PaulaNSilvermanMD

Oncology • Cleveland, OH

Associate Professor, Medicine, Case Western Reserve University School of Medicine

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Office
11100 Euclid Ave
Cleveland, OH 44106
Phone+1 216-844-8500
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Education & Training

Case Western Reserve University/University Hospitals Cleveland Medical CenterFellowship, Hematology and Medical Oncology, 1984 - 1988
Case Western Reserve University/University Hospitals Cleveland Medical CenterResidency, Internal Medicine, 1981 - 1984
Case Western Reserve University School of MedicineClass of 1981

Certifications & Licensure

OH State Medical License 1984 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Top MD Consumers Checkbook

Clinical Trials

Paclitaxel Plus Radiation Therapy in Treating Women With Stage II or Stage III Breast Cancer Start of enrollment: 2000 Jun 08
Completed
Phase 2
Phase II Bevacizumab + Tax In Advanced Breast Cancer Start of enrollment: 2001 Nov 01
Completed
Phase 2
Monoclonal Antibody Compared With Zoledronate in Treating Women With Breast Cancer and Bone Metastases Start of enrollment: 2002 Nov 01
Completed
Phase 1, Phase 2
Vinorelbine and Celecoxib in Treating Women With Relapsed or Metastatic Breast Cancer Start of enrollment: 2003 Nov 01
Terminated
Phase 1
PARP Inhibition for Triple Negative Breast Cancer (ER-/PR-/HER2-)With BRCA1/2 Mutations Start of enrollment: 2010 Feb 01
Completed
Phase 2
Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast Cancer Start of enrollment: 2011 Jan 07
Completed
Phase 2
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer Start of enrollment: 2013 Oct 22
Active, not recruiting
Phase 1, Phase 2
Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Metastatic or Locally Advanced Breast Cancer Start of enrollment: 2014 May 01
Completed
Phase 2
Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate Start of enrollment: 2015 Nov 17
Completed
Phase 2
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Publications & Presentations

PubMed

64 citations
Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (EA2108).
Seema A Khan, Fengmin Zhao, Lori J Goldstein, David Cella, Mark Basik, Mehra Golshan, Thomas B Julian, Barbara A Pockaj, Christine A Lee, Wajeeha Razaq, Joseph A Spara...> ;Journal of Clinical Oncology. 2022 Mar 20
5 citations
Biosimilar strategic implementation at a large health system.
Indrani Kar, Margaret Kronz, Evelina Kolychev, Paula Silverman, Prateek Mendiratta, Benjamin Tomlinson, Jeremy Prunty, Melissa Copley, Seema Patel, Sara Caudill, Lisa ...> ;American Journal of Health-System Pharmacy. 2021 Nov 9
2 citations
Neratinib + capecitabine sustains health-related quality of life in patients with HER2-positive metastatic breast cancer and ≥ 2 prior HER2-directed regimens
Beverly Moy, Mafalda Oliveira, Cristina Saura, William J. Gradishar, Sung Bae Kim, Adam Brufsky, Sara A. Hurvitz, Larisa Ryvo, Daniele Fagnani, Sujith Kalmadi, Paula S...> ;Breast Cancer Research and Treatment. 2021 Apr 28
8 citations
Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast Cancer.
Bora Lim, David Potter, Mohamad Adham Salkeni, Paula Silverman, Tufia C. Haddad, Frédéric Forget, Ahmad Awada, Jean-Luc Canon, Michael Danso, Alain Lortholary, Hugues ...> ;Clinical Cancer Research. 2021 Apr 5
16 citations
Cisplatin +/- rucaparib after preoperative chemotherapy in patients with triple-negative or BRCA mutated breast cancer.
Maitri Kalra, Yan Tong, David R. Jones, Thomas J. Walsh, Michael A. Danso, Cynthia X. Ma, Paula Silverman, Mary Claire King, Sunil Badve, Susan M. Perkins, Kathy D. Mi...> ;NPJ Breast Cancer. 2021 Mar 22
2 citations
Oral GnRH Antagonist Ovarian Suppression After Escape From GnRH Agonist in Breast Cancer Patients.
Kathryn Coyne, Paula Silverman, James H. Liu> ;Clinical Breast Cancer. 2020 May 26
2 citations
Feasibility of a team based prognosis and treatment goal discussion (T-PAT) with women diagnosed with advanced breast cancer.
Mary M. Step, Gretchen A. Ferber, Catherine Downs-Holmes, Paula Silverman> ;Patient Education and Counseling. 2019 Jan 1
98 citations
Survivorship, Version 2.2018: Clinical Practice Guidelines in Oncology
Crystal S. Denlinger, Tara Sanft, K. Scott Baker, Gregory A. Broderick, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Melissa M. Hudson, Nazanin Khakpour,...> ;Journal of the National Comprehensive Cancer Network. 2018 Oct 1
27 citations
Clinicopathological, immunohistochemical and molecular correlation of neural crest transcription factor SOX10 expression in triple-negative breast carcinoma
Aparna Harbhajanka, Satyapal Chahar, Kristy Miskimen, Paula Silverman, Lyndsay Harris, Nicole Williams, Vinay Varadan, Hannah Gilmore> ;Human Pathology. 2018 Jun 9
A breast multi-disciplinary genomic tumor board is feasible and can provide timely and impactful recommendations.
Karen Tsung, Cheryl L. Thompson, Joy Knight, Steve Maximuk, Navid Sadri, Hannah Gilmore, Ruth A. Keri, Shaveta Vinayak, Lyndsay Harris, Paula Silverman> ;The Breast Journal. 2018 Mar 8
364 citations
Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3...
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,...> ;The Lancet. Oncology. 2017 Dec 1
68 citations
Survivorship, Version 2.2017: Clinical practice guidelines in oncology
Crystal S. Denlinger, Tara Sanft, K. Scott Baker, Shrujal S. Baxi, Gregory A. Broderick, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Melissa M. Hudson, ...> ;Journal of the National Comprehensive Cancer Network. 2017 Sep 1
203 citations
Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American Co...
Matthew J. Ellis, Vera J. Suman, Jeremy Hoog, Rodrigo Franco Gonçalves, Souzan Sanati, Chad J. Creighton, Katherine DeSchryver, Erika C. Crouch, Amy Brink, Mark A. Wat...> ;Journal of Clinical Oncology. 2017 Apr 1
1 citations
Understanding age and race disparities in the application of sentinel lymph node biopsy in breast cancer
Archana Radhakrishnan, Paula Silverman, Craig Evan Pollack, Elizabeth R. Pfoh, Robert Shenk, Cheryl L. Thompson> ;Journal of Investigative Medicine. 2016 Dec 1
13 citations
"A rising tide lifts all boats": establishing a multidisciplinary genomic tumor board for breast cancer patients with advanced disease.
Michelle L. McGowan, Roselle Ponsaran, Paula Silverman, Lyndsay Harris, Patricia A. Marshall> ;BMC Medical Genomics. 2016 Nov 21
69 citations
NCCN guidelines® insights survivorship, version 1.2016 featured updates to the NCCN Guidelines
Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Gregory A. Broderick, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Lee W. Jones, ...> ;Journal of the National Comprehensive Cancer Network. 2016 Jun 1
28 citations
Predictors of late-onset heart failure in breast cancer patients treated with doxorubicin
Angel Qin, Cheryl L. Thompson, Paula Silverman> ;Journal of Cancer Survivorship. 2015 Jun 1
15 citations
Differences between nurse practitioner and physician care providers on rates of secondary cancer screening and discussion of lifestyle changes among breast cancer surv...
Tiffany C. Kenison, Paula Silverman, Marla Sustin, Cheryl L. Thompson> ;Journal of Cancer Survivorship. 2015 Jun 1
26 citations
Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors
Steven T. Sizemore, Gina M. Sizemore, Christine N. Booth, Cheryl L. Thompson, Paula Silverman, Gurkan Bebek, Fadi W. Abdul-Karim, Stephanie Avril, Ruth A. Keri> ;Breast Cancer Research and Treatment. 2014 May 22
17 citations
Neglecting to Screen Women Between the Ages of 40 and 49 Years With Mammography: What Is the Impact on Breast Cancer Diagnosis?
Mallory E. Kremer, Catherine Downs-Holmes, Ronald D. Novak, Janice A. Lyons, Paula Silverman, Ramya Pham, Donna Plecha> ;AJR. American Journal of Roentgenology. 2012 Nov 23
49 citations
A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer
Elaina M. Gartner, Paula Silverman, Michael S. Simon, Lawrence E. Flaherty, Judith Abrams, Percy Ivy, Patricia LoRusso> ;Breast Cancer Research and Treatment. 2012 Feb 1
10 citations
A Phase II Study of Radiotherapy and Concurrent Paclitaxel Chemotherapy in Breast-Conserving Treatment for Node-Positive Breast Cancer
William C. Chen, Janice N. Kim, Edward Y. Kim, Paula Silverman, Beth Overmoyer, Brenda W. Cooper, Sue Anthony, Robert Shenk, R. Leeming, Shelli H. Hanks, Janice A. Lyons> ;International Journal of Radiation Oncology, Biology, Physics. 2012 Jan 1
30 citations
Breast cancer: overview & updates.
Catherine Downs-Holmes, Paula Silverman> ;The Nurse Practitioner. 2011 Dec 16
3 citations
Emerging radiation techniques for early-stage breast cancer after breast-conserving surgery.
J. Lyons, Charles Woods, Nicholas Galanopoulos, Paula Silverman> ;Future Oncology. 2011 Jul 6
215 citations
Lower-Dose vs High-Dose Oral Estradiol Therapy of Hormone Receptor-Positive, Aromatase Inhibitor-Resistant Advanced Breast Cancer: A Phase 2 Randomized Study
Matthew J. Ellis, Feng Gao, Farrokh Dehdashti, Donna B. Jeffe, P. Kelly Marcom, Lisa A. Carey, Maura N. Dickler, Paula Silverman, Gini F. Fleming, Aruna Kommareddy, Sh...> ;JAMA. 2009 Aug 19
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Hospital Affiliations

University Hospitals Cleveland Medical CenterCleveland, Ohio
University Hospitals Geauga Medical CenterChardon, Ohio