritov, Dietrich Matern, Patrick J. Hu, Alfred L. Fisher> ;Plos Genetics. 2013 Dec 19
45 citations
Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation
Albert Tzong Yang Chen, Chunfang Guo, Kathleen J. Dumas, Kaveh Ashrafi, Patrick J. Hu> ;Aging Cell. 2013 Oct 1
12 citations
Unexpected Role for Dosage Compensation in the Control of Dauer Arrest, Insulin-Like Signaling, and FoxO Transcription Factor Activity in Caenorhabditis elegans
Kathleen J. Dumas, Colin Delaney, Stephane Flibotte, Donald G. Moerman, Györgyi Csankovszki, Patrick J. Hu> ;Genetics. 2013 Jul 1
18 citations
Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.
Kathleen J. Dumas, Chunfang Guo, Hung Jen Shih, Patrick J. Hu> ;G3. 2013 May 1
13 citations
Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis
Patrick J. Hu, Stewart M. Knoepp, Rong Wu, Kathleen R. Cho> ;Genes, Chromosomes & Cancer. 2012 Mar 1
11 citations
EAK proteins: novel conserved regulators of C. elegans lifespan.
Travis W. Williams, Kathleen J. Dumas, Patrick J. Hu> ;Aging. 2010 Oct 25
44 citations
EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity
Hena Alam, Travis W. Williams, Kathleen J. Dumas, Chunfang Guo, Sawako Yoshina, Shohei Mitani, Patrick J. Hu> ;Cell Metabolism. 2010 Jul 7
29 citations
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.
Kathleen J. Dumas, Chunfang Guo, Xi Wang, Kirk B. Burkhart, Elizabeth J. Adams, Hena Alam, Patrick J. Hu> ;Developmental Biology. 2010 Apr 15
1 citations
DANSing with Caenorhabditis elegans.
Patrick J. Hu, David H. Sherman> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 May 12
17 citations
Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.
Yanmei Zhang, Jinling Xu, Cristina Puscau, Yongsoon Kim, Xi Wang, Hena Alam, Patrick J. Hu> ;Developmental Biology. 2008 Mar 15
Dauer.
Patrick J Hu> ;Wormbook. 2007 Aug 8
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Journal Articles

Insulin/insulin-like growth factor signaling in C. elegans
Murphy CT, Hu PJ, Wormbook

Press Mentions

A Common Insulin Signaling Pathway Across Cancer and DiabetesDecember 4th, 2019

Grant Support

FoxO Phosphorylation in the Control of C. elegans Life SpanNational Institute on Aging2012–Present
EAK-7, a Novel Regulator of FoxO Tumor SuppressorsAmerican Cancer Society2010–Present
Genetic Modifiers of In Vivo Hypoxia ResistanceAmerican Heart Association2011–2012
Novel Regulators Of FOXO Transcription FactorsNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2009
Genetic Analysis Of DAF-18/PTEN Signaling In C.ElegansNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2006
Genetic Analysis Of DAF-18/PTEN Signaling In C.ElegansNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2004