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Paul Spearman, MD, Pediatric Infectious Disease, Cincinnati, OH, Cincinnati Children's Hospital Medical Center

PaulWSpearmanMD

Pediatric Infectious Disease • Cincinnati, OH

Albert B. Sabin Professor and Director, Infectious Diseases, Cincinnati Children's Hospital

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Summary

  • Paul Spearman, MD is the Albert B. Sabin Professor and Director of Infectious Diseases at Cincinnati Children’s Hospital Medical Center. His laboratory studies fundamental aspects of HIV biology and develops new vaccines for human pathogens. HIV assembly processes are a major focus of the laboratory, including the trafficking of the HIV envelope glycoprotein and its interaction with essential host factors. A related project studies how HIV interacts with macrophages and microglia. Dr. Spearman and his colleagues in the CCHMC Vaccine and Treatment Evaluation Unit (VTEU) are engaged in the design and performance of clinical trials for new vaccines in adults and children, with a special interest in employing cutting-edge technologies to define innate and adaptive immune responses to vaccines. Dr. Spearman is currently leading trials for Ebola and RSV vaccine development.

    Dr. Spearman serves on the Board of Scientific Counselors for NCI, the Vaccines and Related Biological Products Advisory Committee for the FDA, and is Past President of the Pediatric Infectious Diseases Society (PIDS). Beyond his research interests, Dr. Spearman is a Pediatric ID clinician and enjoys caring for children and mentoring future leaders in Infectious Diseases.

Education & Training

  • Washington University/B-JH/SLCH Consortium
    Washington University/B-JH/SLCH ConsortiumFellowship, Infectious Disease, 1990 - 1994
  • Ohio State University Hospital
    Ohio State University HospitalResidency, Internal Medicine, 1986 - 1990
  • University of Texas Southwestern Medical School
    University of Texas Southwestern Medical SchoolClass of 1986

Certifications & Licensure

  • OH State Medical License
    OH State Medical License 1987 - 2026
  • IN State Medical License
    IN State Medical License 2021 - 2025
  • KY State Medical License
    KY State Medical License 2021 - 2024
  • GA State Medical License
    GA State Medical License 2005 - 2017
  • TN State Medical License
    TN State Medical License 1994 - 2007
  • American Board of Internal Medicine Infectious Disease
  • American Board of Pediatrics Pediatric Infectious Diseases

Awards, Honors, & Recognition

  • Fellow, Pediatric Infectious Diseases Society (FPIDS) Pediatric Infectious Diseases Society
  • Fellow, Infectious Diseases Society of America (FIDSA) Infectious Diseases Society of America
  • Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Publications & Presentations

PubMed

Press Mentions

  • HIV Status Has No Place in Border Patrol Policy
    HIV Status Has No Place in Border Patrol PolicyJuly 29th, 2019
  • Possible Link Between Virus and Acute Flaccid Myelitis, the 'Polio-Like' Disease
    Possible Link Between Virus and Acute Flaccid Myelitis, the 'Polio-Like' DiseaseApril 29th, 2019
  • US Researchers Look for Long-Lasting Ebola Vaccine
    US Researchers Look for Long-Lasting Ebola VaccineFebruary 1st, 2019
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Grant Support

  • Role Of Vpu In Retroviral Particle AssemblyNational Institute Of Allergy And Infectious Diseases2006–2012
  • Viral And Cellullar Determinants Of HIV-1 AssemblyNational Institute Of Allergy And Infectious Diseases2010
  • Defining Neutralization Breadth In HIV+ Human SerumNational Institute Of Allergy And Infectious Diseases2009–2010
  • Virology CoreNational Institute Of Allergy And Infectious Diseases2006–2010
  • FEI Transmission Electron Microscope With Tomography CapabilityNational Center For Research Resources2009
  • Viral And Cellular Determinants Of HIV-1 AssemblyNational Institute Of Allergy And Infectious Diseases2005–2009
  • Pseudovirion Formation By Live Vector HIV VaccinesNational Institute Of Allergy And Infectious Diseases2006–2007
  • Novel Assays For Inhibitors Of HIV AssemblyNational Institute Of Allergy And Infectious Diseases2005–2007
  • Development Of Enhanced HIV-1 Pseudovirion VaccinesNational Institute Of Allergy And Infectious Diseases2005–2006
  • Normal Volunteer Blood DonationNational Center For Research Resources2005–2006
  • A Probe Study Of The Safety, Tolerability, And Immunogenicity Of Human ImmunoNational Center For Research Resources2005–2006
  • A Probe Study Of The Safety, Tolerability And Immunogenicity Of A Three-DoseNational Center For Research Resources2005–2006
  • A Phase I Safety And Immunogenicity Trial Of An Alphavirus Replicon HIV SubtyNational Center For Research Resources2005–2006
  • Novel Assays For Inhibitors Of HIV AssemblyNational Institute Of Allergy And Infectious Diseases2005
  • A Phase I Dose-Ranging Study Of The Safety, Tolerability, And ImmunogencityNational Center For Research Resources2005
  • Role Of Vpu In Retroviral Particle AssemblyNational Institute Of Allergy And Infectious Diseases2004–2005
  • Development Of Pooled HIV Positive SERA For Basic Investigations Into HIV BIONational Center For Research Resources2004–2005
  • Development Of Enhanced HIV-1 Pseudovirion VaccinesNational Institute Of Allergy And Infectious Diseases2002–2005
  • Viral And Cellular Determinants Of HIV-1 AssemblyNational Institute Of Allergy And Infectious Diseases2001–2005
  • Normal Volunteer Blood Donation .National Center For Research Resources2004
  • A Probe Study Of The Safety, Tolerability And Immunogenicity Of A Three-Dose...National Center For Research Resources2004
  • A Phase I Safety And Immunogenicity Trial Of An Alphavirus Replicon HIV Subty...National Center For Research Resources2004
  • Novel Fret-Based Assays For HIV Assembly InhibitorsNational Institute Of Allergy And Infectious Diseases2003–2004
  • Membrane Binding And Transport Of HIV1 PR55National Institute Of Allergy And Infectious Diseases1997–2001
  • Induction Of KSHV Replication By HIV 1National Cancer Institute2000
  • Development Of Enhanced HIV 1 Pseudovirion VaccinesNational Institute Of Allergy And Infectious Diseases1999–2000

Professional Memberships

Hospital Affiliations

Dr. Paul Spearman, Dr. Paul Spearman, MD, Dr. P Spearman, Dr. Paul W Spearman