RaymondEdwardSoccioMDPhD

Endocrinology • Philadelphia, PA

Diabetes, Lipid Metabolism

Assistant Professor of Medicine

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Office
3400 Civic Center Blvd
Smilow Center for Translational Research, 12th Floor
Philadelphia, PA 19104
Phone+1 215-823-5800
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Education & Training

University of Pennsylvania Health SystemFellowship, Endocrinology, Diabetes, and Metabolism, 2007 - 2011
University of Pennsylvania Health SystemResidency, Internal Medicine, 2005 - 2007
Weill Cornell MedicineClass of 2005

Certifications & Licensure

PA State Medical License 2005 - 2024
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Publications & Presentations

PubMed

Phosphorylated MED1 links transcription recycling and cancer growth.
Zhong Chen, Zhenqing Ye, Raymond E Soccio, Tomoyoshi Nakadai, William Hankey, Yue Zhao, Furong Huang, Fuwen Yuan, Hongyan Wang, Zhifen Cui, Benjamin Sunkel, Dayong Wu,...> ;Nucleic Acids Research. 2022 May 6
2 citations
Galectin-3 in NAFLD: Therapeutic Target or Noncausal Biomarker?
Raymond E. Soccio> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Aug 18
3 citations
Pparγ1 Facilitates ErbB2-Mammary Adenocarcinoma in Mice.
Xuanmao Jiao, Lifeng Tian, Zhao Zhang, Joanna Balcerek, Andrew V. Kossenkov, Mathew C. Casimiro, Chenguang Wang, Yichuan Liu, Adam Ertel, Raymond E. Soccio, Qin Liu, A...> ;Cancers. 2021 Apr 30
56 citations
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Olivia Sveidahl Johansen, Tao Ma, Jakob Bondo Hansen, Lasse K. Markussen, Renate Schreiber, Laia Reverte-Salisa, Hua Dong, Dan Ploug Christensen, Wenfei Sun, Thorsten ...> ;Cell. 2021 Jun 24
10 citations
ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice
Xin Bi, Takashi Kuwano, Paul C. Lee, John S. Millar, Li Li, Yachen Shen, Raymond E. Soccio, Nicholas J. Hand, Daniel J. Rader> ;Circulation Research. 2020 Nov 6
23 citations
Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function
Yachen Shen, Yvonne Su, Francisco J. Silva, Angela H. Weller, Jaimarie Sostre-Colón, Paul M. Titchenell, David J. Steger, Patrick Seale, Raymond E. Soccio> ;Cell Reports. 2020 Mar 3
27 citations
Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene
Kiara K. Benson, Wenxiang Hu, Angela H. Weller, Alexis H. Bennett, Eric Chen, Sumeet A. Khetarpal, Satoshi Yoshino, William P. Bone, Lin Wang, Joshua D. Rabinowitz, Be...> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Nov 12
25 citations
Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response
Wenxiang Hu, Chunjie Jiang, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J. F. Loos, Cheng Hu, Weiping Jia, R...> ;Cell Stem Cell. 2019 Feb 7
39 citations
Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of linc-ADAL in adipocyte metabolism.
Xuan Zhang, Chenyi Xue, Jennie Lin, Jane F. Ferguson, Amber K. Weiner, Wen Liu, Yumiao Han, Christine C. Hinkle, Wenjun Li, Hongfeng Jiang, Sager J. Gosai, Melanie Hac...> ;Science Translational Medicine. 2018 Jun 20
5 citations
Heterozygous Deletion Impacting SMARCAD1 in the Original Kindred with Absent Dermatoglyphs and Associated Features (Baird, 1964).
Xiao Chang, Dong Li, Lifeng Tian, Yichuan Liu, Michael E. March, Tiancheng Wang, Cuiping Hou, Richard J. Levy, Melinda Jen, Raymond E. Soccio, Patrick M. A. Sleiman, H...> ;The Journal of Pediatrics. 2017 Dec 18
32 citations
Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice
Raymond E. Soccio, Zhenghui Li, Eric Chen, Yee Hoon Foong, Kiara K. Benson, Joanna R. DiSpirito, Shannon E. Mullican, Matthew J. Emmett, Erika R. Briggs, Lindsey C. Pe...> ;The Journal of Clinical Investigation. 2017 Apr 3
79 citations
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity
Xin Luo, Keun Woo Ryu, Dae-Seok Kim, Tulip Nandu, Carlos J. Medina, Rebecca Gupte, Bryan A. Gibson, Raymond E. Soccio, Yonghao Yu, Rana K. Gupta, W. Lee Kraus> ;Molecular Cell. 2017 Jan 19
95 citations
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo.
Raymond E. Soccio, Eric Chen, Satyajit R. Rajapurkar, Pegah Safabakhsh, Jill M. Marinis, Joanna R. DiSpirito, Matthew J. Emmett, Erika R. Briggs, Bin Fang, Logan J. Ev...> ;Cell. 2015 Jul 2
220 citations
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Yuxiang Zhang, Bin Fang, Matthew J. Emmett, Manashree Damle, Zheng Sun, Dan Feng, Sean M. Armour, Jarrett R. Remsberg, Jennifer Jager, Raymond E. Soccio, David J. Steg...> ;Science. 2015 Jun 26
331 citations
Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes.
Raymond E. Soccio, Eric Chen, Mitchell A. Lazar> ;Cell Metabolism. 2014 Oct 7
28 citations
Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells
Lifeng Tian, Chenguang Wang, Fred K. Hagen, Michael Gormley, Sankar Addya, Raymond E. Soccio, Mathew C. Casimiro, Jie Zhou, Michael J. Powell, Ping Xu, Haiteng Deng, A...> ;Oncotarget. 2014 Aug 20
50 citations
Species-specific strategies underlying conserved functions of metabolic transcription factors.
Raymond E. Soccio, Geetu Tuteja, Logan J. Everett, Zhaoyu Li, Mitchell A. Lazar, Klaus H. Kaestner> ;Molecular Endocrinology. 2011 Feb 3
53 citations
Clinical, Genetic, and Functional Characterization of Four Patients Carrying Partial Loss-of-Function Mutations in the Steroidogenic Acute Regulatory Protein (StAR)
Taninee Sahakitrungruang, Raymond E. Soccio, Mariarosaria Lang-Muritano, Joanna Walker, John C. Achermann, Walter L. Miller> ;The Journal of Clinical Endocrinology and Metabolism. 2010 Jul 1
87 citations
Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endo...
Raymond E. Soccio, Rachel M. Adams, Kara N. Maxwell, Jan L. Breslow> ;The Journal of Biological Chemistry. 2005 May 13
248 citations
Intracellular Cholesterol Transport
Raymond E. Soccio, Jan L. Breslow> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 Jul 1
28 citations
Cholesterol feeding of mice expressing cholesterol 7α-hydroxylase increases bile acid pool size despite decreased enzyme activity
Michaela Tiemann, Zhihua Han, Raymond E. Soccio, Jaya Bollineni, Sarah Shefer, Ephraim Sehayek, Jan L. Breslow> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 Feb 17
23 citations
Effects of Simvastatin on Plasma Lipoproteins and Response to Arterial Injury in Wild-Type and Apolipoprotein-E-Deficient Mice
Robin P. Choudhury, Angela L. Carrelli, Joshua Stern, Igor Chereshnev, Raymond Soccio, Valerie I. Elmalem, John T. Fallon, Edward A. Fisher, Ernane D. Reis> ;Journal of Vascular Research. 2004 Jan 1
295 citations
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
Kara N. Maxwell, Raymond E. Soccio, Elizabeth M. Duncan, Ephraim Sehayek, Jan L. Breslow> ;Journal of Lipid Research. 2003 Nov 1
232 citations
StAR-related lipid transfer (START) proteins: mediators of intracellular lipid metabolism.
Raymond E. Soccio, Jan L. Breslow> ;The Journal of Biological Chemistry. 2003 Jun 20
130 citations
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain
Michael J. Romanowski, Raymond E. Soccio, Jan L. Breslow, Stephen K. Burley> ;Proceedings of the National Academy of Sciences of the United States of America. 2002 May 14
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