WilliamPaoMD

PubMed

• 3 citations
  Catalyzing the field of precision oncology, one basket at a time.
  W. Pao, Imola K Fodor> ;Nature Medicine. 2018 Apr 10
• 55 citations
  Tissue-Specific Immunoregulation: A Call for Better Understanding of the “Immunostat” in the Context of Cancer
  W. Pao, Chia Huey Ooi, Fabian Birzele, Astrid Ruefli-Brasse, Michael A. Cannarile, Bernhard Reis, Sebastian H. Scharf, David A. Schubert, Klas Hatje, Nadege Pelletier,...> ;Cancer Discovery. 2018 Apr 1
• 199 citations
  Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors
  Sandra Ortiz-Cuaran, Matthias Scheffler, Dennis Plenker, llona Dahmen, Andreas H. Scheel, Lynnette Fernandez-Cuesta, Lydia Meder, Christine M. Lovly, Thorsten Persigeh...> ;Clinical Cancer Research. 2016 Oct 1
• 22 citations
  Twice weekly pulse and daily continuous-dose erlotinib as initial treatment for patients with epidermal growth factor receptor-mutant lung cancers and brain metastases.
  Kathryn C. Arbour, Mark G. Kris, Gregory J. Riely, Ai Ni, Kathryn Beal, Mariza Daras, Sara A. Hayes, Robert J. Young, Christopher R. Rodriguez, Linda Ahn, William Pao,...> ;Cancer. 2018 Jan 1
• 14 citations
  Continued use of afatinib with the addition of cetuximab after progression on afatinib in patients with EGFR mutation-positive non-small-cell lung cancer and acquired ...
  Leora Horn, Scott N. Gettinger, D. Ross Camidge, Egbert F. Smit, Yelena Y. Janjigian, Vincent A. Miller, William Pao, Matthias Freiwald, Jean Fan, Bushi Wang, Vikram K...> ;Lung Cancer. 2017 Nov 1
• 96 citations
  SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer.
  Eiki Ichihara, David Westover, Catherine B. Meador, Yingjun Yan, Joshua A. Bauer, Pengcheng Lu, Fei Ye, Amanda Kulick, Elisa de Stanchina, Robert McEwen, Marc Ladanyi,...> ;Cancer Research. 2017 Jun 1
• 18 citations
  Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors
  Dina Polosukhina, Harold D. Love, Hernan Correa, Zengliu Su, Kimberly B. Dahlman, William Pao, Harold L. Moses, Carlos L. Arteaga, Harold N. Lovvorn, Roy Zent, Peter E...> ;Molecular Oncology. 2017 Apr 1
• 37 citations
  Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies.
  Ryan J. Hartmaier, Jehad Charo, David Fabrizio, Michael E. Goldberg, Lee A. Albacker, W. Pao, Juliann Chmielecki> ;Genome Medicine. 2017 Feb 24
• 38 citations
  Phase 1 study of twice weekly pulse dose and daily low-dose erlotinib as initial treatment for patients with EGFR-mutant lung cancers.
  Helena A. Yu, C.S. Sima, Darren R. Feldman, Lin Liu, B. Vaitheesvaran, J. Cross, Charles M. Rudin, Mark G. Kris, William Pao, Franziska Michor, Gregory J. Riely> ;Annals of Oncology. 2017 Feb 1
• 21 citations
  AACR Cancer Progress Report 2016
  Nancy E. Davidson, Scott A. Armstrong, Lisa M. Coussens, Marcia Cruz-Correa, Ralph J. DeBerardinis, James H. Doroshow, Margaret Foti, Patrick Hwu, Thomas W. Kensler, M...> ;Clinical Cancer Research. 2016 Oct 1
• 5 citations
  CUSTOM-SEQ: a prototype for oncology rapid learning in a comprehensive EHR environment.
  Jeremy L. Warner, Lucy L. Wang, William Pao, Jeffrey A. Sosman, Ravi V. Atreya, Pam Carney, Mia A. Levy> ;Journal of the American Medical Informatics Association. 2016 Jul 1
• 60 citations
  Facilitating a culture of responsible and effective sharing of cancer genome data.
  Lillian L. Siu, Mark Lawler, David Haussler, Bartha Maria Knoppers, Jeremy Lewin, Daniel J. Vis, Rachel G. Liao, Fabrice Andre, Ian Banks, J. Carl Barrett, Carlos Cald...> ;Nature Medicine. 2016 May 5
• 79 citations
  MET Exon 14 Skipping in Non-Small Cell Lung Cancer
  Rebecca S. Heist, Hyo Sup Shim, Shalini Gingipally, Mari Mino-Kenudson, Long P. Le, Justin F. Gainor, Zongli Zheng, Martin J. Aryee, Junfeng Xia, Peilin Jia, Hailing J...> ;The Oncologist. 2016 Apr 1
• 50 citations
  JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.
  Sizhi P. Gao, Qing Chang, Ninghui Mao, Laura Daly, Robert Vogel, Tyler Chan, Shu Hui Liu, Eirini Bournazou, Erez Schori, Haiying Zhang, Monica Red Brewer, William Pao,...> ;Science Signaling. 2016 Mar 29
• 37 citations
  Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women
  Zhaoming Wang, Wei Jie Seow, Kouya Shiraishi, Chao A. Hsiung, Keitaro Matsuo, Jie Liu, Kexin Chen, Taiki Yamji, Yang Yang, I. Shou Chang, Chen Wu, Yun-Chul Hong, Lauri...> ;Human Molecular Genetics. 2016 Feb 1
• 74 citations
  EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
  Katherine R. Amato, Shan Wang, Li Tan, Andrew K. Hastings, Wenqiang Song, Christine M. Lovly, Catherine B. Meador, Fei Ye, Pengcheng Lu, Justin M. Balko, Daniel C. Col...> ;Cancer Research. 2016 Jan 15
• 33 citations
  Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma
  Valentina Pirazzoli, Deborah Ayeni, Catherine B. Meador, Basavaraju G. Sanganahalli, Fahmeed Hyder, Elisa de Stanchina, Sarah B. Goldberg, William Pao, Katerina Politi> ;Clinical Cancer Research. 2016 Jan 15
• 11 citations
  Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients.
  Lin Liu, Fei Li, William Pao, Franziska Michor> ;Plos One. 2015 Nov 4
• 119 citations
  Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types
  Joshua N. Sampson, William Wheeler, Meredith Yeager, Orestis A. Panagiotou, Zhaoming Wang, Sonja I. Berndt, Qing Lan, Christian C. Abnet, Laufey T. Amundadottir, Jonin...> ;Journal of the National Cancer Institute. 2015 Oct 12
• 9 citations
  ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma
  Katherine E. Hutchinson, Douglas B. Johnson, A. Johnson, Violeta Sanchez, Maria G. Kuba, Pengcheng Lu, Xi Chen, Mark C. Kelley, Qingguo Wang, Zhongming Zhao, Mark G. K...> ;Oncotarget. 2015 Jun 13
• 72 citations
  Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never‐smoking women in Asia: a report from the female lung...
  Mitchell J. Machiela, Chao A. Hsiung, Xiao-Ou Shu, Wei Jie Seow, Zhaoming Wang, Keitaro Matsuo, Yun-Chul Hong, Adeline Seow, Chen Wu, H. Dean Hosgood, Kexin Chen, Jiuc...> ;International Journal of Cancer. 2015 Jul 15
• 52 citations
  The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells
  Shannon M. Mumenthaler, Jasmine Foo, Nathan C. Choi, Nicholas Heise, Kevin Leder, David B. Agus, William Pao, Franziska Michor, Parag Mallick> ;Cancer Informatics. 2015 Jul 15
• 28 citations
  Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer
  Timothy D. O’Brien, Peilin Jia, Junfeng Xia, Uma Saxena, Hailing Jin, Huy Vuong, Pora Kim, Qingguo Wang, Martin J. Aryee, Mari Mino-Kenudson, Jeffrey A. Engelman, Long...> ;Methods. 2015 Jul 15
• 231 citations
  Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models
  Catherine Anne Eberlein, Daniel Stetson, Aleksandra Markovets, Katherine Al-Kadhimi, Zhongwu Lai, Paul R. Fisher, Catherine B. Meador, Paula J. Spitzler, Eiki Ichihara...> ;Cancer Research. 2015 Jun 15
• 29 citations
  NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor
  Elena Galvani, Jing Sun, Leticia G. Leon, Rocco Sciarrillo, Ravi S. Narayan, Robert Tjin Tham Sjin, Kwangho Lee, Kadoaki Ohashi, Daniëlle A.M. Heideman, Roberta Alfier...> ;Oncotarget. 2015 Apr 30
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